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Aliases for BTG1 Gene

Aliases for BTG1 Gene

  • B-Cell Translocation Gene 1, Anti-Proliferative 2 3
  • B-Cell Translocation Gene 1 Protein 4

External Ids for BTG1 Gene

Previous GeneCards Identifiers for BTG1 Gene

  • GC12M091929
  • GC12M092827
  • GC12M092469
  • GC12M091039
  • GC12M089601

Summaries for BTG1 Gene

Entrez Gene Summary for BTG1 Gene

  • This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]

GeneCards Summary for BTG1 Gene

BTG1 (B-Cell Translocation Gene 1, Anti-Proliferative) is a Protein Coding gene. Diseases associated with BTG1 include chronic lymphocytic leukemia. Among its related pathways are Diurnally regulated genes with circadian orthologs and Deadenylation-dependent mRNA decay. GO annotations related to this gene include enzyme binding and kinase binding. An important paralog of this gene is TOB1.

UniProtKB/Swiss-Prot for BTG1 Gene

  • Anti-proliferative protein.

Gene Wiki entry for BTG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTG1 Gene

Genomics for BTG1 Gene

Regulatory Elements for BTG1 Gene

Transcription factor binding sites by QIAGEN in the BTG1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BTG1 Gene

92,140,278 bp from pter
92,145,897 bp from pter
5,620 bases
Minus strand

Genomic View for BTG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG1 Gene

Proteins for BTG1 Gene

  • Protein details for BTG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein BTG1
    Protein Accession:
    Secondary Accessions:
    • P31607

    Protein attributes for BTG1 Gene

    171 amino acids
    Molecular mass:
    19209 Da
    Quaternary structure:
    • Interacts with CNOT7 and CNOT8.

neXtProt entry for BTG1 Gene

Proteomics data for BTG1 Gene at MOPED

Post-translational modifications for BTG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BTG1 Gene

Domains for BTG1 Gene

Protein Domains for BTG1 Gene


Graphical View of Domain Structure for InterPro Entry



  • P62324
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG1: view

No data available for Gene Families for BTG1 Gene

Function for BTG1 Gene

Molecular function for BTG1 Gene

GENATLAS Biochemistry: B cell translocation gene 1,widely expressed except in brain and muscle,maximally expressed in the G0/G1 phases of the cell cycle,involved in B cell lymphocytic leukemia with translocation t(8;12)(q24;q22),negative regulator of cell proliferation (antiproliferative),putative tumor suppressor gene,Tob/BTG1 family
UniProtKB/Swiss-Prot Function: Anti-proliferative protein.

Gene Ontology (GO) - Molecular Function for BTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity NAS 11420681
GO:0005515 protein binding IPI 10617598
GO:0019899 enzyme binding IPI 8663146
GO:0019900 kinase binding NAS 9820826
genes like me logo Genes that share ontologies with BTG1: view

Animal Model Products

CRISPR Products

miRNA for BTG1 Gene

miRTarBase miRNAs that target BTG1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BTG1 Gene

Localization for BTG1 Gene

Subcellular locations from

Jensen Localization Image for BTG1 Gene COMPARTMENTS Subcellular localization image for BTG1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 11420681
GO:0005737 cytoplasm IMP 11420681
genes like me logo Genes that share ontologies with BTG1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BTG1 Gene

Pathways for BTG1 Gene

genes like me logo Genes that share pathways with BTG1: view

Pathways by source for BTG1 Gene

1 Qiagen pathway for BTG1 Gene
1 BioSystems pathway for BTG1 Gene
1 KEGG pathway for BTG1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 11420681
GO:0008285 negative regulation of cell proliferation IDA 11420681
GO:0016477 cell migration NAS 15033446
GO:0030308 negative regulation of cell growth NAS 15033446
GO:0045603 positive regulation of endothelial cell differentiation IMP 15033446
genes like me logo Genes that share ontologies with BTG1: view

Compounds for BTG1 Gene

(2) Novoseek inferred chemical compound relationships for BTG1 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 27.4 4
arginine 5.39 1
genes like me logo Genes that share compounds with BTG1: view

Transcripts for BTG1 Gene

mRNA/cDNA for BTG1 Gene

(1028) Selected AceView cDNA sequences:
(11) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTG1 Gene

B-cell translocation gene 1, anti-proliferative:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTG1 Gene

No ASD Table

Relevant External Links for BTG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTG1 Gene

mRNA expression in normal human tissues for BTG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTG1 Gene

This gene is overexpressed in Whole Blood (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BTG1 Gene

SOURCE GeneReport for Unigene cluster for BTG1 Gene Hs.255935

genes like me logo Genes that share expressions with BTG1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for BTG1 Gene

Orthologs for BTG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTG1 35
  • 100 (n)
  • 100 (a)
BTG1 36
  • 100 (a)
(Bos Taurus)
Mammalia BTG1 35
  • 96.3 (n)
  • 99.42 (a)
BTG1 36
  • 99 (a)
(Canis familiaris)
Mammalia BTG1 36
  • 86 (a)
(Mus musculus)
Mammalia 4930430D24Rik 36
  • 83 (a)
4930525M21RIK 36
  • 85 (a)
Btg1 35
  • 96.88 (n)
  • 100 (a)
Btg1 16
Btg1 36
  • 100 (a)
(Monodelphis domestica)
Mammalia BTG1 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Btg1 35
  • 96.3 (n)
  • 99.42 (a)
(Gallus gallus)
Aves BTG1 35
  • 91.12 (n)
  • 93.49 (a)
BTG1 36
  • 93 (a)
(Anolis carolinensis)
Reptilia BTG1 36
  • 89 (a)
African clawed frog
(Xenopus laevis)
Amphibia btg1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia btg1 35
  • 74.16 (n)
  • 77.51 (a)
MGC75680 35
(Danio rerio)
Actinopterygii btg1 35
  • 70.63 (n)
  • 73.81 (a)
btg1 36
  • 65 (a)
wufb14h05 35
fruit fly
(Drosophila melanogaster)
Insecta Tob 36
  • 9 (a)
Species with no ortholog for BTG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG1 Gene

Gene Tree for BTG1 (if available)
Gene Tree for BTG1 (if available)

Paralogs for BTG1 Gene

Paralogs for BTG1 Gene

Selected SIMAP similar genes for BTG1 Gene using alignment to 3 proteins: Pseudogenes for BTG1 Gene

genes like me logo Genes that share paralogs with BTG1: view

Variants for BTG1 Gene

Sequence variations from dbSNP and Humsavar for BTG1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs374368981 -- 92,144,679(+) TTGAG(A/C)CGCCA intron-variant
VAR_021345 -
VAR_021346 -

Structural Variations from Database of Genomic Variants (DGV) for BTG1 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
dgv1480n71 CNV Loss 21882294
nsv899434 CNV Loss 21882294
nsv899436 CNV Loss 21882294

Relevant External Links for BTG1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTG1 Gene

Disorders for BTG1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BTG1 Gene including...

Search for BTG1 Gene in MalaCards »


  • Note=A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.

(3) Novoseek inferred disease relationships for BTG1 Gene

Disease -log(P) Hits PubMed IDs
leukaemia lymphocytic 38.7 1
breast cancer 0 3
cancer 0 1

Relevant External Links for BTG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BTG1: view

Publications for BTG1 Gene

  1. BTG1, a member of a new family of antiproliferative genes. (PMID: 1373383) Rouault J.-P. … Magaud J.-P. (EMBO J. 1992) 3 4 23
  2. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. (PMID: 11136725) Prevot D. … Corbo L. (J. Biol. Chem. 2001) 3 4 23
  3. An anti-proliferative gene BTG1 regulates angiogenesis in vitro. (PMID: 15033446) Iwai K. … Yokoyama M. (Biochem. Biophys. Res. Commun. 2004) 2 3 23
  4. Genetic association between polymorphisms in the BTG1 gene and multiple sclerosis. (PMID: 19515430) CamiA+a-Tato M. … Comabella M. (J. Neuroimmunol. 2009) 3 23 48
  5. Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex. (PMID: 9712883) Rouault J.P. … Corbo L. (J. Biol. Chem. 1998) 3 4

Products for BTG1 Gene

Sources for BTG1 Gene

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