Aliases for TAF2 Gene
- TAF2 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 150kDa 2 3
- TAFII150 3 4 6
- CIF150 3 4 6
- TAF2B 3 4 6
- TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, B, 150kD 2 3
- Transcription Initiation Factor TFIID 150 KDa Subunit 3 4
- RNA Polymerase II TBP-Associated Factor Subunit B 3 4
- 150 KDa Cofactor Of Initiator Function 3 4
External Ids for TAF2 Gene
Previous Symbols for TAF2 Gene
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAF2 Gene
TAF2 (TAF2 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 150kDa) is a Protein Coding gene. Diseases associated with TAF2 include microcephaly-thin corpus callosum-intellectual disability syndrome and mental retardation, autosomal recessive 40. Among its related pathways are GPCR Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include transcription regulatory region DNA binding and metallopeptidase activity.
UniProtKB/Swiss-Prot for TAF2 Gene
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.