External Ids for SYT5 Gene
Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]
GeneCards Summary for SYT5 Gene
SYT5 (Synaptotagmin V) is a Protein Coding gene. Among its related pathways are Metabolism and Integration of energy metabolism. GO annotations related to this gene include protein heterodimerization activity and calcium-dependent phospholipid binding. An important paralog of this gene is SYT11.
UniProtKB/Swiss-Prot for SYT5 Gene
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).