Aliases for TACR2 Gene
External Ids for TACR2 Gene
Previous HGNC Symbols for TACR2 Gene
Previous GeneCards Identifiers for TACR2 Gene
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]
GeneCards Summary for TACR2 Gene
TACR2 (Tachykinin Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include tachykinin receptor activity and substance K receptor activity. An important paralog of this gene is NPFFR1.
UniProtKB/Swiss-Prot for TACR2 Gene
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
The neurokinin (NK) 2 receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK3 receptors. The NK2 receptor is predominantly expressed in the periphery (inflammatory cells and bronchial, gastrointestinal and urinary smooth muscle) with limited expression in the CNS. NK2 receptors are thought to mediate mood control, gastrointestinal contraction and airway and lung function. The receptor displays greater potency for the endogenous agonist neurokinin A than neurokinin B and substance P (NKA > NKB > SP). The human gene encoding the NK2 receptor has been localized on chromosome 10 (10pter-q23).