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Aliases for KLF5 Gene

Aliases for KLF5 Gene

  • Kruppel-Like Factor 5 (Intestinal) 2 3 5
  • Intestinal-Enriched Krueppel-Like Factor 3 4
  • Colon Krueppel-Like Factor 3 4
  • Transcription Factor BTEB2 3 4
  • BTE-Binding Protein 2 3 4
  • BTEB2 3 4
  • CKLF 3 4
  • IKLF 3 4
  • Basic Transcription Element Binding Protein 2 3
  • Basic Transcription Element-Binding Protein 2 4
  • Intestinal-Enriched Kruppel-Like Factor 3
  • Colon Kruppel-Like Factor 3
  • GC Box Binding Protein 2 3
  • GC-Box-Binding Protein 2 4
  • Klf5C Isoform 3

External Ids for KLF5 Gene

Previous HGNC Symbols for KLF5 Gene

  • BTEB2

Previous GeneCards Identifiers for KLF5 Gene

  • GC13P071600
  • GC13P067627
  • GC13P072569
  • GC13P071430
  • GC13P072530
  • GC13P073629
  • GC13P054330

Summaries for KLF5 Gene

Entrez Gene Summary for KLF5 Gene

  • This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for KLF5 Gene

KLF5 (Kruppel-Like Factor 5 (Intestinal)) is a Protein Coding gene. Diseases associated with KLF5 include colorectal cancer. Among its related pathways are Developmental Biology and Adipogenesis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is KLF8.

UniProtKB/Swiss-Prot for KLF5 Gene

  • Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Tocris Summary for KLF5 Gene

Gene Wiki entry for KLF5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF5 Gene

Genomics for KLF5 Gene

Regulatory Elements for KLF5 Gene

Genomic Location for KLF5 Gene

73,054,976 bp from pter
73,077,542 bp from pter
22,567 bases
Plus strand

Genomic View for KLF5 Gene

Genes around KLF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF5 Gene

Proteins for KLF5 Gene

  • Protein details for KLF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Krueppel-like factor 5
    Protein Accession:
    Secondary Accessions:
    • A2TJX0
    • L0R3U5
    • L0R4T9
    • Q9UHP8

    Protein attributes for KLF5 Gene

    457 amino acids
    Molecular mass:
    50792 Da
    Quaternary structure:
    • Interacts with WWP1.

    Three dimensional structures from OCA and Proteopedia for KLF5 Gene

    Alternative splice isoforms for KLF5 Gene


neXtProt entry for KLF5 Gene

Proteomics data for KLF5 Gene at MOPED

Post-translational modifications for KLF5 Gene

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KLF5 Gene

Domains & Families for KLF5 Gene

Protein Domains for KLF5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF5: view

Function for KLF5 Gene

Molecular function for KLF5 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Gene Ontology (GO) - Molecular Function for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17320083
genes like me logo Genes that share ontologies with KLF5: view
genes like me logo Genes that share phenotypes with KLF5: view

Animal Models for KLF5 Gene

MGI Knock Outs for KLF5:

Animal Model Products

Targeted motifs for KLF5 Gene
HOMER Transcription Factor Regulatory Elements motif KLF5
  • Consensus sequence: DGGGYGKGGC Submotif: canonical Cell Type: LoVo GEO ID: GSE49402

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF5 Gene

Localization for KLF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF5 Gene

Subcellular locations from

Jensen Localization Image for KLF5 Gene COMPARTMENTS Subcellular localization image for KLF5 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with KLF5: view

Pathways & Interactions for KLF5 Gene

genes like me logo Genes that share pathways with KLF5: view

Pathways by source for KLF5 Gene

SIGNOR curated interactions for KLF5 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030033 microvillus assembly IEA --
GO:0032534 regulation of microvillus assembly IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
GO:0045600 positive regulation of fat cell differentiation IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KLF5: view

Drugs & Compounds for KLF5 Gene

(8) Drugs for KLF5 Gene - From: Novoseek and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
10058-F4 Pharma C-Myc-Max dimerization inhibitor, Inhibits c-Myc-Max dimerization 0
GANT61 Pharma GLI antagonist, GLI antagonist; inhibits Hedgehog (Hh) signaling 0

(3) Additional Compounds for KLF5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CID 5951923

(5) Tocris Compounds for KLF5 Gene

Compound Action Cas Number
10058-F4 Inhibits c-Myc-Max dimerization 403811-55-2
CID 5951923 Kr�ppel-like factor 5 (KLF5) inhibitor 749872-43-3
GANT 61 GLI antagonist; inhibits Hedgehog (Hh) signaling 500579-04-4
Stauprimide Inhibits NME2 nuclear translocation; primes ESCs for differentiation 154589-96-5
Thiostrepton Antibiotic, inhibits protein synthesis 1393-48-2
genes like me logo Genes that share compounds with KLF5: view

Transcripts for KLF5 Gene

Unigene Clusters for KLF5 Gene

Kruppel-like factor 5 (intestinal):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -

Relevant External Links for KLF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLF5 Gene

mRNA expression in normal human tissues for KLF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF5 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.2), Skin - Sun Exposed (Lower leg) (x6.9), Skin - Not Sun Exposed (Suprapubic) (x6.6), and Colon - Transverse (x4.9).

Protein differential expression in normal tissues from HIPED for KLF5 Gene

This gene is overexpressed in Placenta (40.9) and Prostate (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLF5 Gene

SOURCE GeneReport for Unigene cluster for KLF5 Gene Hs.508234

mRNA Expression by UniProt/SwissProt for KLF5 Gene

Tissue specificity: Expressed only in testis and placenta.
genes like me logo Genes that share expression patterns with KLF5: view

Protein tissue co-expression partners for KLF5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for KLF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLF5 35
  • 93.54 (n)
  • 95.15 (a)
KLF5 36
  • 96 (a)
(Canis familiaris)
Mammalia KLF5 35
  • 94.53 (n)
  • 95.62 (a)
KLF5 36
  • 96 (a)
(Mus musculus)
Mammalia Klf5 35
  • 89.82 (n)
  • 91.63 (a)
Klf5 16
Klf5 36
  • 91 (a)
(Pan troglodytes)
Mammalia KLF5 35
  • 99.64 (n)
  • 99.34 (a)
KLF5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Klf5 35
  • 90.05 (n)
  • 92.99 (a)
(Monodelphis domestica)
Mammalia KLF5 36
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia KLF5 36
  • 97 (a)
(Gallus gallus)
Aves KLF5 35
  • 82.21 (n)
  • 89.22 (a)
KLF5 36
  • 89 (a)
(Anolis carolinensis)
Reptilia KLF5 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klf5 35
  • 72.65 (n)
  • 76.08 (a)
Str.15084 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14648 35
(Danio rerio)
Actinopterygii LOC100006043 35
  • 60.62 (n)
  • 59.8 (a)
klf5a 36
  • 46 (a)
klf5b 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12029 37
  • 79 (a)
CG9895 37
  • 80 (a)
dar1 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea F53F8.1 37
  • 65 (a)
F56F11.3 37
  • 77 (a)
mua-1 37
  • 39 (a)
klf-1 36
  • 19 (a)
klf-2 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for KLF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF5 Gene

Gene Tree for KLF5 (if available)
Gene Tree for KLF5 (if available)

Paralogs for KLF5 Gene

Paralogs for KLF5 Gene

genes like me logo Genes that share paralogs with KLF5: view

Variants for KLF5 Gene

Sequence variations from dbSNP and Humsavar for KLF5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_035555 A colorectal cancer sample
rs1109940 -- 73,078,020(+) ATGCA(C/T)GAGAC downstream-variant-500B
rs1109941 -- 73,077,998(+) CGAAT(A/G)CTTAT downstream-variant-500B
rs1051343 -- 73,075,931(+) CTCAA(A/G)TGACA utr-variant-3-prime
rs1803204 -- 73,075,795(+) GCACA(A/C)AGGCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KLF5 Gene

Variant ID Type Subtype PubMed ID
nsv820122 CNV Gain 19587683
esv22464 CNV Loss 19812545
nsv521789 CNV Loss 19592680
esv274461 CNV Insertion 20981092

Variation tolerance for KLF5 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF5 Gene

Disorders for KLF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search KLF5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLF5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KLF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF5 Gene

Publications for KLF5 Gene

  1. cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. (PMID: 8479902) Sogawa K. … Fujii-Kuriyama Y. (Nucleic Acids Res. 1993) 2 3 4 23 67
  2. A gene encoding an intestinal-enriched member of the KrA1ppel-like factor family expressed in intestinal epithelial cells. (PMID: 9973612) Conkright M.D. … Lingrel J.B. (Nucleic Acids Res. 1999) 2 3 23
  3. Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells. (PMID: 19569049) Guo P. … Dong J.T. (Int. J. Cancer 2010) 3 23
  4. Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension. (PMID: 20086047) Oishi Y. … Nagai R. (FASEB J. 2010) 3 23
  5. The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. (PMID: 20388706) Liu N. … Wang P. (J. Biol. Chem. 2010) 3 23

Products for KLF5 Gene

Sources for KLF5 Gene

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