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Aliases for ST5 Gene

Aliases for ST5 Gene

  • Suppression Of Tumorigenicity 5 2 3 5
  • DENN/MADD Domain Containing 2B 2 3
  • HeLa Tumor Suppression 1 3 4
  • DENND2B 3 4
  • HTS1 3 4
  • DENN Domain-Containing Protein 2B 4
  • P126 3

External Ids for ST5 Gene

Previous GeneCards Identifiers for ST5 Gene

  • GC11M009485
  • GC11M009161
  • GC11M008754
  • GC11M008679
  • GC11M008671
  • GC11M008382

Summaries for ST5 Gene

Entrez Gene Summary for ST5 Gene

  • This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST5 Gene

ST5 (Suppression Of Tumorigenicity 5) is a Protein Coding gene. Diseases associated with ST5 include oral candidiasis and miller fisher syndrome. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is SBF1.

UniProtKB/Swiss-Prot for ST5 Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.

Gene Wiki entry for ST5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST5 Gene

Genomics for ST5 Gene

Regulatory Elements for ST5 Gene

Genomic Location for ST5 Gene

Chromosome:
11
Start:
8,693,351 bp from pter
End:
8,910,951 bp from pter
Size:
217,601 bases
Orientation:
Minus strand

Genomic View for ST5 Gene

Genes around ST5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST5 Gene

Proteins for ST5 Gene

  • Protein details for ST5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78524-ST5_HUMAN
    Recommended name:
    Suppression of tumorigenicity 5 protein
    Protein Accession:
    P78524
    Secondary Accessions:
    • B2R6X7
    • B3KXQ6
    • P78523
    • Q16492
    • Q7KYY2
    • Q7KZ12
    • Q8NE12
    • Q9BQQ6

    Protein attributes for ST5 Gene

    Size:
    1137 amino acids
    Molecular mass:
    126485 Da
    Quaternary structure:
    • Isoform 1 interacts with the SH3 domain of ABL1.
    SequenceCaution:
    • Sequence=AAC50925.1; Type=Frameshift; Positions=159, 169; Evidence={ECO:0000305};

    Alternative splice isoforms for ST5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST5 Gene

Proteomics data for ST5 Gene at MOPED

Post-translational modifications for ST5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ST5 Gene

Domains & Families for ST5 Gene

Gene Families for ST5 Gene

Protein Domains for ST5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P78524

UniProtKB/Swiss-Prot:

ST5_HUMAN :
  • Contains 1 dDENN domain.
Domain:
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 uDENN domain.
genes like me logo Genes that share domains with ST5: view

Function for ST5 Gene

Molecular function for ST5 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.
genes like me logo Genes that share phenotypes with ST5: view

Animal Model Products

miRNA for ST5 Gene

miRTarBase miRNAs that target ST5

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST5 Gene

Localization for ST5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST5 Gene COMPARTMENTS Subcellular localization image for ST5 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 1
extracellular 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ST5 Gene

Pathways & Interactions for ST5 Gene

SuperPathways for ST5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ST5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ST5 Gene

Drugs & Compounds for ST5 Gene

No Compound Related Data Available

Transcripts for ST5 Gene

Unigene Clusters for ST5 Gene

Suppression of tumorigenicity 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g ·
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4:
SP5:
SP6: - - - - - - - - - - - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14:
SP15:
SP16:
SP17: - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - -
SP20: - - - - - - - -
SP21: - - - - - - - - - - - - - - - - -
SP22: - - - - - - -
SP23: - - - - -
SP24: - - - - - - - - - - - - - - -
SP25: - - - -
SP26: - -
SP27: -
SP28:
SP29:
SP30: - - - - - - -

ExUns: 14h · 14i · 14j ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - - - -
SP14: - - - - - - -
SP15: -
SP16: -
SP17:
SP18: - - - - - - - - -
SP19:
SP20: - - -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:

ExUns: 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36 ^ 37a · 37b
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9: - -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:

Relevant External Links for ST5 Gene

GeneLoc Exon Structure for
ST5
ECgene alternative splicing isoforms for
ST5

Expression for ST5 Gene

mRNA expression in normal human tissues for ST5 Gene

Protein differential expression in normal tissues from HIPED for ST5 Gene

This gene is overexpressed in Placenta (14.0), Urinary Bladder (9.7), Testis (8.8), Heart (7.4), Uterus (7.1), and Prostate (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST5 Gene



SOURCE GeneReport for Unigene cluster for ST5 Gene Hs.117715

mRNA Expression by UniProt/SwissProt for ST5 Gene

P78524-ST5_HUMAN
Tissue specificity: Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level).
genes like me logo Genes that share expression patterns with ST5: view

Protein tissue co-expression partners for ST5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ST5 Gene

Orthologs for ST5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST5 35
  • 99.6 (n)
  • 99.54 (a)
ST5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ST5 36
  • 94 (a)
OneToOne
ST5 35
  • 92.17 (n)
  • 93.84 (a)
dog
(Canis familiaris)
Mammalia ST5 35
  • 92.84 (n)
  • 94.96 (a)
ST5 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St5 16
St5 36
  • 93 (a)
OneToOne
St5 35
  • 89.95 (n)
  • 93.3 (a)
oppossum
(Monodelphis domestica)
Mammalia ST5 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST5 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St5 35
  • 89.03 (n)
  • 91.91 (a)
chicken
(Gallus gallus)
Aves ST5 36
  • 81 (a)
OneToOne
ST5 35
  • 74.46 (n)
  • 81.72 (a)
lizard
(Anolis carolinensis)
Reptilia ST5 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1916 35
tropical clawed frog
(Silurana tropicalis)
Amphibia st5 35
  • 72.2 (n)
  • 75.69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8836 35
zebrafish
(Danio rerio)
Actinopterygii st5 36
  • 65 (a)
OneToOne
Dr.16306 35
st5 35
  • 67.53 (n)
  • 70.52 (a)
Species with no ortholog for ST5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST5 Gene

ENSEMBL:
Gene Tree for ST5 (if available)
TreeFam:
Gene Tree for ST5 (if available)

Paralogs for ST5 Gene

genes like me logo Genes that share paralogs with ST5: view

Variants for ST5 Gene

Sequence variations from dbSNP and Humsavar for ST5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3794153 - 8,730,342(-) AGGAA(C/G)ACTGG intron-variant, nc-transcript-variant, reference, missense
rs3812762 - 8,730,093(+) TTCTT(C/G)TCAGC intron-variant, nc-transcript-variant, reference, missense
rs17853683 - 8,714,693(+) AGTTA(A/G)TTCTT nc-transcript-variant, reference, missense
rs17853682 - 8,710,877(+) TCTGC(C/T)GCCAT nc-transcript-variant, reference, missense
rs11042047 - 8,714,015(+) CATCA(A/G)AGTCG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ST5 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
nsv7664 CNV Insertion 18451855
essv24306 CNV CNV 17122850
nsv527920 CNV Loss 19592680
nsv509388 CNV Insertion 20534489
nsv527073 CNV Loss 19592680
nsv7665 CNV Insertion 18451855
nsv435923 CNV Deletion 17901297
nsv513308 CNV Insertion 21212237
nsv832062 CNV Loss 17160897
esv2669920 CNV Deletion 23128226
esv271927 CNV Insertion 20981092
esv273960 CNV Insertion 20981092
nsv7666 CNV Insertion 18451855
esv2744087 CNV Deletion 23290073
esv2744088 CNV Deletion 23290073
esv2744089 CNV Deletion 23290073
esv1699885 CNV Deletion 17803354

Variation tolerance for ST5 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.01; 95.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST5 Gene

HapMap Linkage Disequilibrium report
ST5
Human Gene Mutation Database (HGMD)
ST5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST5 Gene

Disorders for ST5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ST5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
oral candidiasis
  • candidiasis of mouth
miller fisher syndrome
  • fisher's syndrome
perrault syndrome
  • gonadal dysgenesis, xx type
opportunistic mycosis
  • opportunistic mycoses
- elite association - COSMIC cancer census association via MalaCards
Search ST5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ST5

Genetic Association Database (GAD)
ST5
Human Genome Epidemiology (HuGE) Navigator
ST5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST5
genes like me logo Genes that share disorders with ST5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST5 Gene

Publications for ST5 Gene

  1. Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells. (PMID: 1390339) Lichy J.H. … Howley P.M. (Cell Growth Differ. 1992) 2 3 4 67
  2. Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells. (PMID: 10692462) Majidi M. … Lichy J.H. (J. Biol. Chem. 2000) 3 23
  3. Activation of extracellular signal-regulated kinase 2 by a novel Abl- binding protein, ST5. (PMID: 9632734) Majidi M. … Lichy J.H. (J. Biol. Chem. 1998) 3 23
  4. Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression. (PMID: 8972856) Lichy J.H. … Tsai M.M. (Nucleic Acids Res. 1996) 3 23
  5. DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior. (PMID: 25713415) Ioannou M.S. … McPherson P.S. (J. Cell Biol. 2015) 3

Products for ST5 Gene

Sources for ST5 Gene

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