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Aliases for ZEB1 Gene

Aliases for ZEB1 Gene

  • Zinc Finger E-Box Binding Homeobox 1 2 3
  • Transcription Factor 8 (Represses Interleukin 2 Expression) 2 3
  • Posterior Polymorphous Corneal Dystrophy 3 2 3
  • Negative Regulator Of IL2 3 4
  • AREB6 3 4
  • TCF8 3 4
  • Zinc Finger Homeodomain Enhancer-Binding Protein 3
  • Delta-Crystallin Enhancer Binding Factor 1 3
  • NIL-2-A Zinc Finger Protein 4
  • Transcription Factor 8 4
  • DELTAEF1 3
  • ZFHX1A 3
  • FECD6 3
  • NIL2A 3
  • ZFHEP 3
  • PPCD3 3
  • TCF-8 4
  • BZP 3

External Ids for ZEB1 Gene

Previous HGNC Symbols for ZEB1 Gene

  • TCF8
  • PPCD3

Previous GeneCards Identifiers for ZEB1 Gene

  • GC10P031648

Summaries for ZEB1 Gene

Entrez Gene Summary for ZEB1 Gene

  • This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]

GeneCards Summary for ZEB1 Gene

ZEB1 (Zinc Finger E-Box Binding Homeobox 1) is a Protein Coding gene. Diseases associated with ZEB1 include corneal dystrophy, posterior polymorphous, 3 and corneal dystrophy, fuchs endothelial, 6. Among its related pathways are PAK Pathway and TGF-Beta Pathway. GO annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is ZNF324.

UniProtKB/Swiss-Prot for ZEB1 Gene

  • Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5-CANNTG-3). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Gene Wiki entry for ZEB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZEB1 Gene

Genomics for ZEB1 Gene

Regulatory Elements for ZEB1 Gene

Transcription factor binding sites by QIAGEN in the ZEB1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZEB1 Gene

Chromosome:
10
Start:
31,318,495 bp from pter
End:
31,529,814 bp from pter
Size:
211,320 bases
Orientation:
Plus strand

Genomic View for ZEB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZEB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZEB1 Gene

Proteins for ZEB1 Gene

  • Protein details for ZEB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37275-ZEB1_HUMAN
    Recommended name:
    Zinc finger E-box-binding homeobox 1
    Protein Accession:
    P37275
    Secondary Accessions:
    • B4DJV0
    • B4DUW9
    • E9PCM7
    • F5H4I8
    • Q12924
    • Q13800
    • Q2KJ05
    • Q5T968
    • Q5VZ84
    • Q8NB68

    Protein attributes for ZEB1 Gene

    Size:
    1124 amino acids
    Molecular mass:
    124074 Da
    Quaternary structure:
    • Interacts (via N-terminus) with SMARCA4/BRG1.
    SequenceCaution:
    • Sequence=BAG62481.1; Type=Frameshift; Positions=177; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZEB1 Gene

    Alternative splice isoforms for ZEB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZEB1 Gene

Proteomics data for ZEB1 Gene at MOPED

Post-translational modifications for ZEB1 Gene

  • Ubiquitination at Lys 195
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ZEB1 (TCF8)

No data available for DME Specific Peptides for ZEB1 Gene

Domains & Families for ZEB1 Gene

Graphical View of Domain Structure for InterPro Entry

P37275

UniProtKB/Swiss-Prot:

ZEB1_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
  • Contains 7 C2H2-type zinc fingers.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZEB1: view

Function for ZEB1 Gene

Molecular function for ZEB1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5-CANNTG-3). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Gene Ontology (GO) - Molecular Function for ZEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 23814079
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 8138542
genes like me logo Genes that share ontologies with ZEB1: view
genes like me logo Genes that share phenotypes with ZEB1: view

Animal Models for ZEB1 Gene

MGI Knock Outs for ZEB1:

Animal Model Products

Transcription Factor Targets for ZEB1 Gene

Selected GeneGlobe predicted Target genes for ZEB1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZEB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for ZEB1 Gene

Localization for ZEB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZEB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZEB1 Gene COMPARTMENTS Subcellular localization image for ZEB1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ZEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20418909
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZEB1: view

Pathways & Interactions for ZEB1 Gene

genes like me logo Genes that share pathways with ZEB1: view

Pathways by source for ZEB1 Gene

1 Cell Signaling Technology pathway for ZEB1 Gene
2 BioSystems pathways for ZEB1 Gene
1 PharmGKB pathway for ZEB1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epithelial to Mesenchymal Transition (EMT) in human,mouse,rat
    • T Helper Cell Differentiation in human,mouse,rat

SIGNOR curated interactions for ZEB1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ZEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 23814079
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8138542
GO:0006955 immune response TAS 1840704
GO:0007389 pattern specification process IEA --
genes like me logo Genes that share ontologies with ZEB1: view

Drugs & Compounds for ZEB1 Gene

(2) Drugs for ZEB1 Gene - From: NovoSeek, HMDB, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
vitamin d Pharma 1463
genes like me logo Genes that share compounds with ZEB1: view

Transcripts for ZEB1 Gene

Unigene Clusters for ZEB1 Gene

Zinc finger E-box binding homeobox 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZEB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZEB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - -
SP6:

Relevant External Links for ZEB1 Gene

GeneLoc Exon Structure for
ZEB1
ECgene alternative splicing isoforms for
ZEB1

Expression for ZEB1 Gene

mRNA expression in normal human tissues for ZEB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZEB1 Gene

This gene is overexpressed in Rectum (32.4), Fetal gut (10.1), Fetal Brain (9.1), Liver (8.9), and Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZEB1 Gene



SOURCE GeneReport for Unigene cluster for ZEB1 Gene Hs.124503

mRNA Expression by UniProt/SwissProt for ZEB1 Gene

P37275-ZEB1_HUMAN
Tissue specificity: Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.
genes like me logo Genes that share expression patterns with ZEB1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZEB1 Gene

Orthologs for ZEB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZEB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZEB1 35
  • 87.55 (n)
  • 92.28 (a)
ZEB1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZEB1 35
  • 93.5 (n)
  • 94.3 (a)
ZEB1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zeb1 35
  • 85.94 (n)
  • 88.09 (a)
Zeb1 16
Zeb1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZEB1 35
  • 99.25 (n)
  • 99.19 (a)
ZEB1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zeb1 35
  • 84.67 (n)
  • 86.83 (a)
oppossum
(Monodelphis domestica)
Mammalia ZEB1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZEB1 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZEB1 35
  • 83.17 (n)
  • 85.35 (a)
ZEB1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZEB1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zeb1 35
  • 75.25 (n)
  • 78.76 (a)
zebrafish
(Danio rerio)
Actinopterygii zeb1b 35
  • 64.55 (n)
  • 65.41 (a)
zfhx1 35
zeb1a 36
  • 40 (a)
OneToMany
zeb1b 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F58G1.2 36
  • 17 (a)
ManyToMany
tra-4 36
  • 14 (a)
ManyToMany
Species with no ortholog for ZEB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZEB1 Gene

ENSEMBL:
Gene Tree for ZEB1 (if available)
TreeFam:
Gene Tree for ZEB1 (if available)

Paralogs for ZEB1 Gene

Paralogs for ZEB1 Gene

genes like me logo Genes that share paralogs with ZEB1: view

Variants for ZEB1 Gene

Sequence variations from dbSNP and Humsavar for ZEB1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7349 -- 31,528,977(+) GAAAT(C/T)AGCCT utr-variant-3-prime
rs25620 -- 31,426,962(-) TTTTC(-/TCTTC/TTTTC)CTACA intron-variant
rs142781 -- 31,399,087(+) cctcc(G/T)gggtt intron-variant
rs149141 -- 31,479,739(+) GCTAT(C/T)ATCTG intron-variant
rs149144 -- 31,429,519(+) cagac(A/G)ctggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZEB1 Gene

Variant ID Type Subtype PubMed ID
nsv831824 CNV Loss 17160897
nsv831826 CNV Loss 17160897

Variation tolerance for ZEB1 Gene

Residual Variation Intolerance Score: 38.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZEB1 Gene

HapMap Linkage Disequilibrium report
ZEB1
Human Gene Mutation Database (HGMD)
ZEB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZEB1 Gene

Disorders for ZEB1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for ZEB1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
corneal dystrophy, posterior polymorphous, 3
  • ppcd3
corneal dystrophy, fuchs endothelial, 6
  • corneal dystrophy fuchs endothelial late-onset
corneal dystrophy, posterior polymorphous, 1
  • corneal dystrophy, hereditary polymorphous posterior
fuchs' endothelial dystrophy
  • fced
regular astigmatism
- elite association
Search ZEB1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ZEB1_HUMAN
  • Corneal dystrophy, Fuchs endothelial, 6 (FECD6) [MIM:613270]: A corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. {ECO:0000269 PubMed:20036349, ECO:0000269 PubMed:23599324}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Corneal dystrophy, posterior polymorphous, 3 (PPCD3) [MIM:609141]: A subtype of posterior corneal dystrophy, a disease characterized by alterations of Descemet membrane presenting as vesicles, opacities or band-like lesions on slit-lamp examination and specular microscopy. Affected patient typically are asymptomatic. {ECO:0000269 PubMed:16252232, ECO:0000269 PubMed:23599324}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZEB1

Genetic Association Database (GAD)
ZEB1
Human Genome Epidemiology (HuGE) Navigator
ZEB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZEB1
genes like me logo Genes that share disorders with ZEB1: view

No data available for Genatlas for ZEB1 Gene

Publications for ZEB1 Gene

  1. Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells. (PMID: 16252232) Krafchak C.M. … Richards J.E. (Am. J. Hum. Genet. 2005) 2 23 67
  2. The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. (PMID: 1427828) Williams T.M. … Shows T.B. (Genomics 1992) 2 23 67
  3. Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p. (PMID: 20036349) Riazuddin S.A. … Katsanis N. (Am. J. Hum. Genet. 2010) 23 67
  4. Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells. (PMID: 20042643) Li S. … McNamara N.A. (Invest. Ophthalmol. Vis. Sci. 2010) 23 67
  5. Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. (PMID: 20424117) Ohashi S. … Nakagawa H. (Cancer Res. 2010) 23 67

Products for ZEB1 Gene

Sources for ZEB1 Gene

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