Aliases for VAMP2 Gene
External Ids for VAMP2 Gene
Previous Symbols for VAMP2 Gene
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
GeneCards Summary for VAMP2 Gene
VAMP2 (Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2)) is a Protein Coding gene. Diseases associated with VAMP2 include botulism and tetanus. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include phospholipid binding and protein C-terminus binding. An important paralog of this gene is VAMP3.
UniProtKB/Swiss-Prot for VAMP2 Gene
Involved in the targeting and/or fusion of transport vesicles to their target membrane