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Aliases for AURKA Gene

Aliases for AURKA Gene

  • Aurora Kinase A 2 3
  • STK15 3 4 6
  • STK6 3 4 6
  • ARK1 3 4 6
  • BTAK 3 4 6
  • AIK 3 4 6
  • Serine/Threonine-Protein Kinase Aurora-A 3 4
  • Serine/Threonine-Protein Kinase 15 3 4
  • Serine/Threonine-Protein Kinase 6 3 4
  • Breast Tumor-Amplified Kinase 3 4
  • Aurora/IPL1-Related Kinase 1 3 4
  • Serine/Threonine Kinase 6 2 3
  • Aurora-Related Kinase 1 3 4
  • Aurora-A Kinase 2 3
  • Aurora 2 3 4
  • AURORA2 3 6
  • ARK-1 3 4
  • HARK1 3 4
  • AURA 3 4
  • Protein Phosphatase 1, Regulatory Subunit 47 3
  • Serine/Threonine Protein Kinase 15 3
  • Breast-Tumor-Amplified Kinase 3
  • Serine/Threonine Kinase 15 2
  • Aurora/IPL1-Like Kinase 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 47 2
  • IPL1-Related Kinase 3
  • EC 2.7.11.1 4
  • PPP1R47 3
  • AIRK1 4
  • STK7 3
  • AYK1 4
  • IAK1 4

External Ids for AURKA Gene

Previous Symbols for AURKA Gene

  • STK15
  • STK6

Summaries for AURKA Gene

Entrez Gene Summary for AURKA Gene

  • The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AURKA Gene

AURKA (Aurora Kinase A) is a Protein Coding gene. Diseases associated with AURKA include atypical teratoid rhabdoid tumor and laryngeal carcinoma. Among its related pathways are ERK Signaling and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is AURKC.

UniProtKB/Swiss-Prot for AURKA Gene

  • Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

Tocris Summary for AURKA Gene

  • Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each isoform, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis. Aurora A is involved in regulating many of the early mitotic events, including entry into mitosis. Aurora A levels rise during the G2 phase and peak early in mitosis. One target of aurora A is cdc25b, a direct regulator of the cyclin B1-Cdk1 complex, which provides the basis for the role this enzyme plays in regulating entry into mitosis. Aurora A regulates centrosome maturation by moderating the recruitment of proteins, such as TPX-2, Ajuba, Bora and Lats, which are themselves essential for accumulating microtubule spindle components, such as gamma-tubulin. Aurora A is also associated with separation of centrosomes, through phosphorylation of the kinesin motor protein, Eg5. In addition, this enzyme regulates the microtubule network that forms mitotic spindles, through regulation of the EXTAH multiprotein complex. Since their discovery in the 1990s, Aurora kinases have been strongly linked to the progression of human cancers. Aurora A maps to human chromosome 20q13 and Aurora B to human chromosome 17q13.1, which are loci altered frequently in human cancers. Overexpression of Aurora A and B is seen in many cancers, but these enzymes are not oncoproteins, as concomitant oncogenic mutations are required to promote tumor progression. Aurora kinase inhibitors are an intense area of research for the development of anticancer therapies.

Gene Wiki entry for AURKA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKA Gene

Genomics for AURKA Gene

Genomic Location for AURKA Gene

Start:
56,369,389 bp from pter
End:
56,392,454 bp from pter
Size:
23,066 bases
Orientation:
Minus strand

Genomic View for AURKA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AURKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKA Gene

Regulatory Elements for AURKA Gene

Proteins for AURKA Gene

  • Protein details for AURKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14965-AURKA_HUMAN
    Recommended name:
    Aurora kinase A
    Protein Accession:
    O14965
    Secondary Accessions:
    • E1P5F9
    • O60445
    • O75873
    • Q9BQD6
    • Q9UPG5

    Protein attributes for AURKA Gene

    Size:
    403 amino acids
    Molecular mass:
    45809 Da
    Quaternary structure:
    • Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2, BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1. Interacts with PIFO. Interacts with GADD45A, competing with its oligomerization. Interacts (via C-terminus) with AUNIP (via C-terminus). Identified in a complex with AUNIP and NIN. Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation. Interacts with SIRT2.
    Miscellaneous:
    • Centrosome amplification can occur when the cycles are uncoupled, and this amplification is associated with cancer and with an increase in the levels of chromosomal instability
    SequenceCaution:
    • Sequence=BAA23592.1; Type=Frameshift; Positions=105, 125, 129, 235, 241; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AURKA Gene

neXtProt entry for AURKA Gene

Proteomics data for AURKA Gene at MOPED

Post-translational modifications for AURKA Gene

  • Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis. Phosphorylation at Ser-342 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis.
  • Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys143

No data available for DME Specific Peptides for AURKA Gene

Domains for AURKA Gene

Gene Families for AURKA Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
IUPHAR :

Suggested Antigen Peptide Sequences for AURKA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14965

UniProtKB/Swiss-Prot:

AURKA_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • O14965
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.:
    • O14965
genes like me logo Genes that share domains with AURKA: view

Function for AURKA Gene

Molecular function for AURKA Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Activation of CDK1, appears to be an upstream event of AURKA activation. Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators. Inactivated by the G2 checkpoint. Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1). MLN8054 is also a potent and selective inhibitor. Activated during the early phase of cilia disassembly in the presence of PIFO.
UniProtKB/Swiss-Prot Function: Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
UniProtKB/Swiss-Prot Induction: Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.

Enzyme Numbers (IUBMB) for AURKA Gene

Gene Ontology (GO) - Molecular Function for AURKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 14580337
GO:0004674 protein serine/threonine kinase activity EXP --
GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 19774610
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12244051
genes like me logo Genes that share ontologies with AURKA: view
genes like me logo Genes that share phenotypes with AURKA: view

Animal Models for AURKA Gene

MGI Knock Outs for AURKA:

miRNA for AURKA Gene

No data available for Transcription Factor Targeting and HOMER Transcription for AURKA Gene

Localization for AURKA Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKA Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase. Colocalized with SIRT2 at centrosome. Moves to the midbody during both telophase and cytokinesis. Associates with both the pericentriolar material (PCM) and centrioles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AURKA Gene COMPARTMENTS Subcellular localization image for AURKA gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for AURKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000780 condensed nuclear chromosome, centromeric region IBA --
GO:0005634 nucleus IDA 20531406
GO:0005813 centrosome TAS 19774610
GO:0005815 microtubule organizing center --
GO:0005819 spindle TAS 19774610
genes like me logo Genes that share ontologies with AURKA: view

Pathways for AURKA Gene

genes like me logo Genes that share pathways with AURKA: view

Gene Ontology (GO) - Biological Process for AURKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000212 meiotic spindle organization --
GO:0000226 microtubule cytoskeleton organization --
GO:0000278 mitotic cell cycle TAS --
GO:0006468 protein phosphorylation IDA 21600873
genes like me logo Genes that share ontologies with AURKA: view

Compounds for AURKA Gene

(28) ApexBio Compounds for AURKA Gene

Compound Action Cas Number
AMG-900 potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C [945595-80-2]
Anacardic acid selectively activate Aurora kinase A-mediated phosphorylation of histone H3 [16611-84-0]
AT9283 novel inhibitor of aurora kinase [896466-04-9]
Aurora A Inhibitor I novel, potent, and selective inhibitor of Aurora A [1158838-45-9]
AZD1152 selective Aurora B kinase inhibitor [722543-31-9]
Barasertib (AZD1152-HQPA) potent aurora kinase inhibitor [722544-51-6]
CCT129202 ATP-competitively inhibits Aurora A, Aurora B and Aurora C [942947-93-5]
CCT137690 highly selective inhibitor of Aurora A, Aurora B and Aurora C. [1095382-05-0]
CYC116 potent inhibitor of Aurora A/B. [693228-63-6]
Danusertib (PHA-739358) Pan-aurora kinase inhibitor [827318-97-8]
ENMD-2076 selective activity against Aurora A and VEGFR(Flt3). [934353-76-1]
GSK1070916 reversible and ATP-competitive inhibitor of Aurora B/C. [942918-07-2]
Hesperadin Hesperadin potently inhibits Aurora B with IC50 of 250 nM. [422513-13-1]
JNJ-7706621 dual inhibitor of cyclin-dependent kinases (CDK) and Aurora kinases [443797-96-4]
MK-5108 (VX-689) novel, potent and selective inhibitor of Aurora A kinase. [1010085-13-8]
MK-8745 potent and selective Aurora A inhibitor. [885325-71-3]
MLN8054 potent of Aurora A kinase inhibitor [869363-13-3]
MLN8237 (Alisertib) potent small-molecule inhibitor of Aurora A kinase [1028486-01-2]
PF-03814735 novel, potent and reversible inhibitor of Aurora A/B. [942487-16-3]
PHA-680632 novel and potent inhibitor of Aurora kinases. [398493-79-3]
Reversine inhibition of Aurora A and B. [656820-32-5]
SCH-1473759 novel sub-nanomolar Aurora A/B inhibitor [1094069-99-4]
SNS-314 Mesylate potent and selective inhibitor of Aurora A, Aurora B and Aurora C. [1146618-41-8]
TAK-901 novel inhibitor of Aurora A/B. [934541-31-8]
TC-A 2317 hydrochloride Potent Aurora kinase A inhibitor [1245907-03-2]
VX-680 (MK-0457,Tozasertib) potent inhibitor of pan-aurora kinase [639089-54-6]
XL228 protein kinase inhibitor targeting AURORA kinases [898280-07-4]
ZM 447439 novel, potent and selective inhibitor of Aurora kinase [331771-20-1]

(5) Tocris Compounds for AURKA Gene

Compound Action Cas Number
Anacardic acid Noncompetitive PCAF/p300 HAT inhibitor [16611-84-0]
CCT 137690 Potent pan-Aurora kinase inhibitor [1095382-05-0]
Hesperadin hydrochloride Potent Aurora kinase B inhibitor [422513-13-1]
SNS 314 mesylate Potent pan-Aurora kinase inhibitor [1146618-41-8]
TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor [1245907-03-2]

(2) HMDB Compounds for AURKA Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(6) Novoseek inferred chemical compound relationships for AURKA Gene

Compound -log(P) Hits PubMed IDs
threonine 74.2 27
serine 64.1 27
taxane 50.5 2
paclitaxel 15.5 2
estrogen 0 4
genes like me logo Genes that share compounds with AURKA: view

Transcripts for AURKA Gene

Unigene Clusters for AURKA Gene

Aurora kinase A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AURKA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: -
SP8: - - -
SP9: - - - - - - - - -
SP10: - - - - -
SP11: - -
SP12: - - -
SP13:
SP14: - - -
SP15: -
SP16: - -
SP17: - - - -
SP18: - - -

Relevant External Links for AURKA Gene

GeneLoc Exon Structure for
AURKA
ECgene alternative splicing isoforms for
AURKA

Expression for AURKA Gene

mRNA expression in normal human tissues for AURKA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AURKA Gene

This gene is overexpressed in Testis (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AURKA Gene

SOURCE GeneReport for Unigene cluster for AURKA Gene Hs.250822

mRNA Expression by UniProt/SwissProt for AURKA Gene

O14965-AURKA_HUMAN
Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines
genes like me logo Genes that share expressions with AURKA: view

Orthologs for AURKA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AURKA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AURKA 35
  • 99.34 (n)
  • 99.75 (a)
AURKA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AURKA 35
  • 86.4 (n)
  • 89.05 (a)
AURKA 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AURKA 35
  • 89.83 (n)
  • 90.07 (a)
AURKA 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aurka 35
  • 78.76 (n)
  • 84.26 (a)
Aurka 16
Aurka 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AURKA 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AURKA 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aurka 35
  • 80.05 (n)
  • 85.1 (a)
chicken
(Gallus gallus)
Aves AURKA 35
  • 70.94 (n)
  • 75.38 (a)
AURKA 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AURKA 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397925 35
tropical clawed frog
(Silurana tropicalis)
Amphibia aurka 35
  • 63.41 (n)
  • 67.35 (a)
zebrafish
(Danio rerio)
Actinopterygii aurka 35
  • 60.95 (n)
  • 63.32 (a)
aurka 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001793 35
  • 53.39 (n)
  • 56.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta aur 35
  • 54.29 (n)
  • 53.14 (a)
aur 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea air-2 35
  • 57.11 (n)
  • 62.13 (a)
air-2 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPL1 36
  • 38 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AUR2 35
  • 62.41 (n)
  • 66.17 (a)
rice
(Oryza sativa)
Liliopsida Os.613 35
Os01g0191800 35
  • 59.36 (n)
  • 65.02 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7757 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4656 36
  • 65 (a)
OneToMany
Species with no ortholog for AURKA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AURKA Gene

ENSEMBL:
Gene Tree for AURKA (if available)
TreeFam:
Gene Tree for AURKA (if available)

Paralogs for AURKA Gene

Paralogs for AURKA Gene

Pseudogenes.org Pseudogenes for AURKA Gene

genes like me logo Genes that share paralogs with AURKA: view

Variants for AURKA Gene

Sequence variations from dbSNP and Humsavar for AURKA Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs8173 -- 56,369,735(+) GGCTT(C/G)GCCAA utr-variant-3-prime
rs911160 -- 56,382,507(+) TGCTC(C/G)CAATT intron-variant
rs1047972 - 56,386,407(-) AGCGC(A/G)TTCCT reference, missense
rs1476394 -- 56,372,087(+) AGACA(C/G)CAAGC intron-variant
rs2064863 -- 56,387,716(-) TGGAC(A/C)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AURKA Gene

Variant ID Type Subtype PubMed ID
nsv834013 CNV Gain 17160897
esv259662 OTHER Complex 20981092
esv1000250 CNV Insertion 20482838
nsv179276 CNV Insertion 16902084
esv990423 CNV Insertion 20482838
esv1411689 CNV Insertion 17803354
nsv179472 CNV Insertion 16902084

Relevant External Links for AURKA Gene

HapMap Linkage Disequilibrium report
AURKA
Human Gene Mutation Database (HGMD)
AURKA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKA Gene

Disorders for AURKA Gene

(1) OMIM Diseases for AURKA Gene (603072)

(1) University of Copenhagen DISEASES for AURKA Gene

(27) Novoseek inferred disease relationships for AURKA Gene

Disease -log(P) Hits PubMed IDs
laryngeal squamous cell carcinoma 60.4 9
cancer 52.6 42
tumors 48.6 58
solid tumor 37.3 2
chromosomal aberrations 33 3

Relevant External Links for AURKA

Genetic Association Database (GAD)
AURKA
Human Genome Epidemiology (HuGE) Navigator
AURKA
genes like me logo Genes that share disorders with AURKA: view

No data available for UniProtKB/Swiss-Prot for AURKA Gene

Publications for AURKA Gene

  1. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. (PMID: 9771714) Zhou H. … Sen S. (Nat. Genet. 1998) 2 3 4 23
  2. Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk. (PMID: 15867347) Kimura M.T. … Nagase H. (Cancer Res. 2005) 3 4 23 48
  3. Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese. (PMID: 16011022) Chen L. … Zhang X. (Yi Chuan Xue Bao 2005) 3 4 23 48
  4. STK15 polymorphism and breast cancer risk in a population-based study. (PMID: 15271853) Egan K.M. … Nagase H. (Carcinogenesis 2004) 3 23 48
  5. STK15 polymorphisms and association with risk of invasive ovarian cancer. (PMID: 15466974) Dicioccio R.A. … Kruger-Kjaer S. (Cancer Epidemiol. Biomarkers Prev. 2004) 3 23 48

Products for AURKA Gene

  • Addgene plasmids for AURKA

Sources for AURKA Gene

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