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Aliases for TAF13 Gene

Aliases for TAF13 Gene

  • TATA-Box Binding Protein Associated Factor 13 2 3 5
  • TAF13 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 18kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, K, 18kD 2 3
  • Transcription Initiation Factor TFIID 18 KDa Subunit 3 4
  • TAF(II)18 3 4
  • TAFII-18 3 4
  • TAFII18 3 4
  • TAF2K 3 4
  • Transcription Initiation Factor TFIID 18 KD Subunit 3
  • TATA Box Binding Protein Associated Factor 13 3

External Ids for TAF13 Gene

Previous HGNC Symbols for TAF13 Gene

  • TAF2K

Previous GeneCards Identifiers for TAF13 Gene

  • GC01M110076
  • GC01M9C0097
  • GC01U900282
  • GC00M9T0035
  • GC01M109318
  • GC01M109406
  • GC01M109605
  • GC01M107499

Summaries for TAF13 Gene

Entrez Gene Summary for TAF13 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF13 Gene

TAF13 (TATA-Box Binding Protein Associated Factor 13) is a Protein Coding gene. Among its related pathways are Gene Expression and HIV Life Cycle. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein C-terminus binding.

UniProtKB/Swiss-Prot for TAF13 Gene

  • TFIID beta-specific TAFII.

Gene Wiki entry for TAF13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF13 Gene

Genomics for TAF13 Gene

Regulatory Elements for TAF13 Gene

Promoters for TAF13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAF13 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAF13 Gene

Chromosome:
1
Start:
109,062,486 bp from pter
End:
109,076,002 bp from pter
Size:
13,517 bases
Orientation:
Minus strand

Genomic View for TAF13 Gene

Genes around TAF13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF13 Gene

Proteins for TAF13 Gene

  • Protein details for TAF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15543-TAF13_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 13
    Protein Accession:
    Q15543
    Secondary Accessions:
    • B2R5E5
    • Q5TYV6

    Protein attributes for TAF13 Gene

    Size:
    124 amino acids
    Molecular mass:
    14287 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11.

    Three dimensional structures from OCA and Proteopedia for TAF13 Gene

neXtProt entry for TAF13 Gene

Proteomics data for TAF13 Gene at MOPED

Post-translational modifications for TAF13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TAF13 Gene

Domains & Families for TAF13 Gene

Protein Domains for TAF13 Gene

Graphical View of Domain Structure for InterPro Entry

Q15543

UniProtKB/Swiss-Prot:

TAF13_HUMAN :
  • The binding of TAF10 and TAF11 requires distinct domains of TAF13.
  • Belongs to the TAF13 family.
Domain:
  • The binding of TAF10 and TAF11 requires distinct domains of TAF13.
  • Contains 1 histone-fold domain.
Family:
  • Belongs to the TAF13 family.
genes like me logo Genes that share domains with TAF13: view

No data available for Gene Families for TAF13 Gene

Function for TAF13 Gene

Molecular function for TAF13 Gene

UniProtKB/Swiss-Prot Function:
TFIID beta-specific TAFII.

Gene Ontology (GO) - Molecular Function for TAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 7729427
genes like me logo Genes that share ontologies with TAF13: view
genes like me logo Genes that share phenotypes with TAF13: view

Animal Model Products

miRNA for TAF13 Gene

miRTarBase miRNAs that target TAF13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF13 Gene

Localization for TAF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF13 Gene COMPARTMENTS Subcellular localization image for TAF13 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for TAF13 Gene

Pathways & Interactions for TAF13 Gene

genes like me logo Genes that share pathways with TAF13: view

Gene Ontology (GO) - Biological Process for TAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IEA,TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with TAF13: view

No data available for SIGNOR curated interactions for TAF13 Gene

Drugs & Compounds for TAF13 Gene

No Compound Related Data Available

Transcripts for TAF13 Gene

mRNA/cDNA for TAF13 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(73) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAF13 Gene

TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF13 Gene

No ASD Table

Relevant External Links for TAF13 Gene

GeneLoc Exon Structure for
TAF13
ECgene alternative splicing isoforms for
TAF13

Expression for TAF13 Gene

mRNA expression in normal human tissues for TAF13 Gene

Protein differential expression in normal tissues from HIPED for TAF13 Gene

This gene is overexpressed in Fetal Brain (39.3) and Placenta (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF13 Gene



SOURCE GeneReport for Unigene cluster for TAF13 Gene Hs.632426

genes like me logo Genes that share expression patterns with TAF13: view

Protein tissue co-expression partners for TAF13 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF13 Gene

Orthologs for TAF13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAF13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF13 35
  • 94.35 (n)
  • 100 (a)
TAF13 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF13 35
  • 95.7 (n)
  • 99.19 (a)
TAF13 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf13 35
  • 90.32 (n)
  • 100 (a)
Taf13 16
Taf13 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF13 35
  • 100 (n)
  • 100 (a)
TAF13 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF13 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF13 35
  • 82.65 (n)
  • 100 (a)
TAF13 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF13 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6597 35
taf13 35
  • 78.91 (n)
  • 98.98 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4615 35
zebrafish
(Danio rerio)
Actinopterygii taf13 35
  • 74.15 (n)
  • 95.92 (a)
wufc20d03 35
taf13 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1879 35
fruit fly
(Drosophila melanogaster)
Insecta Taf13 37
  • 83 (a)
Taf13 35
  • 67.72 (n)
  • 83.16 (a)
Taf13 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008045 35
  • 65.29 (n)
  • 86.6 (a)
worm
(Caenorhabditis elegans)
Secernentea taf-13 35
  • 58.7 (n)
  • 50 (a)
taf-13 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF13 36
  • 17 (a)
OneToOne
TAF13 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TAF13 35
  • 63.04 (n)
  • 60.87 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4198 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5080 36
  • 66 (a)
OneToOne
Species with no ortholog for TAF13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF13 Gene

ENSEMBL:
Gene Tree for TAF13 (if available)
TreeFam:
Gene Tree for TAF13 (if available)

Paralogs for TAF13 Gene

(1) SIMAP similar genes for TAF13 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TAF13 Gene

genes like me logo Genes that share paralogs with TAF13: view

No data available for Paralogs for TAF13 Gene

Variants for TAF13 Gene

Sequence variations from dbSNP and Humsavar for TAF13 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs522193 -- 109,064,447(+) TATCA(A/G)AATCT utr-variant-3-prime
rs561096 -- 109,073,928(-) ggcag(A/C)ggtgc intron-variant
rs673365 -- 109,075,635(-) TATGA(A/G)CCAAC intron-variant
rs1149166 -- 109,074,420(-) ccctg(A/G)gtact intron-variant
rs1562225 -- 109,070,844(+) AACAA(A/C)CGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF13 Gene

Variant ID Type Subtype PubMed ID
nsv831026 CNV Loss 17160897
esv2669667 CNV Deletion 23128226
esv2715973 CNV Deletion 23290073
esv2715984 CNV Deletion 23290073

Variation tolerance for TAF13 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF13 Gene

HapMap Linkage Disequilibrium report
TAF13
Human Gene Mutation Database (HGMD)
TAF13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF13 Gene

Disorders for TAF13 Gene

Relevant External Links for TAF13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF13

No disorders were found for TAF13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF13 Gene

Publications for TAF13 Gene

  1. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PMID: 7729427) Mengus G. … Davidson I. (EMBO J. 1995) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. (PMID: 21729782) Takahashi H. … Conaway J.W. (Cell 2011) 3
  5. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (PMID: 20850016) Vermeulen M. … Mann M. (Cell 2010) 3

Products for TAF13 Gene

Sources for TAF13 Gene

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