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Aliases for VAMP2 Gene

Aliases for VAMP2 Gene

  • Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2) 2 3
  • SYB2 3 4 6
  • Synaptobrevin-2 3 4
  • VAMP-2 3 4
  • Vesicle Associated Membrane Protein 2 3
  • Vesicle-Associated Membrane Protein 2 3
  • Synaptobrevin 2 3

External Ids for VAMP2 Gene

Previous Symbols for VAMP2 Gene

  • SYB2

Summaries for VAMP2 Gene

Entrez Gene Summary for VAMP2 Gene

  • The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAMP2 Gene

VAMP2 (Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2)) is a Protein Coding gene. Diseases associated with VAMP2 include botulism and tetanus. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include phospholipid binding and protein C-terminus binding. An important paralog of this gene is VAMP3.

UniProtKB/Swiss-Prot for VAMP2 Gene

  • Involved in the targeting and/or fusion of transport vesicles to their target membrane

Gene Wiki entry for VAMP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP2 Gene

Genomics for VAMP2 Gene

Genomic Location for VAMP2 Gene

Start:
8,159,147 bp from pter
End:
8,163,546 bp from pter
Size:
4,400 bases
Orientation:
Minus strand

Genomic View for VAMP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VAMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP2 Gene

Regulatory Elements for VAMP2 Gene

Proteins for VAMP2 Gene

  • Protein details for VAMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63027-VAMP2_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 2
    Protein Accession:
    P63027
    Secondary Accessions:
    • P19065
    • Q9BUC2

    Protein attributes for VAMP2 Gene

    Size:
    116 amino acids
    Molecular mass:
    12663 Da
    Quaternary structure:
    • Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Interacts with BVES and STX4 (By similarity). Interacts with VAPA and VAPB.

    Three dimensional structures from OCA and Proteopedia for VAMP2 Gene

neXtProt entry for VAMP2 Gene

Proteomics data for VAMP2 Gene at MOPED

Post-translational modifications for VAMP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys52, Lys83, and Lys85

Other Protein References for VAMP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for VAMP2 Gene

Domains for VAMP2 Gene

Gene Families for VAMP2 Gene

HGNC:
  • VAMP :Vesicle-associated membrane proteins

Protein Domains for VAMP2 Gene

UniProtKB/Swiss-Prot:

VAMP2_HUMAN
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.:
    • P63027
Family:
  • Belongs to the synaptobrevin family.:
    • P63027
genes like me logo Genes that share domains with VAMP2: view

Function for VAMP2 Gene

Molecular function for VAMP2 Gene

GENATLAS Biochemistry: vesicule associated membrane protein 2,synaptobrevin 2,expressed in neurons forming a synaptic core complex with syntaxin and synaptosome associated proteins,playing a central role in neural exocytosis,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein
UniProtKB/Swiss-Prot Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane

Gene Ontology (GO) - Molecular Function for VAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding ISS --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 17196367
GO:0005516 calmodulin binding ISS --
GO:0005543 phospholipid binding ISS --
genes like me logo Genes that share ontologies with VAMP2: view
genes like me logo Genes that share phenotypes with VAMP2: view

Animal Models for VAMP2 Gene

MGI Knock Outs for VAMP2:

miRNA for VAMP2 Gene

miRTarBase miRNAs that target VAMP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VAMP2 Gene

Localization for VAMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP2 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Note=Neuronal synaptic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAMP2 Gene COMPARTMENTS Subcellular localization image for VAMP2 gene
Compartment Confidence
plasma membrane 4
cytosol 3
endosome 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1976629
GO:0008021 synaptic vesicle TAS 10099709
genes like me logo Genes that share ontologies with VAMP2: view

Pathways for VAMP2 Gene

genes like me logo Genes that share pathways with VAMP2: view

Gene Ontology (GO) - Biological Process for VAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006461 protein complex assembly ISS --
GO:0006887 exocytosis TAS 10099709
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006906 vesicle fusion IBA --
genes like me logo Genes that share ontologies with VAMP2: view

Compounds for VAMP2 Gene

(1) Drugbank Compounds for VAMP2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Botulinum Toxin Type B
  • Botulinum neurotoxin type B precursor
93384-44-2 target binder

(16) Novoseek inferred chemical compound relationships for VAMP2 Gene

Compound -log(P) Hits PubMed IDs
n-ethylmaleimide 50.9 2
glucose 38.9 12
phosphatidylinositol 19.6 1
phorbol 16.9 2
glutamate 10.5 3
genes like me logo Genes that share compounds with VAMP2: view

Transcripts for VAMP2 Gene

Unigene Clusters for VAMP2 Gene

Vesicle-associated membrane protein 2 (synaptobrevin 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP2 Gene

No ASD Table

Relevant External Links for VAMP2 Gene

GeneLoc Exon Structure for
VAMP2
ECgene alternative splicing isoforms for
VAMP2

Expression for VAMP2 Gene

mRNA expression in normal human tissues for VAMP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAMP2 Gene

SOURCE GeneReport for Unigene cluster for VAMP2 Gene Hs.25348

mRNA Expression by UniProt/SwissProt for VAMP2 Gene

P63027-VAMP2_HUMAN
Tissue specificity: Nervous system and skeletal muscle.
genes like me logo Genes that share expressions with VAMP2: view

Orthologs for VAMP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAMP2 36
  • 99.71 (n)
  • 100 (a)
VAMP2 37
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia VAMP2 36
  • 94.25 (n)
  • 99.14 (a)
VAMP2 37
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia VAMP2 36
  • 96.26 (n)
  • 99.14 (a)
mouse
(Mus musculus)
Mammalia Vamp2 36
  • 94.25 (n)
  • 99.14 (a)
Vamp2 16
Vamp2 37
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vamp2 36
  • 93.68 (n)
  • 99.14 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 79 (a)
ManyToMany
VAMP2 36
  • 78.99 (n)
  • 89.13 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 97 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia vamp2-B-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75977 36
vamp2 36
  • 83.33 (n)
  • 97.83 (a)
zebrafish
(Danio rerio)
Actinopterygii vamp2 36
  • 79.35 (n)
  • 95.65 (a)
vamp2 37
  • 91 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005507 36
  • 72.81 (n)
  • 78.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta n-syb 36
  • 76.32 (n)
  • 78.95 (a)
n-syb 37
  • 36 (a)
ManyToMany
Syb 37
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea snb-1 37
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNC1 37
  • 32 (a)
ManyToMany
SNC1 39
SNC2 37
  • 30 (a)
ManyToMany
Species with no ortholog for VAMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAMP2 Gene

ENSEMBL:
Gene Tree for VAMP2 (if available)
TreeFam:
Gene Tree for VAMP2 (if available)

Paralogs for VAMP2 Gene

Paralogs for VAMP2 Gene

Selected SIMAP similar genes for VAMP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VAMP2: view

Variants for VAMP2 Gene

Sequence variations from dbSNP and Humsavar for VAMP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1150 -- 8,159,265(+) GTCTA(A/G)AACAC utr-variant-3-prime
rs930497 -- 8,163,842(+) AGGTC(A/G)GCGAC upstream-variant-2KB
rs959303 -- 8,158,881(+) GACCA(C/T)AGGGC downstream-variant-500B
rs1051498 -- 8,159,201(-) CAATT(C/T)TGTGG utr-variant-3-prime
rs1051667 -- 8,159,379(-) GGGGG(C/G)CCCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VAMP2 Gene

Variant ID Type Subtype PubMed ID
nsv833352 CNV Loss 17160897
nsv907658 CNV Loss 21882294
nsv1964 CNV Insertion 18451855
nsv527475 CNV Loss 19592680
nsv833353 CNV Loss 17160897
dgv3056n71 CNV Loss 21882294

Relevant External Links for VAMP2 Gene

HapMap Linkage Disequilibrium report
VAMP2

Disorders for VAMP2 Gene

(2) MalaCards Diseases for VAMP2 Gene

Search for VAMP2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for VAMP2 Gene

(2) Novoseek inferred disease relationships for VAMP2 Gene

Disease -log(P) Hits PubMed IDs
tetanus 78.7 36
insulinoma 11.9 2

Relevant External Links for VAMP2

Genetic Association Database (GAD)
VAMP2
Human Genome Epidemiology (HuGE) Navigator
VAMP2
genes like me logo Genes that share disorders with VAMP2: view

No data available for UniProtKB/Swiss-Prot for VAMP2 Gene

Publications for VAMP2 Gene

  1. Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. (PMID: 1976629) Archer B.T. III … Suedhof T.C. (J. Biol. Chem. 1990) 2 3 4 23
  2. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PMID: 8760387) Jagadish M.N. … Ward C.W. (Biochem. J. 1996) 3 4 23
  3. Association study between vesicle-associated membrane protein 2 gene polymorphisms and fluvoxamine response in Japanese major depressive patients. (PMID: 17356306) Saito S. … Ozaki N. (Neuropsychobiology 2006) 3 23 49
  4. Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder. (PMID: 18628682) Abou Jamra R. … Schumacher J. (Psychiatr. Genet. 2008) 3 23 49
  5. No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population. (PMID: 18512733) Kawashima K. … Iwata N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23 49

Products for VAMP2 Gene

  • antibodies-online proteins for VAMP2
  • antibodies-online antibodies for VAMP2
  • antibodies-online kits for VAMP2

Sources for VAMP2 Gene

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