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Aliases for KLF5 Gene

Aliases for KLF5 Gene

  • Kruppel-Like Factor 5 (Intestinal) 2 3
  • Intestinal-Enriched Krueppel-Like Factor 3 4
  • Colon Krueppel-Like Factor 3 4
  • Transcription Factor BTEB2 3 4
  • BTE-Binding Protein 2 3 4
  • BTEB2 3 4
  • CKLF 3 4
  • IKLF 3 4
  • Basic Transcription Element Binding Protein 2 3
  • Basic Transcription Element-Binding Protein 2 4
  • Intestinal-Enriched Kruppel-Like Factor 3
  • Colon Kruppel-Like Factor 3
  • GC Box Binding Protein 2 3
  • GC-Box-Binding Protein 2 4
  • Krueppel-Like Factor 5 3
  • Klf5C Isoform 3

External Ids for KLF5 Gene

Previous Symbols for KLF5 Gene

  • BTEB2

Summaries for KLF5 Gene

Entrez Gene Summary for KLF5 Gene

  • This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for KLF5 Gene

KLF5 (Kruppel-Like Factor 5 (Intestinal)) is a Protein Coding gene. Diseases associated with KLF5 include cerebral aneurysms and essential thrombocythemia. Among its related pathways are L1CAM interactions and Adipogenesis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for KLF5 Gene

  • Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes

Tocris Summary for KLF5 Gene

  • The Kruppel-like factor family of zinc finger proteins act as transcription factors. KLF5 has been linked to the maintenance of embryonic stem cell (ESC) pluripotency, as well as the regulation of cell proliferation in the intestinal epithelium.

Gene Wiki entry for KLF5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF5 Gene

Genomics for KLF5 Gene

Genomic Location for KLF5 Gene

73,054,976 bp from pter
73,077,542 bp from pter
22,567 bases
Plus strand

Genomic View for KLF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF5 Gene

Regulatory Elements for KLF5 Gene

Proteins for KLF5 Gene

  • Protein details for KLF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Krueppel-like factor 5
    Protein Accession:
    Secondary Accessions:
    • A2TJX0
    • L0R3U5
    • L0R4T9
    • Q9UHP8

    Protein attributes for KLF5 Gene

    457 amino acids
    Molecular mass:
    50792 Da
    Quaternary structure:
    • Interacts with WWP1.

    Three dimensional structures from OCA and Proteopedia for KLF5 Gene

    Alternative splice isoforms for KLF5 Gene


neXtProt entry for KLF5 Gene

Proteomics data for KLF5 Gene at MOPED

Post-translational modifications for KLF5 Gene

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF5 Gene

Domains for KLF5 Gene

Gene Families for KLF5 Gene

  • ZNF :Zinc fingers, C2H2-type
  • KLF :Kruppel-like transcription factors

Protein Domains for KLF5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q13887
  • Contains 3 C2H2-type zinc fingers.:
    • Q13887
genes like me logo Genes that share domains with KLF5: view

Function for KLF5 Gene

Molecular function for KLF5 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes

Gene Ontology (GO) - Molecular Function for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16595680
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 16595680
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 17320083
genes like me logo Genes that share ontologies with KLF5: view
genes like me logo Genes that share phenotypes with KLF5: view

Animal Models for KLF5 Gene

MGI Knock Outs for KLF5:

miRNA for KLF5 Gene

Targeting motifs for KLF5 Gene
HOMER Transcription Factor Regulatory Elements motif KLF5
  • Consensus sequence: DGGGYGKGGC Submotif: canonical Cell Type: LoVo GeoId: GSE49402

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for KLF5 Gene

Localization for KLF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF5 Gene

Subcellular locations from

Jensen Localization Image for KLF5 Gene COMPARTMENTS Subcellular localization image for KLF5 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with KLF5: view

Pathways for KLF5 Gene

genes like me logo Genes that share pathways with KLF5: view

Pathways by source for KLF5 Gene

1 BioSystems pathway for KLF5 Gene

Gene Ontology (GO) - Biological Process for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001525 angiogenesis IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006366 transcription from RNA polymerase II promoter TAS 8479902
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with KLF5: view

Compounds for KLF5 Gene

(5) Tocris Compounds for KLF5 Gene

Compound Action Cas Number
BI 6015 Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist [93987-29-2]
GANT 61 GLI antagonist; inhibits Hedgehog (Hh) signaling [500579-04-4]
KL 001 Cryptochrome protein stabilizer; lengthens circadian period [309928-48-1]
Stauprimide Inhibits NME2 nuclear translocation; primes ESCs for differentiation [154589-96-5]
UNC 926 hydrochloride L3MBTL1 domain inhibitor [1184136-10-4]

(6) Novoseek inferred chemical compound relationships for KLF5 Gene

Compound -log(P) Hits PubMed IDs
zinc 53.9 12
proline 4.56 3
alanine 0 1
estrogen 0 5
serine 0 1
genes like me logo Genes that share compounds with KLF5: view

Transcripts for KLF5 Gene

Unigene Clusters for KLF5 Gene

Kruppel-like factor 5 (intestinal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -

Relevant External Links for KLF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLF5 Gene

mRNA expression in normal human tissues for KLF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF5 Gene

This gene is overexpressed in Esophagus - Mucosa (9.2), Skin - Sun Exposed (Lower leg) (6.9), Skin - Not Sun Exposed (Suprapubic) (6.6), and Colon - Transverse (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLF5 Gene

SOURCE GeneReport for Unigene cluster for KLF5 Gene Hs.508234

mRNA Expression by UniProt/SwissProt for KLF5 Gene

Tissue specificity: Expressed only in testis and placenta
genes like me logo Genes that share expressions with KLF5: view

Orthologs for KLF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLF5 35
  • 99.64 (n)
  • 99.34 (a)
KLF5 36
  • 99 (a)
(Bos Taurus)
Mammalia KLF5 35
  • 93.54 (n)
  • 95.15 (a)
KLF5 36
  • 96 (a)
(Canis familiaris)
Mammalia KLF5 35
  • 94.53 (n)
  • 95.62 (a)
KLF5 36
  • 96 (a)
(Mus musculus)
Mammalia Klf5 35
  • 89.82 (n)
  • 91.63 (a)
Klf5 16
Klf5 36
  • 91 (a)
(Monodelphis domestica)
Mammalia KLF5 36
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia KLF5 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Klf5 35
  • 90.05 (n)
  • 92.99 (a)
(Gallus gallus)
Aves KLF5 35
  • 82.21 (n)
  • 89.22 (a)
KLF5 36
  • 89 (a)
(Anolis carolinensis)
Reptilia KLF5 36
  • 78 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14648 35
tropical clawed frog
(Silurana tropicalis)
Amphibia klf5 35
  • 72.65 (n)
  • 76.08 (a)
Str.15084 35
(Danio rerio)
Actinopterygii klf5a 36
  • 46 (a)
klf5b 36
  • 51 (a)
LOC100006043 35
  • 60.62 (n)
  • 59.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta dar1 36
  • 16 (a)
CG12029 37
  • 79 (a)
CG9895 37
  • 80 (a)
(Caenorhabditis elegans)
Secernentea klf-1 36
  • 19 (a)
klf-2 36
  • 31 (a)
F53F8.1 37
  • 65 (a)
mua-1 37
  • 39 (a)
F56F11.3 37
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for KLF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF5 Gene

Gene Tree for KLF5 (if available)
Gene Tree for KLF5 (if available)

Paralogs for KLF5 Gene

genes like me logo Genes that share paralogs with KLF5: view

Variants for KLF5 Gene

Sequence variations from dbSNP and Humsavar for KLF5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1051343 -- 73,075,931(+) CTCAA(A/G)TGACA utr-variant-3-prime
rs1109940 -- 73,078,020(+) ATGCA(C/T)GAGAC downstream-variant-500B
rs1109941 -- 73,077,998(+) CGAAT(A/G)CTTAT downstream-variant-500B
rs1803204 -- 73,075,795(+) GCACA(A/C)AGGCG missense, reference
rs3168743 -- 73,076,664(+) TTTAA(A/G)TACAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLF5 Gene

Variant ID Type Subtype PubMed ID
nsv820122 CNV Gain 19587683
esv22464 CNV Loss 19812545
nsv521789 CNV Loss 19592680
esv274461 CNV Insertion 20981092

Relevant External Links for KLF5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF5 Gene

Disorders for KLF5 Gene

(9) Novoseek inferred disease relationships for KLF5 Gene

Disease -log(P) Hits PubMed IDs
colon cancer 30.2 4
cancer 28.6 21
tumors 25.1 30
restenosis 24.5 2
breast cancer 16.1 22

Relevant External Links for KLF5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KLF5: view

No data available for UniProtKB/Swiss-Prot for KLF5 Gene

Publications for KLF5 Gene

  1. cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. (PMID: 8479902) Sogawa K. … Fujii-Kuriyama Y. (Nucleic Acids Res. 1993) 2 3 4 23
  2. A gene encoding an intestinal-enriched member of the KrA1ppel-like factor family expressed in intestinal epithelial cells. (PMID: 9973612) Conkright M.D. … Lingrel J.B. (Nucleic Acids Res. 1999) 2 3 23
  3. Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter. (PMID: 10572182) Shi H. … Teng C.T. (Nucleic Acids Res. 1999) 3 4 23
  4. Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. (PMID: 15735697) Chen C. … Dong J.T. (Oncogene 2005) 3 4 23
  5. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PMID: 17688680) GutiAcrrez-Aguilar R. … Neve B. (BMC Med. Genet. 2007) 3 23 48

Products for KLF5 Gene

  • Addgene plasmids for KLF5

Sources for KLF5 Gene

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