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Aliases for TACC1 Gene

Aliases for TACC1 Gene

  • Transforming, Acidic Coiled-Coil Containing Protein 1 2 3
  • Gastric Cancer Antigen Ga55 3 4
  • Taxin-1 3 4
  • Transforming Acidic Coiled-Coil-Containing Protein 1 3
  • KIAA1103 4
  • Ga55 3

External Ids for TACC1 Gene

Summaries for TACC1 Gene

Entrez Gene Summary for TACC1 Gene

  • This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for TACC1 Gene

TACC1 (Transforming, Acidic Coiled-Coil Containing Protein 1) is a Protein Coding gene. Diseases associated with TACC1 include gliosarcoma and giant cell glioblastoma. Among its related pathways are Aurora A signaling and Aurora B signaling. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC2.

UniProtKB/Swiss-Prot for TACC1 Gene

  • Likely involved in the processes that promote cell division prior to the formation of differentiated tissues

Gene Wiki entry for TACC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACC1 Gene

Genomics for TACC1 Gene

Genomic Location for TACC1 Gene

Start:
38,728,186 bp from pter
End:
38,853,028 bp from pter
Size:
124,843 bases
Orientation:
Plus strand

Genomic View for TACC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TACC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACC1 Gene

Regulatory Elements for TACC1 Gene

Proteins for TACC1 Gene

  • Protein details for TACC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75410-TACC1_HUMAN
    Recommended name:
    Transforming acidic coiled-coil-containing protein 1
    Protein Accession:
    O75410
    Secondary Accessions:
    • B2RBD9
    • D3DSX6
    • Q6Y687
    • Q86YG7
    • Q8IUJ2
    • Q8IUJ3
    • Q8IUJ4
    • Q8IZG2
    • Q8NEY7
    • Q9UPP9

    Protein attributes for TACC1 Gene

    Size:
    805 amino acids
    Molecular mass:
    87794 Da
    Quaternary structure:
    • Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.

    Alternative splice isoforms for TACC1 Gene

neXtProt entry for TACC1 Gene

Proteomics data for TACC1 Gene at MOPED

Post-translational modifications for TACC1 Gene

  • Isoform 1 is heavily phosphorylated; isoform 6 is not.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys169 and Lys49

No data available for DME Specific Peptides for TACC1 Gene

Domains for TACC1 Gene

Protein Domains for TACC1 Gene

UniProtKB/Swiss-Prot:

TACC1_HUMAN
Domain:
  • Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.:
    • O75410
Family:
  • Belongs to the TACC family.:
    • O75410
genes like me logo Genes that share domains with TACC1: view

No data available for Gene Families for TACC1 Gene

Function for TACC1 Gene

Molecular function for TACC1 Gene

GENATLAS Biochemistry: transforming acidic coiled-coil gene 1,highly expressed during early embryogenesis,potentially promoting tumorigenicity in breast cancers with amplification of the 8p11 region
UniProtKB/Swiss-Prot Function: Likely involved in the processes that promote cell division prior to the formation of differentiated tissues

Gene Ontology (GO) - Molecular Function for TACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11903063
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with TACC1: view

Phenotypes for TACC1 Gene

GenomeRNAi human phenotypes for TACC1:
genes like me logo Genes that share phenotypes with TACC1: view

miRNA for TACC1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TACC1 Gene

Localization for TACC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACC1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TACC1 Gene COMPARTMENTS Subcellular localization image for TACC1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
GO:0015630 microtubule cytoskeleton IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with TACC1: view

Pathways for TACC1 Gene

genes like me logo Genes that share pathways with TACC1: view

Pathways by source for TACC1 Gene

2 BioSystems pathways for TACC1 Gene

Gene Ontology (GO) - Biological Process for TACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0007049 cell cycle IEA --
GO:0008283 cell proliferation IBA --
GO:0021987 cerebral cortex development IBA --
GO:0022008 neurogenesis IEA --
genes like me logo Genes that share ontologies with TACC1: view

Transcripts for TACC1 Gene

Unigene Clusters for TACC1 Gene

Transforming, acidic coiled-coil containing protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TACC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - -
SP5: - -
SP6:
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - -
SP12: - - -
SP13: - -
SP14:
SP15:
SP16:

ExUns: 16c ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TACC1 Gene

GeneLoc Exon Structure for
TACC1
ECgene alternative splicing isoforms for
TACC1

Expression for TACC1 Gene

mRNA expression in normal human tissues for TACC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TACC1 Gene

SOURCE GeneReport for Unigene cluster for TACC1 Gene Hs.279245

mRNA Expression by UniProt/SwissProt for TACC1 Gene

O75410-TACC1_HUMAN
Tissue specificity: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.
genes like me logo Genes that share expressions with TACC1: view

Orthologs for TACC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TACC1 36
  • 99.63 (n)
  • 99.63 (a)
TACC1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TACC1 36
  • 79.96 (n)
  • 77.22 (a)
TACC1 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TACC1 36
  • 87.62 (n)
  • 86.32 (a)
TACC1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tacc1 36
  • 80.16 (n)
  • 77.43 (a)
Tacc1 16
Tacc1 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TACC1 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TACC1 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tacc1 36
  • 80.34 (n)
  • 76.82 (a)
chicken
(Gallus gallus)
Aves TACC1 36
  • 69.05 (n)
  • 68.93 (a)
TACC1 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TACC1 37
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5836 36
tacc1 36
  • 65.44 (n)
  • 63.64 (a)
zebrafish
(Danio rerio)
Actinopterygii tacc1 36
  • 57.17 (n)
  • 52.75 (a)
tacc1 37
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tacc 37
  • 10 (a)
OneToMany
Species with no ortholog for TACC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACC1 Gene

ENSEMBL:
Gene Tree for TACC1 (if available)
TreeFam:
Gene Tree for TACC1 (if available)

Paralogs for TACC1 Gene

Paralogs for TACC1 Gene

Pseudogenes.org Pseudogenes for TACC1 Gene

genes like me logo Genes that share paralogs with TACC1: view

Variants for TACC1 Gene

Sequence variations from dbSNP and Humsavar for TACC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs11467 -- 38,787,396(+) GACGC(A/G)GCGCC utr-variant-5-prime, intron-variant
rs14128 -- 38,848,695(+) TTAAA(A/G)ATGTG utr-variant-3-prime
rs15455 -- 38,852,353(+) TATGG(A/T)GGAGG utr-variant-3-prime
rs769067 -- 38,743,430(+) AATGG(G/T)TGGGG intron-variant
rs869471 -- 38,836,865(-) ACAAA(A/C)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TACC1 Gene

Variant ID Type Subtype PubMed ID
nsv831296 CNV Gain 17160897
esv25816 CNV Loss 19812545
nsv396891 CNV Insertion 16902084
nsv528721 CNV Loss 19592680

Relevant External Links for TACC1 Gene

HapMap Linkage Disequilibrium report
TACC1

Disorders for TACC1 Gene

(5) Novoseek inferred disease relationships for TACC1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 46.3 9
ovarian cancer 20.1 1
tumors 19 10
gastric cancer 19 3
cancer 18.5 2

Relevant External Links for TACC1

Genetic Association Database (GAD)
TACC1
Human Genome Epidemiology (HuGE) Navigator
TACC1
genes like me logo Genes that share disorders with TACC1: view

No data available for UniProtKB/Swiss-Prot for TACC1 Gene

Publications for TACC1 Gene

  1. Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. (PMID: 10435627) Still I.H. … Cowell J.K. (Oncogene 1999) 3 4 23
  2. The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. (PMID: 11121038) Gergely F. … Raff J.W. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  3. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. (PMID: 11903063) Lauffart B. … Still I.H. (Biochem. J. 2002) 3 4 23
  4. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PMID: 12165861) Conte N. … Birnbaum D. (Oncogene 2002) 3 4 23
  5. Altered splicing pattern of TACC1 mRNA in gastric cancer. (PMID: 12547166) Line A. … Rees R.C. (Cancer Genet. Cytogenet. 2002) 3 4 23

Products for TACC1 Gene

Sources for TACC1 Gene

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