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Aliases for TCEA1 Gene

Aliases for TCEA1 Gene

  • Transcription Elongation Factor A1 2 3
  • Transcription Elongation Factor A (SII), 1 2 3 5
  • Transcription Elongation Factor S-II Protein 1 3 4
  • Transcription Elongation Factor TFIIS.O 3 4
  • Transcription Factor IIS 2 3
  • GTF2S 3 4
  • TFIIS 3 4
  • TF2S 3
  • TCEA 3
  • SII 3

External Ids for TCEA1 Gene

Previous HGNC Symbols for TCEA1 Gene

  • TCEA
  • GTF2S

Previous GeneCards Identifiers for TCEA1 Gene

  • GC03P036581
  • GC08M054818
  • GC08M054582
  • GC08M054929
  • GC08M055041
  • GC08M050347
  • GC08M054879

Summaries for TCEA1 Gene

GeneCards Summary for TCEA1 Gene

TCEA1 (Transcription Elongation Factor A1) is a Protein Coding gene. Among its related pathways are Gene Expression and HIV Life Cycle. GO annotations related to this gene include nucleic acid binding and translation elongation factor activity. An important paralog of this gene is TCEA2.

UniProtKB/Swiss-Prot for TCEA1 Gene

  • Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.

Gene Wiki entry for TCEA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEA1 Gene

Genomics for TCEA1 Gene

Regulatory Elements for TCEA1 Gene

Promoters for TCEA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCEA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCEA1 Gene

Chromosome:
8
Start:
53,966,552 bp from pter
End:
54,022,529 bp from pter
Size:
55,978 bases
Orientation:
Minus strand

Genomic View for TCEA1 Gene

Genes around TCEA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEA1 Gene

Proteins for TCEA1 Gene

  • Protein details for TCEA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23193-TCEA1_HUMAN
    Recommended name:
    Transcription elongation factor A protein 1
    Protein Accession:
    P23193
    Secondary Accessions:
    • A6NF25
    • A8K339
    • Q15563
    • Q6FG87

    Protein attributes for TCEA1 Gene

    Size:
    301 amino acids
    Molecular mass:
    33970 Da
    Quaternary structure:
    • Interacts with EAF2 (By similarity). Associates with UBR5 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters.
    Miscellaneous:
    • S-II binds to RNA-polymerase II in the absence of transcription.

    Three dimensional structures from OCA and Proteopedia for TCEA1 Gene

    Alternative splice isoforms for TCEA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEA1 Gene

Proteomics data for TCEA1 Gene at MOPED

Post-translational modifications for TCEA1 Gene

  • Ubiquitination at Lys 29, Lys 67, and Lys 252
  • Modification sites at PhosphoSitePlus

Other Protein References for TCEA1 Gene

No data available for DME Specific Peptides for TCEA1 Gene

Domains & Families for TCEA1 Gene

Gene Families for TCEA1 Gene

Graphical View of Domain Structure for InterPro Entry

P23193

UniProtKB/Swiss-Prot:

TCEA1_HUMAN :
  • Contains 1 TFIIS central domain.
  • Belongs to the TFS-II family.
  • Contains 1 TFIIS-type zinc finger.
Domain:
  • Contains 1 TFIIS central domain.
  • Contains 1 TFIIS N-terminal domain.
Family:
  • Belongs to the TFS-II family.
Similarity:
  • Contains 1 TFIIS-type zinc finger.
genes like me logo Genes that share domains with TCEA1: view

Function for TCEA1 Gene

Molecular function for TCEA1 Gene

GENATLAS Biochemistry:
transcription elongation factor A for RNA polymerase II,SII class,widely expressed,fused with PLAG1 in translocation (3;8)(p21;q12) in salivary tumors (see PSA2)
UniProtKB/Swiss-Prot Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.

Gene Ontology (GO) - Molecular Function for TCEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IEA --
genes like me logo Genes that share ontologies with TCEA1: view
genes like me logo Genes that share phenotypes with TCEA1: view

Animal Models for TCEA1 Gene

MGI Knock Outs for TCEA1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCEA1 Gene

Localization for TCEA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEA1 Gene COMPARTMENTS Subcellular localization image for TCEA1 gene
Compartment Confidence
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TCEA1 Gene

Pathways & Interactions for TCEA1 Gene

genes like me logo Genes that share pathways with TCEA1: view

Pathways by source for TCEA1 Gene

1 Qiagen pathway for TCEA1 Gene

SIGNOR curated interactions for TCEA1 Gene

Activates:

Gene Ontology (GO) - Biological Process for TCEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TCEA1: view

Drugs & Compounds for TCEA1 Gene

No Compound Related Data Available

Transcripts for TCEA1 Gene

Unigene Clusters for TCEA1 Gene

Transcription elongation factor A (SII), 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEA1 Gene

No ASD Table

Relevant External Links for TCEA1 Gene

GeneLoc Exon Structure for
TCEA1
ECgene alternative splicing isoforms for
TCEA1

Expression for TCEA1 Gene

mRNA expression in normal human tissues for TCEA1 Gene

Protein differential expression in normal tissues from HIPED for TCEA1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.9) and Lymph node (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCEA1 Gene



SOURCE GeneReport for Unigene cluster for TCEA1 Gene Hs.491745

genes like me logo Genes that share expression patterns with TCEA1: view

Protein tissue co-expression partners for TCEA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCEA1 Gene

Orthologs for TCEA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCEA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEA1 35
  • 99.89 (n)
  • 99.67 (a)
TCEA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCEA1 36
  • 97 (a)
OneToOne
TCEA1 35
  • 90.03 (n)
  • 96.35 (a)
dog
(Canis familiaris)
Mammalia TCEA1 35
  • 93.56 (n)
  • 97.33 (a)
TCEA1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcea1 16
Tcea1 36
  • 88 (a)
OneToOne
Tcea1 35
  • 92 (n)
  • 97 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TCEA1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC498453 35
  • 92.14 (n)
  • 96.68 (a)
chicken
(Gallus gallus)
Aves TCEA1 36
  • 90 (a)
OneToOne
TCEA1 35
  • 82.11 (n)
  • 90 (a)
lizard
(Anolis carolinensis)
Reptilia TCEA1 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.238 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76031 35
tcea1 35
  • 75.08 (n)
  • 81.82 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1255 35
zebrafish
(Danio rerio)
Actinopterygii tcea1 36
  • 75 (a)
OneToOne
tcea1 35
  • 74.11 (n)
  • 78 (a)
wufj48e12 35
fruit fly
(Drosophila melanogaster)
Insecta CG8117 36
  • 48 (a)
ManyToMany
TfIIS 36
  • 49 (a)
ManyToMany
CG8117 37
  • 49 (a)
TfIIS 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea T24H10.1 35
  • 55.51 (n)
  • 51.67 (a)
T24H10.1 37
  • 48 (a)
T24H10.1 36
  • 43 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DST1 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons TFIIS 35
  • 52.93 (n)
  • 40 (a)
rice
(Oryza sativa)
Liliopsida Os07g0229700 35
  • 45.91 (n)
  • 37.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2769 36
  • 47 (a)
OneToMany
Species with no ortholog for TCEA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCEA1 Gene

ENSEMBL:
Gene Tree for TCEA1 (if available)
TreeFam:
Gene Tree for TCEA1 (if available)

Paralogs for TCEA1 Gene

Paralogs for TCEA1 Gene

(4) SIMAP similar genes for TCEA1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TCEA1 Gene

genes like me logo Genes that share paralogs with TCEA1: view

Variants for TCEA1 Gene

Sequence variations from dbSNP and Humsavar for TCEA1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3209642 -- 53,973,108(+) GGAGA(C/T)AGAAG intron-variant
rs4738544 -- 53,984,015(+) GAATC(A/G)CTTGA intron-variant
rs4738556 -- 53,994,093(+) ACGCC(C/T)GTAAT intron-variant
rs6473900 -- 54,000,430(+) CATTC(C/T)TCTAC intron-variant
rs6473901 -- 54,005,448(+) tttca(C/T)aggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCEA1 Gene

Variant ID Type Subtype PubMed ID
essv22151 CNV CNV 17122850
esv2487551 CNV Deletion 19546169

Variation tolerance for TCEA1 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEA1 Gene

HapMap Linkage Disequilibrium report
TCEA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEA1 Gene

Disorders for TCEA1 Gene

UniProtKB/Swiss-Prot

TCEA1_HUMAN
  • Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1. {ECO:0000269 PubMed:10029085}.

Relevant External Links for TCEA1

Genetic Association Database (GAD)
TCEA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEA1

No disorders were found for TCEA1 Gene.

No data available for MalaCards and Genatlas for TCEA1 Gene

Publications for TCEA1 Gene

  1. Characterization of the gene encoding the human transcriptional elongation factor TFIIS. (PMID: 8112616) Park H.R. … Yoo O. (Gene 1994) 2 3 4 67
  2. Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3. (PMID: 8812434) DiMarco S.P. … Warren S.T. (Genomics 1996) 2 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3

Products for TCEA1 Gene

Sources for TCEA1 Gene

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