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Aliases for SYT5 Gene

Aliases for SYT5 Gene

  • Synaptotagmin V 2 3 4
  • Synaptotagmin 5 2 3
  • SytV 3 4
  • Synaptotagmin-5 3

External Ids for SYT5 Gene

Summaries for SYT5 Gene

Entrez Gene Summary for SYT5 Gene

  • Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SYT5 Gene

SYT5 (Synaptotagmin V) is a Protein Coding gene. Among its related pathways are Metabolism and Integration of energy metabolism. GO annotations related to this gene include protein heterodimerization activity and calcium-dependent phospholipid binding. An important paralog of this gene is SYT11.

UniProtKB/Swiss-Prot for SYT5 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).

Gene Wiki entry for SYT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT5 Gene

Genomics for SYT5 Gene

Genomic Location for SYT5 Gene

Start:
55,171,199 bp from pter
End:
55,180,441 bp from pter
Size:
9,243 bases
Orientation:
Minus strand

Genomic View for SYT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT5 Gene

Regulatory Elements for SYT5 Gene

Proteins for SYT5 Gene

  • Protein details for SYT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00445-SYT5_HUMAN
    Recommended name:
    Synaptotagmin-5
    Protein Accession:
    O00445
    Secondary Accessions:
    • B3KWJ8
    • B7Z300
    • Q86X72

    Protein attributes for SYT5 Gene

    Size:
    386 amino acids
    Molecular mass:
    42900 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.;
    Quaternary structure:
    • Homodimer. Can also form heterodimers with SYT6. Interacts with both alpha- and beta-tubulin (By similarity).

    Alternative splice isoforms for SYT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYT5 Gene

Proteomics data for SYT5 Gene at MOPED

Post-translational modifications for SYT5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT5 Gene

No data available for DME Specific Peptides for SYT5 Gene

Domains for SYT5 Gene

Gene Families for SYT5 Gene

HGNC:
  • SYT :Synaptotagmins

Protein Domains for SYT5 Gene

UniProtKB/Swiss-Prot:

SYT5_HUMAN
Domain:
  • Contains 2 C2 domains.:
    • O00445
Family:
  • Belongs to the synaptotagmin family.:
    • O00445
genes like me logo Genes that share domains with SYT5: view

Function for SYT5 Gene

Molecular function for SYT5 Gene

GENATLAS Biochemistry: synaptotagmin 5,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved in exocytosis and endocytosis
UniProtKB/Swiss-Prot Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).

Gene Ontology (GO) - Molecular Function for SYT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYT5: view

Phenotypes for SYT5 Gene

genes like me logo Genes that share phenotypes with SYT5: view

Animal Models for SYT5 Gene

MGI Knock Outs for SYT5:

miRNA for SYT5 Gene

miRTarBase miRNAs that target SYT5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SYT5 Gene

Localization for SYT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT5 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Note=In mast cells, localizes to the endocytic recycling compartment. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT5 Gene COMPARTMENTS Subcellular localization image for SYT5 gene
Compartment Confidence
endosome 5
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SYT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005886 plasma membrane IBA --
GO:0008021 synaptic vesicle --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SYT5: view

Pathways for SYT5 Gene

genes like me logo Genes that share pathways with SYT5: view

Pathways by source for SYT5 Gene

Gene Ontology (GO) - Biological Process for SYT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006906 vesicle fusion IBA --
GO:0007268 synaptic transmission TAS 9177789
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017156 calcium ion-dependent exocytosis IEA --
genes like me logo Genes that share ontologies with SYT5: view

Compounds for SYT5 Gene

(2) HMDB Compounds for SYT5 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Norepinephrine
  • (-)-(R)-Norepinephrine
51-41-2
genes like me logo Genes that share compounds with SYT5: view

Transcripts for SYT5 Gene

Unigene Clusters for SYT5 Gene

Synaptotagmin V:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: -
SP3: - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for SYT5 Gene

GeneLoc Exon Structure for
SYT5
ECgene alternative splicing isoforms for
SYT5

Expression for SYT5 Gene

mRNA expression in normal human tissues for SYT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT5 Gene

This gene is overexpressed in Brain - Cortex (5.9), Brain - Putamen (basal ganglia) (5.7), Brain - Nucleus accumbens (basal ganglia) (5.5), Brain - Frontal Cortex (BA9) (5.3), Brain - Caudate (basal ganglia) (5.2), Brain - Hippocampus (5.1), Brain - Anterior cingulate cortex (BA24) (4.8), and Pituitary (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SYT5 Gene

SOURCE GeneReport for Unigene cluster for SYT5 Gene Hs.631566

genes like me logo Genes that share expressions with SYT5: view

Orthologs for SYT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT5 36
  • 99.27 (n)
  • 99.06 (a)
SYT5 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYT5 36
  • 92.51 (n)
  • 95.72 (a)
SYT5 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT5 36
  • 90.5 (n)
  • 94.56 (a)
SYT5 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt5 36
  • 85.7 (n)
  • 91.8 (a)
Syt5 16
Syt5 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt5 36
  • 86.16 (n)
  • 91.53 (a)
lizard
(Anolis carolinensis)
Reptilia SYT5 37
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii syt1b 37
  • 48 (a)
OneToMany
syt5a 37
  • 47 (a)
OneToMany
syt5b 37
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3020 38
  • 35 (a)
syt 38
  • 59 (a)
CG5559 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea snt-1 38
  • 53 (a)
Y75B7AL.3 38
  • 53 (a)
F42G9.7 38
  • 45 (a)
C08G5.4 38
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8468 37
  • 52 (a)
OneToMany
Species with no ortholog for SYT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYT5 Gene

ENSEMBL:
Gene Tree for SYT5 (if available)
TreeFam:
Gene Tree for SYT5 (if available)

Paralogs for SYT5 Gene

Paralogs for SYT5 Gene

genes like me logo Genes that share paralogs with SYT5: view

Variants for SYT5 Gene

Sequence variations from dbSNP and Humsavar for SYT5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2301278 -- 55,179,056(-) GACTC(C/T)AGGAC reference, synonymous-codon, utr-variant-5-prime
rs2301279 - 55,179,030(-) CCGGA(G/T)CCCCC reference, missense
rs3745922 -- 55,179,485(-) GTCAG(C/T)CCCGC upstream-variant-2KB, intron-variant
rs3786866 -- 55,172,856(-) ACACG(C/T)TGGCT intron-variant, downstream-variant-500B
rs3786867 -- 55,172,832(-) GAGAA(C/T)TCCCT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SYT5 Gene

Variant ID Type Subtype PubMed ID
nsv912453 CNV Loss 21882294

Relevant External Links for SYT5 Gene

HapMap Linkage Disequilibrium report
SYT5

Disorders for SYT5 Gene

No disorders were found for SYT5 Gene.

No data available for UniProtKB/Swiss-Prot for SYT5 Gene

Publications for SYT5 Gene

  1. Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location. (PMID: 9177789) Craxton M.A. … Goedert M. (Genomics 1997) 2 3 4 23
  2. Evidence for the association of synaptotagmin with glutathione S-transferases: implications for a novel function in human breast cancer. (PMID: 15820774) Sreenath A.S. … Reddanna P. (Clin. Biochem. 2005) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for SYT5 Gene

Sources for SYT5 Gene

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