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Aliases for STAU1 Gene

Aliases for STAU1 Gene

  • Staufen Double-Stranded RNA Binding Protein 1 2 3 5
  • STAU 3 4
  • Staufen, RNA Binding Protein, Homolog 1 (Drosophila) 2
  • Protein Phosphatase 1, Regulatory Subunit 150 3
  • Staufen (Drosophila, RNA-Binding Protein) 2
  • Staufen, RNA Binding Protein (Drosophila) 2
  • Staufen, RNA Binding Protein, Homolog 1 3
  • Regulatory Subunit 150 2
  • Protein Phosphatase 1 2
  • PPP1R150 3

External Ids for STAU1 Gene

Previous HGNC Symbols for STAU1 Gene

  • STAU

Previous GeneCards Identifiers for STAU1 Gene

  • GC20M047164
  • GC20M047729
  • GC20M044479

Summaries for STAU1 Gene

Entrez Gene Summary for STAU1 Gene

  • Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAU1 Gene

STAU1 (Staufen Double-Stranded RNA Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and double-stranded RNA binding. An important paralog of this gene is TARBP2.

UniProtKB/Swiss-Prot for STAU1 Gene

  • Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.

Gene Wiki entry for STAU1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAU1 Gene

Genomics for STAU1 Gene

Regulatory Elements for STAU1 Gene

Enhancers for STAU1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STAU1 on UCSC Golden Path with GeneCards custom track

Promoters for STAU1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STAU1 on UCSC Golden Path with GeneCards custom track

Genomic Location for STAU1 Gene

Chromosome:
20
Start:
49,113,339 bp from pter
End:
49,188,370 bp from pter
Size:
75,032 bases
Orientation:
Minus strand

Genomic View for STAU1 Gene

Genes around STAU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAU1 Gene

Proteins for STAU1 Gene

  • Protein details for STAU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95793-STAU1_HUMAN
    Recommended name:
    Double-stranded RNA-binding protein Staufen homolog 1
    Protein Accession:
    O95793
    Secondary Accessions:
    • A8K9Z4
    • E1P5Y1
    • E1P608
    • Q5JW29
    • Q6GTM4
    • Q9H5B4
    • Q9H5B5
    • Q9Y3Q2

    Protein attributes for STAU1 Gene

    Size:
    577 amino acids
    Molecular mass:
    63182 Da
    Quaternary structure:
    • Binds tubulin. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with the influenza virus nonstructural protein NS1.

    Three dimensional structures from OCA and Proteopedia for STAU1 Gene

    Alternative splice isoforms for STAU1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAU1 Gene

Proteomics data for STAU1 Gene at MOPED

Post-translational modifications for STAU1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STAU1 Gene

Domains & Families for STAU1 Gene

Gene Families for STAU1 Gene

Protein Domains for STAU1 Gene

Suggested Antigen Peptide Sequences for STAU1 Gene

Graphical View of Domain Structure for InterPro Entry

O95793

UniProtKB/Swiss-Prot:

STAU1_HUMAN :
  • One of the DRDB could be involved in RER binding.
Domain:
  • One of the DRDB could be involved in RER binding.
  • The C-terminal contains the tubulin binding domain (TBD).
  • Contains 3 DRBM (double-stranded RNA-binding) domains.
genes like me logo Genes that share domains with STAU1: view

Function for STAU1 Gene

Molecular function for STAU1 Gene

GENATLAS Biochemistry:
Drosophila Staufen homolog 1,involved,in mRNA transport and localization
UniProtKB/Swiss-Prot Function:
Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
genes like me logo Genes that share phenotypes with STAU1: view

Animal Models for STAU1 Gene

MGI Knock Outs for STAU1:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STAU1 Gene

Localization for STAU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAU1 Gene

Cytoplasm. Rough endoplasmic reticulum. Note=Localizes exclusively with the rough reticulum endoplasmic (RER).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAU1 Gene COMPARTMENTS Subcellular localization image for STAU1 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
extracellular 5
plasma membrane 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for STAU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19029303
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005875 microtubule associated complex TAS 10022909
GO:0016020 membrane IDA 19946888
GO:0030425 dendrite IDA 15121898
genes like me logo Genes that share ontologies with STAU1: view

Pathways & Interactions for STAU1 Gene

SuperPathways for STAU1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STAU1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STAU1 Gene

Drugs & Compounds for STAU1 Gene

No Compound Related Data Available

Transcripts for STAU1 Gene

Unigene Clusters for STAU1 Gene

Staufen, RNA binding protein, homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAU1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - -
SP6: -
SP7: - -
SP8: - - -
SP9:
SP10: - - - -
SP11:

Relevant External Links for STAU1 Gene

GeneLoc Exon Structure for
STAU1
ECgene alternative splicing isoforms for
STAU1

Expression for STAU1 Gene

mRNA expression in normal human tissues for STAU1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STAU1 Gene

This gene is overexpressed in Lung (9.8), Fetal Brain (6.3), and Islet of Langerhans (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAU1 Gene



SOURCE GeneReport for Unigene cluster for STAU1 Gene Hs.596704

mRNA Expression by UniProt/SwissProt for STAU1 Gene

O95793-STAU1_HUMAN
Tissue specificity: Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
genes like me logo Genes that share expression patterns with STAU1: view

Protein tissue co-expression partners for STAU1 Gene

No data available for mRNA differential expression in normal tissues for STAU1 Gene

Orthologs for STAU1 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAU1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Stau1 35
  • 87.12 (n)
  • 91.41 (a)
Stau1 16
Stau1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STAU1 35
  • 99.71 (n)
  • 99.83 (a)
STAU1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stau1 35
  • 87.18 (n)
  • 91.82 (a)
cow
(Bos Taurus)
Mammalia STAU1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAU1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAU1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAU1 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves STAU1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAU1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8280 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398937 35
zebrafish
(Danio rerio)
Actinopterygii stau1 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta stau 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea stau-1 36
  • 21 (a)
OneToMany
Species with no ortholog for STAU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAU1 Gene

ENSEMBL:
Gene Tree for STAU1 (if available)
TreeFam:
Gene Tree for STAU1 (if available)

Paralogs for STAU1 Gene

Paralogs for STAU1 Gene

(3) SIMAP similar genes for STAU1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for STAU1 Gene

genes like me logo Genes that share paralogs with STAU1: view

Variants for STAU1 Gene

Sequence variations from dbSNP and Humsavar for STAU1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs168345 -- 49,121,807(+) aagag(C/T)tggtt intron-variant
rs191543 -- 49,181,727(-) atgca(A/G)aggta intron-variant
rs482058 -- 49,182,856(-) CTACT(A/T)TTTTT intron-variant
rs508890 -- 49,174,660(+) ctgcc(A/G)ggcat intron-variant
rs537254 -- 49,175,451(+) GTAAT(A/G)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAU1 Gene

Variant ID Type Subtype PubMed ID
esv2670489 CNV Deletion 23128226
nsv435739 CNV Deletion 17901297

Variation tolerance for STAU1 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STAU1 Gene

Disorders for STAU1 Gene

Relevant External Links for STAU1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAU1

No disorders were found for STAU1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAU1 Gene

Publications for STAU1 Gene

  1. Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. (PMID: 15680326) Kim Y.K. … Maquat L.E. (Cell 2005) 2 3 23 67
  2. Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization. (PMID: 8884277) DesGroseillers L. … Lemieux N. (Genomics 1996) 2 3 23
  3. The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus. (PMID: 18498651) Chatel-Chaix L. … Desgroseillers L. (Retrovirology 2008) 3 23
  4. Expression and intracytoplasmic distribution of staufen and calreticulin in maturing human oocytes. (PMID: 25620022) De Santis L. … Brevini T.A. (J. Assist. Reprod. Genet. 2015) 3
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3

Products for STAU1 Gene

Sources for STAU1 Gene

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