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Aliases for STX3 Gene

Aliases for STX3 Gene

  • Syntaxin 3 2 3
  • STX3A 3 4 6
  • Syntaxin 3A 2 3
  • Syntaxin-3 3

External Ids for STX3 Gene

Previous HGNC Symbols for STX3 Gene

  • STX3A

Previous GeneCards Identifiers for STX3 Gene

  • GC11P059280
  • GC11P059522
  • GC11P055873
  • GC11P059480

Summaries for STX3 Gene

Entrez Gene Summary for STX3 Gene

  • The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for STX3 Gene

STX3 (Syntaxin 3) is a Protein Coding gene. Diseases associated with STX3 include microvillus inclusion disease. Among its related pathways are Disease and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include SNAP receptor activity and arachidonic acid binding. An important paralog of this gene is STX4.

UniProtKB/Swiss-Prot for STX3 Gene

  • Potentially involved in docking of synaptic vesicles at presynaptic active zones

Gene Wiki entry for STX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX3 Gene

Genomics for STX3 Gene

Regulatory Elements for STX3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STX3 Gene

Start:
59,713,456 bp from pter
End:
59,805,882 bp from pter
Size:
92,427 bases
Orientation:
Plus strand

Genomic View for STX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX3 Gene

Proteins for STX3 Gene

  • Protein details for STX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13277-STX3_HUMAN
    Recommended name:
    Syntaxin-3
    Protein Accession:
    Q13277
    Secondary Accessions:
    • B4DME0
    • O43750
    • O43751
    • Q15360

    Protein attributes for STX3 Gene

    Size:
    289 amino acids
    Molecular mass:
    33155 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX3 Gene

Proteomics data for STX3 Gene at MOPED

Post-translational modifications for STX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STX3 Gene

Antibody Products

No data available for DME Specific Peptides for STX3 Gene

Domains for STX3 Gene

Protein Domains for STX3 Gene

Suggested Antigen Peptide Sequences for STX3 Gene

Graphical View of Domain Structure for InterPro Entry

Q13277

UniProtKB/Swiss-Prot:

STX3_HUMAN :
  • Q13277
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX3: view

No data available for Gene Families for STX3 Gene

Function for STX3 Gene

Molecular function for STX3 Gene

UniProtKB/Swiss-Prot Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones

Gene Ontology (GO) - Molecular Function for STX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 17693260
GO:0050544 arachidonic acid binding ISS --
genes like me logo Genes that share ontologies with STX3: view

Phenotypes for STX3 Gene

GenomeRNAi human phenotypes for STX3:
genes like me logo Genes that share phenotypes with STX3: view

Animal Model Products

miRNA for STX3 Gene

miRTarBase miRNAs that target STX3

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STX3 Gene

Localization for STX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX3 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX3 Gene COMPARTMENTS Subcellular localization image for STX3 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 4
cytosol 3
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for STX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005773 vacuole TAS 16339081
GO:0005886 plasma membrane IDA 21720706
GO:0005911 cell-cell junction IDA 15576373
GO:0008021 synaptic vesicle IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with STX3: view

Pathways for STX3 Gene

genes like me logo Genes that share pathways with STX3: view

Pathways by source for STX3 Gene

1 Qiagen pathway for STX3 Gene
1 BioSystems pathway for STX3 Gene
2 Reactome pathways for STX3 Gene

Gene Ontology (GO) - Biological Process for STX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006836 neurotransmitter transport --
GO:0006886 intracellular protein transport IBA --
GO:0006887 exocytosis --
GO:0008284 positive regulation of cell proliferation IMP 21720706
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with STX3: view

Compounds for STX3 Gene

(5) Novoseek inferred chemical compound relationships for STX3 Gene

Compound -log(P) Hits PubMed IDs
neurotoxin c 88.1 1
n-ethylmaleimide 52 4
cholesterol 0 2
sodium 0 1
calcium 0 2
genes like me logo Genes that share compounds with STX3: view

Transcripts for STX3 Gene

Unigene Clusters for STX3 Gene

Syntaxin 3:
Representative Sequences:

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2: - - -
SP3:
SP4:
SP5: - -

Relevant External Links for STX3 Gene

GeneLoc Exon Structure for
STX3
ECgene alternative splicing isoforms for
STX3

Expression for STX3 Gene

mRNA expression in normal human tissues for STX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STX3 Gene

This gene is overexpressed in Whole Blood (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX3 Gene

SOURCE GeneReport for Unigene cluster for STX3 Gene Hs.180711

genes like me logo Genes that share expressions with STX3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STX3 Gene

Orthologs for STX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for STX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX3 35
  • 99.42 (n)
  • 99.65 (a)
STX3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STX3 35
  • 88.43 (n)
  • 95.83 (a)
STX3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX3 35
  • 81.16 (n)
  • 91.7 (a)
STX3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stx3 35
  • 91.78 (n)
  • 98.26 (a)
Stx3 16
Stx3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STX3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx3 35
  • 91.44 (n)
  • 98.26 (a)
chicken
(Gallus gallus)
Aves STX3 35
  • 76.59 (n)
  • 83.97 (a)
STX3 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX3 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14996 35
stx3 35
  • 72.61 (n)
  • 79.72 (a)
zebrafish
(Danio rerio)
Actinopterygii STX3 (2 of 2) 36
  • 56 (a)
OneToMany
stx3a 35
  • 72.63 (n)
  • 76.49 (a)
stx3a 36
  • 75 (a)
OneToMany
zgc65954 35
fruit fly
(Drosophila melanogaster)
Insecta Syx1A 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-64 36
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for STX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX3 Gene

ENSEMBL:
Gene Tree for STX3 (if available)
TreeFam:
Gene Tree for STX3 (if available)

Paralogs for STX3 Gene

Paralogs for STX3 Gene

Selected SIMAP similar genes for STX3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STX3: view

Variants for STX3 Gene

Sequence variations from dbSNP and Humsavar for STX3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs15535 -- 59,801,746(+) CTAAT(C/T)GTGTA utr-variant-3-prime, intron-variant
rs471502 -- 59,769,845(-) cacac(A/T)cacac intron-variant
rs472198 -- 59,794,127(-) TTAGC(A/C)AAAGG intron-variant
rs477945 -- 59,795,309(-) TGCGG(A/G)GAAGG intron-variant
rs478167 -- 59,774,628(-) gtctc(A/G)aactc intron-variant

Relevant External Links for STX3 Gene

HapMap Linkage Disequilibrium report
STX3
Human Gene Mutation Database (HGMD)
STX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STX3 Gene

Disorders for STX3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for STX3 Gene including...

Search for STX3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for STX3 Gene

(2) Novoseek inferred disease relationships for STX3 Gene

Disease -log(P) Hits PubMed IDs
tetanus 20 1
cystic fibrosis 4.59 1

Relevant External Links for STX3

Genetic Association Database (GAD)
STX3
Human Genome Epidemiology (HuGE) Navigator
STX3
genes like me logo Genes that share disorders with STX3: view

No data available for UniProtKB/Swiss-Prot for STX3 Gene

Publications for STX3 Gene

  1. Human syntaxin 3 is localized apically in human intestinal cells. (PMID: 9378770) Delgrossi M.H. … le Bivic A. (J. Cell Sci. 1997) 3 4 23
  2. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PMID: 10080545) Martin-Martin B. … Mollinedo F. (J. Leukoc. Biol. 1999) 3 4 23
  3. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. (PMID: 16339081) Low S.H. … Weimbs T. (Mol. Biol. Cell 2006) 2 3 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. (PMID: 9614185) Galli T. … Louvard D. (Mol. Biol. Cell 1998) 3 23

Products for STX3 Gene

  • Addgene plasmids for STX3

Sources for STX3 Gene

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