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Aliases for TAF2 Gene

Aliases for TAF2 Gene

  • TAF2 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 150kDa 2 3
  • TAFII150 3 4 6
  • CIF150 3 4 6
  • TAF2B 3 4 6
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, B, 150kD 2 3
  • Transcription Initiation Factor TFIID 150 KDa Subunit 3 4
  • RNA Polymerase II TBP-Associated Factor Subunit B 3 4
  • 150 KDa Cofactor Of Initiator Function 3 4
  • TBP-Associated Factor 150 KDa 3 4
  • TAF(II)150 3 4
  • MRT40 3 6
  • Transcription Initiation Factor TFIID Subunit 2 3
  • Cofactor Of Initiator Function, 150kD Subunit 3
  • TAFII-150 4

External Ids for TAF2 Gene

Previous HGNC Symbols for TAF2 Gene

  • TAF2B

Previous GeneCards Identifiers for TAF2 Gene

  • GC08M120749
  • GC08M120411
  • GC08M120699
  • GC08M120812
  • GC08M116063
  • GC08M120743

Summaries for TAF2 Gene

Entrez Gene Summary for TAF2 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF2 Gene

TAF2 (TAF2 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 150kDa) is a Protein Coding gene. Diseases associated with TAF2 include mental retardation, autosomal recessive 40 and microcephaly-thin corpus callosum-intellectual disability syndrome. Among its related pathways are GPCR Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include transcription regulatory region DNA binding and metallopeptidase activity.

UniProtKB/Swiss-Prot for TAF2 Gene

  • Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.

Gene Wiki entry for TAF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF2 Gene

Genomics for TAF2 Gene

Regulatory Elements for TAF2 Gene

Genomic Location for TAF2 Gene

Start:
119,730,774 bp from pter
End:
119,832,863 bp from pter
Size:
102,090 bases
Orientation:
Minus strand

Genomic View for TAF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF2 Gene

Proteins for TAF2 Gene

  • Protein details for TAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1X5-TAF2_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 2
    Protein Accession:
    Q6P1X5
    Secondary Accessions:
    • B2RE82
    • O43487
    • O43604
    • O60668
    • Q86WW7
    • Q8IWK4

    Protein attributes for TAF2 Gene

    Size:
    1199 amino acids
    Molecular mass:
    136971 Da
    Quaternary structure:
    • Component of transcription factor TFIID which is composed of TBP and a number of TBP-associated factors. Interacts with TAF2C1. Component of the TFTC-HAT complex.
    Miscellaneous:
    • PubMed:9418870 was unable to show an association between TAF2 and TFIID
    SequenceCaution:
    • Sequence=AAC68502.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH64830.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for TAF2 Gene

Proteomics data for TAF2 Gene at MOPED

Post-translational modifications for TAF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF2 Gene

No data available for DME Specific Peptides for TAF2 Gene

Domains for TAF2 Gene

Protein Domains for TAF2 Gene

Suggested Antigen Peptide Sequences for TAF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P1X5

UniProtKB/Swiss-Prot:

TAF2_HUMAN :
  • Q6P1X5
Family:
  • Belongs to the TAF2 family.
genes like me logo Genes that share domains with TAF2: view

No data available for Gene Families for TAF2 Gene

Function for TAF2 Gene

Molecular function for TAF2 Gene

UniProtKB/Swiss-Prot Function: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.

Gene Ontology (GO) - Molecular Function for TAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 9418870
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0044212 transcription regulatory region DNA binding IMP 10409744
genes like me logo Genes that share ontologies with TAF2: view
genes like me logo Genes that share phenotypes with TAF2: view

Animal Model Products

miRNA for TAF2 Gene

miRTarBase miRNAs that target TAF2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAF2 Gene

Localization for TAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF2 Gene COMPARTMENTS Subcellular localization image for TAF2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005669 colocalizes_with transcription factor TFIID complex IDA 10409744
GO:0033276 transcription factor TFTC complex IDA 10373431
genes like me logo Genes that share ontologies with TAF2: view

Pathways for TAF2 Gene

genes like me logo Genes that share pathways with TAF2: view

Gene Ontology (GO) - Biological Process for TAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IMP 10409744
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TAF2: view

Transcripts for TAF2 Gene

Unigene Clusters for TAF2 Gene

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:

ExUns: 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b
SP1: - - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7: - - -
SP8:

Relevant External Links for TAF2 Gene

GeneLoc Exon Structure for
TAF2
ECgene alternative splicing isoforms for
TAF2

Expression for TAF2 Gene

mRNA expression in normal human tissues for TAF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF2 Gene

SOURCE GeneReport for Unigene cluster for TAF2 Gene Hs.122752

mRNA Expression by UniProt/SwissProt for TAF2 Gene

Q6P1X5-TAF2_HUMAN
Tissue specificity: Expressed in all tissues tested.
genes like me logo Genes that share expressions with TAF2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TAF2 Gene

Orthologs for TAF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF2 35
  • 99.83 (n)
  • 99.83 (a)
TAF2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAF2 35
  • 89.46 (n)
  • 95.83 (a)
TAF2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF2 35
  • 93.27 (n)
  • 98.08 (a)
TAF2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf2 35
  • 88.65 (n)
  • 95.74 (a)
Taf2 16
Taf2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf2 35
  • 88.3 (n)
  • 94.74 (a)
chicken
(Gallus gallus)
Aves TAF2 35
  • 82.58 (n)
  • 93.64 (a)
TAF2 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF2 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32372 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16985 35
taf2 35
  • 78.52 (n)
  • 91.43 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
taf2 36
  • 82 (a)
OneToOne
wu:fc56a05 35
  • 73.87 (n)
  • 85.53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005731 35
  • 53.39 (n)
  • 53.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta Taf2 35
  • 53.75 (n)
  • 53.68 (a)
Taf2 36
  • 46 (a)
OneToOne
Taf2 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea taf-2 35
  • 45.32 (n)
  • 34.49 (a)
taf-2 36
  • 31 (a)
OneToOne
taf-2 37
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF2 36
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7615 36
  • 59 (a)
OneToOne
Species with no ortholog for TAF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF2 Gene

ENSEMBL:
Gene Tree for TAF2 (if available)
TreeFam:
Gene Tree for TAF2 (if available)

Paralogs for TAF2 Gene

genes like me logo Genes that share paralogs with TAF2: view

No data available for Paralogs for TAF2 Gene

Variants for TAF2 Gene

Sequence variations from dbSNP and Humsavar for TAF2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2634 -- 119,819,869(-) CATCA(C/G)CCTTC intron-variant
rs953614 -- 119,782,481(+) GAACA(C/T)AGGAA intron-variant
rs953615 -- 119,782,879(+) GGCAC(A/G)TGCCT intron-variant
rs956748 - 119,732,109(+) GGCTG(C/T)AGATT reference, missense
rs956749 - 119,732,159(+) GCATA(C/T)TCATC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for TAF2 Gene

Variant ID Type Subtype PubMed ID
nsv891418 CNV Gain 21882294
nsv510171 CNV Loss 20534489
esv2678251 CNV Deletion 23128226
esv25627 CNV Loss 19812545
esv2485427 CNV Deletion 19546169
esv2310118 CNV Deletion 18987734
esv273446 CNV Insertion 20981092
esv268830 CNV Insertion 20981092

Relevant External Links for TAF2 Gene

HapMap Linkage Disequilibrium report
TAF2
Human Gene Mutation Database (HGMD)
TAF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF2 Gene

Disorders for TAF2 Gene

(1) OMIM Diseases for TAF2 Gene (604912)

UniProtKB/Swiss-Prot

TAF2_HUMAN
  • Mental retardation, autosomal recessive 40 (MRT40) [MIM:615599]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT40 affected individuals also show microcephaly, spasticity, thin corpus callosum, pyramidal signs. {ECO:0000269 PubMed:24084144}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with TAF2: view

Publications for TAF2 Gene

  1. Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex. (PMID: 9774672) Martinez E. … Roeder R.G. (Mol. Cell. Biol. 1998) 2 3 4
  2. CIF150, a human cofactor for transcription factor IID-dependent initiator function. (PMID: 9418870) Kaufmann J. … Muller R. (Mol. Cell. Biol. 1998) 2 3 4
  3. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PMID: 12601814) Cavusoglu N. … van Dorsselaer A. (Proteomics 2003) 3 4
  4. Microcephaly thin corpus callosum intellectual disability syndrome caused by mutated TAF2. (PMID: 24084144) Hellman-Aharony S. … Basel-Vanagaite L. (Pediatr. Neurol. 2013) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TAF2 Gene

Sources for TAF2 Gene

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