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Aliases for BST1 Gene

Aliases for BST1 Gene

  • Bone Marrow Stromal Cell Antigen 1 2 3 5
  • ADP-Ribosyl Cyclase 2 2 3 4
  • Bone Marrow Stromal Antigen 1 3 4
  • Cyclic ADP-Ribose Hydrolase 2 3 4
  • NAD(+) Nucleosidase 2 3
  • CADPr Hydrolase 2 3 4
  • BST-1 3 4
  • CD157 Antigen 4
  • EC 3.2.2.6 4
  • CD157 3

External Ids for BST1 Gene

Previous GeneCards Identifiers for BST1 Gene

  • GC04P015519
  • GC04P015646
  • GC04P015392
  • GC04P015455
  • GC04P015380
  • GC04P015055

Summaries for BST1 Gene

Entrez Gene Summary for BST1 Gene

  • Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]

GeneCards Summary for BST1 Gene

BST1 (Bone Marrow Stromal Cell Antigen 1) is a Protein Coding gene. Among its related pathways are Pancreatic secretion and Metabolism. GO annotations related to this gene include transferase activity and NAD+ nucleosidase activity. An important paralog of this gene is CD38.

UniProtKB/Swiss-Prot for BST1 Gene

  • Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Gene Wiki entry for BST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BST1 Gene

Genomics for BST1 Gene

Regulatory Elements for BST1 Gene

Enhancers for BST1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BST1 on UCSC Golden Path with GeneCards custom track

Promoters for BST1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BST1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BST1 Gene

Chromosome:
4
Start:
15,702,950 bp from pter
End:
15,774,190 bp from pter
Size:
71,241 bases
Orientation:
Plus strand

Genomic View for BST1 Gene

Genes around BST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BST1 Gene

Proteins for BST1 Gene

  • Protein details for BST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10588-BST1_HUMAN
    Recommended name:
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
    Protein Accession:
    Q10588
    Secondary Accessions:
    • B2R6A2
    • Q1XII0
    • Q5U0K0
    • Q96EN3

    Protein attributes for BST1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35724 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for BST1 Gene

    Alternative splice isoforms for BST1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BST1 Gene

Proteomics data for BST1 Gene at MOPED

Post-translational modifications for BST1 Gene

  • Glycosylation at Asn 66, Asn 95, Asn 148, and Asn 192
  • Modification sites at PhosphoSitePlus

Other Protein References for BST1 Gene

Antibody Products

No data available for DME Specific Peptides for BST1 Gene

Domains & Families for BST1 Gene

Gene Families for BST1 Gene

Protein Domains for BST1 Gene

Suggested Antigen Peptide Sequences for BST1 Gene

Graphical View of Domain Structure for InterPro Entry

Q10588

UniProtKB/Swiss-Prot:

BST1_HUMAN :
  • Belongs to the ADP-ribosyl cyclase family.
Family:
  • Belongs to the ADP-ribosyl cyclase family.
genes like me logo Genes that share domains with BST1: view

Function for BST1 Gene

Molecular function for BST1 Gene

GENATLAS Biochemistry:
bone marrow stromal antigens,involved in pre-B-cell growth,expressed in various tissues
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
UniProtKB/Swiss-Prot Function:
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Enzyme Numbers (IUBMB) for BST1 Gene

Gene Ontology (GO) - Molecular Function for BST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003953 NAD+ nucleosidase activity IBA --
genes like me logo Genes that share ontologies with BST1: view
genes like me logo Genes that share phenotypes with BST1: view

Animal Models for BST1 Gene

MGI Knock Outs for BST1:

Animal Model Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for BST1 Gene

Localization for BST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BST1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BST1 Gene COMPARTMENTS Subcellular localization image for BST1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for BST1 Gene

Pathways & Interactions for BST1 Gene

genes like me logo Genes that share pathways with BST1: view

Pathways by source for BST1 Gene

1 GeneGo (Thomson Reuters) pathway for BST1 Gene

Gene Ontology (GO) - Biological Process for BST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030890 positive regulation of B cell proliferation IBA --
genes like me logo Genes that share ontologies with BST1: view

No data available for SIGNOR curated interactions for BST1 Gene

Drugs & Compounds for BST1 Gene

(8) Drugs for BST1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Experimental Nutra Target 850,854
Adenosine-5'-Diphosphate Monothiophosphate Experimental Pharma Target 0
Etheno-Nad Experimental Pharma Target 0
Etheno-Nadp Experimental Pharma Target 0
nicotinamide mononucleotide Experimental Pharma Target 0

(8) Additional Compounds for BST1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(E)-3-(2,3-Dihydroxyphenyl)-2-propenoic acid
  • ADPribose 2'-phosphate
  • APX
38481-04-8
Adenosine diphosphate ribose
  • (Rib5)ppA
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • A5'pp5Rib
  • Adenosine 5'-diphosphoribose
  • Adenosine diphosphate ribose
20762-30-5
ADP-ribose 2'-phosphate
  • 2'-Phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate]
  • ADP-D-Ribose 2'-phosphate
  • ADPribose 2'-phosphate
26303-90-2
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with BST1: view

Transcripts for BST1 Gene

Unigene Clusters for BST1 Gene

Bone marrow stromal cell antigen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BST1 Gene

No ASD Table

Relevant External Links for BST1 Gene

GeneLoc Exon Structure for
BST1
ECgene alternative splicing isoforms for
BST1

Expression for BST1 Gene

mRNA expression in normal human tissues for BST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BST1 Gene

This gene is overexpressed in Whole Blood (x27.4).

Protein differential expression in normal tissues from HIPED for BST1 Gene

This gene is overexpressed in Serum (23.1), Monocytes (17.1), and Neutrophil (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BST1 Gene



SOURCE GeneReport for Unigene cluster for BST1 Gene Hs.720344

mRNA Expression by UniProt/SwissProt for BST1 Gene

Q10588-BST1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with BST1: view

Primer Products

No data available for Protein tissue co-expression partners for BST1 Gene

Orthologs for BST1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BST1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BST1 35
  • 82.53 (n)
  • 76.55 (a)
BST1 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BST1 35
  • 82.63 (n)
  • 78.32 (a)
BST1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bst1 35
  • 79.21 (n)
  • 74.91 (a)
Bst1 16
Bst1 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BST1 35
  • 98.32 (n)
  • 96.54 (a)
BST1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bst1 35
  • 78.55 (n)
  • 72.56 (a)
oppossum
(Monodelphis domestica)
Mammalia BST1 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BST1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves BST1 35
  • 64.61 (n)
  • 54.44 (a)
BST1 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bst1 35
  • 57.98 (n)
  • 50.58 (a)
zebrafish
(Danio rerio)
Actinopterygii CR318624.1 36
  • 34 (a)
OneToMany
Species with no ortholog for BST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BST1 Gene

ENSEMBL:
Gene Tree for BST1 (if available)
TreeFam:
Gene Tree for BST1 (if available)

Paralogs for BST1 Gene

Paralogs for BST1 Gene

(1) SIMAP similar genes for BST1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BST1: view

Variants for BST1 Gene

Sequence variations from dbSNP and Humsavar for BST1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2302465 - 15,707,569(-) TAAAA(C/T)GACGG reference, missense
rs2302464 - 15,707,629(-) TCTGT(C/T)GACAC reference, missense
rs2302466 - 15,705,556(-) CCAGC(A/G)CCACT reference, missense
rs6840615 - 15,705,627(+) ACTCT(A/G)TTCCC reference, missense
rs2103 -- 15,736,860(-) TATGA(C/T)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BST1 Gene

Variant ID Type Subtype PubMed ID
dgv1586e1 CNV Complex 17122850
dgv1587e1 CNV Complex 17122850
nsv428439 CNV Gain+Loss 18775914
dgv864n67 CNV Loss 20364138
esv27101 CNV Loss 19812545
nsv10459 CNV Loss 18304495
nsv822495 CNV Loss 20364138

Variation tolerance for BST1 Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.62; 82.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BST1 Gene

Human Gene Mutation Database (HGMD)
BST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BST1 Gene

Disorders for BST1 Gene

Relevant External Links for BST1

Genetic Association Database (GAD)
BST1
Human Genome Epidemiology (HuGE) Navigator
BST1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BST1

No disorders were found for BST1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BST1 Gene

Publications for BST1 Gene

  1. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. (PMID: 8202488) Kaisho T. … Hirano T. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 67
  2. CD38 and CD157 ectoenzymes mark cell subsets in the human corneal limbus. (PMID: 19052657) Horenstein A.L. … Malavasi F. (Mol. Med. 2009) 3 23
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. CD157 is an important mediator of neutrophil adhesion and migration. (PMID: 15328157) Funaro A. … Malavasi F. (Blood 2004) 3 23

Products for BST1 Gene

Sources for BST1 Gene

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