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Aliases for SUPT5H Gene

Aliases for SUPT5H Gene

  • Suppressor Of Ty 5 Homolog (S. Cerevisiae) 2 3
  • SPT5 3 4 6
  • DRB Sensitivity-Inducing Factor 160 KDa Subunit 3 4
  • DRB Sensitivity-Inducing Factor Large Subunit 3 4
  • Tat-Cotransactivator 1 Protein 3 4
  • DSIF Large Subunit 3 4
  • DSIF P160 3 4
  • SPT5H 3 4
  • HSPT5 3 4
  • Suppressor Of Ty (S.Cerevisiae) 5 Homolog 2
  • Transcription Elongation Factor SPT5 3
  • Tat-CT1 Protein 4
  • Tat-CT1 3

External Ids for SUPT5H Gene

Summaries for SUPT5H Gene

GeneCards Summary for SUPT5H Gene

SUPT5H (Suppressor Of Ty 5 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Disease and Gene Expression. GO annotations related to this gene include protein heterodimerization activity and enzyme binding.

UniProtKB/Swiss-Prot for SUPT5H Gene

  • Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3 terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

Gene Wiki entry for SUPT5H Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT5H Gene

Genomics for SUPT5H Gene

Genomic Location for SUPT5H Gene

Start:
39,436,156 bp from pter
End:
39,476,670 bp from pter
Size:
40,515 bases
Orientation:
Plus strand

Genomic View for SUPT5H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUPT5H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT5H Gene

Regulatory Elements for SUPT5H Gene

Proteins for SUPT5H Gene

  • Protein details for SUPT5H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00267-SPT5H_HUMAN
    Recommended name:
    Transcription elongation factor SPT5
    Protein Accession:
    O00267
    Secondary Accessions:
    • O43279
    • Q59G52
    • Q99639

    Protein attributes for SUPT5H Gene

    Size:
    1087 amino acids
    Molecular mass:
    121000 Da
    Quaternary structure:
    • Interacts with SUPT4H1 to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of WHSC2/NELFA, COBRA1/NELFB, TH1L/NELFD and RDBP/NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with PRMT1/HRMT1L2, HTATSF1/TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin.
    SequenceCaution:
    • Sequence=BAD92494.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUPT5H Gene

    Alternative splice isoforms for SUPT5H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUPT5H Gene

Proteomics data for SUPT5H Gene at MOPED

Post-translational modifications for SUPT5H Gene

  • Methylated by PRMT1/HRMT1L2 and PRMT5/SKB1. Methylation negatively regulates interaction with P-TEFb and RNA polymerase II.
  • Phosphorylated by CDK7 and CDK9. Phosphorylation by P-TEFb alleviates transcriptional pausing and can stimulate transcriptional elongation from the HIV-1 LTR. P-TEFb dependent phosphorylation is stimulated by the HIV-1 Tat protein. Phosphorylation may also stimulate interaction with PIN1. Bulk phosphorylation occurs predominantly in mitosis.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys147, Lys199, Lys213, Lys306, Lys323, Lys650, and Lys718

No data available for DME Specific Peptides for SUPT5H Gene

Domains for SUPT5H Gene

UniProtKB/Swiss-Prot:

SPT5H_HUMAN
Domain:
  • Contains 5 KOW domains.:
    • O00267
Family:
  • Belongs to the SPT5 family.:
    • O00267
genes like me logo Genes that share domains with SUPT5H: view

No data available for Gene Families for SUPT5H Gene

Function for SUPT5H Gene

Molecular function for SUPT5H Gene

GENATLAS Biochemistry: putative chromatin structure regulator yeast Spt5 homolog,(histones group)
UniProtKB/Swiss-Prot Function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3 terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

Gene Ontology (GO) - Molecular Function for SUPT5H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 10075709
GO:0019899 enzyme binding IPI 10075709
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046982 protein heterodimerization activity IPI 9450929
genes like me logo Genes that share ontologies with SUPT5H: view
genes like me logo Genes that share phenotypes with SUPT5H: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUPT5H Gene

Localization for SUPT5H Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPT5H Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUPT5H Gene COMPARTMENTS Subcellular localization image for SUPT5H gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SUPT5H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10075709
GO:0005654 nucleoplasm TAS --
GO:0032044 DSIF complex IDA 9450929
genes like me logo Genes that share ontologies with SUPT5H: view

Pathways for SUPT5H Gene

genes like me logo Genes that share pathways with SUPT5H: view

Pathways by source for SUPT5H Gene

1 Cell Signaling Technology pathway for SUPT5H Gene
1 BioSystems pathway for SUPT5H Gene

Gene Ontology (GO) - Biological Process for SUPT5H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 10075709
GO:0006338 chromatin remodeling NAS 10075709
GO:0006354 DNA-templated transcription, elongation IDA 10075709
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
genes like me logo Genes that share ontologies with SUPT5H: view

Compounds for SUPT5H Gene

(1) Novoseek inferred chemical compound relationships for SUPT5H Gene

Compound -log(P) Hits PubMed IDs
5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 87 3
genes like me logo Genes that share compounds with SUPT5H: view

Transcripts for SUPT5H Gene

Unigene Clusters for SUPT5H Gene

Suppressor of Ty 5 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT5H Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - -
SP2:
SP3: - - - - - - - - - -
SP4: - -
SP5:
SP6: - - - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b
SP1: - -
SP2:
SP3: - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SUPT5H Gene

GeneLoc Exon Structure for
SUPT5H
ECgene alternative splicing isoforms for
SUPT5H

Expression for SUPT5H Gene

mRNA expression in normal human tissues for SUPT5H Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUPT5H Gene

SOURCE GeneReport for Unigene cluster for SUPT5H Gene Hs.631604

mRNA Expression by UniProt/SwissProt for SUPT5H Gene

O00267-SPT5H_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with SUPT5H: view

Orthologs for SUPT5H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUPT5H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUPT5H 36
  • 99.51 (n)
  • 99.91 (a)
SUPT5H 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUPT5H 36
  • 93.2 (n)
  • 99.45 (a)
SUPT5H 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUPT5H 36
  • 92.76 (n)
  • 99.63 (a)
SUPT5H 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Supt5 36
  • 88.34 (n)
  • 96.85 (a)
Supt5 16
Supt5 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUPT5H 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUPT5H 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Supt5h 36
  • 88.76 (n)
  • 97.13 (a)
chicken
(Gallus gallus)
Aves SUPT5H 36
  • 84.12 (n)
  • 95.08 (a)
SUPT5H 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUPT5H 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5044 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2822 36
supt5h 36
  • 77.1 (n)
  • 90.77 (a)
zebrafish
(Danio rerio)
Actinopterygii supt5h 36
  • 76.79 (n)
  • 87.78 (a)
supt5h 37
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005021 36
  • 62.29 (n)
  • 60.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spt5 36
  • 60.38 (n)
  • 58.95 (a)
Spt5 37
  • 54 (a)
OneToOne
Spt5 38
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea spt-5 36
  • 49.29 (n)
  • 45.29 (a)
spt-5 37
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR187W 36
  • 45.32 (n)
  • 30.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT5 36
  • 42.36 (n)
  • 34.06 (a)
SPT5 37
  • 26 (a)
OneToOne
SPT5 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00891g 36
  • 43.27 (n)
  • 34.56 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GTA2 36
  • 46.46 (n)
  • 38.28 (a)
rice
(Oryza sativa)
Liliopsida Os02g0772000 36
  • 47.82 (n)
  • 38.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06929 36
  • 47.67 (n)
  • 36.3 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spt5 36
  • 47.05 (n)
  • 41.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 58 (a)
OneToOne
Species with no ortholog for SUPT5H:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUPT5H Gene

ENSEMBL:
Gene Tree for SUPT5H (if available)
TreeFam:
Gene Tree for SUPT5H (if available)

Paralogs for SUPT5H Gene

No data available for Paralogs for SUPT5H Gene

Variants for SUPT5H Gene

Sequence variations from dbSNP and Humsavar for SUPT5H Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1932 -- 39,445,862(-) AGCAG(C/T)CTTGG utr-variant-5-prime, intron-variant
rs878754 -- 39,460,535(-) GTCTC(A/G)AACTC intron-variant
rs1048912 -- 39,476,568(+) GGAAT(C/T)TGAGT utr-variant-3-prime
rs1048917 -- 39,476,579(+) AGAGT(C/T)TGGGG utr-variant-3-prime
rs1048918 -- 39,476,595(+) TCCCC(A/C)CCTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SUPT5H Gene

Variant ID Type Subtype PubMed ID
nsv911685 CNV Loss 21882294
dgv3863n71 CNV Loss 21882294
nsv523856 CNV Loss 19592680

Relevant External Links for SUPT5H Gene

HapMap Linkage Disequilibrium report
SUPT5H
Human Gene Mutation Database (HGMD)
SUPT5H

Disorders for SUPT5H Gene

(1) University of Copenhagen DISEASES for SUPT5H Gene

(2) Novoseek inferred disease relationships for SUPT5H Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 29.9 1
shock 0 2
genes like me logo Genes that share disorders with SUPT5H: view

No data available for UniProtKB/Swiss-Prot for SUPT5H Gene

Publications for SUPT5H Gene

  1. Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5. (PMID: 8975720) Chiang P.-W. … Kurnit D.M. (Genomics 1996) 2 3 4 23
  2. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. (PMID: 9450929) Wada T. … Handa H. (Genes Dev. 1998) 3 4 23
  3. Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. (PMID: 9857195) Wada T. … Handa H. (EMBO J. 1998) 3 4 23
  4. Structure and function of the human transcription elongation factor DSIF. (PMID: 10075709) Yamaguchi Y. … Handa H. (J. Biol. Chem. 1999) 3 4 23
  5. Tat-SF1 protein associates with RAP30 and human SPT5 proteins. (PMID: 10454543) Kim J.B. … Sharp P.A. (Mol. Cell. Biol. 1999) 3 4 23

Products for SUPT5H Gene

Sources for SUPT5H Gene

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