Aliases for VAMP7 Gene
External Ids for VAMP7 Gene
Previous HGNC Symbols for VAMP7 Gene
Previous GeneCards Identifiers for VAMP7 Gene
This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
GeneCards Summary for VAMP7 Gene
VAMP7 (Vesicle Associated Membrane Protein 7) is a Protein Coding gene. Diseases associated with VAMP7 include Tetanus and Immunodeficiency, Centromere Instability And Facial Anomalies Syndrome. Among its related pathways are Vesicle-mediated transport and Delta508-CFTR traffic / ER-to-Golgi in CF. GO annotations related to this gene include syntaxin binding and SNAP receptor activity.
UniProtKB/Swiss-Prot for VAMP7 Gene
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.