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Aliases for TCF7 Gene

Aliases for TCF7 Gene

  • Transcription Factor 7 2 3
  • Transcription Factor 7 (T-Cell Specific, HMG-Box) 2 3 5
  • T-Cell-Specific Transcription Factor 1 3 4
  • T-Cell-Factor-7 2 3
  • TCF-1 3 4
  • T-Cell Factor 1 4
  • TCF-7 4
  • TCF1 4

External Ids for TCF7 Gene

Previous GeneCards Identifiers for TCF7 Gene

  • GC05P133100
  • GC05P133965
  • GC05P133481
  • GC05P133526
  • GC05P133478
  • GC05P128635

Summaries for TCF7 Gene

Entrez Gene Summary for TCF7 Gene

  • This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]

GeneCards Summary for TCF7 Gene

TCF7 (Transcription Factor 7) is a Protein Coding gene. Diseases associated with TCF7 include Cleidocranial Dysplasia and Colorectal Cancer. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and Arrhythmogenic right ventricular cardiomyopathy (ARVC). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TCF7L2.

UniProtKB/Swiss-Prot for TCF7 Gene

  • Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5-WWCAAAG-3) found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Gene Wiki entry for TCF7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF7 Gene

Genomics for TCF7 Gene

Regulatory Elements for TCF7 Gene

Enhancers for TCF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G134113 2 FANTOM5 Ensembl ENCODE dbSUPER 27.6 +15.8 15823 34.1 HDGF PKNOX1 ARNT AGO1 WRNIP1 ARID4B YBX1 ZNF2 YY1 ZNF143 TCF7 C5orf24 VDAC1 SKP1 CDKL3 MTND4LP30 JADE2 CDKN2AIPNL SAR1B UBE2B
GH05G134098 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -14.4 -14368 4.1 PKNOX1 FOXA2 MLX WRNIP1 ARID4B DMAP1 YBX1 YY1 ZNF143 ZNF263 TCF7 JADE2 CDKL3 PPP2CA LOC105379185 LOC101060024
GH05G134062 0.7 dbSUPER 20.4 -51.3 -51316 1.1 PKNOX1 FOXA2 NFXL1 POLR2A EED PRDM10 RELB IKZF2 MTA2 CBFB TCF7 VDAC1 ENSG00000271128 GC05P134014
GH05G134149 1.1 ENCODE dbSUPER 12.7 +35.1 35072 1.8 ELF3 FOXA2 ARID4B RARA SCRT2 HMG20B SMAD5 CEBPB KAT8 CEBPA TCF7 SKP1 PIR58605 PIR61120
GH05G134048 1.1 ENCODE dbSUPER 11.4 -67.5 -67489 0.2 ELF3 ARID4B DNMT3B THRB RARA GATA4 CREM THAP11 HMG20B SP5 TCF7 VDAC1 ENSG00000271128 GC05P134014
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCF7 on UCSC Golden Path with GeneCards custom track

Promoters for TCF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187040 397 1401 HDGF AGO1 ZNF48 GLIS2 ELK1 ZNF143 ZNF263 SP3 SP5 SMARCA4

Genomic Location for TCF7 Gene

Chromosome:
5
Start:
134,114,703 bp from pter
End:
134,151,865 bp from pter
Size:
37,163 bases
Orientation:
Plus strand

Genomic View for TCF7 Gene

Genes around TCF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF7 Gene

Proteins for TCF7 Gene

  • Protein details for TCF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36402-TCF7_HUMAN
    Recommended name:
    Transcription factor 7
    Protein Accession:
    P36402
    Secondary Accessions:
    • B3KSH3
    • Q86WR9
    • Q9UKI4

    Protein attributes for TCF7 Gene

    Size:
    384 amino acids
    Molecular mass:
    41642 Da
    Quaternary structure:
    • Binds the armadillo repeat of CTNNB1 and forms a stable complex (PubMed:9488439 PubMed:9783587). Interacts with AES, TLE1, TLE2, TLE3 and TLE4 (PubMed:9783587, PubMed:11266540). Interacts with MLLT11 (PubMed:26079538).
    SequenceCaution:
    • Sequence=CAA87441.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for TCF7 Gene

Post-translational modifications for TCF7 Gene

  • Ubiquitination at Lys52, isoforms=3, 4, 5, 6, 7, 8, 2, 9, 10, 11, 12, 13, 14, 15, 16253, and Lys294
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TCF7 (TCF7)
  • Abcam antibodies for TCF7

No data available for DME Specific Peptides for TCF7 Gene

Domains & Families for TCF7 Gene

Protein Domains for TCF7 Gene

Suggested Antigen Peptide Sequences for TCF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36402

UniProtKB/Swiss-Prot:

TCF7_HUMAN :
  • Belongs to the TCF/LEF family.
Family:
  • Belongs to the TCF/LEF family.
genes like me logo Genes that share domains with TCF7: view

No data available for Gene Families for TCF7 Gene

Function for TCF7 Gene

Molecular function for TCF7 Gene

GENATLAS Biochemistry:
transcription factor 7,T cell specific
UniProtKB/Swiss-Prot Function:
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5-WWCAAAG-3) found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
UniProtKB/Swiss-Prot Induction:
By TCF7L2 and CTNNB1.

Gene Ontology (GO) - Molecular Function for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 9783587
genes like me logo Genes that share ontologies with TCF7: view
genes like me logo Genes that share phenotypes with TCF7: view

Animal Model Products

CRISPR Products

miRNA for TCF7 Gene

miRTarBase miRNAs that target TCF7

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TCF7
  • Applied Biological Materials Clones for TCF7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCF7 Gene

Localization for TCF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 18579517
GO:0005654 nucleoplasm TAS,IDA --
GO:0005667 transcription factor complex IBA --
GO:0005719 nuclear euchromatin IEA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with TCF7: view

Pathways & Interactions for TCF7 Gene

genes like me logo Genes that share pathways with TCF7: view

SIGNOR curated interactions for TCF7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS,IEA 1569101
GO:0006955 immune response TAS 1569101
genes like me logo Genes that share ontologies with TCF7: view

Drugs & Compounds for TCF7 Gene

No Compound Related Data Available

Transcripts for TCF7 Gene

Unigene Clusters for TCF7 Gene

Transcription factor 7 (T-cell specific, HMG-box):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TCF7
  • Applied Biological Materials Clones for TCF7

Alternative Splicing Database (ASD) splice patterns (SP) for TCF7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - -
SP13: - - - -
SP14: - - - - - - -
SP15: -
SP16: -
SP17: - - -
SP18:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7:
SP8:
SP9: -
SP10: - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for TCF7 Gene

GeneLoc Exon Structure for
TCF7
ECgene alternative splicing isoforms for
TCF7

Expression for TCF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF7 Gene

This gene is overexpressed in Whole Blood (x13.3).

Protein differential expression in normal tissues from HIPED for TCF7 Gene

This gene is overexpressed in Serum (32.7), CD8 Tcells (14.2), CD4 Tcells (9.8), and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCF7 Gene



Protein tissue co-expression partners for TCF7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCF7 Gene:

TCF7

SOURCE GeneReport for Unigene cluster for TCF7 Gene:

Hs.573153

mRNA Expression by UniProt/SwissProt for TCF7 Gene:

P36402-TCF7_HUMAN
Tissue specificity: Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.

Evidence on tissue expression from TISSUES for TCF7 Gene

  • Blood(4.4)
  • Liver(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with TCF7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF7 Gene

Orthologs for TCF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF7 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia TCF7 34 35
  • 91.78 (n)
cow
(Bos Taurus)
Mammalia TCF7 34 35
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Tcf7 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF7 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCF7 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCF1 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF7 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tcf7 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pan 36 35
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea pop-1 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11069 35
  • 25 (a)
OneToMany
Species where no ortholog for TCF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TCF7 Gene

ENSEMBL:
Gene Tree for TCF7 (if available)
TreeFam:
Gene Tree for TCF7 (if available)

Paralogs for TCF7 Gene

Paralogs for TCF7 Gene

genes like me logo Genes that share paralogs with TCF7: view

Variants for TCF7 Gene

Sequence variations from dbSNP and Humsavar for TCF7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000002889 -- 134,132,755(+) GGGGG(G/T)GTGGT intron-variant, upstream-variant-2KB
rs1000005993 -- 134,128,273(+) CAGTT(A/T)TGTGT intron-variant, utr-variant-5-prime
rs1000100201 -- 134,128,496(+) TAGCT(A/G)GGGGA intron-variant, utr-variant-5-prime
rs1000100827 -- 134,142,445(+) AGGAG(C/G)GGGTG intron-variant
rs1000188656 -- 134,115,247(+) GCAGA(-/GC)GTCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TCF7 Gene

Variant ID Type Subtype PubMed ID
esv2678103 CNV deletion 23128226
esv3606842 CNV loss 21293372
nsv1073496 CNV deletion 25765185
nsv1112885 CNV deletion 24896259
nsv1145070 CNV deletion 24896259
nsv5011 CNV insertion 18451855
nsv599732 CNV loss 21841781

Variation tolerance for TCF7 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF7 Gene

Human Gene Mutation Database (HGMD)
TCF7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF7 Gene

Disorders for TCF7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TCF7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cleidocranial dysplasia
  • cleidocranial dysplasia, forme fruste, with brachydactyly
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TCF7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCF7

Genetic Association Database (GAD)
TCF7
Human Genome Epidemiology (HuGE) Navigator
TCF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF7
genes like me logo Genes that share disorders with TCF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCF7 Gene

Publications for TCF7 Gene

  1. A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. (PMID: 12765974) Noble J.A. … Erlich H.A. (Diabetes 2003) 3 22 46 64
  2. The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. (PMID: 1569101) van de Wetering M. … Clevers H. (J. Biol. Chem. 1992) 3 4 22 64
  3. AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. (PMID: 26079538) Park J. … Tse W. (Oncotarget 2015) 3 4 64
  4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for TCF7 Gene

  • Addgene plasmids for TCF7

Sources for TCF7 Gene

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