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Aliases for TACR1 Gene

Aliases for TACR1 Gene

  • Tachykinin Receptor 1 2 3 4
  • NK-1 Receptor 3 4
  • TAC1R 3 4
  • NK-1R 3 4
  • NK1R 3 4
  • SPR 3 4
  • Tachykinin Receptor 1 (Substance P Receptor; Neurokinin-1 Receptor) 3
  • Neurokinin-1 Receptor) 6
  • Substance-P Receptor 3
  • NKIR 3

External Ids for TACR1 Gene

Previous HGNC Symbols for TACR1 Gene

  • TAC1R

Previous GeneCards Identifiers for TACR1 Gene

  • GC02M075413
  • GC02M075233
  • GC02M075250
  • GC02M075187
  • GC02M075129

Summaries for TACR1 Gene

Entrez Gene Summary for TACR1 Gene

  • This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

GeneCards Summary for TACR1 Gene

TACR1 (Tachykinin Receptor 1) is a Protein Coding gene. Diseases associated with TACR1 include causalgia and social phobia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include tachykinin receptor activity and substance P receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for TACR1 Gene

  • This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K

Tocris Summary for TACR1 Gene

  • The neurokinin (NK) 1 receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum, amygdala and some hypothalamic and thalamic nuclei) and peripheral tissues. NK1 receptors are thought to mediate central stress reactions, mood control, excitatory neurotransmission, immune modulation and airway and lung function. The receptor displays greater potency for the endogenous agonist substance P than Neurokinin A and Neurokinin B (SP > NKA > NKB). The human gene encoding the NK1 receptor has been localized on chromosome 2 (2p13.1-p12).

Gene Wiki entry for TACR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACR1 Gene

Genomics for TACR1 Gene

Regulatory Elements for TACR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TACR1 Gene

75,046,463 bp from pter
75,199,700 bp from pter
153,238 bases
Minus strand

Genomic View for TACR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TACR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACR1 Gene

Proteins for TACR1 Gene

  • Protein details for TACR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Substance-P receptor
    Protein Accession:
    Secondary Accessions:
    • A8K150

    Protein attributes for TACR1 Gene

    407 amino acids
    Molecular mass:
    46251 Da
    Quaternary structure:
    • Interacts with ARRB1.

    Three dimensional structures from OCA and Proteopedia for TACR1 Gene

    Alternative splice isoforms for TACR1 Gene


neXtProt entry for TACR1 Gene

Proteomics data for TACR1 Gene at MOPED

Post-translational modifications for TACR1 Gene

  • Glycosylation at Asn14 and Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for TACR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TACR1 Gene

Domains for TACR1 Gene

Gene Families for TACR1 Gene

Suggested Antigen Peptide Sequences for TACR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TACR1: view

Function for TACR1 Gene

Molecular function for TACR1 Gene

GENATLAS Biochemistry:
tachykinin 1 receptor,substance P/neurokinine 1 receptor,G protein coupled receptor superfamily,expressed in mucosal but non peripheral mononuclear cells,involved in mucosal immunomodulation
UniProtKB/Swiss-Prot Function:
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K

Gene Ontology (GO) - Molecular Function for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004995 tachykinin receptor activity TAS 8985172
GO:0005515 protein binding IPI 17986524
GO:0016496 substance P receptor activity IEA --
genes like me logo Genes that share ontologies with TACR1: view
genes like me logo Genes that share phenotypes with TACR1: view

Animal Models for TACR1 Gene

MGI Knock Outs for TACR1:

Animal Model Products

miRNA for TACR1 Gene

miRTarBase miRNAs that target TACR1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TACR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TACR1 Gene

Localization for TACR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TACR1 Gene COMPARTMENTS Subcellular localization image for TACR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1657150
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TACR1: view

Pathways for TACR1 Gene

genes like me logo Genes that share pathways with TACR1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002118 aggressive behavior IEA --
GO:0002526 acute inflammatory response IEA --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0003051 angiotensin-mediated drinking behavior IEA --
GO:0006954 inflammatory response TAS 10854844
genes like me logo Genes that share ontologies with TACR1: view

Drugs for TACR1 Gene

(9) Drugbank Compounds for TACR1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • 3-(((2R,3S)-3-(P-Fluorophenyl)-2-(((alphar)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-delta(2)-1,2,4-triazolin-5-one
170729-80-3 Target antagonist approved, investigational
  • Vapreotida
103222-11-3 23725064 Target antagonist approved, investigational
  • (+-)-Ketamine
6740-88-1 3821 Target antagonist approved
  • 2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]propanamide
290297-26-6 Target antagonist approved
Target investigational

(5) Tocris Compounds for TACR1 Gene

Compound Action Cas Number
[Sar9,Met(O2)11]-Substance P Potent, selective NK1 agonist [110880-55-2]
CP 99994 dihydrochloride High affinity NK1 antagonist [145148-39-6]
GR 73632 Potent, selective NK1 agonist [133156-06-6]
L-733,060 hydrochloride Potent NK1 antagonist [148687-76-7]
RP 67580 Potent and selective NK1 antagonist [135911-02-3]

(3) ApexBio Compounds for TACR1 Gene

Compound Action Cas Number
Aprepitant Substance P (SP) inhibitor [170729-80-3]
Fosaprepitant Neurokinin-1 antagonist [172673-20-0]
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist [265121-04-8]

(5) HMDB Compounds for TACR1 Gene

Compound Synonyms Cas Number PubMed IDs
  • MK-0517
  • Ca
Substance P
  • Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
  • BMY 41606

(43) IUPHAR Ligand for TACR1 Gene

Ligand Type Action Affinity Pubmed IDs
aprepitant Antagonist Antagonist 10.7
vofopitant Antagonist Antagonist 10.6
T2328 Antagonist Antagonist 10.1
LY303870 Antagonist Antagonist 10
ZD6021 Antagonist Antagonist 9.9
[Sar9,Met(O2)11]SP Agonist Full agonist 9.9
saredutant Antagonist Antagonist 9.7
ezlopitant Antagonist Antagonist 9.7
CP 99994 Antagonist Antagonist 9.7
[125I]L703,606 Antagonist Antagonist 9.5
SCH 206272 Antagonist Antagonist 9.4
casopitant Antagonist Antagonist 9.4
vestipitant Antagonist Antagonist 9.37
R116031 Antagonist Antagonist 9.35
septide Agonist Full agonist 9.3
physalaemin Agonist Full agonist 9.2
rolapitant Antagonist Antagonist 9.18
neurokinin A Agonist Full agonist 9.1
netupitant Antagonist Antagonist 9.02
befetupitant Antagonist Antagonist 9
SR 140,333 Antagonist Antagonist 9
eledoisin Agonist Full agonist 8.6
phyllomedusin Agonist Full agonist 8.5
L-703,606 Antagonist Antagonist 8.4
FK 224 Antagonist Antagonist 8.3
substance P-(4-11) Agonist Full agonist 8
osanetant Antagonist Antagonist 7.8
neurokinin B Agonist Full agonist 7.7
RP67580 Antagonist Antagonist 7.7
neuropeptide-alpha Agonist Full agonist 7.7
substance P-OMe Agonist Full agonist 7.5
kassinin Agonist Full agonist 7.1
substance P Agonist Full agonist 6.9
R-486 Antagonist Antagonist 6.6
neuropeptide K Agonist Full agonist 6.5
substance P-(6-11) Agonist Full agonist 6.5
hemokinin 1 Agonist Full agonist 6.3
FK888 Antagonist Antagonist 6.1
[3H]SP (human, mouse, rat) Agonist Full agonist
[18F]SPA-RQ Antagonist Antagonist
[3H]BH-[Sar9,Met(O2)11]SP None None
[Pro9]SP Agonist Full agonist
[125I]SP (human, mouse, rat) Agonist Full agonist

(112) Novoseek inferred chemical compound relationships for TACR1 Gene

Compound -log(P) Hits PubMed IDs
aprepitant 93.2 54
septide 90.9 37
fk 888 88.4 14
cp 96345 88.2 6
senktide 87.2 11
genes like me logo Genes that share compounds with TACR1: view

Compound Products

Transcripts for TACR1 Gene

mRNA/cDNA for TACR1 Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TACR1 Gene

Tachykinin receptor 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TACR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACR1 Gene

No ASD Table

Relevant External Links for TACR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TACR1 Gene

mRNA expression in normal human tissues for TACR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACR1 Gene

This gene is overexpressed in Adipose - Subcutaneous (4.5) and Cervix - Endocervix (4.5).

Protein differential expression in normal tissues for TACR1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TACR1 Gene

SOURCE GeneReport for Unigene cluster for TACR1 Gene Hs.633301

genes like me logo Genes that share expressions with TACR1: view

Expression partners for TACR1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TACR1 Gene

Orthologs for TACR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TACR1 35
  • 89.76 (n)
  • 94.1 (a)
NK1R 36
  • 94 (a)
(Canis familiaris)
Mammalia TACR1 35
  • 92.96 (n)
  • 97.54 (a)
TACR1 36
  • 98 (a)
(Mus musculus)
Mammalia Tacr1 35
  • 89.76 (n)
  • 94.59 (a)
Tacr1 16
Tacr1 36
  • 95 (a)
(Pan troglodytes)
Mammalia TACR1 35
  • 99.51 (n)
  • 99.75 (a)
TACR1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tacr1 35
  • 89.35 (n)
  • 94.59 (a)
(Monodelphis domestica)
Mammalia TACR1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
(Gallus gallus)
Aves TACR1 35
  • 78.21 (n)
  • 79.12 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia TACR1 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tacr1 35
  • 71.7 (n)
  • 74.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20126 35
(Danio rerio)
Actinopterygii tacr1a 35
  • 70.82 (n)
  • 71.32 (a)
tacr1a 36
  • 67 (a)
tacr1b 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10626 37
  • 32 (a)
NepYr 37
  • 32 (a)
Takr86C 37
  • 37 (a)
Takr99D 37
  • 45 (a)
Takr86C 36
  • 24 (a)
Takr99D 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea C49A9.7 37
  • 36 (a)
C50F7.1 37
  • 28 (a)
tkr-1 37
  • 36 (a)
Y59H11AL.1 37
  • 29 (a)
tkr-1 36
  • 29 (a)
tkr-2 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for TACR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TACR1 Gene

Gene Tree for TACR1 (if available)
Gene Tree for TACR1 (if available)

Paralogs for TACR1 Gene

(15) SIMAP similar genes for TACR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TACR1: view

Variants for TACR1 Gene

Sequence variations from dbSNP and Humsavar for TACR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs881 -- 75,049,302(-) TATGG(C/G)TTAGG utr-variant-3-prime
rs1037 -- 75,049,317(-) TGCAA(A/C/G)AAGGG utr-variant-3-prime
rs3686 -- 75,165,853(-) CATGA(A/G)CTGGG intron-variant
rs713082 -- 75,046,339(+) AGAGT(C/T)AAGAG downstream-variant-500B
rs726506 -- 75,181,892(+) ATTAG(C/G)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TACR1 Gene

Variant ID Type Subtype PubMed ID
dgv4168n71 CNV Gain 21882294
nsv834262 CNV Gain 17160897
nsv874299 CNV Gain 21882294
nsv527009 CNV Gain 19592680
nsv520917 CNV Gain 19592680
dgv32n64 CNV Loss 17921354
nsv525695 CNV Loss 19592680
nsv874300 CNV Gain 21882294
nsv874301 CNV Gain 21882294
esv2664298 CNV Deletion 23128226
dgv1200e1 CNV Complex 17122850
nsv438354 CNV Loss 16468122
esv28202 CNV Loss 19812545
esv2720214 CNV Deletion 23290073
nsv10035 CNV Gain 18304495
esv2489063 CNV Insertion 19546169
esv272151 CNV Insertion 20981092
esv274003 CNV Insertion 20981092
esv1335930 CNV Insertion 17803354

Relevant External Links for TACR1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACR1 Gene

Disorders for TACR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TACR1 Gene in MalaCards »

(2) Diseases for TACR1 Gene

(6) University of Copenhagen DISEASES for TACR1 Gene

(65) Novoseek inferred disease relationships for TACR1 Gene

Disease -log(P) Hits PubMed IDs
astrocytoma 61.4 27
inflammation 55.7 62
hyperalgesia 53.2 16
migraine 30.4 8
asthma 29 11

Relevant External Links for TACR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TACR1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for TACR1 Gene

Publications for TACR1 Gene

  1. Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. (PMID: 8384323) Fong T.M. … Strader C.D. (Nature 1993) 3 4 23
  2. Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. (PMID: 1310144) Fong T.M. … Strader C.D. (Mol. Pharmacol. 1992) 3 4 23
  3. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough. (PMID: 16893949) Park H.K. … Kim Y.Y. (Thorax 2006) 3 23 48
  4. Candidate-gene approach in fibromyalgia syndrome: association analysis of the genes encoding substance P receptor, dopamine transporter and alpha1-antitrypsin. (PMID: 20074437) Ablin J.N. … Orr-Urtreger A. (Clin. Exp. Rheumatol. 2009) 3 23 48
  5. Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. (PMID: 1657150) Gerard N.P. … Gerard C. (Biochemistry 1991) 2 3 4

Products for TACR1 Gene

Sources for TACR1 Gene

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