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Aliases for BRDT Gene

Aliases for BRDT Gene

  • Bromodomain Testis Associated 2 3
  • Bromodomain, Testis-Specific 2 3 5
  • Cancer/Testis Antigen 9 2 3 4
  • RING3-Like Protein 3 4
  • CT9 3 4
  • BRD6 3

External Ids for BRDT Gene

Previous GeneCards Identifiers for BRDT Gene

  • GC01P092874
  • GC01P091615
  • GC01P091752
  • GC01P091886
  • GC01P092126
  • GC01P092414
  • GC01P090535

Summaries for BRDT Gene

Entrez Gene Summary for BRDT Gene

  • BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for BRDT Gene

BRDT (Bromodomain Testis Associated) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity and lysine-acetylated histone binding. An important paralog of this gene is BRD3.

UniProtKB/Swiss-Prot for BRDT Gene

  • Testis-specific chromatin protein that specifically binds histone H4 acetylated at Lys-5 and Lys-8 (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.

Gene Wiki entry for BRDT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRDT Gene

Genomics for BRDT Gene

Regulatory Elements for BRDT Gene

Enhancers for BRDT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BRDT on UCSC Golden Path with GeneCards custom track

Genomic Location for BRDT Gene

Chromosome:
1
Start:
91,949,371 bp from pter
End:
92,014,428 bp from pter
Size:
65,058 bases
Orientation:
Plus strand

Genomic View for BRDT Gene

Genes around BRDT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRDT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRDT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRDT Gene

Proteins for BRDT Gene

  • Protein details for BRDT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q58F21-BRDT_HUMAN
    Recommended name:
    Bromodomain testis-specific protein
    Protein Accession:
    Q58F21
    Secondary Accessions:
    • A6NF68
    • B7Z811
    • B7Z890
    • B7ZAX7
    • D3DT32
    • O14789
    • Q05DQ4
    • Q6P5T1
    • Q7Z4A6
    • Q8IWI6

    Protein attributes for BRDT Gene

    Size:
    947 amino acids
    Molecular mass:
    107954 Da
    Quaternary structure:
    • Interacts with mRNA splicing machinery proteins SRSF2, DDX5, HNRNPK and TARDBP. Interacts with the acetylated N-terminus of histone H1, H2, H3 and H4. Interacts with P-TEFb components CDK9 and CCNT1/cyclin-T1. Interacts with SMARCE1 (By similarity). Interacts with the acetylated N-terminus of histone H1.4, H2A, H2B, H3 and H4.
    Miscellaneous:
    • BRDT is a promising target for male contraception. Inhibition by thienodiazepine inhibitor (+)-JQ1 that binds Asn-109, prevents recognition of acetylated histone H4, causing a complete and reversible contraceptive effect in male mice (PubMed:22901802).
    SequenceCaution:
    • Sequence=AAH05281.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH47900.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH62700.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRDT Gene

    Alternative splice isoforms for BRDT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRDT Gene

Proteomics data for BRDT Gene at MOPED

Post-translational modifications for BRDT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BRDT Gene

Domains & Families for BRDT Gene

Protein Domains for BRDT Gene

Suggested Antigen Peptide Sequences for BRDT Gene

Graphical View of Domain Structure for InterPro Entry

Q58F21

UniProtKB/Swiss-Prot:

BRDT_HUMAN :
  • Bromo domains mediate interaction with histones that have acetylated lysine residues at specific positions (PubMed:22464331). Bromo domain 1 mediates binding with histone H4 acetylated at Lys-5 and Lys-8 (H4K5ac and H4K8ac, respectively) (PubMed:22901802).
Domain:
  • Bromo domains mediate interaction with histones that have acetylated lysine residues at specific positions (PubMed:22464331). Bromo domain 1 mediates binding with histone H4 acetylated at Lys-5 and Lys-8 (H4K5ac and H4K8ac, respectively) (PubMed:22901802).
  • Contains 2 bromo domains.
  • Contains 1 NET domain.
genes like me logo Genes that share domains with BRDT: view

No data available for Gene Families for BRDT Gene

Function for BRDT Gene

Molecular function for BRDT Gene

GENATLAS Biochemistry:
bromodomain testis specific gene,with homology to RING3 (D6S113E) and Drosophila fsh
UniProtKB/Swiss-Prot Function:
Testis-specific chromatin protein that specifically binds histone H4 acetylated at Lys-5 and Lys-8 (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.
genes like me logo Genes that share phenotypes with BRDT: view

Animal Models for BRDT Gene

MGI Knock Outs for BRDT:
  • Brdt tm1a(EUCOMM)Wtsi

Animal Model Products

miRNA for BRDT Gene

miRTarBase miRNAs that target BRDT

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRDT Gene

Localization for BRDT Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRDT Gene

Nucleus. Note=Detected on chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRDT Gene COMPARTMENTS Subcellular localization image for BRDT gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for BRDT Gene

Pathways & Interactions for BRDT Gene

SuperPathways for BRDT Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRDT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001207 histone displacement ISS --
GO:0006338 chromatin remodeling IEA,ISS --
GO:0006397 mRNA processing IEA --
GO:0007140 male meiosis IEA,ISS --
GO:0007141 male meiosis I IEA,ISS --
genes like me logo Genes that share ontologies with BRDT: view

No data available for Pathways by source and SIGNOR curated interactions for BRDT Gene

Drugs & Compounds for BRDT Gene

(2) Drugs for BRDT Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(+)-JQ1 Pharma Potent, selective BET bromodomain inhibitor; cell permeable 0
XD14 Pharma 0
genes like me logo Genes that share compounds with BRDT: view

Transcripts for BRDT Gene

Unigene Clusters for BRDT Gene

Bromodomain, testis-specific:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRDT Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - - - - - -
SP6:
SP7: -
SP8:
SP9: - -
SP10: - - -
SP11: - -
SP12: -
SP13:
SP14: - - -
SP15:

ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for BRDT Gene

GeneLoc Exon Structure for
BRDT
ECgene alternative splicing isoforms for
BRDT

Expression for BRDT Gene

mRNA expression in normal human tissues for BRDT Gene

mRNA differential expression in normal tissues according to GTEx for BRDT Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for BRDT Gene

This gene is overexpressed in Plasma (47.7), Monocytes (10.2), and Testis (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BRDT Gene



SOURCE GeneReport for Unigene cluster for BRDT Gene Hs.482520

mRNA Expression by UniProt/SwissProt for BRDT Gene

Q58F21-BRDT_HUMAN
Tissue specificity: Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder.
genes like me logo Genes that share expression patterns with BRDT: view

Protein tissue co-expression partners for BRDT Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BRDT Gene

Orthologs for BRDT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BRDT Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia BRDT 35
  • 87.09 (n)
  • 82.68 (a)
BRDT 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brdt 35
  • 77.14 (n)
  • 74.41 (a)
Brdt 16
Brdt 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRDT 35
  • 99.27 (n)
  • 98.85 (a)
BRDT 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brdt 35
  • 77.33 (n)
  • 76.4 (a)
cow
(Bos Taurus)
Mammalia BRDT 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRDT 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRDT 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRDT 35
  • 64.47 (n)
  • 55.26 (a)
BRDT 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRDT 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brdt 35
  • 60.44 (n)
  • 54.53 (a)
zebrafish
(Danio rerio)
Actinopterygii brdt 35
  • 59.45 (n)
  • 55.27 (a)
brdt 36
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fs(1)h 37
  • 47 (a)
fs(1)h 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BDF2 38
Species with no ortholog for BRDT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRDT Gene

ENSEMBL:
Gene Tree for BRDT (if available)
TreeFam:
Gene Tree for BRDT (if available)

Paralogs for BRDT Gene

Paralogs for BRDT Gene

Pseudogenes.org Pseudogenes for BRDT Gene

genes like me logo Genes that share paralogs with BRDT: view

Variants for BRDT Gene

Sequence variations from dbSNP and Humsavar for BRDT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10783071 - 91,962,938(+) AACTA(A/C)AGTTG intron-variant, reference, missense
rs1156281 - 91,977,138(+) GAAAA(A/C)TCAGT reference, missense
rs3088232 - 91,979,700(-) GAAGA(A/C/G)TTCCC reference, missense
rs55806733 - 91,962,759(+) AATGT(C/T)TCTGC intron-variant, reference, missense
rs56273490 - 91,962,771(+) AAGTC(A/G)ACAAA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BRDT Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV Deletion 23290073
nsv462517 CNV Gain 19166990
nsv524845 CNV Gain 19592680
nsv830581 CNV Loss 17160897
dgv264n71 CNV Gain 21882294
esv2750842 CNV Gain 17911159
esv2659029 CNV Deletion 23128226
nsv871606 CNV Loss 21882294
nsv871508 CNV Gain 21882294

Variation tolerance for BRDT Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.16; 90.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BRDT Gene

Disorders for BRDT Gene

Relevant External Links for BRDT

Genetic Association Database (GAD)
BRDT
Human Genome Epidemiology (HuGE) Navigator
BRDT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRDT

No disorders were found for BRDT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRDT Gene

Publications for BRDT Gene

  1. Identification and characterization of BRDT: a testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh. (PMID: 9367677) Jones M.H. … Shimane M. (Genomics 1997) 2 3 4 23 67
  2. Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. (PMID: 17690245) Bisgrove D.A. … Verdin E. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23
  3. Molecular cloning and expression of a novel alternative splice variant of BRDT gene. (PMID: 15647849) Zheng Y. … Sha J.-H. (Int. J. Mol. Med. 2005) 3 23
  4. Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9. (PMID: 10704737) Scanlan M.J. … Old L.J. (Cancer Lett. 2000) 3 23
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for BRDT Gene

Sources for BRDT Gene

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