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Aliases for STX5 Gene

Aliases for STX5 Gene

  • Syntaxin 5 2 3 5
  • Syntaxin 5A 2 3
  • STX5A 3 4
  • SED5 3

External Ids for STX5 Gene

Previous HGNC Symbols for STX5 Gene

  • STX5A

Previous GeneCards Identifiers for STX5 Gene

  • GC11M062331
  • GC11M062574
  • GC11M058904

Summaries for STX5 Gene

Entrez Gene Summary for STX5 Gene

  • This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for STX5 Gene

STX5 (Syntaxin 5) is a Protein Coding gene. Diseases associated with STX5 include endometriosis. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include protein N-terminus binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for STX5 Gene

  • Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.

Gene Wiki entry for STX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX5 Gene

Genomics for STX5 Gene

Regulatory Elements for STX5 Gene

Enhancers for STX5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STX5 on UCSC Golden Path with GeneCards custom track

Promoters for STX5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STX5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the STX5 gene promoter:

Genomic Location for STX5 Gene

Chromosome:
11
Start:
62,806,860 bp from pter
End:
62,832,091 bp from pter
Size:
25,232 bases
Orientation:
Minus strand

Genomic View for STX5 Gene

Genes around STX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX5 Gene

Proteins for STX5 Gene

  • Protein details for STX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13190-STX5_HUMAN
    Recommended name:
    Syntaxin-5
    Protein Accession:
    Q13190
    Secondary Accessions:
    • B2R8T2
    • F8W8Q9
    • Q5U0D4
    • Q7Z3T6
    • Q9BUG1

    Protein attributes for STX5 Gene

    Size:
    355 amino acids
    Molecular mass:
    39673 Da
    Quaternary structure:
    • Part of a ternary complex containing STX5A, NSFL1C and VCP (By similarity). Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2, YKT6 and VTI1A (By similarity). Interacts with COG4 (PubMed:19536132). Interacts with GM130/GOLGA2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for STX5 Gene

    Alternative splice isoforms for STX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX5 Gene

Proteomics data for STX5 Gene at MOPED

Post-translational modifications for STX5 Gene

  • Ubiquitination at Lys 82, Lys 148, and Lys 241
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STX5 (STX5)

No data available for DME Specific Peptides for STX5 Gene

Domains & Families for STX5 Gene

Gene Families for STX5 Gene

Protein Domains for STX5 Gene

Suggested Antigen Peptide Sequences for STX5 Gene

Graphical View of Domain Structure for InterPro Entry

Q13190

UniProtKB/Swiss-Prot:

STX5_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX5: view

Function for STX5 Gene

Molecular function for STX5 Gene

UniProtKB/Swiss-Prot Function:
Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.

Gene Ontology (GO) - Molecular Function for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IEA,IDA 15215310
genes like me logo Genes that share ontologies with STX5: view
genes like me logo Genes that share phenotypes with STX5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STX5

miRNA for STX5 Gene

miRTarBase miRNAs that target STX5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX5 Gene

Localization for STX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX5 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein. Golgi apparatus membrane. Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. {ECO:0000250 UniProtKB:Q08851}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX5 Gene COMPARTMENTS Subcellular localization image for STX5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5
cytosol 3
plasma membrane 3
endosome 2
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS --
genes like me logo Genes that share ontologies with STX5: view

Pathways & Interactions for STX5 Gene

genes like me logo Genes that share pathways with STX5: view

Gene Ontology (GO) - Biological Process for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0034498 early endosome to Golgi transport IMP 17389686
GO:0042147 retrograde transport, endosome to Golgi IDA 15215310
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with STX5: view

No data available for SIGNOR curated interactions for STX5 Gene

Drugs & Compounds for STX5 Gene

(1) Drugs for STX5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with STX5: view

Transcripts for STX5 Gene

Unigene Clusters for STX5 Gene

Syntaxin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5: -
SP6:

Relevant External Links for STX5 Gene

GeneLoc Exon Structure for
STX5
ECgene alternative splicing isoforms for
STX5

Expression for STX5 Gene

mRNA expression in normal human tissues for STX5 Gene

Protein differential expression in normal tissues from HIPED for STX5 Gene

This gene is overexpressed in Cervix (13.6) and Peripheral blood mononuclear cells (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX5 Gene



SOURCE GeneReport for Unigene cluster for STX5 Gene Hs.654602

genes like me logo Genes that share expression patterns with STX5: view

Protein tissue co-expression partners for STX5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STX5 Gene

Orthologs for STX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STX5 35
  • 94.08 (n)
  • 98.59 (a)
STX5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX5 35
  • 93.52 (n)
  • 98.03 (a)
STX5 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STX5 35
  • 99.22 (n)
  • 99.67 (a)
STX5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx5 35
  • 89.74 (n)
  • 94.67 (a)
mouse
(Mus musculus)
Mammalia Stx5a 16
Stx5a 36
  • 94 (a)
OneToOne
Stx5a 35
  • 89.45 (n)
  • 93.79 (a)
oppossum
(Monodelphis domestica)
Mammalia STX5 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX5 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX5 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1892 35
stx5 35
  • 72.72 (n)
  • 83.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14190 35
zebrafish
(Danio rerio)
Actinopterygii stx5a 35
  • 74.59 (n)
  • 80.5 (a)
wufb81g12 35
stx5a 36
  • 80 (a)
OneToMany
stx5al 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Syx5 35
  • 59.91 (n)
  • 58.36 (a)
Syx5 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea syx-5 35
  • 48.4 (n)
  • 43.42 (a)
syx-5 36
  • 33 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR210C 35
  • 47.77 (n)
  • 40.14 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17798g 35
  • 45.49 (n)
  • 35.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SED5 35
  • 43.72 (n)
  • 38.04 (a)
SED5 36
  • 30 (a)
OneToOne
SED5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP32 35
  • 48.53 (n)
  • 41.7 (a)
rice
(Oryza sativa)
Liliopsida Os01g0179200 35
  • 48.75 (n)
  • 43.42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01907 35
  • 51.03 (n)
  • 46.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sed5 35
  • 49.23 (n)
  • 41.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2930 36
  • 49 (a)
OneToOne
Species with no ortholog for STX5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX5 Gene

ENSEMBL:
Gene Tree for STX5 (if available)
TreeFam:
Gene Tree for STX5 (if available)

Paralogs for STX5 Gene

No data available for Paralogs for STX5 Gene

Variants for STX5 Gene

Sequence variations from dbSNP and Humsavar for STX5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_035642 A breast cancer sample
VAR_052248 -
VAR_052249 -
rs524034 -- 62,811,766(-) ctcat(C/G)cctgt intron-variant
rs631987 -- 62,811,755(+) gtgct(A/G)ggatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX5 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
esv991674 OTHER Inversion 20482838

Variation tolerance for STX5 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX5 Gene

HapMap Linkage Disequilibrium report
STX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX5 Gene

Disorders for STX5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STX5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
endometriosis
- elite association - COSMIC cancer census association via MalaCards
Search STX5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STX5

Genetic Association Database (GAD)
STX5
Human Genome Epidemiology (HuGE) Navigator
STX5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX5
genes like me logo Genes that share disorders with STX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STX5 Gene

Publications for STX5 Gene

  1. Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein. (PMID: 9188044) Ravichandran V. … Roche P.A. (J. Mol. Neurosci. 1997) 2 3 4 23 67
  2. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. (PMID: 19536132) Laufman O. … Lev S. (EMBO J. 2009) 3 23
  3. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PMID: 18167358) Diao A. … Lowe M. (J. Biol. Chem. 2008) 3 23
  4. Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. (PMID: 17389686) Amessou M. … Johannes L. (J. Cell. Sci. 2007) 3 23
  5. rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility. (PMID: 14565970) Williams A.L. … Hay J.C. (Mol. Biol. Cell 2004) 3 23

Products for STX5 Gene

Sources for STX5 Gene

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