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Aliases for STX4 Gene

Aliases for STX4 Gene

  • Syntaxin 4 2 3 5
  • Renal Carcinoma Antigen NY-REN-31 3 4
  • Syntaxin 4A (Placental) 2 3
  • STX4A 3 4
  • P35-2 3

External Ids for STX4 Gene

Previous HGNC Symbols for STX4 Gene

  • STX4A

Previous GeneCards Identifiers for STX4 Gene

  • GC16P030953
  • GC16P031044
  • GC16P028606

Summaries for STX4 Gene

GeneCards Summary for STX4 Gene

STX4 (Syntaxin 4) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include SNARE binding and sphingomyelin phosphodiesterase activator activity. An important paralog of this gene is STX1B.

UniProtKB/Swiss-Prot for STX4 Gene

  • Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

Gene Wiki entry for STX4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX4 Gene

Genomics for STX4 Gene

Regulatory Elements for STX4 Gene

Promoters for STX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STX4 on UCSC Golden Path with GeneCards custom track

Genomic Location for STX4 Gene

Chromosome:
16
Start:
31,032,889 bp from pter
End:
31,042,975 bp from pter
Size:
10,087 bases
Orientation:
Plus strand

Genomic View for STX4 Gene

Genes around STX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX4 Gene

Proteins for STX4 Gene

  • Protein details for STX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12846-STX4_HUMAN
    Recommended name:
    Syntaxin-4
    Protein Accession:
    Q12846
    Secondary Accessions:
    • A8MXY0
    • Q15525
    • Q6FHE8

    Protein attributes for STX4 Gene

    Size:
    297 amino acids
    Molecular mass:
    34180 Da
    Quaternary structure:
    • Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity).

    Alternative splice isoforms for STX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX4 Gene

Proteomics data for STX4 Gene at MOPED

Post-translational modifications for STX4 Gene

  • Ubiquitination at Lys 44, Lys 91, and Lys 243
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for STX4 Gene

Domains & Families for STX4 Gene

Gene Families for STX4 Gene

Protein Domains for STX4 Gene

Graphical View of Domain Structure for InterPro Entry

Q12846

UniProtKB/Swiss-Prot:

STX4_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX4: view

Function for STX4 Gene

Molecular function for STX4 Gene

UniProtKB/Swiss-Prot Function:
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.
genes like me logo Genes that share phenotypes with STX4: view

Animal Models for STX4 Gene

MGI Knock Outs for STX4:

Animal Model Products

  • Taconic Biosciences Mouse Models for STX4

miRNA for STX4 Gene

miRTarBase miRNAs that target STX4

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STX4 Gene

Localization for STX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX4 Gene

Cell membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX4 Gene COMPARTMENTS Subcellular localization image for STX4 gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
plasma membrane 5
vacuole 5
golgi apparatus 3
lysosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000322 storage vacuole IEA --
GO:0005622 intracellular IDA 24055037
GO:0005737 cytoplasm IEA --
GO:0008021 synaptic vesicle IBA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with STX4: view

Pathways & Interactions for STX4 Gene

genes like me logo Genes that share pathways with STX4: view

Gene Ontology (GO) - Biological Process for STX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA,IBA --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0016192 vesicle-mediated transport IEA --
GO:0017157 regulation of exocytosis IMP 20434989
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with STX4: view

No data available for SIGNOR curated interactions for STX4 Gene

Drugs & Compounds for STX4 Gene

(7) Drugs for STX4 Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenprocoumon Approved Pharma 27
Warfarin Approved Pharma 422

(3) Additional Compounds for STX4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STX4: view

Transcripts for STX4 Gene

Unigene Clusters for STX4 Gene

Syntaxin 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - -
SP8: -
SP9:
SP10: -
SP11: -
SP12:
SP13: -

ExUns: 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for STX4 Gene

GeneLoc Exon Structure for
STX4
ECgene alternative splicing isoforms for
STX4

Expression for STX4 Gene

mRNA expression in normal human tissues for STX4 Gene

Protein differential expression in normal tissues from HIPED for STX4 Gene

This gene is overexpressed in Nasal epithelium (19.8) and Lavage (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX4 Gene



SOURCE GeneReport for Unigene cluster for STX4 Gene Hs.83734

mRNA Expression by UniProt/SwissProt for STX4 Gene

Q12846-STX4_HUMAN
Tissue specificity: Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation.
genes like me logo Genes that share expression patterns with STX4: view

Protein tissue co-expression partners for STX4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STX4 Gene

Orthologs for STX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STX4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STX4 35
  • 92.23 (n)
  • 95.05 (a)
STX4 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX4 35
  • 91.67 (n)
  • 94.26 (a)
STX4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stx4a 35
  • 87.91 (n)
  • 90.51 (a)
Stx4a 16
Stx4a 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STX4 35
  • 92.3 (n)
  • 91.7 (a)
rat
(Rattus norvegicus)
Mammalia Stx4 35
  • 86.21 (n)
  • 89.83 (a)
oppossum
(Monodelphis domestica)
Mammalia STX4 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX4 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX4 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4372 35
zebrafish
(Danio rerio)
Actinopterygii stx4 35
  • 58.56 (n)
  • 53.42 (a)
zgc56272 35
stx4 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Syx4 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-2 36
  • 24 (a)
ManyToMany
syx-3 36
  • 21 (a)
ManyToMany
syx-4 36
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSO1 36
  • 22 (a)
ManyToMany
SSO2 36
  • 23 (a)
ManyToMany
Species with no ortholog for STX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX4 Gene

ENSEMBL:
Gene Tree for STX4 (if available)
TreeFam:
Gene Tree for STX4 (if available)

Paralogs for STX4 Gene

Paralogs for STX4 Gene

(10) SIMAP similar genes for STX4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STX4: view

Variants for STX4 Gene

Sequence variations from dbSNP and Humsavar for STX4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs732172 -- 31,038,712(-) TAAGG(A/G)TGGCG intron-variant
rs732173 -- 31,038,702(-) GGGAG(G/T)CTGGC intron-variant
rs1131554 -- 31,034,240(+) ATTCG(G/T)CAGAC upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs1051195 -- 31,038,148(+) TTGGA(G/T)CAGAT reference, missense
rs6565212 -- 31,031,104(+) GAGGG(C/T)ACCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for STX4 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv35n68 CNV Loss 17160897
dgv2670n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv833193 CNV Gain+Loss 17160897

Variation tolerance for STX4 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX4 Gene

HapMap Linkage Disequilibrium report
STX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX4 Gene

Disorders for STX4 Gene

Relevant External Links for STX4

Genetic Association Database (GAD)
STX4
Human Genome Epidemiology (HuGE) Navigator
STX4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX4

No disorders were found for STX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX4 Gene

Publications for STX4 Gene

  1. Isolation and sequence analysis of the human syntaxin-encoding gene. (PMID: 8206394) Li H. … Seth A. (Gene 1994) 2 3 4 67
  2. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. (PMID: 16339081) Low S.H. … Weimbs T. (Mol. Biol. Cell 2006) 2 3 23
  3. Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines. (PMID: 20434989) Kennedy M.J. … Ehlers M.D. (Cell 2010) 3 23
  4. Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. (PMID: 18588921) Brochetta C. … Blank U. (Biochim. Biophys. Acta 2008) 3 23
  5. A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. (PMID: 16677249) Logan M.R. … Moqbel R. (Allergy 2006) 3 23

Products for STX4 Gene

Sources for STX4 Gene

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