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Aliases for STK10 Gene

Aliases for STK10 Gene

  • Serine/Threonine Kinase 10 2 3
  • Lymphocyte-Oriented Kinase 2 3 4
  • LOK 3 4 6
  • EC 2.7.11.1 4 63
  • Serine/Threonine-Protein Kinase 10 3
  • EC 2.7.11 63
  • PRO2729 3

External Ids for STK10 Gene

Previous GeneCards Identifiers for STK10 Gene

  • GC05M171705
  • GC05M172172
  • GC05M171405
  • GC05M171451
  • GC05M171403
  • GC05M166567

Summaries for STK10 Gene

Entrez Gene Summary for STK10 Gene

  • This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK10 Gene

STK10 (Serine/Threonine Kinase 10) is a Protein Coding gene. Diseases associated with STK10 include cholecystolithiasis and testicular germ cell tumor. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein homodimerization activity and protein serine/threonine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for STK10 Gene

  • Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.

Gene Wiki entry for STK10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK10 Gene

Genomics for STK10 Gene

Regulatory Elements for STK10 Gene

Genomic Location for STK10 Gene

Start:
172,042,070 bp from pter
End:
172,188,386 bp from pter
Size:
146,317 bases
Orientation:
Minus strand

Genomic View for STK10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK10 Gene

Proteins for STK10 Gene

  • Protein details for STK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94804-STK10_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 10
    Protein Accession:
    O94804
    Secondary Accessions:
    • A6ND35
    • B2R8F5
    • B3KMY1
    • Q6NSK0
    • Q9UIW4

    Protein attributes for STK10 Gene

    Size:
    968 amino acids
    Molecular mass:
    112135 Da
    Quaternary structure:
    • Homodimer; homodimerization is required for activation segment autophosphorylation.
    Miscellaneous:
    • Inhibition by erlotinib, an orally administered EGFR tyrosine kinase inhibitor used for treatment, enhances STK10-dependent lymphocytic responses, possibly leading to the aggravation of skin inflammation observed upon treatment by erlotinib.
    SequenceCaution:
    • Sequence=BAG51143.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STK10 Gene

neXtProt entry for STK10 Gene

Proteomics data for STK10 Gene at MOPED

Post-translational modifications for STK10 Gene

  • Autophosphorylates following homodimerization, leading to activation of the protein
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for STK10 Gene

Gene Families for STK10 Gene

Suggested Antigen Peptide Sequences for STK10 Gene

Graphical View of Domain Structure for InterPro Entry

O94804

UniProtKB/Swiss-Prot:

STK10_HUMAN :
  • O94804
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK10: view

Function for STK10 Gene

Molecular function for STK10 Gene

GENATLAS Biochemistry: serine/threonine kinase 10
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by the pyrrole-indolinone inhibitor SU11274 (K00593): intercalates between the ATP-binding Lys-65 and alpha-C glutamate (Glu-81), resulting in a partial disordering of the lysine side chain. Also specifically inhibited by erlotinib. Slightly inhibited by gefitinib.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.

Enzyme Numbers (IUBMB) for STK10 Gene

Gene Ontology (GO) - Molecular Function for STK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 18239682
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12639966
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STK10: view
genes like me logo Genes that share phenotypes with STK10: view

Animal Models for STK10 Gene

MGI Knock Outs for STK10:

miRNA for STK10 Gene

miRTarBase miRNAs that target STK10

No data available for Transcription Factor Targeting and HOMER Transcription for STK10 Gene

Localization for STK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK10 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK10 Gene COMPARTMENTS Subcellular localization image for STK10 gene
Compartment Confidence
plasma membrane 5
cytosol 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for STK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IDA 19255442
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with STK10: view

Pathways for STK10 Gene

SuperPathways for STK10 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK10: view

Pathways by source for STK10 Gene

1 Qiagen pathway for STK10 Gene

Interacting Proteins for STK10 Gene

Gene Ontology (GO) - Biological Process for STK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 9278426
GO:0007049 cell cycle IEA --
GO:0023014 signal transduction by protein phosphorylation TAS 12639966
GO:0035556 intracellular signal transduction IBA --
GO:0046777 protein autophosphorylation IDA 12639966
genes like me logo Genes that share ontologies with STK10: view

Compounds for STK10 Gene

(2) HMDB Compounds for STK10 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(3) Novoseek inferred chemical compound relationships for STK10 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 37.2 4
threonine 23.5 2
serine 8.26 2
genes like me logo Genes that share compounds with STK10: view

Transcripts for STK10 Gene

Unigene Clusters for STK10 Gene

Serine/threonine kinase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - - - - - -
SP2:
SP3: - -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -

ExUns: 17b · 17c · 17d ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:

Relevant External Links for STK10 Gene

GeneLoc Exon Structure for
STK10
ECgene alternative splicing isoforms for
STK10

Expression for STK10 Gene

mRNA expression in normal human tissues for STK10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK10 Gene

This gene is overexpressed in Whole Blood (15.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK10 Gene

SOURCE GeneReport for Unigene cluster for STK10 Gene Hs.744005

mRNA Expression by UniProt/SwissProt for STK10 Gene

O94804-STK10_HUMAN
Tissue specificity: Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.
genes like me logo Genes that share expressions with STK10: view

Orthologs for STK10 Gene

This gene was present in the common ancestor of animals.

Orthologs for STK10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK10 35
  • 99.36 (n)
  • 99.28 (a)
STK10 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK10 35
  • 89.44 (n)
  • 90.37 (a)
STK10 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK10 35
  • 89.45 (n)
  • 91.62 (a)
STK10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk10 35
  • 86.09 (n)
  • 88.72 (a)
Stk10 16
Stk10 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK10 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK10 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk10 35
  • 84.02 (n)
  • 85.82 (a)
chicken
(Gallus gallus)
Aves STK10 35
  • 73.83 (n)
  • 73.91 (a)
STK10 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK10 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia stk10-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia stk10 35
  • 67.91 (n)
  • 69 (a)
Str.20235 35
zebrafish
(Danio rerio)
Actinopterygii stk10 35
  • 66.7 (n)
  • 64.08 (a)
stk10 36
  • 56 (a)
OneToOne
zgc63495 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010551 35
  • 35.22 (n)
  • 17.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta slik 35
  • 58.25 (n)
  • 49.93 (a)
slik 36
  • 23 (a)
OneToMany
CG4527 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea gck-4 35
  • 49.29 (n)
  • 39.86 (a)
gck-4 36
  • 27 (a)
OneToMany
C04A11.3 37
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8272 36
  • 34 (a)
OneToMany
Species with no ortholog for STK10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK10 Gene

ENSEMBL:
Gene Tree for STK10 (if available)
TreeFam:
Gene Tree for STK10 (if available)

Paralogs for STK10 Gene

Paralogs for STK10 Gene

Selected SIMAP similar genes for STK10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STK10: view

Variants for STK10 Gene

Sequence variations from dbSNP and Humsavar for STK10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs11720 -- 172,043,795(+) TTTTC(C/T)TCCTG utr-variant-3-prime
rs13713 -- 172,044,475(-) CATCC(A/G)GGCTG utr-variant-3-prime
rs15963 -- 172,044,041(+) TGCTT(C/T)TCCAT utr-variant-3-prime
rs730537 -- 172,180,972(-) TTCTA(C/T)ATGTA intron-variant
rs753809 -- 172,142,872(-) GTGAC(C/G)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK10 Gene

Variant ID Type Subtype PubMed ID
nsv462523 CNV Loss 19166990
esv2677017 CNV Deletion 23128226
esv2141451 CNV Deletion 18987734
esv2731089 CNV Deletion 23290073
esv2674681 CNV Deletion 23128226
nsv10770 CNV Loss 18304495
dgv1872e1 CNV Complex 17122850
nsv10771 CNV Loss 18304495
esv2673910 CNV Deletion 23128226

Relevant External Links for STK10 Gene

HapMap Linkage Disequilibrium report
STK10
Human Gene Mutation Database (HGMD)
STK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK10 Gene

Disorders for STK10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for STK10 Gene including...

Search for STK10 Gene in MalaCards »

UniProtKB/Swiss-Prot

STK10_HUMAN
  • Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. {ECO:0000269 PubMed:16175573}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for STK10 Gene

Relevant External Links for STK10

Genetic Association Database (GAD)
STK10
Human Genome Epidemiology (HuGE) Navigator
STK10
genes like me logo Genes that share disorders with STK10: view

Publications for STK10 Gene

  1. Molecular cloning of the human gene STK10 encoding lymphocyte- oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. (PMID: 10199912) Kuramochi S. … Karasuyama H. (Immunogenetics 1999) 2 3 4 23
  2. Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells. (PMID: 11903060) Tao L. … August A. (Biochem. J. 2002) 3 4 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. (PMID: 12639966) Walter S.A. … Hill R.J. (J. Biol. Chem. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for STK10 Gene

Sources for STK10 Gene

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