Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SYN2 Gene

Aliases for SYN2 Gene

  • Synapsin II 2 3 4
  • Synapsin-2 3
  • SYNII 3

External Ids for SYN2 Gene

Summaries for SYN2 Gene

Entrez Gene Summary for SYN2 Gene

  • This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. [provided by RefSeq, Feb 2014]

GeneCards Summary for SYN2 Gene

SYN2 (Synapsin II) is a Protein Coding gene. Diseases associated with SYN2 include schizophrenia and bipolar disorder. Among its related pathways are Transmission across Chemical Synapses and Transmission across Chemical Synapses.

UniProtKB/Swiss-Prot for SYN2 Gene

  • Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).

Gene Wiki entry for SYN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYN2 Gene

Genomics for SYN2 Gene

Genomic Location for SYN2 Gene

12,004,366 bp from pter
12,192,032 bp from pter
187,667 bases
Plus strand

Genomic View for SYN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYN2 Gene

Regulatory Elements for SYN2 Gene

Proteins for SYN2 Gene

  • Protein details for SYN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8MY98

    Protein attributes for SYN2 Gene

    582 amino acids
    Molecular mass:
    62847 Da
    Quaternary structure:
    • Interacts with CAPON.
    • Sequence=AC022234; Type=Frameshift; Positions=71; Evidence={ECO:0000305}; Sequence=AC022234; Type=Miscellaneous discrepancy; Note=Several in-frame stop codons.; Evidence={ECO:0000305};

    Alternative splice isoforms for SYN2 Gene


neXtProt entry for SYN2 Gene

Proteomics data for SYN2 Gene at MOPED

Post-translational modifications for SYN2 Gene

  • Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYN2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SYN2 Gene

Domains for SYN2 Gene

Suggested Antigen Peptide Sequences for SYN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The A region binds phospholipids with a preference for negatively charged species.:
    • Q92777
  • Belongs to the synapsin family.:
    • Q92777
genes like me logo Genes that share domains with SYN2: view

No data available for Gene Families for SYN2 Gene

Function for SYN2 Gene

Molecular function for SYN2 Gene

GENATLAS Biochemistry: synapsin II,synaptic vesicles associated phosphoprotein,with two alternative forms SYNIIA,SYNIIB,involved in the fine regulation of neurotransmitter release
UniProtKB/Swiss-Prot Function: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).

Gene Ontology (GO) - Molecular Function for SYN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005524 ATP binding TAS 15217342
genes like me logo Genes that share ontologies with SYN2: view
genes like me logo Genes that share phenotypes with SYN2: view

Animal Models for SYN2 Gene

MGI Knock Outs for SYN2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SYN2 Gene

Localization for SYN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYN2 Gene

Cell junction, synapse.

Subcellular locations from

Jensen Localization Image for SYN2 Gene COMPARTMENTS Subcellular localization image for SYN2 gene
Compartment Confidence
cytosol 3
mitochondrion 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SYN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane ISS --
GO:0045202 synapse ISS --
genes like me logo Genes that share ontologies with SYN2: view

Pathways for SYN2 Gene

genes like me logo Genes that share pathways with SYN2: view

Interacting Proteins for SYN2 Gene

Selected Interacting proteins: Q92777-SYN2_HUMAN for SYN2 Gene via I2D

Gene Ontology (GO) - Biological Process for SYN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission TAS 8964517
GO:0007269 neurotransmitter secretion ISS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SYN2: view

Transcripts for SYN2 Gene

Unigene Clusters for SYN2 Gene

Synapsin II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYN2 Gene

No ASD Table

Relevant External Links for SYN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYN2 Gene

mRNA expression in normal human tissues for SYN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYN2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (7.4), Brain - Frontal Cortex (BA9) (6.9), Brain - Cortex (5.9), Brain - Amygdala (5.4), and Brain - Nucleus accumbens (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SYN2 Gene

SOURCE GeneReport for Unigene cluster for SYN2 Gene Hs.445503

mRNA Expression by UniProt/SwissProt for SYN2 Gene

Tissue specificity: Central and peripheral nervous systems
genes like me logo Genes that share expressions with SYN2: view

Orthologs for SYN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYN2 35
  • 97.59 (n)
  • 97.59 (a)
(Bos Taurus)
Mammalia SYN2 35
  • 91.81 (n)
  • 94.96 (a)
(Canis familiaris)
Mammalia SYN2 35
  • 91.44 (n)
  • 94.06 (a)
(Mus musculus)
Mammalia Syn2 35
  • 88.66 (n)
  • 92.57 (a)
Syn2 16
(Rattus norvegicus)
Mammalia Syn2 35
  • 89 (n)
  • 91.88 (a)
(Gallus gallus)
Aves SYN2 35
  • 75.8 (n)
  • 77.76 (a)
African clawed frog
(Xenopus laevis)
Amphibia syn2-A 35
(Danio rerio)
Actinopterygii Dr.13414 35
syn2a 35
  • 69.34 (n)
  • 68.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syn 37
  • 47 (a)
Species with no ortholog for SYN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYN2 Gene

Gene Tree for SYN2 (if available)
Gene Tree for SYN2 (if available)

Paralogs for SYN2 Gene

Selected SIMAP similar genes for SYN2 Gene using alignment to 2 proteins: Pseudogenes for SYN2 Gene

genes like me logo Genes that share paralogs with SYN2: view

No data available for Paralogs for SYN2 Gene

Variants for SYN2 Gene

Sequence variations from dbSNP and Humsavar for SYN2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs60834 -- 12,112,265(-) CTGAT(C/G)AAAGA intron-variant
rs92090 -- 12,136,141(-) CTGAA(A/C)TTTCA intron-variant
rs160113 -- 12,103,739(-) ATGCT(A/G)TTTCT intron-variant
rs160114 -- 12,102,941(-) ATTTT(A/C)TCTCA intron-variant
rs160208 -- 12,117,794(-) GCTGC(C/T)AACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYN2 Gene

Variant ID Type Subtype PubMed ID
dgv810e201 CNV Deletion 23290073
dgv850e199 CNV Deletion 23128226
nsv460427 CNV Loss 19166990
nsv519277 CNV Loss 19592680
esv2504613 CNV Deletion 19546169
esv2584673 CNV Insertion 19546169
esv1768590 CNV Insertion 17803354
nsv7351 OTHER Inversion 18451855
nsv236690 CNV Loss 16902084
esv2724931 CNV Deletion 23290073
esv2193425 CNV Deletion 18987734
esv2724932 CNV Deletion 23290073
esv1007552 CNV Deletion 20482838
esv1015927 CNV Deletion 17803354
nsv236830 CNV Loss 16902084
esv268675 CNV Insertion 20981092
esv274410 CNV Insertion 20981092

Relevant External Links for SYN2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYN2 Gene

Disorders for SYN2 Gene

(1) OMIM Diseases for SYN2 Gene (600755)

(1) University of Copenhagen DISEASES for SYN2 Gene

Relevant External Links for SYN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SYN2: view

No data available for UniProtKB/Swiss-Prot for SYN2 Gene

Publications for SYN2 Gene

  1. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. (PMID: 16131404) Lee H.J. … Fukumaki Y. (Behav Brain Funct 2005) 3 23 48
  2. Association of synapsin 2 with schizophrenia in families of Northern European ancestry. (PMID: 17766091) Saviouk V. … Brzustowicz L.M. (Schizophr. Res. 2007) 3 23
  3. Localization of the synapsin II (SYN2) gene to human chromosome 3 and mouse chromosome 6. (PMID: 8530057) Li L. … Jenkins N.A. (Genomics 1995) 2 3
  4. Cloning and sequencing analysis of a human synapsin IIb-encoding brain cDNA. (PMID: 8964517) Xie Y. (Gene 1996) 3 4
  5. Cloning of cDNAs encoding human synapsins IIa and IIb. (PMID: 10565545) Porton B. … Greengard P. (DNA Seq. 1999) 3 4

Products for SYN2 Gene

Sources for SYN2 Gene

Back to Top