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Aliases for TCF7 Gene

Aliases for TCF7 Gene

  • Transcription Factor 7 (T-Cell Specific, HMG-Box) 2 3
  • T-Cell-Specific Transcription Factor 1 3 4
  • TCF-1 3 4
  • Transcription Factor 7 3
  • T-Cell Factor 1 4
  • TCF-7 4
  • TCF1 4

External Ids for TCF7 Gene

Previous GeneCards Identifiers for TCF7 Gene

  • GC05P133100
  • GC05P133965
  • GC05P133481
  • GC05P133526
  • GC05P133478
  • GC05P128635

Summaries for TCF7 Gene

Entrez Gene Summary for TCF7 Gene

  • The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TCF7 Gene

TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is TCF7L2.

UniProtKB/Swiss-Prot for TCF7 Gene

  • Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5-WWCAAAG-3) found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1

Gene Wiki entry for TCF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF7 Gene

Genomics for TCF7 Gene

Regulatory Elements for TCF7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TCF7 Gene

Start:
134,114,711 bp from pter
End:
134,151,865 bp from pter
Size:
37,155 bases
Orientation:
Plus strand

Genomic View for TCF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF7 Gene

Proteins for TCF7 Gene

neXtProt entry for TCF7 Gene

Proteomics data for TCF7 Gene at MOPED

Post-translational modifications for TCF7 Gene

  • Ubiquitination at Lys52, Lys253, Lys271, Lys294, and Lys317
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TCF7 (TCF7)

No data available for DME Specific Peptides for TCF7 Gene

Domains for TCF7 Gene

Protein Domains for TCF7 Gene

Suggested Antigen Peptide Sequences for TCF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36402

UniProtKB/Swiss-Prot:

TCF7_HUMAN :
  • P36402
Domain:
  • Contains 1 HMG box DNA-binding domain.
Family:
  • Belongs to the TCF/LEF family.
genes like me logo Genes that share domains with TCF7: view

No data available for Gene Families for TCF7 Gene

Function for TCF7 Gene

Molecular function for TCF7 Gene

GENATLAS Biochemistry: transcription factor 7,T cell specific
UniProtKB/Swiss-Prot Function: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5-WWCAAAG-3) found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1
UniProtKB/Swiss-Prot Induction: By TCF7L2 and CTNNB1.

Gene Ontology (GO) - Molecular Function for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003682 chromatin binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 16442529
GO:0008013 beta-catenin binding IDA 9488439
genes like me logo Genes that share ontologies with TCF7: view
genes like me logo Genes that share phenotypes with TCF7: view

Animal Models for TCF7 Gene

MGI Knock Outs for TCF7:

Animal Model Products

CRISPR Products

miRNA for TCF7 Gene

miRTarBase miRNAs that target TCF7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCF7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TCF7 Gene

Localization for TCF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF7 Gene COMPARTMENTS Subcellular localization image for TCF7 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18579517
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA --
genes like me logo Genes that share ontologies with TCF7: view

Pathways for TCF7 Gene

genes like me logo Genes that share pathways with TCF7: view

PCR Array Products

Gene Ontology (GO) - Biological Process for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006955 immune response TAS 1569101
GO:0007420 brain development IBA --
genes like me logo Genes that share ontologies with TCF7: view

Transcripts for TCF7 Gene

Unigene Clusters for TCF7 Gene

Transcription factor 7 (T-cell specific, HMG-box):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCF7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCF7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - -
SP13: - - - -
SP14: - - - - - - -
SP15: -
SP16: -
SP17: - - -
SP18:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7:
SP8:
SP9: -
SP10: - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for TCF7 Gene

GeneLoc Exon Structure for
TCF7
ECgene alternative splicing isoforms for
TCF7

Expression for TCF7 Gene

mRNA expression in normal human tissues for TCF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF7 Gene

This gene is overexpressed in Whole Blood (13.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCF7 Gene

SOURCE GeneReport for Unigene cluster for TCF7 Gene Hs.573153

mRNA Expression by UniProt/SwissProt for TCF7 Gene

P36402-TCF7_HUMAN
Tissue specificity: Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
genes like me logo Genes that share expressions with TCF7: view

In Situ Assay Products

Orthologs for TCF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF7 35
  • 99.73 (n)
  • 100 (a)
TCF7 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCF7 35
  • 91.41 (n)
  • 92.71 (a)
TCF7 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCF7 35
  • 91.78 (n)
  • 95.28 (a)
TCF7 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf7 16
Tcf7 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCF7 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF7 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCF1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF7 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tcf7 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pan 36
  • 10 (a)
OneToMany
pan 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea pop-1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11069 36
  • 25 (a)
OneToMany
Species with no ortholog for TCF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TCF7 Gene

ENSEMBL:
Gene Tree for TCF7 (if available)
TreeFam:
Gene Tree for TCF7 (if available)

Paralogs for TCF7 Gene

Paralogs for TCF7 Gene

genes like me logo Genes that share paralogs with TCF7: view

Variants for TCF7 Gene

Sequence variations from dbSNP and Humsavar for TCF7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs30489 -- 134,145,776(-) TTGTC(C/T)ATTAC missense, reference, intron-variant, downstream-variant-500B
rs30490 -- 134,129,949(-) GGGGT(C/G)GGGGA intron-variant
rs30491 -- 134,115,522(-) CACTC(C/T)CCACC upstream-variant-2KB, intron-variant
rs30492 -- 134,114,887(-) gccgg(A/G)gcgcg upstream-variant-2KB, utr-variant-5-prime
rs40273 -- 134,146,657(-) GAAGT(C/T)CTGCA utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TCF7 Gene

Variant ID Type Subtype PubMed ID
nsv5011 CNV Insertion 18451855
esv2678103 CNV Deletion 23128226

Relevant External Links for TCF7 Gene

HapMap Linkage Disequilibrium report
TCF7
Human Gene Mutation Database (HGMD)
TCF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF7 Gene

Disorders for TCF7 Gene

(1) University of Copenhagen DISEASES for TCF7 Gene

(6) Novoseek inferred disease relationships for TCF7 Gene

Disease -log(P) Hits PubMed IDs
colon cancer 38.2 5
colorectal cancer 11.6 2
tumors 9.41 3
gastric cancer 0 1
lymphoma 0 1

Relevant External Links for TCF7

Genetic Association Database (GAD)
TCF7
Human Genome Epidemiology (HuGE) Navigator
TCF7
genes like me logo Genes that share disorders with TCF7: view

No data available for UniProtKB/Swiss-Prot for TCF7 Gene

Publications for TCF7 Gene

  1. A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. (PMID: 12765974) Noble J.A. … Erlich H.A. (Diabetes 2003) 3 23 48
  2. The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. (PMID: 1569101) van de Wetering M. … Clevers H. (J. Biol. Chem. 1992) 3 4 23
  3. Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. (PMID: 16424171) Willinger T. … Callan M.F. (J. Immunol. 2006) 3 23
  4. LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. (PMID: 18579517) Hebenstreit D. … Li-Weber M. (J. Biol. Chem. 2008) 3 23
  5. Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. (PMID: 1989880) van de Wetering M. … Clevers H. (EMBO J. 1991) 3 4

Products for TCF7 Gene

  • Addgene plasmids for TCF7

Sources for TCF7 Gene

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