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Aliases for TACR2 Gene

Aliases for TACR2 Gene

  • Tachykinin Receptor 2 2 3 4
  • Neurokinin A Receptor 3 4
  • NK-2 Receptor 3 4
  • NKNAR 3 4
  • TAC2R 3 4
  • NK-2R 3 4
  • NK2R 3 4
  • SKR 3 4
  • Seven Transmembrane Helix Receptor 3
  • Neurokinin 2 Receptor) 6
  • Neurokinin 2 Receptor 3
  • Substance K Receptor 3
  • Substance-K Receptor 3

External Ids for TACR2 Gene

Previous HGNC Symbols for TACR2 Gene

  • TAC2R
  • NKNAR

Previous GeneCards Identifiers for TACR2 Gene

  • GC10M069975
  • GC10M070250
  • GC10M071056
  • GC10M070509
  • GC10M070834
  • GC10M071163
  • GC10M065163

Summaries for TACR2 Gene

Entrez Gene Summary for TACR2 Gene

  • This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]

GeneCards Summary for TACR2 Gene

TACR2 (Tachykinin Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include tachykinin receptor activity and substance K receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for TACR2 Gene

  • This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

Tocris Summary for TACR2 Gene

  • The neurokinin (NK) 2 receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK3 receptors. The NK2 receptor is predominantly expressed in the periphery (inflammatory cells and bronchial, gastrointestinal and urinary smooth muscle) with limited expression in the CNS. NK2 receptors are thought to mediate mood control, gastrointestinal contraction and airway and lung function. The receptor displays greater potency for the endogenous agonist neurokinin A than neurokinin B and substance P (NKA > NKB > SP). The human gene encoding the NK2 receptor has been localized on chromosome 10 (10pter-q23).

Gene Wiki entry for TACR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACR2 Gene

Genomics for TACR2 Gene

Regulatory Elements for TACR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TACR2 Gene

Start:
69,403,903 bp from pter
End:
69,416,918 bp from pter
Size:
13,016 bases
Orientation:
Minus strand

Genomic View for TACR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TACR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACR2 Gene

Proteins for TACR2 Gene

  • Protein details for TACR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21452-NK2R_HUMAN
    Recommended name:
    Substance-K receptor
    Protein Accession:
    P21452
    Secondary Accessions:
    • A8K7I1
    • Q4QRI5
    • Q8NGQ8
    • Q9UDE6
    • Q9UDE7

    Protein attributes for TACR2 Gene

    Size:
    398 amino acids
    Molecular mass:
    44442 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TACR2 Gene

Proteomics data for TACR2 Gene at MOPED

Post-translational modifications for TACR2 Gene

  • Glycosylation at Asn11 and Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for TACR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TACR2 Gene

Domains for TACR2 Gene

Gene Families for TACR2 Gene

HGNC:
  • TACR :GPCR / Class A : Tachykinin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for TACR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21452

UniProtKB/Swiss-Prot:

NK2R_HUMAN :
  • P21452
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TACR2: view

Function for TACR2 Gene

Molecular function for TACR2 Gene

GENATLAS Biochemistry: tachykinin 2 receptor,neurokinin A receptor (substance K), G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

Gene Ontology (GO) - Molecular Function for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004995 tachykinin receptor activity TAS 8307161
GO:0005515 protein binding IPI 23597562
GO:0016497 substance K receptor activity IEA --
genes like me logo Genes that share ontologies with TACR2: view

Animal Model Products

CRISPR Products

miRNA for TACR2 Gene

miRTarBase miRNAs that target TACR2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TACR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TACR2 Gene

Localization for TACR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TACR2 Gene COMPARTMENTS Subcellular localization image for TACR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2173708
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TACR2: view

Pathways for TACR2 Gene

genes like me logo Genes that share pathways with TACR2: view

Pathways by source for TACR2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 2173708
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007217 tachykinin receptor signaling pathway TAS 8307161
GO:0007588 excretion TAS 10862829
GO:0014057 positive regulation of acetylcholine secretion, neurotransmission IEA --
genes like me logo Genes that share ontologies with TACR2: view

Compounds for TACR2 Gene

(5) Tocris Compounds for TACR2 Gene

Compound Action Cas Number
[bAla8]-Neurokinin A(4-10) NK2 agonist [122063-01-8]
GR 159897 Non-peptide, potent NK2 antagonist [158848-32-9]
GR 64349 Potent, selective NK2 agonist [137593-52-3]
GR 94800 Potent, selective NK2 antagonist [141636-65-9]
MEN 10376 Potent, selective NK2 antagonist [135306-85-3]

(1) HMDB Compounds for TACR2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(26) IUPHAR Ligand for TACR2 Gene

Ligand Type Action Affinity Pubmed IDs
MEN 15596 Antagonist Antagonist 10.3
YM44781 Antagonist Antagonist 9.9
GR94800 Antagonist Antagonist 9.8
saredutant Antagonist Antagonist 9.7
GR159897 Antagonist Antagonist 9.5
SCH 206272 Antagonist Antagonist 9.4
MEN10627 Antagonist Antagonist 9.2
neurokinin A Agonist Full agonist 9.1
SB 414240 Antagonist Antagonist 9
nepadutant Antagonist Antagonist 8.7
ZM-274773 Antagonist Antagonist 8.62
YM44778 Antagonist Antagonist 8.6
MEN 10376 Antagonist Antagonist 8.1
osanetant Antagonist Antagonist 7.8
neurokinin B Agonist Full agonist 7.7
talnetant Antagonist Antagonist 6.9
[Phe(Me)7]neurokinin B Agonist Full agonist 6.9
substance P Agonist Full agonist 6.9
YM49598 Antagonist Antagonist 6.8
R396 Antagonist Antagonist 6.5
hemokinin 1 Agonist Full agonist 6.3
FK888 Antagonist Antagonist 6.1
[betaAla8]neurokinin A-(4-10) Agonist Full agonist 6
ZM 253270 Antagonist Antagonist 3.8
[3H]GR100679 None None
[125I]NKA (human, mouse, rat) None None

(63) Novoseek inferred chemical compound relationships for TACR2 Gene

Compound -log(P) Hits PubMed IDs
senktide 92.3 12
sr48968 91.5 14
cyclo(gln-trp-phe-gly-leu-met) 91.1 4
gr 71251 90 1
nepadutant 88.7 4
genes like me logo Genes that share compounds with TACR2: view

Transcripts for TACR2 Gene

mRNA/cDNA for TACR2 Gene

Unigene Clusters for TACR2 Gene

Tachykinin receptor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TACR2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACR2 Gene

No ASD Table

Relevant External Links for TACR2 Gene

GeneLoc Exon Structure for
TACR2
ECgene alternative splicing isoforms for
TACR2

Expression for TACR2 Gene

mRNA expression in normal human tissues for TACR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACR2 Gene

This gene is overexpressed in Colon - Sigmoid (15.3), Esophagus - Gastroesophageal Junction (9.6), and Esophagus - Muscularis (6.2).

SOURCE GeneReport for Unigene cluster for TACR2 Gene Hs.88372

genes like me logo Genes that share expressions with TACR2: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for TACR2 Gene

Orthologs for TACR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TACR2 35
  • 98.83 (n)
  • 98.24 (a)
TACR2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TACR2 35
  • 88.74 (n)
  • 88.92 (a)
TACR2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TACR2 35
  • 87.6 (n)
  • 87.07 (a)
TACR2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tacr2 35
  • 85.09 (n)
  • 86.05 (a)
Tacr2 16
Tacr2 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TACR2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TACR2 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tacr2 35
  • 86.23 (n)
  • 88.16 (a)
chicken
(Gallus gallus)
Aves TACR2 35
  • 67.82 (n)
  • 65.13 (a)
TACR2 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TACR2 36
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tacr2 35
  • 61.04 (n)
  • 56.4 (a)
tacr2 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GPRTAK1 35
  • 54.11 (n)
  • 41.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lkr 36
  • 21 (a)
ManyToMany
Takr86C 35
  • 50.67 (n)
  • 38.29 (a)
Takr86C 36
  • 22 (a)
ManyToMany
Takr99D 36
  • 26 (a)
ManyToMany
CG10626 37
  • 31 (a)
Takr99D 37
  • 37 (a)
Takr86C 37
  • 35 (a)
NepYr 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea tkr-1 36
  • 27 (a)
ManyToMany
tkr-2 36
  • 29 (a)
ManyToMany
tkr-3 36
  • 22 (a)
ManyToMany
tkr-1 37
  • 33 (a)
Y59H11AL.1 37
  • 33 (a)
C49A9.7 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for TACR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TACR2 Gene

ENSEMBL:
Gene Tree for TACR2 (if available)
TreeFam:
Gene Tree for TACR2 (if available)

Paralogs for TACR2 Gene

Selected SIMAP similar genes for TACR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TACR2: view

Variants for TACR2 Gene

Sequence variations from dbSNP and Humsavar for TACR2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs986525 -- 69,406,671(-) CTGTT(A/C/T)TAGTA intron-variant
rs1135419 -- 69,408,946(-) AACCT(C/G)CGCCA synonymous-codon, reference
rs1135420 -- 69,408,940(-) CGCCA(A/C/T)CTGCA missense, reference, synonymous-codon
rs1135421 -- 69,405,072(-) TCTGG(A/G)TTCCG reference, synonymous-codon
rs1227958 -- 69,411,190(+) AGGCT(G/T)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TACR2 Gene

Variant ID Type Subtype PubMed ID
nsv895696 CNV Gain 21882294

Relevant External Links for TACR2 Gene

HapMap Linkage Disequilibrium report
TACR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACR2 Gene

Disorders for TACR2 Gene

(1) University of Copenhagen DISEASES for TACR2 Gene

(14) Novoseek inferred disease relationships for TACR2 Gene

Disease -log(P) Hits PubMed IDs
asthma 43.9 8
airways disease 30.3 1
inflammation 21.3 8
erythroleukemia 6.82 2
hyperalgesia 4.6 1

Relevant External Links for TACR2

Genetic Association Database (GAD)
TACR2
Human Genome Epidemiology (HuGE) Navigator
TACR2
genes like me logo Genes that share disorders with TACR2: view

No data available for UniProtKB/Swiss-Prot for TACR2 Gene

Publications for TACR2 Gene

  1. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. (PMID: 2173708) Gerard N.P. … Gerard C. (J. Biol. Chem. 1990) 3 4 23
  2. Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis. (PMID: 1848773) Kris R.M. … Schlessinger J. (Cell Growth Differ. 1991) 3 4 23
  3. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough. (PMID: 16893949) Park H.K. … Kim Y.Y. (Thorax 2006) 3 23 48
  4. Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough. (PMID: 19583679) Kim T.B. … Kim Y.Y. (J Clin Pharm Ther 2009) 3 23 48
  5. Distribution pattern of tachykinin NK2 receptors in human colon: involvement in the regulation of intestinal motility. (PMID: 17503489) Jaafari N. … JulAc Y. (J. Comp. Neurol. 2007) 3 23

Products for TACR2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TACR2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for TACR2
  • Block miRNA regulation of TACR2 using miScript Target Protectors

Sources for TACR2 Gene

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