Aliases for SURF1 Gene
External Ids for SURF1 Gene
Previous GeneCards Identifiers for SURF1 Gene
This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008]
GeneCards Summary for SURF1 Gene
SURF1 (SURF1, Cytochrome C Oxidase Assembly Factor) is a Protein Coding gene. Diseases associated with SURF1 include Leigh Syndrome and Charcot-Marie-Tooth Disease, Type 4K. Among its related pathways are Metabolism and Type II diabetes mellitus. GO annotations related to this gene include cytochrome-c oxidase activity.
UniProtKB/Swiss-Prot for SURF1 Gene
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.