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Aliases for SSTR2 Gene

Aliases for SSTR2 Gene

  • Somatostatin Receptor 2 2 3 5
  • SRIF-1 3 4
  • SS2R 3 4
  • SS-2-R 4
  • SS2-R 4

External Ids for SSTR2 Gene

Previous GeneCards Identifiers for SSTR2 Gene

  • GC17P071046
  • GC17P074201
  • GC17P071625
  • GC17P071758
  • GC17P068672
  • GC17P071161
  • GC17P066570

Summaries for SSTR2 Gene

Entrez Gene Summary for SSTR2 Gene

  • Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSTR2 Gene

SSTR2 (Somatostatin Receptor 2) is a Protein Coding gene. Diseases associated with SSTR2 include olfactory neuroblastoma and pancreatic endocrine carcinoma. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide binding. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for SSTR2 Gene

  • Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Tocris Summary for SSTR2 Gene

  • Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.

Gene Wiki entry for SSTR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSTR2 Gene

Genomics for SSTR2 Gene

Regulatory Elements for SSTR2 Gene

Genomic Location for SSTR2 Gene

Chromosome:
17
Start:
73,165,012 bp from pter
End:
73,176,633 bp from pter
Size:
11,622 bases
Orientation:
Plus strand

Genomic View for SSTR2 Gene

Genes around SSTR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSTR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR2 Gene

Proteins for SSTR2 Gene

  • Protein details for SSTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30874-SSR2_HUMAN
    Recommended name:
    Somatostatin receptor type 2
    Protein Accession:
    P30874
    Secondary Accessions:
    • A8K3Y0
    • B2R9P7
    • Q4VBP0
    • Q96GE0
    • Q96TF2
    • Q9BWH1

    Protein attributes for SSTR2 Gene

    Size:
    369 amino acids
    Molecular mass:
    41333 Da
    Quaternary structure:
    • Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).

    Alternative splice isoforms for SSTR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSTR2 Gene

Proteomics data for SSTR2 Gene at MOPED

Post-translational modifications for SSTR2 Gene

  • Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity).
  • Glycosylation at Asn 9, Asn 22, Asn 29, and Asn 32
  • Modification sites at PhosphoSitePlus

Other Protein References for SSTR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SSTR2 (Somatostatin R2/SSTR2)

No data available for DME Specific Peptides for SSTR2 Gene

Domains & Families for SSTR2 Gene

Gene Families for SSTR2 Gene

Suggested Antigen Peptide Sequences for SSTR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30874

UniProtKB/Swiss-Prot:

SSR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SSTR2: view

Function for SSTR2 Gene

Molecular function for SSTR2 Gene

GENATLAS Biochemistry:
somatostatin receptor gene 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
genes like me logo Genes that share phenotypes with SSTR2: view

Animal Models for SSTR2 Gene

MGI Knock Outs for SSTR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SSTR2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSTR2 Gene

Localization for SSTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR2 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSTR2 Gene COMPARTMENTS Subcellular localization image for SSTR2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SSTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with SSTR2: view

Pathways & Interactions for SSTR2 Gene

genes like me logo Genes that share pathways with SSTR2: view

Gene Ontology (GO) - Biological Process for SSTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006937 regulation of muscle contraction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007267 cell-cell signaling TAS 1346068
GO:0008285 negative regulation of cell proliferation TAS 9892014
GO:0021549 cerebellum development IEA --
genes like me logo Genes that share ontologies with SSTR2: view

No data available for SIGNOR curated interactions for SSTR2 Gene

Drugs & Compounds for SSTR2 Gene

(83) Drugs for SSTR2 Gene - From: Novoseek, DGIdb, DrugBank, IUPHAR, Tocris, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Octreotide Approved, Investigational Pharma Full agonist, Agonist, binder, Target sst2, sst3 and sst5 agonist 198
Vapreotide Approved, Investigational Pharma Full agonist, Agonist, Target, inducer 2
Pasireotide Approved Pharma inhibitor, agonist, Target 0
lanreotide Pharma Full agonist, Agonist 74
Seglitide Pharma sst2 and sst5 agonist 0

(24) Additional Compounds for SSTR2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
analog 3
Antagonist
analog 30
Antagonist
analog 31
Antagonist
CST-14
Full agonist, Agonist
MK-678
Full agonist, Agonist

(5) Tocris Compounds for SSTR2 Gene

Compound Action Cas Number
L-803,087 trifluoroacetate Potent and selective sst4 agonist 217480-26-7
Octreotide sst2, sst3 and sst5 agonist 83150-76-9
Seglitide sst2 and sst5 agonist 81377-02-8
Somatostatin Influences growth hormone release 51110-01-1
Somatostatin 1-28 sst receptor agonist 74315-46-1
genes like me logo Genes that share compounds with SSTR2: view

Transcripts for SSTR2 Gene

mRNA/cDNA for SSTR2 Gene

Unigene Clusters for SSTR2 Gene

Somatostatin receptor 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for SSTR2 Gene

GeneLoc Exon Structure for
SSTR2
ECgene alternative splicing isoforms for
SSTR2

Expression for SSTR2 Gene

mRNA expression in normal human tissues for SSTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSTR2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.9), Brain - Cerebellum (x4.8), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for SSTR2 Gene

This gene is overexpressed in Cerebral cortex (61.4) and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SSTR2 Gene



SOURCE GeneReport for Unigene cluster for SSTR2 Gene Hs.514451

mRNA Expression by UniProt/SwissProt for SSTR2 Gene

P30874-SSR2_HUMAN
Tissue specificity: Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.
genes like me logo Genes that share expression patterns with SSTR2: view

Protein tissue co-expression partners for SSTR2 Gene

Primer Products

In Situ Assay Products

Orthologs for SSTR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSTR2 35
  • 92.12 (n)
  • 94.84 (a)
SSTR2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSTR2 35
  • 93.04 (n)
  • 94.85 (a)
SSTR2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sstr2 35
  • 88.26 (n)
  • 93.77 (a)
Sstr2 16
Sstr2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SSTR2 35
  • 99.64 (n)
  • 100 (a)
SSTR2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sstr2 35
  • 87.99 (n)
  • 92.95 (a)
oppossum
(Monodelphis domestica)
Mammalia SSTR2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSTR2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSTR2 35
  • 81.07 (n)
  • 88.32 (a)
SS2R 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSTR2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sstr2 35
  • 73.53 (n)
  • 84.62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19621 35
zebrafish
(Danio rerio)
Actinopterygii LOC100333578 35
  • 66.67 (n)
  • 68.64 (a)
SSTR2 (1 of 2) 36
  • 63 (a)
OneToMany
SSTR2 (2 of 2) 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 37
  • 41 (a)
Drostar1 37
  • 39 (a)
star1 35
  • 53.86 (n)
  • 48.51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRALS3 35
  • 52.07 (n)
  • 41.61 (a)
worm
(Caenorhabditis elegans)
Secernentea npr-24 35
  • 45.56 (n)
  • 35.74 (a)
Species with no ortholog for SSTR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSTR2 Gene

ENSEMBL:
Gene Tree for SSTR2 (if available)
TreeFam:
Gene Tree for SSTR2 (if available)

Paralogs for SSTR2 Gene

genes like me logo Genes that share paralogs with SSTR2: view

Variants for SSTR2 Gene

Sequence variations from dbSNP and Humsavar for SSTR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs714925 -- 73,167,530(+) AGCCA(A/G)GTGAA intron-variant
rs1466113 -- 73,169,179(+) TGAGA(C/G)TTTAA intron-variant
rs895907 -- 73,164,158(+) tgtgt(A/G)tACCT upstream-variant-2KB
rs728291 -- 73,167,649(+) AAACA(A/C)TTCTC intron-variant
rs998571 -- 73,169,153(-) TCTGG(C/T)TTAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSTR2 Gene

Variant ID Type Subtype PubMed ID
nsv833534 CNV Loss 17160897

Variation tolerance for SSTR2 Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSTR2 Gene

HapMap Linkage Disequilibrium report
SSTR2
Human Gene Mutation Database (HGMD)
SSTR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSTR2 Gene

Disorders for SSTR2 Gene

MalaCards: The human disease database

(17) MalaCards diseases for SSTR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
olfactory neuroblastoma
  • asthesioneuroblastoma
pancreatic endocrine carcinoma
  • carcinoma of endocrine pancreas
neuroendocrine tumor
  • neuroendocrine neoplasm
pituitary adenoma
  • adenoma of the pituitary gland
acromegaly
  • somatotroph adenoma
- elite association - COSMIC cancer census association via MalaCards
Search SSTR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSTR2

Genetic Association Database (GAD)
SSTR2
Human Genome Epidemiology (HuGE) Navigator
SSTR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSTR2
genes like me logo Genes that share disorders with SSTR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSTR2 Gene

Publications for SSTR2 Gene

  1. Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization. (PMID: 18653781) Grant M. … Kumar U. (Mol. Endocrinol. 2008) 3 4 23 67
  2. Internalized somatostatin receptor subtype 2 in neuroendocrine tumors of octreotide-treated patients. (PMID: 20228164) Reubi J.C. … Christ E. (J. Clin. Endocrinol. Metab. 2010) 3 23
  3. Somatostatin receptor 2 expression determined by immunohistochemistry in cold thyroid nodules exceeds that of hot thyroid nodules, papillary thyroid carcinoma, and Graves' disease. (PMID: 20450431) Sancak S. … Paschke R. (Thyroid 2010) 3 23
  4. Somatostatin analogues inhibit cancer cell proliferation in an SSTR2-dependent manner via both cytostatic and cytotoxic pathways. (PMID: 19148511) Zou Y. … Zhou T. (Oncol. Rep. 2009) 3 23
  5. Association of SSTR2 polymorphisms and glucose homeostasis phenotypes: the Insulin Resistance Atherosclerosis Family Study. (PMID: 19324939) Sutton B.S. … Bowden D.W. (Diabetes 2009) 3 23

Products for SSTR2 Gene

Sources for SSTR2 Gene

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