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Aliases for TAL1 Gene

Aliases for TAL1 Gene

  • T-Cell Acute Lymphocytic Leukemia 1 2 3
  • TCL5 3 4 6
  • SCL 3 4 6
  • Class A Basic Helix-Loop-Helix Protein 17 3 4
  • T-Cell Leukemia/Lymphoma Protein 5 3 4
  • Stem Cell Protein 3 4
  • BHLHa17 3 4
  • Tal-1 3 4
  • T-Cell Acute Lymphocytic Leukemia Protein 1 3
  • Tal-1 Product 3

External Ids for TAL1 Gene

Previous Symbols for TAL1 Gene

  • TCL5

Summaries for TAL1 Gene

GeneCards Summary for TAL1 Gene

TAL1 (T-Cell Acute Lymphocytic Leukemia 1) is a Protein Coding gene. Diseases associated with TAL1 include t-cell leukemia and cd3epsilon deficiency. Among its related pathways are Lymphocyte Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is LYL1.

UniProtKB/Swiss-Prot for TAL1 Gene

  • Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Gene Wiki entry for TAL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAL1 Gene

Genomics for TAL1 Gene

Genomic Location for TAL1 Gene

Start:
47,216,290 bp from pter
End:
47,232,266 bp from pter
Size:
15,977 bases
Orientation:
Minus strand

Genomic View for TAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAL1 Gene

Regulatory Elements for TAL1 Gene

Transcription factor binding sites by QIAGEN in the TAL1 gene promoter:

Proteins for TAL1 Gene

  • Protein details for TAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17542-TAL1_HUMAN
    Recommended name:
    T-cell acute lymphocytic leukemia protein 1
    Protein Accession:
    P17542
    Secondary Accessions:
    • D3DQ24

    Protein attributes for TAL1 Gene

    Size:
    331 amino acids
    Molecular mass:
    34271 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for TAL1 Gene

    Alternative splice isoforms for TAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAL1 Gene

Proteomics data for TAL1 Gene at MOPED

Post-translational modifications for TAL1 Gene

  • Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).
  • Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys185, Lys234, and Lys241

Other Protein References for TAL1 Gene

No data available for DME Specific Peptides for TAL1 Gene

Domains for TAL1 Gene

Gene Families for TAL1 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for TAL1 Gene

Suggested Antigen Peptide Sequences for TAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17542

UniProtKB/Swiss-Prot:

TAL1_HUMAN
Domain:
  • The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1:
    • P17542
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • P17542
genes like me logo Genes that share domains with TAL1: view

Function for TAL1 Gene

Molecular function for TAL1 Gene

UniProtKB/Swiss-Prot Function: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding --
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IEA --
GO:0001085 RNA polymerase II transcription factor binding IPI 15920471
genes like me logo Genes that share ontologies with TAL1: view
genes like me logo Genes that share phenotypes with TAL1: view

Animal Models for TAL1 Gene

MGI Knock Outs for TAL1:

Transcription Factor Targeting for TAL1 Gene

Selected GeneGlobe predicted Target genes for TAL1
Targeting motifs for TAL1 Gene
HOMER Transcription Factor Regulatory Elements motif TAL1
  • Consensus sequence: ANCAGCTG Submotif: canonical Cell Type: HPC7 GeoId: GSE13511

No data available for Enzyme Numbers (IUBMB) and miRNA for TAL1 Gene

Localization for TAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAL1 Gene COMPARTMENTS Subcellular localization image for TAL1 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 colocalizes_with histone deacetylase complex IDA 19497860
GO:0000790 nuclear chromatin IDA 20855495
GO:0005634 nucleus IDA 19497860
GO:0005667 transcription factor complex IDA 15920471
GO:0033193 colocalizes_with Lsd1/2 complex IDA 19497860
genes like me logo Genes that share ontologies with TAL1: view

Pathways for TAL1 Gene

SuperPathways for TAL1 Gene

Superpath Contained pathways
1 Lymphocyte Signaling
genes like me logo Genes that share pathways with TAL1: view

Pathways by source for TAL1 Gene

1 Cell Signaling Technology pathway for TAL1 Gene

Gene Ontology (GO) - Biological Process for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001525 angiogenesis IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter ISS --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007626 locomotory behavior IEA --
genes like me logo Genes that share ontologies with TAL1: view

Compounds for TAL1 Gene

(6) Novoseek inferred chemical compound relationships for TAL1 Gene

Compound -log(P) Hits PubMed IDs
tal 2 88.9 10
retinoic acid 7.55 7
etoposide 5.68 1
oligonucleotide 0 1
serine 0 4
genes like me logo Genes that share compounds with TAL1: view

Transcripts for TAL1 Gene

Unigene Clusters for TAL1 Gene

T-cell acute lymphocytic leukemia 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - - - - -
SP4:

Relevant External Links for TAL1 Gene

GeneLoc Exon Structure for
TAL1
ECgene alternative splicing isoforms for
TAL1

Expression for TAL1 Gene

mRNA expression in normal human tissues for TAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAL1 Gene

This gene is overexpressed in Whole Blood (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAL1 Gene

SOURCE GeneReport for Unigene cluster for TAL1 Gene Hs.705618

mRNA Expression by UniProt/SwissProt for TAL1 Gene

P17542-TAL1_HUMAN
Tissue specificity: Leukemic stem cell
genes like me logo Genes that share expressions with TAL1: view

Orthologs for TAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAL1 35
  • 99.9 (n)
  • 99.7 (a)
TAL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAL1 35
  • 90.52 (n)
  • 92.97 (a)
TAL1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAL1 35
  • 90.42 (n)
  • 93.27 (a)
TAL1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tal1 35
  • 88.75 (n)
  • 93.31 (a)
Tal1 16
Tal1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAL1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAL1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tal1 35
  • 88.05 (n)
  • 94.81 (a)
chicken
(Gallus gallus)
Aves SCL 36
  • 82 (a)
OneToOne
TAL1 35
  • 72.46 (n)
  • 70.57 (a)
lizard
(Anolis carolinensis)
Reptilia TAL1 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398028 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tal1 35
  • 68.45 (n)
  • 72.32 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12172 35
zebrafish
(Danio rerio)
Actinopterygii tal1 35
  • 68.73 (n)
  • 65.89 (a)
tal1 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HLH3B 36
  • 19 (a)
OneToMany
Species with no ortholog for TAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAL1 Gene

ENSEMBL:
Gene Tree for TAL1 (if available)
TreeFam:
Gene Tree for TAL1 (if available)

Paralogs for TAL1 Gene

Paralogs for TAL1 Gene

Selected SIMAP similar genes for TAL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TAL1: view

Variants for TAL1 Gene

Sequence variations from dbSNP and Humsavar for TAL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2845 -- 47,228,408(+) GAATC(A/G)TTCTA intron-variant
rs7664 -- 47,216,345(-) TGTGT(A/C)TATAT utr-variant-3-prime
rs741958 -- 47,226,609(-) GGGCA(A/G)AGGAC intron-variant
rs743269 -- 47,225,705(+) GCCGC(C/G)CCCCG missense, reference, intron-variant
rs751852 -- 47,225,750(+) CTCCG(C/T)TGCGG missense, reference, intron-variant

Relevant External Links for TAL1 Gene

HapMap Linkage Disequilibrium report
TAL1
Human Gene Mutation Database (HGMD)
TAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAL1 Gene

Disorders for TAL1 Gene

UniProtKB/Swiss-Prot

TAL1_HUMAN
  • Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.

(1) University of Copenhagen DISEASES for TAL1 Gene

(19) Novoseek inferred disease relationships for TAL1 Gene

Disease -log(P) Hits PubMed IDs
t-all 95.2 126
t-cell childhood acute lymphoblastic leukemia 82.4 4
leukemia t-cell 73.9 15
leukemogenesis 70.5 7
erythroleukemia 68.3 7

Genatlas disease for TAL1 Gene

acute lymphoblastic leukemia (T cell) with interstitial deletion 5 to TAL1 (stem-cell leukemia) or with translocations t(1;14)(p32;q11),t(1;7)(p32;p35),t(1;3)(p34;p21),t(1;5)(p32;q31),see SCL,SIL,TCTA

Relevant External Links for TAL1

Genetic Association Database (GAD)
TAL1
Human Genome Epidemiology (HuGE) Navigator
TAL1
Tumor Gene Database (TGDB):
TAL1
genes like me logo Genes that share disorders with TAL1: view

Publications for TAL1 Gene

  1. The SCL gene product: a positive regulator of erythroid differentiation. (PMID: 1396592) Aplan P.D. … Kirsch I.R. (EMBO J. 1992) 3 4 23
  2. Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. (PMID: 2230650) Chen Q. … Baer R. (J. Exp. Med. 1990) 3 4 23
  3. Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. (PMID: 8437851) Cheng J.-T. … Baer R. (Oncogene 1993) 3 4 23
  4. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. (PMID: 9171354) Aplan P.D. … Gross K.W. (EMBO J. 1997) 3 23
  5. The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition. (PMID: 9507011) Park S.T. … Sun X.H. (J. Biol. Chem. 1998) 3 23

Products for TAL1 Gene

Sources for TAL1 Gene

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