Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STXBP3 Gene

Aliases for STXBP3 Gene

  • Syntaxin Binding Protein 3 2 3 5
  • Protein Unc-18 Homolog 3 3 4
  • Protein Unc-18 Homolog C 3 4
  • Platelet Sec1 Protein 3 4
  • UNC-18C 3 4
  • Unc18-3 3 4
  • PSP 3 4
  • Syntaxin 4 Binding Protein 3
  • MUNC18-3 3
  • MUNC18C 3

External Ids for STXBP3 Gene

Previous GeneCards Identifiers for STXBP3 Gene

  • GC01M109954
  • GC01P108266
  • GC01P108387
  • GC01P108635
  • GC01P109001
  • GC01P109094
  • GC01P109289
  • GC01P107182

Summaries for STXBP3 Gene

GeneCards Summary for STXBP3 Gene

STXBP3 (Syntaxin Binding Protein 3) is a Protein Coding gene. Among its related pathways are Translocation of GLUT4 to the plasma membrane and Platelet activation, signaling and aggregation. GO annotations related to this gene include syntaxin binding and syntaxin-1 binding. An important paralog of this gene is STXBP1.

UniProtKB/Swiss-Prot for STXBP3 Gene

  • Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.

Gene Wiki entry for STXBP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STXBP3 Gene

Genomics for STXBP3 Gene

Regulatory Elements for STXBP3 Gene

Enhancers for STXBP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STXBP3 on UCSC Golden Path with GeneCards custom track

Promoters for STXBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STXBP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for STXBP3 Gene

108,746,663 bp from pter
108,809,526 bp from pter
62,864 bases
Plus strand

Genomic View for STXBP3 Gene

Genes around STXBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STXBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STXBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STXBP3 Gene

Proteins for STXBP3 Gene

  • Protein details for STXBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Syntaxin-binding protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K269
    • A8K5K7
    • Q53FW1
    • Q86YJ3
    • Q9UPD7

    Protein attributes for STXBP3 Gene

    592 amino acids
    Molecular mass:
    67764 Da
    Quaternary structure:
    • Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion (By similarity). Interacts with STX4.

neXtProt entry for STXBP3 Gene

Proteomics data for STXBP3 Gene at MOPED

Post-translational modifications for STXBP3 Gene

  • Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STXBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STXBP3 Gene

Domains & Families for STXBP3 Gene

Protein Domains for STXBP3 Gene


Suggested Antigen Peptide Sequences for STXBP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STXBP/unc-18/SEC1 family.
  • Belongs to the STXBP/unc-18/SEC1 family.
genes like me logo Genes that share domains with STXBP3: view

No data available for Gene Families for STXBP3 Gene

Function for STXBP3 Gene

Molecular function for STXBP3 Gene

UniProtKB/Swiss-Prot Function:
Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.
genes like me logo Genes that share phenotypes with STXBP3: view

Animal Models for STXBP3 Gene

MGI Knock Outs for STXBP3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STXBP3 Gene

Localization for STXBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STXBP3 Gene

Cytoplasm, cytosol. Cell membrane. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated.

Subcellular locations from

Jensen Localization Image for STXBP3 Gene COMPARTMENTS Subcellular localization image for STXBP3 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
nucleus 3
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for STXBP3 Gene

Pathways & Interactions for STXBP3 Gene

genes like me logo Genes that share pathways with STXBP3: view

Pathways by source for STXBP3 Gene

Gene Ontology (GO) - Biological Process for STXBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0006904 vesicle docking involved in exocytosis IEA --
GO:0007596 blood coagulation TAS --
GO:0015758 glucose transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with STXBP3: view

No data available for SIGNOR curated interactions for STXBP3 Gene

Drugs & Compounds for STXBP3 Gene

(1) Additional Compounds for STXBP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STXBP3: view

Transcripts for STXBP3 Gene

Unigene Clusters for STXBP3 Gene

Syntaxin binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STXBP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - -

Relevant External Links for STXBP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STXBP3 Gene

mRNA expression in normal human tissues for STXBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STXBP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STXBP3 Gene

SOURCE GeneReport for Unigene cluster for STXBP3 Gene Hs.530436

mRNA Expression by UniProt/SwissProt for STXBP3 Gene

Tissue specificity: Megakaryocytes and platelets.
genes like me logo Genes that share expression patterns with STXBP3: view

Protein tissue co-expression partners for STXBP3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for STXBP3 Gene

Orthologs for STXBP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STXBP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STXBP3 35
  • 93.02 (n)
  • 94.09 (a)
  • 94 (a)
(Canis familiaris)
Mammalia STXBP3 35
  • 93.75 (n)
  • 94.76 (a)
  • 95 (a)
(Mus musculus)
Mammalia Stxbp3a 35
  • 87.93 (n)
  • 92.05 (a)
Stxbp3 16
Stxbp3a 36
  • 91 (a)
Stxbp3b 36
  • 84 (a)
(Pan troglodytes)
Mammalia STXBP3 35
  • 99.66 (n)
  • 99.83 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Stxbp3 35
  • 87.39 (n)
  • 91.22 (a)
(Monodelphis domestica)
Mammalia STXBP3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia STXBP3 36
  • 87 (a)
(Gallus gallus)
Aves STXBP3 35
  • 77.05 (n)
  • 76.98 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia STXBP3 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stxbp3 35
  • 69.35 (n)
  • 69.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16785 35
(Danio rerio)
Actinopterygii stxbp3 35
  • 61.21 (n)
  • 60.63 (a)
wufb71h06 35
stxbp3 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rop 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea T07A9.10 37
  • 30 (a)
unc-18 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC1 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for STXBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STXBP3 Gene

Gene Tree for STXBP3 (if available)
Gene Tree for STXBP3 (if available)

Paralogs for STXBP3 Gene

Paralogs for STXBP3 Gene

(3) SIMAP similar genes for STXBP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STXBP3: view

Variants for STXBP3 Gene

Sequence variations from dbSNP and Humsavar for STXBP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1044136 - 108,796,668(+) GATAG(A/G)AAATG reference, missense
rs1044137 - 108,807,501(+) TGCGT(G/T)GTGCT reference, missense
rs2275344 - 108,782,496(+) ACATC(A/C/G)ACATA reference, missense
rs754756 -- 108,787,066(+) aaaat(G/T)tgatt intron-variant
rs994440 -- 108,791,983(+) attgc(C/T)gagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STXBP3 Gene

Variant ID Type Subtype PubMed ID
esv1070190 CNV Deletion 17803354
nsv823908 CNV Loss 20364138
nsv2287 CNV Loss 18451855
esv29430 CNV Loss 19812545

Variation tolerance for STXBP3 Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 49.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STXBP3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STXBP3 Gene

Disorders for STXBP3 Gene

Relevant External Links for STXBP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STXBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STXBP3 Gene

Publications for STXBP3 Gene

  1. Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. (PMID: 10194441) Reed G.L. … Fitzgerald M.L. (Blood 1999) 2 3 4 23 67
  2. Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. (PMID: 18588921) Brochetta C. … Blank U. (Biochim. Biophys. Acta 2008) 3 23
  3. Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. (PMID: 15576373) Fu J. … Malik A.B. (J. Biol. Chem. 2005) 3 23
  4. Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. (PMID: 15707389) Hodgkinson C.P. … Sale G.J. (Biochem. J. 2005) 3 23
  5. Munc18-syntaxin complexes and exocytosis in human platelets. (PMID: 12649283) Houng A. … Reed G.L. (J. Biol. Chem. 2003) 3 23

Products for STXBP3 Gene

Sources for STXBP3 Gene