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Aliases for TAF2 Gene

Aliases for TAF2 Gene

  • TATA-Box Binding Protein Associated Factor 2 2 3 5
  • TAF2 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 150kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, B, 150kD 2 3
  • Transcription Initiation Factor TFIID 150 KDa Subunit 3 4
  • RNA Polymerase II TBP-Associated Factor Subunit B 3 4
  • 150 KDa Cofactor Of Initiator Function 3 4
  • TBP-Associated Factor 150 KDa 3 4
  • TAF(II)150 3 4
  • TAFII150 3 4
  • CIF150 3 4
  • TAF2B 3 4
  • Cofactor Of Initiator Function, 150kD Subunit 3
  • TATA Box Binding Protein Associated Factor 2 3
  • TAFII-150 4
  • MRT40 3

External Ids for TAF2 Gene

Previous HGNC Symbols for TAF2 Gene

  • TAF2B

Previous GeneCards Identifiers for TAF2 Gene

  • GC08M120749
  • GC08M120411
  • GC08M120699
  • GC08M120812
  • GC08M116063
  • GC08M120743

Summaries for TAF2 Gene

Entrez Gene Summary for TAF2 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF2 Gene

TAF2 (TATA-Box Binding Protein Associated Factor 2) is a Protein Coding gene. Diseases associated with TAF2 include mental retardation, autosomal recessive 40 and microcephaly-thin corpus callosum-intellectual disability syndrome. Among its related pathways are Gene Expression and HIV Life Cycle. GO annotations related to this gene include binding and metallopeptidase activity.

UniProtKB/Swiss-Prot for TAF2 Gene

  • Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.

Gene Wiki entry for TAF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF2 Gene

Genomics for TAF2 Gene

Regulatory Elements for TAF2 Gene

Promoters for TAF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAF2 Gene

Chromosome:
8
Start:
119,730,773 bp from pter
End:
119,832,863 bp from pter
Size:
102,091 bases
Orientation:
Minus strand

Genomic View for TAF2 Gene

Genes around TAF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF2 Gene

Proteins for TAF2 Gene

  • Protein details for TAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1X5-TAF2_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 2
    Protein Accession:
    Q6P1X5
    Secondary Accessions:
    • B2RE82
    • O43487
    • O43604
    • O60668
    • Q86WW7
    • Q8IWK4

    Protein attributes for TAF2 Gene

    Size:
    1199 amino acids
    Molecular mass:
    136971 Da
    Quaternary structure:
    • Component of transcription factor TFIID which is composed of TBP and a number of TBP-associated factors. Interacts with TAF2C1. Component of the TFTC-HAT complex.
    Miscellaneous:
    • PubMed:9418870 was unable to show an association between TAF2 and TFIID.
    SequenceCaution:
    • Sequence=AAC68502.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH64830.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for TAF2 Gene

Proteomics data for TAF2 Gene at MOPED

Post-translational modifications for TAF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF2 Gene

Antibody Products

No data available for DME Specific Peptides for TAF2 Gene

Domains & Families for TAF2 Gene

Protein Domains for TAF2 Gene

Suggested Antigen Peptide Sequences for TAF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P1X5

UniProtKB/Swiss-Prot:

TAF2_HUMAN :
  • Belongs to the TAF2 family.
Family:
  • Belongs to the TAF2 family.
genes like me logo Genes that share domains with TAF2: view

No data available for Gene Families for TAF2 Gene

Function for TAF2 Gene

Molecular function for TAF2 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.

Gene Ontology (GO) - Molecular Function for TAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly IBA --
GO:0008237 metallopeptidase activity IEA --
GO:0044212 transcription regulatory region DNA binding IMP 10409744
genes like me logo Genes that share ontologies with TAF2: view
genes like me logo Genes that share phenotypes with TAF2: view

Human Phenotype Ontology for TAF2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for TAF2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF2 Gene

Localization for TAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF2 Gene COMPARTMENTS Subcellular localization image for TAF2 gene
Compartment Confidence
nucleus 5
cytosol 2
chloroplast 1

No data available for Gene Ontology (GO) - Cellular Components for TAF2 Gene

Pathways & Interactions for TAF2 Gene

genes like me logo Genes that share pathways with TAF2: view

Gene Ontology (GO) - Biological Process for TAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006508 proteolysis IEA --
GO:0016032 viral process TAS --
GO:1901796 regulation of signal transduction by p53 class mediator TAS --
genes like me logo Genes that share ontologies with TAF2: view

No data available for SIGNOR curated interactions for TAF2 Gene

Drugs & Compounds for TAF2 Gene

No Compound Related Data Available

Transcripts for TAF2 Gene

Unigene Clusters for TAF2 Gene

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:

ExUns: 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b
SP1: - - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7: - - -
SP8:

Relevant External Links for TAF2 Gene

GeneLoc Exon Structure for
TAF2
ECgene alternative splicing isoforms for
TAF2

Expression for TAF2 Gene

mRNA expression in normal human tissues for TAF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF2 Gene

This gene is overexpressed in Urine (56.3) and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF2 Gene



SOURCE GeneReport for Unigene cluster for TAF2 Gene Hs.122752

mRNA Expression by UniProt/SwissProt for TAF2 Gene

Q6P1X5-TAF2_HUMAN
Tissue specificity: Expressed in all tissues tested.
genes like me logo Genes that share expression patterns with TAF2: view

Protein tissue co-expression partners for TAF2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TAF2 Gene

Orthologs for TAF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF2 35
  • 89.46 (n)
  • 95.83 (a)
TAF2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF2 35
  • 93.27 (n)
  • 98.08 (a)
TAF2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf2 35
  • 88.65 (n)
  • 95.74 (a)
Taf2 16
Taf2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF2 35
  • 99.83 (n)
  • 99.83 (a)
TAF2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf2 35
  • 88.3 (n)
  • 94.74 (a)
oppossum
(Monodelphis domestica)
Mammalia TAF2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF2 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF2 35
  • 82.58 (n)
  • 93.64 (a)
TAF2 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16985 35
taf2 35
  • 78.52 (n)
  • 91.43 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32372 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
wu:fc56a05 35
  • 73.87 (n)
  • 85.53 (a)
taf2 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Taf2 37
  • 52 (a)
Taf2 35
  • 53.75 (n)
  • 53.68 (a)
Taf2 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005731 35
  • 53.39 (n)
  • 53.7 (a)
worm
(Caenorhabditis elegans)
Secernentea taf-2 37
  • 32 (a)
taf-2 35
  • 45.32 (n)
  • 34.49 (a)
taf-2 36
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF2 36
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7615 36
  • 59 (a)
OneToOne
Species with no ortholog for TAF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF2 Gene

ENSEMBL:
Gene Tree for TAF2 (if available)
TreeFam:
Gene Tree for TAF2 (if available)

Paralogs for TAF2 Gene

genes like me logo Genes that share paralogs with TAF2: view

No data available for Paralogs for TAF2 Gene

Variants for TAF2 Gene

Sequence variations from dbSNP and Humsavar for TAF2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_027854 -
rs9297605 - 119,791,397(+) ACATA(A/C/G)TGTAG reference, missense
rs956749 - 119,732,159(+) GCATA(C/T)TCATC reference, missense
rs956748 - 119,732,109(+) GGCTG(C/T)AGATT reference, missense
rs34154779 - 119,783,437(+) TTGTT(C/T)TAATA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAF2 Gene

Variant ID Type Subtype PubMed ID
nsv891418 CNV Gain 21882294
nsv510171 CNV Loss 20534489
esv2678251 CNV Deletion 23128226
esv25627 CNV Loss 19812545
esv2485427 CNV Deletion 19546169
esv2310118 CNV Deletion 18987734
esv273446 CNV Insertion 20981092
esv268830 CNV Insertion 20981092

Variation tolerance for TAF2 Gene

Residual Variation Intolerance Score: 9.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.20; 76.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF2 Gene

HapMap Linkage Disequilibrium report
TAF2
Human Gene Mutation Database (HGMD)
TAF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF2 Gene

Disorders for TAF2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TAF2 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TAF2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TAF2_HUMAN
  • Mental retardation, autosomal recessive 40 (MRT40) [MIM:615599]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT40 affected individuals also show microcephaly, spasticity, thin corpus callosum, pyramidal signs. {ECO:0000269 PubMed:24084144}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TAF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF2
genes like me logo Genes that share disorders with TAF2: view

No data available for Genatlas for TAF2 Gene

Publications for TAF2 Gene

  1. Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex. (PMID: 9774672) Martinez E. … Roeder R.G. (Mol. Cell. Biol. 1998) 2 3 4 67
  2. CIF150, a human cofactor for transcription factor IID-dependent initiator function. (PMID: 9418870) Kaufmann J. … Muller R. (Mol. Cell. Biol. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells. (PMID: 24515614) Zhang Y. … Wei S.J. (Protein Cell 2014) 3

Products for TAF2 Gene

Sources for TAF2 Gene

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