Aliases for KLF5 Gene
External Ids for KLF5 Gene
Previous HGNC Symbols for KLF5 Gene
Previous GeneCards Identifiers for KLF5 Gene
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
GeneCards Summary for KLF5 Gene
KLF5 (Kruppel-Like Factor 5 (Intestinal)) is a Protein Coding gene. Diseases associated with KLF5 include cerebral aneurysms and essential thrombocythemia. Among its related pathways are L1CAM interactions and Fatty acid, triacylglycerol, and ketone body metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF2.
UniProtKB/Swiss-Prot for KLF5 Gene
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes
The Kruppel-like factor family of zinc finger proteins act as transcription factors. KLF5 has been linked to the maintenance of embryonic stem cell (ESC) pluripotency, as well as the regulation of cell proliferation in the intestinal epithelium.