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Aliases for TAF4 Gene

Aliases for TAF4 Gene

  • TATA-Box Binding Protein Associated Factor 4 2 3 5
  • TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C1, 130kD 2 3
  • Transcription Initiation Factor TFIID 130 KDa Subunit 3 4
  • Transcription Initiation Factor TFIID 135 KDa Subunit 3 4
  • RNA Polymerase II TBP-Associated Factor Subunit C 3 4
  • TBP-Associated Factor 4 3 4
  • TAF(II)130 3 4
  • TAF(II)135 3 4
  • TAFII-130 3 4
  • TAFII-135 3 4
  • TAFII130 3 4
  • TAFII135 3 4
  • TAF2C1 3 4
  • TAF2C 3 4
  • TAF4A 3 4
  • TAF4A RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135 KD 3
  • Transcription Initiation Factor TFIID 135 KD Subunit 3
  • TATA Box Binding Protein Associated Factor 4 3

External Ids for TAF4 Gene

Previous HGNC Symbols for TAF4 Gene

  • TAF4A
  • TAF2C1
  • TAF2C

Previous GeneCards Identifiers for TAF4 Gene

  • GC20M060313
  • GC20M061166
  • GC20M061235
  • GC20M059983
  • GC20M060529
  • GC20M057327

Summaries for TAF4 Gene

Entrez Gene Summary for TAF4 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF4 Gene

TAF4 (TATA-Box Binding Protein Associated Factor 4) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is TAF4B.

UniProtKB/Swiss-Prot for TAF4 Gene

  • Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.

Gene Wiki entry for TAF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF4 Gene

Genomics for TAF4 Gene

Regulatory Elements for TAF4 Gene

Enhancers for TAF4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAF4 on UCSC Golden Path with GeneCards custom track

Promoters for TAF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAF4 Gene

Chromosome:
20
Start:
61,953,469 bp from pter
End:
62,065,810 bp from pter
Size:
112,342 bases
Orientation:
Minus strand

Genomic View for TAF4 Gene

Genes around TAF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF4 Gene

Proteins for TAF4 Gene

  • Protein details for TAF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00268-TAF4_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 4
    Protein Accession:
    O00268
    Secondary Accessions:
    • A6NGD9
    • Q5TBP6
    • Q99721
    • Q9BR40
    • Q9BX42

    Protein attributes for TAF4 Gene

    Size:
    1085 amino acids
    Molecular mass:
    110114 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ATF7; the interaction inhibits ATF7-mediated tranactivation. Interacts with SV40 Large T antigen.

    Three dimensional structures from OCA and Proteopedia for TAF4 Gene

neXtProt entry for TAF4 Gene

Proteomics data for TAF4 Gene at MOPED

Post-translational modifications for TAF4 Gene

  • Ubiquitination at Lys 611
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for Taf4

No data available for DME Specific Peptides for TAF4 Gene

Domains & Families for TAF4 Gene

Graphical View of Domain Structure for InterPro Entry

O00268

UniProtKB/Swiss-Prot:

TAF4_HUMAN :
  • Contains 1 TAFH (NHR1) domain.
  • Belongs to the TAF4 family.
Domain:
  • Contains 1 TAFH (NHR1) domain.
Family:
  • Belongs to the TAF4 family.
genes like me logo Genes that share domains with TAF4: view

No data available for Gene Families for TAF4 Gene

Function for TAF4 Gene

Molecular function for TAF4 Gene

UniProtKB/Swiss-Prot Function:
Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.

Gene Ontology (GO) - Molecular Function for TAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 7729427
genes like me logo Genes that share ontologies with TAF4: view
genes like me logo Genes that share phenotypes with TAF4: view

Animal Models for TAF4 Gene

MGI Knock Outs for TAF4:

Animal Model Products

miRNA for TAF4 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAF4 Gene

Localization for TAF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF4 Gene COMPARTMENTS Subcellular localization image for TAF4 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005669 transcription factor TFIID complex IEA,IDA 14580349
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TAF4: view

Pathways & Interactions for TAF4 Gene

genes like me logo Genes that share pathways with TAF4: view

Gene Ontology (GO) - Biological Process for TAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0016032 viral process IEA,TAS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 12771217
genes like me logo Genes that share ontologies with TAF4: view

No data available for SIGNOR curated interactions for TAF4 Gene

Drugs & Compounds for TAF4 Gene

(1) Drugs for TAF4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cholecalciferol Approved Nutra Fat-soluble secosteroids 810,804
genes like me logo Genes that share compounds with TAF4: view

Transcripts for TAF4 Gene

Unigene Clusters for TAF4 Gene

TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1: - - - - -
SP2: - -
SP3:
SP4:

Relevant External Links for TAF4 Gene

GeneLoc Exon Structure for
TAF4
ECgene alternative splicing isoforms for
TAF4

Expression for TAF4 Gene

mRNA expression in normal human tissues for TAF4 Gene

Protein differential expression in normal tissues from HIPED for TAF4 Gene

This gene is overexpressed in Liver (28.9) and Pancreatic juice (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF4 Gene



SOURCE GeneReport for Unigene cluster for TAF4 Gene Hs.18857

genes like me logo Genes that share expression patterns with TAF4: view

Protein tissue co-expression partners for TAF4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF4 Gene

Orthologs for TAF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF4 35
  • 88.6 (n)
  • 94.9 (a)
TAF4 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF4 35
  • 89.25 (n)
  • 96.11 (a)
TAF4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf4a 35
  • 83.74 (n)
  • 86.5 (a)
Taf4 16
Taf4a 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF4 35
  • 99.42 (n)
  • 99.45 (a)
TAF4 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAF4 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF4 35
  • 77.51 (n)
  • 87.31 (a)
TAF4 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF4 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19609 35
taf4 35
  • 73.59 (n)
  • 79.78 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34362 35
zebrafish
(Danio rerio)
Actinopterygii LOC100149942 35
  • 63.99 (n)
  • 68.26 (a)
TAF4 (1 of 2) 36
  • 74 (a)
OneToMany
TAF4 (2 of 2) 36
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Taf4 37
  • 52 (a)
Taf4 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-4 36
  • 25 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2415 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8870 36
  • 41 (a)
OneToMany
Species with no ortholog for TAF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF4 Gene

ENSEMBL:
Gene Tree for TAF4 (if available)
TreeFam:
Gene Tree for TAF4 (if available)

Paralogs for TAF4 Gene

Paralogs for TAF4 Gene

(2) SIMAP similar genes for TAF4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TAF4: view

Variants for TAF4 Gene

Sequence variations from dbSNP and Humsavar for TAF4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6089604 - 62,007,569(+) GGTAA(A/G)GTTGA reference, missense
rs1046137 -- 61,975,026(-) GAGCG(C/T)GTGTG utr-variant-3-prime
rs731657 -- 62,060,182(+) TGCCC(C/T)GGGAG intron-variant
rs1079755 -- 62,040,206(+) caaaa(A/G)ctaga intron-variant
rs744777 -- 62,056,261(+) agaaC(A/G)CGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF4 Gene

Variant ID Type Subtype PubMed ID
nsv913012 CNV Loss 21882294
dgv1340e1 CNV Complex 17122850
nsv428378 CNV Loss 18775914
nsv913026 CNV Loss 21882294
nsv509781 CNV Insertion 20534489
nsv913029 CNV Loss 21882294
esv2722759 CNV Deletion 23290073
esv2722760 CNV Deletion 23290073
esv2645658 CNV Insertion 19546169
esv1495793 CNV Insertion 17803354
esv1724276 CNV Insertion 17803354
esv1507005 CNV Insertion 17803354
esv2722762 CNV Deletion 23290073
esv2550695 CNV Deletion 19546169
esv2375011 CNV Deletion 18987734
esv4304 CNV Deletion 18987735
esv8279 CNV Loss 19470904
esv2722763 CNV Deletion 23290073
esv2662438 CNV Deletion 23128226
nsv179612 CNV Loss 16902084
esv1640297 CNV Deletion 17803354
nsv828768 CNV Gain 20364138
esv999370 CNV Insertion 20482838
esv2564070 CNV Deletion 19546169
nsv512623 CNV Loss 21212237
esv2722764 CNV Deletion 23290073
esv25248 CNV Gain+Loss 19812545
nsv821030 CNV Deletion 20802225
dgv709e201 CNV Deletion 23290073
esv2722766 CNV Deletion 23290073
dgv710e201 CNV Deletion 23290073
esv2722770 CNV Deletion 23290073
esv2722773 CNV Deletion 23290073
esv2722774 CNV Deletion 23290073
esv2722775 CNV Deletion 23290073
esv2722776 CNV Deletion 23290073
nsv828769 CNV Gain 20364138
esv23198 CNV Loss 19812545

Variation tolerance for TAF4 Gene

Residual Variation Intolerance Score: 5.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TAF4 Gene

Disorders for TAF4 Gene

Relevant External Links for TAF4

Genetic Association Database (GAD)
TAF4
Human Genome Epidemiology (HuGE) Navigator
TAF4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF4

No disorders were found for TAF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF4 Gene

Publications for TAF4 Gene

  1. Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells. (PMID: 9192867) Mengus G. … Davidson I. (Genes Dev. 1997) 2 3 4 67
  2. TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes. (PMID: 19635797) Gazit K. … Dikstein R. (J. Biol. Chem. 2009) 3 23
  3. Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions. (PMID: 15641800) Watt K. … McEwan I.J. (Biochemistry 2005) 3 23
  4. The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs. (PMID: 10594036) Gangloff Y.-G. … Davidson I. (Mol. Cell. Biol. 2000) 3 23
  5. Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. (PMID: 8942982) Tanese N. … Admon A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3

Products for TAF4 Gene

Sources for TAF4 Gene

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