Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TCF3 Gene

Aliases for TCF3 Gene

  • Transcription Factor 3 2 3 4
  • Immunoglobulin Transcription Factor 1 2 3 4
  • Kappa-E2-Binding Factor 2 3 4
  • E2A 3 4 6
  • Class B Basic Helix-Loop-Helix Protein 21 3 4
  • Transcription Factor E2-Alpha 2 3
  • Transcription Factor ITF-1 3 4
  • VDR Interacting Repressor 2 3
  • BHLHb21 3 4
  • TCF-3 3 4
  • ITF1 3 4
  • Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) 3
  • Negative Vitamin D Response Element-Binding Protein 3
  • E2A Immunoglobulin Enhancer-Binding Factor E12/E47 2
  • Immunoglobulin Enhancer-Binding Factor E12/E47 4
  • Vitamin D Receptor-Interacting Repressor 3
  • Transcription Factor 3 Variant 3 3
  • Helix-Loop-Helix Protein HE47 3
  • VDIR 3
  • E47 3

External Ids for TCF3 Gene

Previous GeneCards Identifiers for TCF3 Gene

  • GC19M001671
  • GC19M001549
  • GC19M001560
  • GC19M001384

Summaries for TCF3 Gene

Entrez Gene Summary for TCF3 Gene

  • This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

GeneCards Summary for TCF3 Gene

TCF3 (Transcription Factor 3) is a Protein Coding gene. Diseases associated with TCF3 include childhood leukemia and autosomal agammaglobulinemia. Among its related pathways are Signaling by GPCR and L1CAM interactions. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is TCF4.

UniProtKB/Swiss-Prot for TCF3 Gene

  • Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5-CANNTG-3. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region

Gene Wiki entry for TCF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF3 Gene

Genomics for TCF3 Gene

Regulatory Elements for TCF3 Gene

Transcription factor binding sites by QIAGEN in the TCF3 gene promoter:

Genomic Location for TCF3 Gene

Start:
1,609,290 bp from pter
End:
1,652,605 bp from pter
Size:
43,316 bases
Orientation:
Minus strand

Genomic View for TCF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF3 Gene

Proteins for TCF3 Gene

  • Protein details for TCF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15923-TFE2_HUMAN
    Recommended name:
    Transcription factor E2-alpha
    Protein Accession:
    P15923
    Secondary Accessions:
    • P15883
    • Q14208
    • Q14635
    • Q14636
    • Q2TB39
    • Q2TB40
    • Q9UPI9

    Protein attributes for TCF3 Gene

    Size:
    654 amino acids
    Molecular mass:
    67600 Da
    Quaternary structure:
    • Forms a heterodimer with ASH1 and TWIST2. Isoform E12 interacts with RALGAPA1 and FIGLA. Efficient DNA binding requires dimerization with another bHLH protein. Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with NEUROD2, PTF1A and TGFB1I1. Forms a heterodimer with MYOG; heterodimerization enhances MYOG DNA-binding and transcriptional activities (By similarity). Homodimer. Heterodimer. Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Interacts with EP300 and UBE2I.
    SequenceCaution:
    • Sequence=AAA52331.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TCF3 Gene

    Alternative splice isoforms for TCF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCF3 Gene

Proteomics data for TCF3 Gene at MOPED

Post-translational modifications for TCF3 Gene

No data available for DME Specific Peptides for TCF3 Gene

Domains for TCF3 Gene

Gene Families for TCF3 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for TCF3 Gene

Suggested Antigen Peptide Sequences for TCF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15923

UniProtKB/Swiss-Prot:

TFE2_HUMAN :
  • P15923
Domain:
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TCF3: view

Function for TCF3 Gene

Molecular function for TCF3 Gene

GENATLAS Biochemistry: transcription factor 3,heterodimerizing with all myogenic bHLH vproteins and binding DNA cooperatively with PBXs/MEISs/PKNOX1
UniProtKB/Swiss-Prot Function: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5-CANNTG-3. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region

Gene Ontology (GO) - Molecular Function for TCF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 14576336
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 14576336
GO:0003677 DNA binding NAS 2105528
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 2493990
genes like me logo Genes that share ontologies with TCF3: view
genes like me logo Genes that share phenotypes with TCF3: view

Animal Models for TCF3 Gene

MGI Knock Outs for TCF3:

Transcription Factor Targeting for TCF3 Gene

Selected GeneGlobe predicted Target genes for TCF3
Targeting motifs for TCF3 Gene
HOMER Transcription Factor Regulatory Elements motif TCF3
  • Consensus sequence: ANACAGCTGC Submotif: canonical Cell Type: proBcell GeoId: GSE21978

No data available for Enzyme Numbers (IUBMB) for TCF3 Gene

Localization for TCF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF3 Gene COMPARTMENTS Subcellular localization image for TCF3 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TCF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000788 nuclear nucleosome IEA --
GO:0000790 nuclear chromatin IDA 21828274
GO:0005634 nucleus NAS 2493990
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 10775504
genes like me logo Genes that share ontologies with TCF3: view

Pathways for TCF3 Gene

genes like me logo Genes that share pathways with TCF3: view

Gene Ontology (GO) - Biological Process for TCF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14576336
GO:0001779 natural killer cell differentiation IEA --
GO:0002326 B cell lineage commitment NAS 12435739
GO:0006351 transcription, DNA-templated IDA 10775504
GO:0006355 regulation of transcription, DNA-templated NAS 2493990
genes like me logo Genes that share ontologies with TCF3: view

Transcripts for TCF3 Gene

Unigene Clusters for TCF3 Gene

Transcription factor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCF3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c · 18d ·
SP1: -
SP2:
SP3:
SP4: - - - -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 18e · 18f ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21a · 21b · 21c · 21d · 21e · 21f · 21g ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - -
SP9: -
SP10: - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - - - - -
SP14: - - - - - -
SP15: - - - - - - - - -
SP16: -
SP17: - -
SP18: - - - - -
SP19: - - -
SP20: - - - - - - -
SP21:

Relevant External Links for TCF3 Gene

GeneLoc Exon Structure for
TCF3
ECgene alternative splicing isoforms for
TCF3

Expression for TCF3 Gene

mRNA expression in normal human tissues for TCF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCF3 Gene

SOURCE GeneReport for Unigene cluster for TCF3 Gene Hs.371282

genes like me logo Genes that share expressions with TCF3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCF3 Gene

Orthologs for TCF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF3 35
  • 98.64 (n)
  • 98.93 (a)
TCF3 36
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCF3 35
  • 84.69 (n)
  • 84.95 (a)
TCF3 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCF3 35
  • 83.92 (n)
  • 81.48 (a)
TCF3 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf3 35
  • 79.9 (n)
  • 80.47 (a)
Tcf3 16
Tcf3 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCF3 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF3 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcf3 35
  • 79.19 (n)
  • 78.88 (a)
chicken
(Gallus gallus)
Aves TCF3 35
  • 71.34 (n)
  • 71.5 (a)
TCF3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF3 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52608 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tcf3 35
  • 61.9 (n)
  • 63.33 (a)
zebrafish
(Danio rerio)
Actinopterygii e12 35
tcf3a 36
  • 49 (a)
OneToMany
tcf3b 35
  • 61.29 (n)
  • 58.39 (a)
tcf3b 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta da 36
  • 23 (a)
OneToMany
da 37
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea hlh-2 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for TCF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCF3 Gene

ENSEMBL:
Gene Tree for TCF3 (if available)
TreeFam:
Gene Tree for TCF3 (if available)

Paralogs for TCF3 Gene

Paralogs for TCF3 Gene

Pseudogenes.org Pseudogenes for TCF3 Gene

genes like me logo Genes that share paralogs with TCF3: view

Variants for TCF3 Gene

Sequence variations from dbSNP and Humsavar for TCF3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8140 -- 1,619,340(-) ATGTC(A/G)CTGGG reference, synonymous-codon, nc-transcript-variant
rs14990 -- 1,611,141(-) TGAAA(A/C)TTAGC utr-variant-3-prime, intron-variant, nc-transcript-variant
rs732690 -- 1,613,228(+) CAGCA(A/G)AGCCC intron-variant
rs740434 -- 1,633,884(+) CACCC(C/T)CTGGG intron-variant
rs740435 -- 1,633,924(+) TTGTC(G/T)GGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF3 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3602n71 CNV Loss 21882294
dgv3603n71 CNV Loss 21882294
dgv3607n71 CNV Loss 21882294
dgv3608n71 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3610n71 CNV Loss 21882294
nsv910540 CNV Loss 21882294
dgv3611n71 CNV Loss 21882294
nsv828379 CNV Gain 20364138
esv2667087 CNV Deletion 23128226
esv28953 CNV Gain 19812545
nsv138347 CNV Loss 16902084
esv2717846 CNV Deletion 23290073
nsv828380 CNV Gain 20364138
esv2717847 CNV Deletion 23290073
esv2717848 CNV Deletion 23290073
esv2717849 CNV Deletion 23290073
nsv910543 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294

Relevant External Links for TCF3 Gene

HapMap Linkage Disequilibrium report
TCF3
Human Gene Mutation Database (HGMD)
TCF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF3 Gene

Disorders for TCF3 Gene

UniProtKB/Swiss-Prot

TFE2_HUMAN
  • Note=Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1. TCF3-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family. Translocation t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT.

(1) University of Copenhagen DISEASES for TCF3 Gene

(3) Novoseek inferred disease relationships for TCF3 Gene

Disease -log(P) Hits PubMed IDs
lymphoblastic leukemia acute 30.4 2
tumors 6.54 3
leukemia 0 2

Genatlas disease for TCF3 Gene

acute lymphoblastic leukemia,pre-B cell,with translocation t(1;19)(q23;p13);see PBX1
genes like me logo Genes that share disorders with TCF3: view

Publications for TCF3 Gene

  1. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. (PMID: 1967983) Kamps M.P. … Baltimore D. (Cell 1990) 2 3 4
  2. Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor. (PMID: 2308859) Henthorn P. … Kadesch T. (Nucleic Acids Res. 1990) 2 3 4
  3. Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. (PMID: 14752053) Kim J.Y. … Choi H.S. (Mol. Endocrinol. 2004) 3 4
  4. Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif. (PMID: 2105528) Henthorn P. … Kadesch T. (Science 1990) 3 4
  5. Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains. (PMID: 2112746) Voronova A. … Baltimore D. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4

Products for TCF3 Gene

  • Addgene plasmids for TCF3

Sources for TCF3 Gene

Back to Top

Content