Aliases for TACR1 Gene
External Ids for TACR1 Gene
Previous HGNC Symbols for TACR1 Gene
Previous GeneCards Identifiers for TACR1 Gene
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]
GeneCards Summary for TACR1 Gene
TACR1 (Tachykinin Receptor 1) is a Protein Coding gene. Diseases associated with TACR1 include causalgia and social phobia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include tachykinin receptor activity and substance P receptor activity. An important paralog of this gene is NPFFR1.
UniProtKB/Swiss-Prot for TACR1 Gene
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K
The neurokinin (NK) 1 receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum, amygdala and some hypothalamic and thalamic nuclei) and peripheral tissues. NK1 receptors are thought to mediate central stress reactions, mood control, excitatory neurotransmission, immune modulation and airway and lung function. The receptor displays greater potency for the endogenous agonist substance P than Neurokinin A and Neurokinin B (SP > NKA > NKB). The human gene encoding the NK1 receptor has been localized on chromosome 2 (2p13.1-p12).