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Aliases for TADA2A Gene

Aliases for TADA2A Gene

  • Transcriptional Adaptor 2A 2 3 5
  • ADA2-Like Protein 3 4
  • TADA2L 3 4
  • Transcriptional Adaptor 2 (ADA2 Homolog, Yeast)-Like 2
  • Transcriptional Adaptor 2 Alpha 3
  • Transcriptional Adapter 2-Like 4
  • ADA2A 3
  • KL04P 3
  • HADA2 3
  • ADA2 3

External Ids for TADA2A Gene

Previous HGNC Symbols for TADA2A Gene

  • TADA2L

Previous GeneCards Identifiers for TADA2A Gene

  • GC17P032842
  • GC17P035767
  • GC17P031705

Summaries for TADA2A Gene

Entrez Gene Summary for TADA2A Gene

  • Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]

GeneCards Summary for TADA2A Gene

TADA2A (Transcriptional Adaptor 2A) is a Protein Coding gene. Diseases associated with TADA2A include chromosome 17q12 deletion syndrome. Among its related pathways are Chromatin organization and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription cofactor activity. An important paralog of this gene is TADA2B.

UniProtKB/Swiss-Prot for TADA2A Gene

  • Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.

Gene Wiki entry for TADA2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TADA2A Gene

Genomics for TADA2A Gene

Regulatory Elements for TADA2A Gene

Promoters for TADA2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TADA2A on UCSC Golden Path with GeneCards custom track

Genomic Location for TADA2A Gene

Chromosome:
17
Start:
37,406,874 bp from pter
End:
37,479,730 bp from pter
Size:
72,857 bases
Orientation:
Plus strand

Genomic View for TADA2A Gene

Genes around TADA2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TADA2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TADA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TADA2A Gene

Proteins for TADA2A Gene

  • Protein details for TADA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75478-TAD2A_HUMAN
    Recommended name:
    Transcriptional adapter 2-alpha
    Protein Accession:
    O75478
    Secondary Accessions:
    • A8MVD0
    • B3KMU9
    • Q9BVJ0
    • Q9UCW2
    • Q9UP49

    Protein attributes for TADA2A Gene

    Size:
    443 amino acids
    Molecular mass:
    51506 Da
    Quaternary structure:
    • Interacts with GCN5 and NR3C1. Associated with the P/CAF protein in the PCAF complex. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Three dimensional structures from OCA and Proteopedia for TADA2A Gene

    Alternative splice isoforms for TADA2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TADA2A Gene

Proteomics data for TADA2A Gene at MOPED

Post-translational modifications for TADA2A Gene

  • Ubiquitination at Lys 132, Lys 398, and Lys 407
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TADA2A Gene

Domains & Families for TADA2A Gene

Gene Families for TADA2A Gene

Protein Domains for TADA2A Gene

Suggested Antigen Peptide Sequences for TADA2A Gene

Graphical View of Domain Structure for InterPro Entry

O75478

UniProtKB/Swiss-Prot:

TAD2A_HUMAN :
  • Contains 1 SANT domain.
Domain:
  • Contains 1 SANT domain.
  • Contains 1 SWIRM domain.
genes like me logo Genes that share domains with TADA2A: view

Function for TADA2A Gene

Molecular function for TADA2A Gene

UniProtKB/Swiss-Prot Function:
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.

Gene Ontology (GO) - Molecular Function for TADA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with TADA2A: view
genes like me logo Genes that share phenotypes with TADA2A: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TADA2A Gene

Localization for TADA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA2A Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TADA2A Gene COMPARTMENTS Subcellular localization image for TADA2A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TADA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS 8552087
GO:0072686 mitotic spindle IEA --
genes like me logo Genes that share ontologies with TADA2A: view

Pathways & Interactions for TADA2A Gene

genes like me logo Genes that share pathways with TADA2A: view

Pathways by source for TADA2A Gene

Gene Ontology (GO) - Biological Process for TADA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016573 histone acetylation IEA --
GO:0031647 regulation of protein stability IEA --
GO:0035066 positive regulation of histone acetylation IBA --
GO:0043966 histone H3 acetylation IDA 9674425
genes like me logo Genes that share ontologies with TADA2A: view

No data available for SIGNOR curated interactions for TADA2A Gene

Drugs & Compounds for TADA2A Gene

No Compound Related Data Available

Transcripts for TADA2A Gene

Unigene Clusters for TADA2A Gene

Transcriptional adaptor 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TADA2A Gene

No ASD Table

Relevant External Links for TADA2A Gene

GeneLoc Exon Structure for
TADA2A
ECgene alternative splicing isoforms for
TADA2A

Expression for TADA2A Gene

mRNA expression in normal human tissues for TADA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TADA2A Gene



SOURCE GeneReport for Unigene cluster for TADA2A Gene Hs.500066

mRNA Expression by UniProt/SwissProt for TADA2A Gene

O75478-TAD2A_HUMAN
Tissue specificity: Expressed in all tissues, but most abundantly in testis.
genes like me logo Genes that share expression patterns with TADA2A: view

Protein tissue co-expression partners for TADA2A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for TADA2A Gene

Orthologs for TADA2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TADA2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TADA2A 35
  • 99.85 (n)
  • 99.77 (a)
cow
(Bos Taurus)
Mammalia TADA2A 35
  • 94.28 (n)
  • 98.65 (a)
dog
(Canis familiaris)
Mammalia TADA2A 35
  • 95.33 (n)
  • 98.87 (a)
mouse
(Mus musculus)
Mammalia Tada2a 35
  • 90.67 (n)
  • 97.07 (a)
Tada2a 16
rat
(Rattus norvegicus)
Mammalia Tada2a 35
  • 90.52 (n)
  • 97.52 (a)
chicken
(Gallus gallus)
Aves TADA2A 35
  • 81.04 (n)
  • 90.52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10606 35
tada2a 35
  • 76.47 (n)
  • 84.84 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1143 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12657 35
tada2a 35
  • 71.6 (n)
  • 81.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ada2a 35
  • 44.31 (n)
  • 38.66 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER318C 35
  • 43.15 (n)
  • 30.64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADA2 35
  • 44.18 (n)
  • 31.1 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01496g 35
  • 43.86 (n)
  • 30.64 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ADA2B 35
  • 46.25 (n)
  • 34.63 (a)
rice
(Oryza sativa)
Liliopsida Os03g0750800 35
  • 46.07 (n)
  • 33.75 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04459 35
  • 44.2 (n)
  • 32.13 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ada2 35
  • 42.9 (n)
  • 31.87 (a)
Species with no ortholog for TADA2A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TADA2A Gene

ENSEMBL:
Gene Tree for TADA2A (if available)
TreeFam:
Gene Tree for TADA2A (if available)

Paralogs for TADA2A Gene

Paralogs for TADA2A Gene

(1) SIMAP similar genes for TADA2A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TADA2A: view

Variants for TADA2A Gene

Sequence variations from dbSNP and Humsavar for TADA2A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs7211875 - 37,411,381(+) TGGGT(C/T)CCTTT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1054865 - 37,440,563(+) ACTAT(A/G)TGAAG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2522969 - 37,471,118(+) TCCAT(G/T)CCAAT nc-transcript-variant, reference, missense
rs954421 -- 37,413,654(+) cgatg(C/T)cccca intron-variant
rs853208 -- 37,466,352(+) GTAGC(A/C)GAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TADA2A Gene

Variant ID Type Subtype PubMed ID
dgv955e1 CNV Complex 17122850
dgv549e199 CNV Deletion 23128226
esv1010097 CNV Gain 20482838
nsv9543 CNV Loss 18304495
nsv435684 CNV Deletion 17901297
esv2715889 CNV Deletion 23290073
dgv550e199 CNV Deletion 23128226
dgv524n67 CNV Loss 20364138
esv2661747 CNV Deletion 23128226

Variation tolerance for TADA2A Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TADA2A Gene

HapMap Linkage Disequilibrium report
TADA2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TADA2A Gene

Disorders for TADA2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for TADA2A Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 17q12 deletion syndrome
  • 17q12 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TADA2A

Genetic Association Database (GAD)
TADA2A
Human Genome Epidemiology (HuGE) Navigator
TADA2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TADA2A
genes like me logo Genes that share disorders with TADA2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TADA2A Gene

Publications for TADA2A Gene

  1. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PMID: 8552087) Candau R. … Berger S.L. (Mol. Cell. Biol. 1996) 2 3 4 67
  2. A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. (PMID: 12972612) Barlev N.A. … Berger S.L. (Mol. Cell. Biol. 2003) 3 23
  3. Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors. (PMID: 9649342) AlmlAPf T. … Wright A.P. (Biochemistry 1998) 3 23
  4. Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor. (PMID: 9154805) Henriksson A. … Wright A.P.H. (Mol. Cell. Biol. 1997) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TADA2A Gene

Sources for TADA2A Gene

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