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Aliases for TAL2 Gene

Aliases for TAL2 Gene

  • T-Cell Acute Lymphocytic Leukemia 2 2 3
  • Class A Basic Helix-Loop-Helix Protein 19 3 4
  • TAL-2 3 4
  • T-Cell Acute Lymphocytic Leukemia Protein 2 3
  • BHLHA19 4

External Ids for TAL2 Gene

Previous GeneCards Identifiers for TAL2 Gene

  • GC09P099225
  • GC09P100168
  • GC09P101882
  • GC09P103804
  • GC09P105504
  • GC09P107464
  • GC09P108424
  • GC09P078026

Summaries for TAL2 Gene

Entrez Gene Summary for TAL2 Gene

  • This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]

GeneCards Summary for TAL2 Gene

TAL2 (T-Cell Acute Lymphocytic Leukemia 2) is a Protein Coding gene. Diseases associated with TAL2 include lymphoblastic leukemia and leukemia. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is LYL1.

Gene Wiki entry for TAL2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAL2 Gene

Genomics for TAL2 Gene

Regulatory Elements for TAL2 Gene

Genomic Location for TAL2 Gene

Start:
105,662,457 bp from pter
End:
105,663,112 bp from pter
Size:
656 bases
Orientation:
Plus strand

Genomic View for TAL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAL2 Gene

Proteins for TAL2 Gene

  • Protein details for TAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16559-TAL2_HUMAN
    Recommended name:
    T-cell acute lymphocytic leukemia protein 2
    Protein Accession:
    Q16559
    Secondary Accessions:
    • A0AVI7

    Protein attributes for TAL2 Gene

    Size:
    108 amino acids
    Molecular mass:
    12291 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAL2 Gene

Proteomics data for TAL2 Gene at MOPED

Post-translational modifications for TAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAL2 Gene

Domains for TAL2 Gene

Gene Families for TAL2 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for TAL2 Gene

Suggested Antigen Peptide Sequences for TAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16559

UniProtKB/Swiss-Prot:

TAL2_HUMAN :
  • Q16559
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TAL2: view

Function for TAL2 Gene

Molecular function for TAL2 Gene

GENATLAS Biochemistry: helix loop helix protein,homologous to TAL1,involved in T cell acute lymphoblastic leukemia,with translocation t(7;9)(q35;q34)

Gene Ontology (GO) - Molecular Function for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TAL2: view
genes like me logo Genes that share phenotypes with TAL2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAL2 Gene

Localization for TAL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAL2 Gene COMPARTMENTS Subcellular localization image for TAL2 gene
Compartment Confidence
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TAL2 Gene

Pathways for TAL2 Gene

SuperPathways for TAL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009791 post-embryonic development IEA --
GO:0021794 thalamus development IEA --
GO:0030901 midbrain development IEA --
genes like me logo Genes that share ontologies with TAL2: view

No data available for Pathways by source for TAL2 Gene

Transcripts for TAL2 Gene

mRNA/cDNA for TAL2 Gene

(4) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAL2 Gene

T-cell acute lymphocytic leukemia 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAL2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAL2 Gene

No ASD Table

Relevant External Links for TAL2 Gene

GeneLoc Exon Structure for
TAL2
ECgene alternative splicing isoforms for
TAL2

Expression for TAL2 Gene

mRNA expression in normal human tissues for TAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAL2 Gene

This gene is overexpressed in Muscle - Skeletal (8.5).

SOURCE GeneReport for Unigene cluster for TAL2 Gene Hs.247978

genes like me logo Genes that share expressions with TAL2: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for TAL2 Gene

Orthologs for TAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAL2 35
  • 100 (n)
  • 100 (a)
TAL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAL2 35
  • 90.16 (n)
  • 95.24 (a)
TAL2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAL2 35
  • 91.75 (n)
  • 94.06 (a)
TAL2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tal2 35
  • 86.11 (n)
  • 86.11 (a)
Tal2 16
Tal2 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAL2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAL2 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tal2 35
  • 85.19 (n)
  • 85.19 (a)
chicken
(Gallus gallus)
Aves TAL2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAL2 36
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tal2 35
  • 60.78 (n)
  • 61.76 (a)
tal2 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HLH3B 36
  • 14 (a)
OneToMany
Species with no ortholog for TAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAL2 Gene

ENSEMBL:
Gene Tree for TAL2 (if available)
TreeFam:
Gene Tree for TAL2 (if available)

Paralogs for TAL2 Gene

Paralogs for TAL2 Gene

Selected SIMAP similar genes for TAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAL2: view

Variants for TAL2 Gene

Sequence variations from dbSNP and Humsavar for TAL2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs652574 -- 105,660,545(+) CCACC(A/G)CGCCC upstream-variant-2KB
rs7027450 -- 105,663,101(+) TCTAA(A/G)TAAAA utr-variant-3-prime
rs7041188 -- 105,660,636(+) CTGCC(A/G)CCCCC upstream-variant-2KB
rs7041949 -- 105,660,916(+) TTGGA(A/G)CCTGT upstream-variant-2KB
rs7851062 -- 105,662,011(+) ACTCC(A/G)TCTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAL2 Gene

Variant ID Type Subtype PubMed ID
nsv519023 CNV Gain 19592680

Relevant External Links for TAL2 Gene

HapMap Linkage Disequilibrium report
TAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAL2 Gene

Disorders for TAL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TAL2 Gene including...

Search for TAL2 Gene in MalaCards »

UniProtKB/Swiss-Prot

TAL2_HUMAN
  • Note=A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB.

Genatlas disease for TAL2 Gene

acute lymphoblastic leukemia (T cell) with breakpoint in t(7;9)(q35;q34) translocation

Relevant External Links for TAL2

Genetic Association Database (GAD)
TAL2
Tumor Gene Database (TGDB):
TAL2
genes like me logo Genes that share disorders with TAL2: view

Publications for TAL2 Gene

  1. TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. (PMID: 1763056) Xia Y. … Baer R.J. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23
  2. Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity. (PMID: 8152805) Xia Y. … Baer R. (Oncogene 1994) 3 4 23
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. (PMID: 19448620) Perry J.R. … Murabito J.M. (Nat. Genet. 2009) 3 48

Products for TAL2 Gene

Sources for TAL2 Gene

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