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Aliases for TAF12 Gene

Aliases for TAF12 Gene

  • TAF12 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 20kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, J, 20kD 2 3
  • Transcription Initiation Factor TFIID 20/15 KDa Subunits 3 4
  • TAFII-20/TAFII-15 3 4
  • TAFII20/TAFII15 3 4
  • TAFII20 3 4
  • TAF2J 3 4
  • Transcription Initiation Factor TFIID Subunit 12 3
  • TAF15 4

External Ids for TAF12 Gene

Previous HGNC Symbols for TAF12 Gene

  • TAF2J

Previous GeneCards Identifiers for TAF12 Gene

  • GC01P028822
  • GC01M027888
  • GC01M028434
  • GC01M028750
  • GC01M028801
  • GC01M028915
  • GC01M027182

Summaries for TAF12 Gene

Entrez Gene Summary for TAF12 Gene

  • Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for TAF12 Gene

TAF12 (TAF12 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 20kDa) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding.

UniProtKB/Swiss-Prot for TAF12 Gene

  • TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription

Gene Wiki entry for TAF12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF12 Gene

Genomics for TAF12 Gene

Regulatory Elements for TAF12 Gene

Genomic Location for TAF12 Gene

Start:
28,589,323 bp from pter
End:
28,643,101 bp from pter
Size:
53,779 bases
Orientation:
Minus strand

Genomic View for TAF12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF12 Gene

Proteins for TAF12 Gene

  • Protein details for TAF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16514-TAF12_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 12
    Protein Accession:
    Q16514
    Secondary Accessions:
    • D3DPM5
    • Q15775
    • Q5T077

    Protein attributes for TAF12 Gene

    Size:
    161 amino acids
    Molecular mass:
    17924 Da
    Quaternary structure:
    • TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP; additional interactions between TAFII20 and TAFII28 or TAFII30 were detected. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, STAF65-gamma/KIAA0764, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Interacts (isoform TAFII15 and isoform TAFII20) with ATF7 (via the transactivation domain); the interaction is prevented by sumoylation of ATF7 and promotes (isoform TAFII20 only) the transactivation of ATF7.

    Three dimensional structures from OCA and Proteopedia for TAF12 Gene

    Alternative splice isoforms for TAF12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF12 Gene

Proteomics data for TAF12 Gene at MOPED

Post-translational modifications for TAF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF12 Gene

Domains for TAF12 Gene

Protein Domains for TAF12 Gene

Suggested Antigen Peptide Sequences for TAF12 Gene

Graphical View of Domain Structure for InterPro Entry

Q16514

UniProtKB/Swiss-Prot:

TAF12_HUMAN :
  • Q16514
Domain:
  • Contains 1 histone-fold domain.
Family:
  • Belongs to the TAF12 family.
genes like me logo Genes that share domains with TAF12: view

No data available for Gene Families for TAF12 Gene

Function for TAF12 Gene

Molecular function for TAF12 Gene

UniProtKB/Swiss-Prot Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription

Gene Ontology (GO) - Molecular Function for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15601843
GO:0003700 contributes_to sequence-specific DNA binding transcription factor activity IDA 9603525
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 protein binding IPI 11438666
genes like me logo Genes that share ontologies with TAF12: view

Phenotypes for TAF12 Gene

genes like me logo Genes that share phenotypes with TAF12: view

miRNA for TAF12 Gene

miRTarBase miRNAs that target TAF12

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAF12 Gene

Localization for TAF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF12 Gene COMPARTMENTS Subcellular localization image for TAF12 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000125 PCAF complex IDA 9674425
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 14580349
genes like me logo Genes that share ontologies with TAF12: view

Pathways for TAF12 Gene

genes like me logo Genes that share pathways with TAF12: view

Gene Ontology (GO) - Biological Process for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006352 DNA-templated transcription, initiation IDA 9603525
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF12: view

Transcripts for TAF12 Gene

Unigene Clusters for TAF12 Gene

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for TAF12 Gene

GeneLoc Exon Structure for
TAF12
ECgene alternative splicing isoforms for
TAF12

Expression for TAF12 Gene

mRNA expression in normal human tissues for TAF12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TAF12 Gene

SOURCE GeneReport for Unigene cluster for TAF12 Gene Hs.530251

mRNA Expression by UniProt/SwissProt for TAF12 Gene

Q16514-TAF12_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with TAF12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAF12 Gene

Orthologs for TAF12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF12 35
  • 99.38 (n)
  • 98.76 (a)
TAF12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 91 (a)
OneToMany
TAF12 35
  • 95.24 (n)
  • 99.38 (a)
TAF12 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
TAF12 35
  • 96.48 (n)
  • 98.76 (a)
mouse
(Mus musculus)
Mammalia Taf12 35
  • 91.1 (n)
  • 96.27 (a)
Taf12 16
Taf12 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF12 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF12 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf12 35
  • 91.72 (n)
  • 96.89 (a)
chicken
(Gallus gallus)
Aves TAF12 35
  • 84.06 (n)
  • 95.03 (a)
TAF12 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF12 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia taf12-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7323 35
taf12 35
  • 73.5 (n)
  • 81.37 (a)
zebrafish
(Danio rerio)
Actinopterygii taf12 35
  • 73.79 (n)
  • 84.28 (a)
taf12 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003135 35
  • 64.06 (n)
  • 70.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Taf12 35
  • 54.82 (n)
  • 55.92 (a)
Taf12 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea taf-12 36
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF12 36
  • 12 (a)
OneToOne
TAF12 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4626 36
  • 36 (a)
OneToOne
Species with no ortholog for TAF12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF12 Gene

ENSEMBL:
Gene Tree for TAF12 (if available)
TreeFam:
Gene Tree for TAF12 (if available)

Paralogs for TAF12 Gene

No data available for Paralogs for TAF12 Gene

Variants for TAF12 Gene

Sequence variations from dbSNP and Humsavar for TAF12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1804642 -- 28,621,989(-) TCCAT(C/G)GCCAA missense, reference
rs2995157 -- 28,611,559(+) agaga(C/G)acaga intron-variant
rs2995158 -- 28,635,827(-) TTTTT(A/T)AAAAA intron-variant
rs3001307 -- 28,611,990(+) TCTGT(C/T)CTTTT intron-variant
rs3001308 -- 28,613,986(+) tgtaa(C/T)cccag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF12 Gene

Variant ID Type Subtype PubMed ID
nsv506924 CNV Insertion 20534489
nsv819244 CNV Loss 19587683
nsv822209 CNV Loss 20364138
esv2660216 CNV Deletion 23128226
esv2665007 CNV Deletion 23128226

Relevant External Links for TAF12 Gene

HapMap Linkage Disequilibrium report
TAF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF12 Gene

Disorders for TAF12 Gene

(1) University of Copenhagen DISEASES for TAF12 Gene

genes like me logo Genes that share disorders with TAF12: view

No data available for UniProtKB/Swiss-Prot for TAF12 Gene

Publications for TAF12 Gene

  1. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PMID: 15735663) Hamard P.J. … Chatton B. (Oncogene 2005) 3 4 23
  2. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PMID: 7729427) Mengus G. … Davidson I. (EMBO J. 1995) 2 3 4
  3. The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs. (PMID: 10594036) Gangloff Y.-G. … Davidson I. (Mol. Cell. Biol. 2000) 3 4 23
  4. Evolutionary conservation of human TATA-binding-polypeptide- associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PMID: 7667268) Hisatake K. … Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 23
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for TAF12 Gene

Sources for TAF12 Gene

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