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Aliases for SYT5 Gene

Aliases for SYT5 Gene

  • Synaptotagmin 5 2 3 5
  • Synaptotagmin V 2 3 4
  • SytV 3 4

External Ids for SYT5 Gene

Previous GeneCards Identifiers for SYT5 Gene

  • GC19M056548
  • GC19M056109
  • GC19M060360
  • GC19M060376
  • GC19M055684
  • GC19M052007

Summaries for SYT5 Gene

Entrez Gene Summary for SYT5 Gene

  • Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SYT5 Gene

SYT5 (Synaptotagmin 5) is a Protein Coding gene. Among its related pathways are Metabolism and Integration of energy metabolism. GO annotations related to this gene include calcium ion binding and transporter activity. An important paralog of this gene is SYT4.

UniProtKB/Swiss-Prot for SYT5 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).

Gene Wiki entry for SYT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT5 Gene

Genomics for SYT5 Gene

Regulatory Elements for SYT5 Gene

Promoters for SYT5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYT5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYT5 Gene

Chromosome:
19
Start:
55,171,199 bp from pter
End:
55,180,441 bp from pter
Size:
9,243 bases
Orientation:
Minus strand

Genomic View for SYT5 Gene

Genes around SYT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT5 Gene

Proteins for SYT5 Gene

  • Protein details for SYT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00445-SYT5_HUMAN
    Recommended name:
    Synaptotagmin-5
    Protein Accession:
    O00445
    Secondary Accessions:
    • B3KWJ8
    • B7Z300
    • Q86X72

    Protein attributes for SYT5 Gene

    Size:
    386 amino acids
    Molecular mass:
    42900 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with both alpha- and beta-tubulin (By similarity).

    Alternative splice isoforms for SYT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYT5 Gene

Proteomics data for SYT5 Gene at MOPED

Post-translational modifications for SYT5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SYT5 Gene

Domains & Families for SYT5 Gene

Gene Families for SYT5 Gene

Protein Domains for SYT5 Gene

Suggested Antigen Peptide Sequences for SYT5 Gene

Graphical View of Domain Structure for InterPro Entry

O00445

UniProtKB/Swiss-Prot:

SYT5_HUMAN :
  • Contains 2 C2 domains.
  • Belongs to the synaptotagmin family.
Domain:
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT5: view

Function for SYT5 Gene

Molecular function for SYT5 Gene

GENATLAS Biochemistry:
synaptotagmin 5,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved in exocytosis and endocytosis
UniProtKB/Swiss-Prot Function:
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).

Gene Ontology (GO) - Molecular Function for SYT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005544 calcium-dependent phospholipid binding IBA --
genes like me logo Genes that share ontologies with SYT5: view
genes like me logo Genes that share phenotypes with SYT5: view

Animal Models for SYT5 Gene

MGI Knock Outs for SYT5:

Animal Model Products

  • Taconic Biosciences Mouse Models for SYT5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYT5 Gene

Localization for SYT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT5 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Note=In mast cells, localizes to the endocytic recycling compartment. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT5 Gene COMPARTMENTS Subcellular localization image for SYT5 gene
Compartment Confidence
endosome 3
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SYT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IBA --
GO:0031045 dense core granule IEA --
GO:0055038 recycling endosome membrane IEA --
genes like me logo Genes that share ontologies with SYT5: view

Pathways & Interactions for SYT5 Gene

genes like me logo Genes that share pathways with SYT5: view

Pathways by source for SYT5 Gene

Gene Ontology (GO) - Biological Process for SYT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0048488 synaptic vesicle endocytosis IBA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT5: view

No data available for SIGNOR curated interactions for SYT5 Gene

Drugs & Compounds for SYT5 Gene

(2) Drugs for SYT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Norepinephrine Approved Pharma 595
calcium Nutra 0
genes like me logo Genes that share compounds with SYT5: view

Transcripts for SYT5 Gene

Unigene Clusters for SYT5 Gene

Synaptotagmin V:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: -
SP3: - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for SYT5 Gene

GeneLoc Exon Structure for
SYT5
ECgene alternative splicing isoforms for
SYT5

Expression for SYT5 Gene

mRNA expression in normal human tissues for SYT5 Gene

mRNA differential expression in normal tissues according to GTEx for SYT5 Gene

This gene is overexpressed in Brain - Cortex (x5.9), Brain - Putamen (basal ganglia) (x5.7), Brain - Nucleus accumbens (basal ganglia) (x5.5), Brain - Frontal Cortex (BA9) (x5.3), Brain - Caudate (basal ganglia) (x5.2), Brain - Hippocampus (x5.1), Brain - Anterior cingulate cortex (BA24) (x4.8), and Pituitary (x4.0).

Protein differential expression in normal tissues from HIPED for SYT5 Gene

This gene is overexpressed in Brain (53.1) and Bone (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYT5 Gene



SOURCE GeneReport for Unigene cluster for SYT5 Gene Hs.631566

genes like me logo Genes that share expression patterns with SYT5: view

Protein tissue co-expression partners for SYT5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SYT5 Gene

Orthologs for SYT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYT5 35
  • 92.51 (n)
  • 95.72 (a)
SYT5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT5 35
  • 90.5 (n)
  • 94.56 (a)
SYT5 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt5 35
  • 85.7 (n)
  • 91.8 (a)
Syt5 16
Syt5 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYT5 35
  • 99.27 (n)
  • 99.06 (a)
SYT5 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt5 35
  • 86.16 (n)
  • 91.53 (a)
lizard
(Anolis carolinensis)
Reptilia SYT5 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii syt1b 36
  • 48 (a)
OneToMany
syt5a 36
  • 47 (a)
OneToMany
syt5b 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3020 37
  • 35 (a)
CG5559 37
  • 40 (a)
syt 37
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea C08G5.4 37
  • 39 (a)
F42G9.7 37
  • 45 (a)
snt-1 37
  • 53 (a)
Y75B7AL.3 37
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8468 36
  • 52 (a)
OneToMany
Species with no ortholog for SYT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYT5 Gene

ENSEMBL:
Gene Tree for SYT5 (if available)
TreeFam:
Gene Tree for SYT5 (if available)

Paralogs for SYT5 Gene

Paralogs for SYT5 Gene

genes like me logo Genes that share paralogs with SYT5: view

Variants for SYT5 Gene

Sequence variations from dbSNP and Humsavar for SYT5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_034528 -
rs2301279 - 55,179,030(-) CCGGA(G/T)CCCCC reference, missense
rs2301278 -- 55,179,056(-) GACTC(C/T)AGGAC reference, synonymous-codon, utr-variant-5-prime
rs3826887 -- 55,180,577(-) GGTCT(C/T)CAATG upstream-variant-2KB
rs3745922 -- 55,179,485(-) GTCAG(C/T)CCCGC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SYT5 Gene

Variant ID Type Subtype PubMed ID
nsv912453 CNV Loss 21882294

Variation tolerance for SYT5 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT5 Gene

HapMap Linkage Disequilibrium report
SYT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT5 Gene

Disorders for SYT5 Gene

Relevant External Links for SYT5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT5

No disorders were found for SYT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT5 Gene

Publications for SYT5 Gene

  1. Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location. (PMID: 9177789) Craxton M.A. … Goedert M. (Genomics 1997) 2 3 4 23 67
  2. Evidence for the association of synaptotagmin with glutathione S-transferases: implications for a novel function in human breast cancer. (PMID: 15820774) Sreenath A.S. … Reddanna P. (Clin. Biochem. 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. Cloning, expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of human synaptotagmin 5 C2A domain. (PMID: 22102235) Qiu X. … Gao Y. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2011) 3

Products for SYT5 Gene

Sources for SYT5 Gene

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