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Aliases for TAF13 Gene

Aliases for TAF13 Gene

  • TATA-Box Binding Protein Associated Factor 13 2 3 5
  • TAF13 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 18kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, K, 18kD 2 3
  • Transcription Initiation Factor TFIID 18 KDa Subunit 3 4
  • TAF(II)18 3 4
  • TAFII-18 3 4
  • TAFII18 3 4
  • TAF2K 3 4
  • Transcription Initiation Factor TFIID 18 KD Subunit 3
  • Transcription Initiation Factor TFIID Subunit 13 3
  • MRT60 3

External Ids for TAF13 Gene

Previous HGNC Symbols for TAF13 Gene

  • TAF2K

Previous GeneCards Identifiers for TAF13 Gene

  • GC01M110076
  • GC01M9C0097
  • GC01U900282
  • GC00M9T0035
  • GC01M109318
  • GC01M109406
  • GC01M109605
  • GC01M107499

Summaries for TAF13 Gene

Entrez Gene Summary for TAF13 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF13 Gene

TAF13 (TATA-Box Binding Protein Associated Factor 13) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and PEDF Induced Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein C-terminus binding.

UniProtKB/Swiss-Prot for TAF13 Gene

  • TFIID beta-specific TAFII.

Gene Wiki entry for TAF13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF13 Gene

Genomics for TAF13 Gene

Regulatory Elements for TAF13 Gene

Enhancers for TAF13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G109049 0.7 ENCODE 17.3 +25.5 25458 1.3 PKNOX1 ZNF217 ZNF121 GATA3 CTBP1 PBX2 HMBOX1 FOSL2 ZBTB33 FOS TAF13 TMEM167B RANP5
GH01G109074 1.2 ENCODE 9.6 +0.1 79 2.3 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 TAF13 RANP5
GH01G108961 1.1 ENCODE 5.7 +112.8 112811 2.6 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B GNAI3 RPL17P7 PRPF38B RPS27P6 C1orf194 WDR47 TAF13 GC01P108959 ENSG00000274068
GH01G109079 1.4 Ensembl ENCODE dbSUPER 0.7 -4.2 -4233 1.4 HDGF PKNOX1 ARNT DMAP1 ZNF48 NCOA1 ZNF592 SMARCA4 NBN KDM1A C1orf194 TAF13 TMEM167B
GH01G109084 0.6 ENCODE 0.4 -8.8 -8782 0.1 ZNF362 ZEB2 ZNF384 DPF2 GABPA FOSL1 ZSCAN21 JUND NBN RBFOX2 TAF13 TMEM167B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAF13 on UCSC Golden Path with GeneCards custom track

Promoters for TAF13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TAF13 Gene

109,062,486 bp from pter
109,076,002 bp from pter
13,517 bases
Minus strand

Genomic View for TAF13 Gene

Genes around TAF13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF13 Gene

Proteins for TAF13 Gene

  • Protein details for TAF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription initiation factor TFIID subunit 13
    Protein Accession:
    Secondary Accessions:
    • B2R5E5
    • Q5TYV6

    Protein attributes for TAF13 Gene

    124 amino acids
    Molecular mass:
    14287 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11.

    Three dimensional structures from OCA and Proteopedia for TAF13 Gene

neXtProt entry for TAF13 Gene

Post-translational modifications for TAF13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF13 Gene

Domains & Families for TAF13 Gene

Protein Domains for TAF13 Gene

Graphical View of Domain Structure for InterPro Entry



  • The binding of TAF10 and TAF11 requires distinct domains of TAF13.
  • Belongs to the TAF13 family.
  • The binding of TAF10 and TAF11 requires distinct domains of TAF13.
  • Belongs to the TAF13 family.
genes like me logo Genes that share domains with TAF13: view

No data available for Gene Families for TAF13 Gene

Function for TAF13 Gene

Molecular function for TAF13 Gene

UniProtKB/Swiss-Prot Function:
TFIID beta-specific TAFII.

Gene Ontology (GO) - Molecular Function for TAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 9695952
GO:0005515 protein binding IPI 7729427
GO:0008022 protein C-terminus binding IPI 7729427
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TAF13: view
genes like me logo Genes that share phenotypes with TAF13: view

Animal Model Products

CRISPR Products

miRNA for TAF13 Gene

miRTarBase miRNAs that target TAF13

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF13 Gene

Localization for TAF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF13 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF13 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex NAS 9695952
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with TAF13: view

Pathways & Interactions for TAF13 Gene

genes like me logo Genes that share pathways with TAF13: view

Gene Ontology (GO) - Biological Process for TAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation NAS 9695952
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF13: view

No data available for SIGNOR curated interactions for TAF13 Gene

Drugs & Compounds for TAF13 Gene

No Compound Related Data Available

Transcripts for TAF13 Gene

mRNA/cDNA for TAF13 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(73) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAF13 Gene

TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF13 Gene

No ASD Table

Relevant External Links for TAF13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAF13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF13 Gene

Protein differential expression in normal tissues from HIPED for TAF13 Gene

This gene is overexpressed in Fetal Brain (39.3) and Placenta (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF13 Gene

Protein tissue co-expression partners for TAF13 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAF13 Gene:


SOURCE GeneReport for Unigene cluster for TAF13 Gene:


Evidence on tissue expression from TISSUES for TAF13 Gene

  • Nervous system(4.4)
  • Liver(2)
genes like me logo Genes that share expression patterns with TAF13: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF13 Gene

Orthologs for TAF13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAF13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TAF13 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia TAF13 35
  • 96 (a)
(Canis familiaris)
Mammalia TAF13 34 35
  • 95.7 (n)
(Bos Taurus)
Mammalia TAF13 34 35
  • 94.35 (n)
(Mus musculus)
Mammalia Taf13 34 16 35
  • 90.32 (n)
(Gallus gallus)
Aves TAF13 34 35
  • 82.65 (n)
(Anolis carolinensis)
Reptilia TAF13 35
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia taf13 34
  • 78.91 (n)
Str.6597 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4615 34
(Danio rerio)
Actinopterygii taf13 34 35
  • 74.15 (n)
wufc20d03 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1879 34
fruit fly
(Drosophila melanogaster)
Insecta Taf13 36 34 35
  • 67.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008045 34
  • 65.29 (n)
(Caenorhabditis elegans)
Secernentea taf-13 34 35
  • 58.7 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF13 35 37
  • 17 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TAF13 34
  • 63.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5080 35
  • 66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4198 34
Species where no ortholog for TAF13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF13 Gene

Gene Tree for TAF13 (if available)
Gene Tree for TAF13 (if available)

Paralogs for TAF13 Gene

(1) SIMAP similar genes for TAF13 Gene using alignment to 2 proteins: Pseudogenes for TAF13 Gene

genes like me logo Genes that share paralogs with TAF13: view

No data available for Paralogs for TAF13 Gene

Variants for TAF13 Gene

Sequence variations from dbSNP and Humsavar for TAF13 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000070937 -- 109,076,050(+) TGGGC(C/T)TAGCC upstream-variant-2KB
rs1000108754 -- 109,065,688(+) GAGGC(A/C/G)GAGGC intron-variant
rs1000121332 -- 109,075,839(+) AAGCA(C/G)ACCCG intron-variant
rs1000458207 -- 109,070,684(+) CCACC(A/G)TACCC intron-variant
rs1000658248 -- 109,069,458(+) GACAA(-/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF13 Gene

Variant ID Type Subtype PubMed ID
esv2669667 CNV deletion 23128226
esv2715973 CNV deletion 23290073
esv2715984 CNV deletion 23290073
esv3587147 CNV loss 21293372
esv3894001 CNV gain 25118596
nsv1078062 CNV deletion 25765185
nsv1119707 CNV deletion 24896259
nsv831026 CNV loss 17160897
nsv954947 CNV deletion 24416366

Variation tolerance for TAF13 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF13 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF13 Gene

Disorders for TAF13 Gene

Relevant External Links for TAF13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TAF13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF13 Gene

Publications for TAF13 Gene

  1. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PMID: 7729427) Mengus G. … Davidson I. (EMBO J. 1995) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family. (PMID: 9695952) Birck C. … Moras D. (Cell 1998) 3 4 64
  5. Hypomorphic Pathogenic Variants in TAF13 Are Associated with Autosomal-Recessive Intellectual Disability and Microcephaly. (PMID: 28257693) Tawamie H. … Abou Jamra R. (Am. J. Hum. Genet. 2017) 3 64

Products for TAF13 Gene

Sources for TAF13 Gene

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