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Aliases for TACR1 Gene

Aliases for TACR1 Gene

  • Tachykinin Receptor 1 2 3 4
  • NK-1 Receptor 3 4
  • TAC1R 3 4
  • NK-1R 3 4
  • NK1R 3 4
  • SPR 3 4
  • Tachykinin Receptor 1 (Substance P Receptor; Neurokinin-1 Receptor) 3
  • NKIR 3

External Ids for TACR1 Gene

Previous HGNC Symbols for TACR1 Gene

  • TAC1R

Previous GeneCards Identifiers for TACR1 Gene

  • GC02M075413
  • GC02M075233
  • GC02M075250
  • GC02M075187
  • GC02M075129

Summaries for TACR1 Gene

Entrez Gene Summary for TACR1 Gene

  • This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

GeneCards Summary for TACR1 Gene

TACR1 (Tachykinin Receptor 1) is a Protein Coding gene. Diseases associated with TACR1 include neurotrophic keratopathy and cystitis. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and substance P receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for TACR1 Gene

  • This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K

Tocris Summary for TACR1 Gene

  • The neurokinin 1 (NK1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum and amygdala) and peripheral tissues.

Gene Wiki entry for TACR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACR1 Gene

Genomics for TACR1 Gene

Regulatory Elements for TACR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TACR1 Gene

Chromosome:
2
Start:
75,046,463 bp from pter
End:
75,199,700 bp from pter
Size:
153,238 bases
Orientation:
Minus strand

Genomic View for TACR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TACR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACR1 Gene

Proteins for TACR1 Gene

  • Protein details for TACR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25103-NK1R_HUMAN
    Recommended name:
    Substance-P receptor
    Protein Accession:
    P25103
    Secondary Accessions:
    • A8K150

    Protein attributes for TACR1 Gene

    Size:
    407 amino acids
    Molecular mass:
    46251 Da
    Quaternary structure:
    • Interacts with ARRB1.

    Three dimensional structures from OCA and Proteopedia for TACR1 Gene

    Alternative splice isoforms for TACR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TACR1 Gene

Proteomics data for TACR1 Gene at MOPED

Post-translational modifications for TACR1 Gene

  • Glycosylation at Asn 14 and Asn 18
  • Modification sites at PhosphoSitePlus

Other Protein References for TACR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TACR1 Gene

Domains & Families for TACR1 Gene

Gene Families for TACR1 Gene

Suggested Antigen Peptide Sequences for TACR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25103

UniProtKB/Swiss-Prot:

NK1R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TACR1: view

Function for TACR1 Gene

Molecular function for TACR1 Gene

GENATLAS Biochemistry:
tachykinin 1 receptor,substance P/neurokinine 1 receptor,G protein coupled receptor superfamily,expressed in mucosal but non peripheral mononuclear cells,involved in mucosal immunomodulation
UniProtKB/Swiss-Prot Function:
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K

Gene Ontology (GO) - Molecular Function for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004995 tachykinin receptor activity TAS 8985172
GO:0005515 protein binding IPI 17986524
GO:0016496 substance P receptor activity IBA --
genes like me logo Genes that share ontologies with TACR1: view
genes like me logo Genes that share phenotypes with TACR1: view

Animal Models for TACR1 Gene

MGI Knock Outs for TACR1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TACR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TACR1 Gene

Localization for TACR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TACR1 Gene COMPARTMENTS Subcellular localization image for TACR1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
endosome 2
extracellular 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1657150
GO:0016021 integral component of membrane --
GO:0071944 cell periphery --
genes like me logo Genes that share ontologies with TACR1: view

Pathways & Interactions for TACR1 Gene

genes like me logo Genes that share pathways with TACR1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 10854844
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 1657150
GO:0007217 tachykinin receptor signaling pathway IDA 17986524
genes like me logo Genes that share ontologies with TACR1: view

No data available for SIGNOR curated interactions for TACR1 Gene

Drugs & Compounds for TACR1 Gene

(112) Drugs for TACR1 Gene - From: NovoSeek, IUPHAR, DGIdb, DrugBank, ApexBio, HMDB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprepitant Approved, Investigational Pharma Antagonist, antagonist, Target Substance P (SP) inhibitor 148
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 148
Vapreotide Approved, Investigational Pharma Full agonist, Agonist, Target, antagonist 2
netupitant Approved Pharma Antagonist, Target, antagonist 0
Ketamine Approved Pharma Channel blocker, Target, antagonist 416

(53) Additional Compounds for TACR1 Gene - From: NovoSeek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GR 73632
133156-06-6
LY303870
Antagonist
[<sup>3</sup>H]BH-[Sar<sup>9</sup>,Met(O<sub>2</sub>)<sup>11</sup>]SP
[Pro<sup>9</sup>]SP
Full agonist, Agonist
neuropeptide-alpha
Full agonist, Agonist
genes like me logo Genes that share compounds with TACR1: view

Drug Products

Transcripts for TACR1 Gene

mRNA/cDNA for TACR1 Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TACR1 Gene

Tachykinin receptor 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TACR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACR1 Gene

No ASD Table

Relevant External Links for TACR1 Gene

GeneLoc Exon Structure for
TACR1
ECgene alternative splicing isoforms for
TACR1

Expression for TACR1 Gene

mRNA expression in normal human tissues for TACR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACR1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.5) and Cervix - Endocervix (x4.5).

Protein differential expression in normal tissues from HIPED for TACR1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TACR1 Gene



SOURCE GeneReport for Unigene cluster for TACR1 Gene Hs.633301

genes like me logo Genes that share expression patterns with TACR1: view

Protein tissue co-expression partners for TACR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TACR1 Gene

Orthologs for TACR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TACR1 35
  • 89.76 (n)
  • 94.1 (a)
NK1R 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TACR1 35
  • 92.96 (n)
  • 97.54 (a)
TACR1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tacr1 35
  • 89.76 (n)
  • 94.59 (a)
Tacr1 16
Tacr1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TACR1 35
  • 99.51 (n)
  • 99.75 (a)
TACR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tacr1 35
  • 89.35 (n)
  • 94.59 (a)
oppossum
(Monodelphis domestica)
Mammalia TACR1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TACR1 35
  • 78.21 (n)
  • 79.12 (a)
ASPR 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TACR1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tacr1 35
  • 71.7 (n)
  • 74.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20126 35
zebrafish
(Danio rerio)
Actinopterygii tacr1a 35
  • 70.82 (n)
  • 71.32 (a)
tacr1a 36
  • 67 (a)
OneToMany
tacr1b 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10626 37
  • 32 (a)
NepYr 37
  • 32 (a)
Takr86C 37
  • 37 (a)
Takr99D 37
  • 45 (a)
Takr86C 36
  • 24 (a)
ManyToMany
Takr99D 36
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C49A9.7 37
  • 36 (a)
C50F7.1 37
  • 28 (a)
tkr-1 37
  • 36 (a)
Y59H11AL.1 37
  • 29 (a)
tkr-1 36
  • 29 (a)
ManyToMany
tkr-2 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for TACR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TACR1 Gene

ENSEMBL:
Gene Tree for TACR1 (if available)
TreeFam:
Gene Tree for TACR1 (if available)

Paralogs for TACR1 Gene

(15) SIMAP similar genes for TACR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TACR1: view

Variants for TACR1 Gene

Sequence variations from dbSNP and Humsavar for TACR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs881 -- 75,049,302(-) TATGG(C/G)TTAGG utr-variant-3-prime
rs1037 -- 75,049,317(-) TGCAA(A/C/G)AAGGG utr-variant-3-prime
rs713082 -- 75,046,339(+) AGAGT(C/T)AAGAG downstream-variant-500B
rs727156 -- 75,053,080(+) TGAAA(C/T)TTCAT intron-variant
rs735668 -- 75,135,918(+) TCTCC(A/C)TTTCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TACR1 Gene

Variant ID Type Subtype PubMed ID
dgv4168n71 CNV Gain 21882294
nsv834262 CNV Gain 17160897
nsv874299 CNV Gain 21882294
nsv527009 CNV Gain 19592680
nsv520917 CNV Gain 19592680
dgv32n64 CNV Loss 17921354
nsv525695 CNV Loss 19592680
nsv874300 CNV Gain 21882294
nsv874301 CNV Gain 21882294
esv2664298 CNV Deletion 23128226
dgv1200e1 CNV Complex 17122850
nsv438354 CNV Loss 16468122
esv28202 CNV Loss 19812545
esv2720214 CNV Deletion 23290073
nsv10035 CNV Gain 18304495
esv2489063 CNV Insertion 19546169
esv272151 CNV Insertion 20981092
esv274003 CNV Insertion 20981092
esv1335930 CNV Insertion 17803354

Variation tolerance for TACR1 Gene

Residual Variation Intolerance Score: 24.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TACR1 Gene

HapMap Linkage Disequilibrium report
TACR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACR1 Gene

Disorders for TACR1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TACR1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
neurotrophic keratopathy
  • neurotrophic keratitis
cystitis
telogen effluvium
causalgia
  • complex regional pain syndrome, type ii
mood disorder
  • episodic mood disorder
- elite association
Search TACR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TACR1

Genetic Association Database (GAD)
TACR1
Human Genome Epidemiology (HuGE) Navigator
TACR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TACR1
genes like me logo Genes that share disorders with TACR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACR1 Gene

Publications for TACR1 Gene

  1. Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis. (PMID: 17643344) Rodgers J. … Kennedy P.G. (Parasitol. Int. 2007) 23 25 26 67
  2. Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting. Results from a randomized, double-blind, placebo-controlled trial in Latin America. (PMID: 12784346) Poli-Bigelli S. … Lawson F. (Cancer 2003) 23 25 26 67
  3. Practical asymmetric synthesis of aprepitant, a potent human NK-1 receptor antagonist, via a stereoselective Lewis acid-catalyzed trans acetalization reaction. (PMID: 12227806) Zhao M.M. … Bishop B.C. (J. Org. Chem. 2002) 23 25 26 67
  4. MicroRNAs may mediate the down-regulation of neurokinin-1 receptor in chronic bladder pain syndrome. (PMID: 20008142) Sanchez Freire V. … Monastyrskaya K. (Am. J. Pathol. 2010) 23 67
  5. A new frontier in the treatment of cancer: NK-1 receptor antagonists. (PMID: 20015033) MuA+oz M. … CoveA+as R. (Curr. Med. Chem. 2010) 23 67

Products for TACR1 Gene

Sources for TACR1 Gene

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