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Aliases for TACR2 Gene

Aliases for TACR2 Gene

  • Tachykinin Receptor 2 2 3 4 5
  • Neurokinin A Receptor 3 4
  • NK-2 Receptor 3 4
  • NKNAR 3 4
  • TAC2R 3 4
  • NK-2R 3 4
  • NK2R 3 4
  • SKR 3 4
  • Seven Transmembrane Helix Receptor 3
  • Neurokinin 2 Receptor 3
  • Substance K Receptor 3

External Ids for TACR2 Gene

Previous HGNC Symbols for TACR2 Gene

  • TAC2R
  • NKNAR

Previous GeneCards Identifiers for TACR2 Gene

  • GC10M069975
  • GC10M070250
  • GC10M071056
  • GC10M070509
  • GC10M070834
  • GC10M071163
  • GC10M065163

Summaries for TACR2 Gene

Entrez Gene Summary for TACR2 Gene

  • This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]

GeneCards Summary for TACR2 Gene

TACR2 (Tachykinin Receptor 2) is a Protein Coding gene. Diseases associated with TACR2 include asthma. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and substance K receptor activity. An important paralog of this gene is NPY1R.

UniProtKB/Swiss-Prot for TACR2 Gene

  • This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

Tocris Summary for TACR2 Gene

  • The neurokinin 2 (NK2) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK3 receptors. The NK2 receptor is predominantly expressed in the periphery (including inflammatory cells and bronchial smooth muscle).

Gene Wiki entry for TACR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACR2 Gene

Genomics for TACR2 Gene

Regulatory Elements for TACR2 Gene

Genomic Location for TACR2 Gene

Chromosome:
10
Start:
69,403,903 bp from pter
End:
69,416,918 bp from pter
Size:
13,016 bases
Orientation:
Minus strand

Genomic View for TACR2 Gene

Genes around TACR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACR2 Gene

Proteins for TACR2 Gene

  • Protein details for TACR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21452-NK2R_HUMAN
    Recommended name:
    Substance-K receptor
    Protein Accession:
    P21452
    Secondary Accessions:
    • A8K7I1
    • Q4QRI5
    • Q8NGQ8
    • Q9UDE6
    • Q9UDE7

    Protein attributes for TACR2 Gene

    Size:
    398 amino acids
    Molecular mass:
    44442 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TACR2 Gene

Proteomics data for TACR2 Gene at MOPED

Post-translational modifications for TACR2 Gene

  • Glycosylation at Asn 11 and Asn 19
  • Modification sites at PhosphoSitePlus

Other Protein References for TACR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TACR2 Gene

Domains & Families for TACR2 Gene

Gene Families for TACR2 Gene

Suggested Antigen Peptide Sequences for TACR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21452

UniProtKB/Swiss-Prot:

NK2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TACR2: view

Function for TACR2 Gene

Molecular function for TACR2 Gene

GENATLAS Biochemistry:
tachykinin 2 receptor,neurokinin A receptor (substance K), G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

Gene Ontology (GO) - Molecular Function for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004995 tachykinin receptor activity IEA,TAS 8307161
GO:0016497 substance K receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with TACR2: view

Phenotypes for TACR2 Gene

genes like me logo Genes that share phenotypes with TACR2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TACR2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TACR2 Gene

Localization for TACR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TACR2 Gene COMPARTMENTS Subcellular localization image for TACR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TACR2: view

Pathways & Interactions for TACR2 Gene

genes like me logo Genes that share pathways with TACR2: view

Pathways by source for TACR2 Gene

SIGNOR curated interactions for TACR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 2173708
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007588 excretion TAS 10862829
GO:0014057 positive regulation of acetylcholine secretion, neurotransmission IEA --
genes like me logo Genes that share ontologies with TACR2: view

Drugs & Compounds for TACR2 Gene

(63) Drugs for TACR2 Gene - From: Novoseek, IUPHAR, DGIdb, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 154
Osanetant Investigational Pharma Antagonist, antagonist 0
substance P Investigational Pharma Full agonist, Agonist 217
MEN 10376 Pharma Antagonist 0
Nepadutant Pharma Antagonist, antagonist 0

(33) Additional Compounds for TACR2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[betaAla<sup>8</sup>]neurokinin A-(4-10)
Full agonist, Agonist
MEN 15596
Antagonist
[bAla8]-Neurokinin A(4-10)
122063-01-8
[Lys5,MeLeu9,Nle10]-NKA(4-10)
137565-28-7
GR 159897
158848-32-9

(5) Tocris Compounds for TACR2 Gene

Compound Action Cas Number
[bAla8]-Neurokinin A(4-10) NK2 agonist 122063-01-8
[Lys5,MeLeu9,Nle10]-NKA(4-10) Selective NK2 agonist 137565-28-7
GR 159897 Non-peptide, potent NK2 antagonist 158848-32-9
GR 64349 Potent, selective NK2 agonist 137593-52-3
MDL 29,913 Selective NK2 antagonist 135721-56-1

(2) ApexBio Compounds for TACR2 Gene

Compound Action Cas Number
Fosaprepitant Neurokinin-1 antagonist 172673-20-0
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist 265121-04-8
genes like me logo Genes that share compounds with TACR2: view

Drug Products

Transcripts for TACR2 Gene

mRNA/cDNA for TACR2 Gene

Unigene Clusters for TACR2 Gene

Tachykinin receptor 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACR2 Gene

No ASD Table

Relevant External Links for TACR2 Gene

GeneLoc Exon Structure for
TACR2
ECgene alternative splicing isoforms for
TACR2

Expression for TACR2 Gene

mRNA expression in normal human tissues for TACR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACR2 Gene

This gene is overexpressed in Colon - Sigmoid (x15.3), Esophagus - Gastroesophageal Junction (x9.6), and Esophagus - Muscularis (x6.2).

SOURCE GeneReport for Unigene cluster for TACR2 Gene Hs.88372

genes like me logo Genes that share expression patterns with TACR2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TACR2 Gene

Orthologs for TACR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TACR2 35
  • 88.74 (n)
  • 88.92 (a)
TACR2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TACR2 35
  • 87.6 (n)
  • 87.07 (a)
TACR2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tacr2 35
  • 85.09 (n)
  • 86.05 (a)
Tacr2 16
Tacr2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TACR2 35
  • 98.83 (n)
  • 98.24 (a)
TACR2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tacr2 35
  • 86.23 (n)
  • 88.16 (a)
oppossum
(Monodelphis domestica)
Mammalia TACR2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TACR2 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TACR2 35
  • 67.82 (n)
  • 65.13 (a)
TACR2 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TACR2 36
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tacr2 35
  • 61.04 (n)
  • 56.4 (a)
tacr2 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10626 37
  • 31 (a)
NepYr 37
  • 34 (a)
Takr86C 37
  • 35 (a)
Takr99D 37
  • 37 (a)
Takr86C 35
  • 50.67 (n)
  • 38.29 (a)
Lkr 36
  • 21 (a)
ManyToMany
Takr86C 36
  • 22 (a)
ManyToMany
Takr99D 36
  • 26 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRTAK1 35
  • 54.11 (n)
  • 41.56 (a)
worm
(Caenorhabditis elegans)
Secernentea C49A9.7 37
  • 31 (a)
tkr-1 37
  • 33 (a)
Y59H11AL.1 37
  • 33 (a)
tkr-1 36
  • 27 (a)
ManyToMany
tkr-2 36
  • 29 (a)
ManyToMany
tkr-3 36
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for TACR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TACR2 Gene

ENSEMBL:
Gene Tree for TACR2 (if available)
TreeFam:
Gene Tree for TACR2 (if available)

Paralogs for TACR2 Gene

(6) SIMAP similar genes for TACR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TACR2: view

Variants for TACR2 Gene

Sequence variations from dbSNP and Humsavar for TACR2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_014680 -
rs5030920 - 69,416,256(-) GGGCA(C/T)CACAG reference, missense
rs57500981 - 69,416,185(+) CACGG(C/T)CACCA reference, missense
VAR_061222 -
VAR_061223 -

Structural Variations from Database of Genomic Variants (DGV) for TACR2 Gene

Variant ID Type Subtype PubMed ID
nsv895696 CNV Gain 21882294

Variation tolerance for TACR2 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.10; 87.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TACR2 Gene

HapMap Linkage Disequilibrium report
TACR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACR2 Gene

Disorders for TACR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TACR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search TACR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TACR2

Genetic Association Database (GAD)
TACR2
Human Genome Epidemiology (HuGE) Navigator
TACR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TACR2
genes like me logo Genes that share disorders with TACR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACR2 Gene

Publications for TACR2 Gene

  1. Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis. (PMID: 1848773) Kris R.M. … Schlessinger J. (Cell Growth Differ. 1991) 3 4 23 67
  2. Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough. (PMID: 19583679) Kim T.B. … Kim Y.Y. (J Clin Pharm Ther 2009) 3 23
  3. Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells. (PMID: 18203813) Mizuta K. … Emala C.W. (Am. J. Physiol. Lung Cell Mol. Physiol. 2008) 3 23
  4. Occurrence and pharmacological characterization of four human tachykinin NK2 receptor variants. (PMID: 18601911) Ahlstedt I. … LindstrAPm E. (Biochem. Pharmacol. 2008) 3 23
  5. Qualitative and quantitative analysis of tachykinin NK2 receptors in chemically defined human colonic neuronal pathways. (PMID: 18219665) Jaafari N. … JulAc Y. (J. Comp. Neurol. 2008) 3 23

Products for TACR2 Gene

Sources for TACR2 Gene

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