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Aliases for TAT Gene

Aliases for TAT Gene

  • Tyrosine Aminotransferase 2 3
  • EC 2.6.1.5 4 63
  • L-Tyrosine:2-Oxoglutarate Aminotransferase 4

External Ids for TAT Gene

Previous GeneCards Identifiers for TAT Gene

  • GC16M062492
  • GC16M072323
  • GC16M071336
  • GC16M071376
  • GC16M070158
  • GC16M057368

Summaries for TAT Gene

Entrez Gene Summary for TAT Gene

  • This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAT Gene

TAT (Tyrosine Aminotransferase) is a Protein Coding gene. Diseases associated with TAT include tyrosinemia, type ii and hanhart syndrome. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include pyridoxal phosphate binding and L-phenylalanine:2-oxoglutarate aminotransferase activity. An important paralog of this gene is CCBL2.

UniProtKB/Swiss-Prot for TAT Gene

  • Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAT Gene

Genomics for TAT Gene

Regulatory Elements for TAT Gene

Genomic Location for TAT Gene

Start:
71,565,660 bp from pter
End:
71,577,130 bp from pter
Size:
11,471 bases
Orientation:
Minus strand

Genomic View for TAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAT Gene

Proteins for TAT Gene

  • Protein details for TAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17735-ATTY_HUMAN
    Recommended name:
    Tyrosine aminotransferase
    Protein Accession:
    P17735
    Secondary Accessions:
    • B2R8I1
    • D3DWS2

    Protein attributes for TAT Gene

    Size:
    454 amino acids
    Molecular mass:
    50399 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for TAT Gene

neXtProt entry for TAT Gene

Proteomics data for TAT Gene at MOPED

Post-translational modifications for TAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for TAT Gene

Suggested Antigen Peptide Sequences for TAT Gene

Graphical View of Domain Structure for InterPro Entry

P17735

UniProtKB/Swiss-Prot:

ATTY_HUMAN :
  • P17735
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with TAT: view

No data available for Gene Families for TAT Gene

Function for TAT Gene

Molecular function for TAT Gene

GENATLAS Biochemistry: tyrosine aminotransferase,catalyzing the first step of tyrosine catabolism
UniProtKB/Swiss-Prot CatalyticActivity: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
UniProtKB/Swiss-Prot Function: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.

Enzyme Numbers (IUBMB) for TAT Gene

Gene Ontology (GO) - Molecular Function for TAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004838 L-tyrosine:2-oxoglutarate aminotransferase activity TAS --
GO:0008483 transaminase activity --
GO:0016597 amino acid binding IEA --
GO:0016829 lyase activity --
GO:0030170 pyridoxal phosphate binding IEA --
genes like me logo Genes that share ontologies with TAT: view

Animal Model Products

CRISPR Products

miRNA for TAT Gene

miRTarBase miRNAs that target TAT

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAT Gene

Localization for TAT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAT Gene COMPARTMENTS Subcellular localization image for TAT gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 2
extracellular 2
mitochondrion 2
plasma membrane 2
endosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TAT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAT Gene

Pathways for TAT Gene

genes like me logo Genes that share pathways with TAT: view

PCR Array Products

UniProtKB/Swiss-Prot P17735-ATTY_HUMAN

  • Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6

Gene Ontology (GO) - Biological Process for TAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006103 2-oxoglutarate metabolic process IDA 7999802
GO:0006520 cellular amino acid metabolic process --
GO:0006536 glutamate metabolic process IDA 7999802
GO:0006559 L-phenylalanine catabolic process TAS --
GO:0006572 tyrosine catabolic process IDA 7999802
genes like me logo Genes that share ontologies with TAT: view

Compounds for TAT Gene

(10) HMDB Compounds for TAT Gene

Compound Synonyms Cas Number PubMed IDs
2-Oxo-4-methylthiobutanoic acid
  • 2-Oxo-4-methylthiobutanoate
583-92-6
4-Hydroxyphenylpyruvic acid
  • (p-Hydroxyphenyl)pyruvate
156-39-8
Famotidine
  • Amfamox
76824-35-6
L-Glutamic acid
  • (2S)-2-Aminopentanedioate
56-86-0
L-Methionine
  • (2S)-2-amino-4-(methylsulfanyl)butanoic acid
63-68-3

(4) Drugbank Compounds for TAT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
L-Phenylalanine
  • (S)-alpha-Amino-beta-phenylpropionic acid
63-91-2 target
L-Tyrosine
  • 2-Amino-3-(p-hydroxyphenyl)propionic acid
60-18-4 target
Pyridoxal Phosphate
  • Codecarboxylase
54-47-7 target cofactor

(104) Novoseek inferred chemical compound relationships for TAT Gene

Compound -log(P) Hits PubMed IDs
argininamide 81.9 5
polytar 78.1 2
pnu 145156e 70.8 2
st-pc 58.5 3
tat-1 57.9 4
genes like me logo Genes that share compounds with TAT: view

Transcripts for TAT Gene

Unigene Clusters for TAT Gene

Tyrosine aminotransferase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAT

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAT Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:

Relevant External Links for TAT Gene

GeneLoc Exon Structure for
TAT
ECgene alternative splicing isoforms for
TAT

Expression for TAT Gene

mRNA expression in normal human tissues for TAT Gene

mRNA differential expression in normal tissues according to GTEx for TAT Gene

This gene is overexpressed in Liver (51.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TAT Gene

SOURCE GeneReport for Unigene cluster for TAT Gene Hs.161640

genes like me logo Genes that share expressions with TAT: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TAT Gene

Orthologs for TAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAT 35
  • 99.49 (n)
  • 99.56 (a)
TAT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAT 35
  • 90.16 (n)
  • 92.17 (a)
TAT 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAT 35
  • 90.6 (n)
  • 93.17 (a)
TAT 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tat 35
  • 86.2 (n)
  • 92.07 (a)
Tat 16
Tat 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAT 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAT 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tat 35
  • 87.15 (n)
  • 91.63 (a)
chicken
(Gallus gallus)
Aves TAT 35
  • 76.28 (n)
  • 82.16 (a)
TAT 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAT 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32186 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15963 35
tat 35
  • 70.13 (n)
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7145 35
zebrafish
(Danio rerio)
Actinopterygii tat 35
  • 68.05 (n)
  • 72.81 (a)
tat 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000327 35
  • 57.08 (n)
  • 56.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1461 35
  • 57.13 (n)
  • 52.74 (a)
CG1461 36
  • 42 (a)
OneToOne
CG1461 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea tatn-1 35
  • 51.21 (n)
  • 44.2 (a)
tatn-1 36
  • 39 (a)
OneToOne
F42D1.2 37
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA3 36
  • 20 (a)
OneToMany
HIS5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G36160 35
  • 47.86 (n)
  • 35.01 (a)
rice
(Oryza sativa)
Liliopsida Os02g0302700 35
  • 47.04 (n)
  • 38.67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10155 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToOne
Species with no ortholog for TAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAT Gene

ENSEMBL:
Gene Tree for TAT (if available)
TreeFam:
Gene Tree for TAT (if available)

Paralogs for TAT Gene

Paralogs for TAT Gene

genes like me logo Genes that share paralogs with TAT: view

Variants for TAT Gene

Sequence variations from dbSNP and Humsavar for TAT Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1544808 -- 71,578,768(+) ttaaa(A/G)aatat upstream-variant-2KB
rs2032921 -- 71,578,542(-) ACGTA(C/T)TGTAA upstream-variant-2KB
rs2113223 -- 71,574,012(-) ATAGC(C/T)GTCAG intron-variant
rs2247603 -- 71,575,461(-) GTTAC(C/T)GTTTA intron-variant
rs2432519 -- 71,574,537(-) GTGGC(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAT Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855

Relevant External Links for TAT Gene

HapMap Linkage Disequilibrium report
TAT
Human Gene Mutation Database (HGMD)
TAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAT Gene

Disorders for TAT Gene

(1) OMIM Diseases for TAT Gene (613018)

UniProtKB/Swiss-Prot

ATTY_HUMAN
  • Tyrosinemia 2 (TYRSN2) [MIM:276600]: An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation. {ECO:0000269 PubMed:1357662}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(87) Novoseek inferred disease relationships for TAT Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 91.1 164
tyrosinemia type ii 84.1 9
equine infectious anemia 74.2 8
aids dementia complex 70.9 6
aids 66.7 65

Genatlas disease for TAT Gene

tyrosinemia II,oculocutaneous,Richner-Hanhart syndrome,with palmoplantar keratoderma (hyperkeratosis),ectodermal dysplasia and corneal dystrophy

Relevant External Links for TAT

Genetic Association Database (GAD)
TAT
genes like me logo Genes that share disorders with TAT: view

Publications for TAT Gene

  1. Cloning and expression of human tyrosine aminotransferase cDNA. (PMID: 7999802) Seralini G.E. … Labrie F. (Biochim. Biophys. Acta 1995) 3 4 23
  2. Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II. (PMID: 1357662) Natt E. … Scherer G. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  3. Isolation and characterization of the human tyrosine aminotransferase gene. (PMID: 1973834) Rettenmeier R. … Scherer G. (Nucleic Acids Res. 1990) 3 4 23
  4. Nucleotide sequence of the human tyrosine aminotransferase gene. (PMID: 7908801) Zelenin S.M. … Mertvetsov N.P. (Bioorg. Khim. 1994) 3 4 23
  5. Clinical and mutational investigations of tyrosinemia type II in Northern Tunisia: identification and structural characterization of two novel TAT mutations. (PMID: 16574453) Charfeddine C. … Abdelhak S. (Mol. Genet. Metab. 2006) 3 23

Products for TAT Gene

Sources for TAT Gene

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