Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SSRP1 Gene

Aliases for SSRP1 Gene

  • Structure Specific Recognition Protein 1 2 3 5
  • Chromatin-Specific Transcription Elongation Factor 80 KDa Subunit 3 4
  • Facilitates Chromatin Transcription Complex 80 KDa Subunit 3 4
  • Facilitates Chromatin Transcription Complex Subunit SSRP1 3 4
  • Recombination Signal Sequence Recognition Protein 1 3 4
  • Facilitates Chromatin Remodeling 80 KDa Subunit 2 3
  • FACT 80 KDa Subunit 3 4
  • FACTp80 3 4
  • FACT80 3 4
  • HSSRP1 3 4
  • T160 3 4
  • Structure-Specific Recognition Protein 1 4
  • FACT Complex Subunit SSRP1 3
  • High Mobility Group Box 3
  • Cisplatin-DNA SSRP 3
  • FACT 3

External Ids for SSRP1 Gene

Previous GeneCards Identifiers for SSRP1 Gene

  • GC11M059487
  • GC11M058606
  • GC11M056868
  • GC11M056850
  • GC11M057093
  • GC11M053442

Summaries for SSRP1 Gene

Entrez Gene Summary for SSRP1 Gene

  • The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSRP1 Gene

SSRP1 (Structure Specific Recognition Protein 1) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Regulation of TP53 Activity. GO annotations related to this gene include poly(A) RNA binding and chromatin binding. An important paralog of this gene is TOX3.

UniProtKB/Swiss-Prot for SSRP1 Gene

  • Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of Ser-392 of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.

Gene Wiki entry for SSRP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSRP1 Gene

Genomics for SSRP1 Gene

Regulatory Elements for SSRP1 Gene

Enhancers for SSRP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G057287 1.2 Ensembl ENCODE dbSUPER 28.2 +46.5 46492 2.8 SOX13 TFAP4 JUN MAX YY1 ZFHX2 POLR2A NR2F6 FOS ZNF548 SSRP1 TNKS1BP1 ENSG00000254662 P2RX3 APLNR GC11P057311
GH11G057710 1.1 ENCODE 24.8 -376.7 -376682 3.3 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 SSRP1 ENSG00000269570 MED19 YPEL4 SELENOH ENSG00000254732 BTBD18 CTNND1 SMTNL1 TMX2-CTNND1
GH11G057276 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16 +57.2 57158 4.1 HDAC1 TBP PKNOX1 ATF1 CREB3L1 SIN3A FEZF1 RAD21 YY1 ZNF766 SSRP1 APLNR ENSG00000254662 TNKS1BP1 P2RX3 SLC43A3 UBE2L6 GC11P057311
GH11G057899 1.6 Ensembl ENCODE dbSUPER 15.4 -566.6 -566562 6.6 HDGF FOXA2 PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 SSRP1 ENSG00000269570 YPEL4 MED19 OR5AZ1P ENSG00000255266
GH11G057973 1.2 ENCODE 19.8 -638.2 -638239 0.5 CREB3L1 AGO1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D SSRP1 ZDHHC5 ENSG00000269570 CLP1 MED19 GC11M057954 CYCSP26
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSRP1 on UCSC Golden Path with GeneCards custom track

Promoters for SSRP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039866 277 1201 ATF1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ETS1

Genomic Location for SSRP1 Gene

Chromosome:
11
Start:
57,325,985 bp from pter
End:
57,335,877 bp from pter
Size:
9,893 bases
Orientation:
Minus strand

Genomic View for SSRP1 Gene

Genes around SSRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSRP1 Gene

Proteins for SSRP1 Gene

  • Protein details for SSRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08945-SSRP1_HUMAN
    Recommended name:
    FACT complex subunit SSRP1
    Protein Accession:
    Q08945
    Secondary Accessions:
    • Q5BJG8

    Protein attributes for SSRP1 Gene

    Size:
    709 amino acids
    Molecular mass:
    81075 Da
    Quaternary structure:
    • Interacts with MYOG (via C-terminal region) (By similarity). Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H (PubMed:10421373). Also component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B (PubMed:11239457, PubMed:12393879). Binds to histone H3-H4 tetramers, but not to intact nucleosomes. Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292). Interacts with isoform gamma of TP63 (PubMed:12374749). Interacts with FYTTD1/UIF (PubMed:19836239). Interacts with SRF (By similarity). Interacts with NEK9 (PubMed:14660563).
    Miscellaneous:
    • Autoantibodies against SSRP1 are present in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases.
    SequenceCaution:
    • Sequence=AAH91486.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SSRP1 Gene

neXtProt entry for SSRP1 Gene

Post-translational modifications for SSRP1 Gene

  • Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity.
  • Sumoylated.
  • Ubiquitinated. Polyubiquitinated following caspase cleavage resulting in degradation of the N-terminal ubiquitinated part of the cleaved protein.
  • Ubiquitination at isoforms=39, isoforms=63, Lys84, Lys90, Lys105, isoforms=228, isoforms=233, posLast=304304, isoforms=319, Lys325, and Lys566
  • Modification sites at PhosphoSitePlus

Other Protein References for SSRP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SSRP1 (SSRP1)
  • Cloud-Clone Corp. Antibodies for SSRP1

No data available for DME Specific Peptides for SSRP1 Gene

Domains & Families for SSRP1 Gene

Suggested Antigen Peptide Sequences for SSRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08945

UniProtKB/Swiss-Prot:

SSRP1_HUMAN :
  • The HMG box DNA-binding domain mediates DNA-binding. It has both affinity and specificity for DNA damaged globally with cisplatin.
  • Belongs to the SSRP1 family.
Domain:
  • The HMG box DNA-binding domain mediates DNA-binding. It has both affinity and specificity for DNA damaged globally with cisplatin.
Family:
  • Belongs to the SSRP1 family.
genes like me logo Genes that share domains with SSRP1: view

No data available for Gene Families for SSRP1 Gene

Function for SSRP1 Gene

Molecular function for SSRP1 Gene

GENATLAS Biochemistry:
structure specific recognition protein 1,essential for transcription,binding specifically to DNA modified by the anticancer agent cysplatin,81kDa,80kDa subunit of the chromatin specific elongation factor FACT,interacting with nucleosomes and histone H2A/H2B dimers,indicating that it may promote nucleosome disruption upon transcription (see FACT140)
UniProtKB/Swiss-Prot Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of Ser-392 of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.

Gene Ontology (GO) - Molecular Function for SSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 16902406
genes like me logo Genes that share ontologies with SSRP1: view
genes like me logo Genes that share phenotypes with SSRP1: view

Animal Models for SSRP1 Gene

MGI Knock Outs for SSRP1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SSRP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSRP1 Gene

Localization for SSRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSRP1 Gene

Nucleus. Nucleus, nucleolus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. {ECO:0000250 UniProtKB:Q05344}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSRP1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with SSRP1: view

Pathways & Interactions for SSRP1 Gene

genes like me logo Genes that share pathways with SSRP1: view

Gene Ontology (GO) - Biological Process for SSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SSRP1: view

No data available for SIGNOR curated interactions for SSRP1 Gene

Drugs & Compounds for SSRP1 Gene

(2) Drugs for SSRP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SSRP1: view

Transcripts for SSRP1 Gene

Unigene Clusters for SSRP1 Gene

Structure specific recognition protein 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SSRP1

Alternative Splicing Database (ASD) splice patterns (SP) for SSRP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: - - -
SP2: -
SP3: -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SSRP1 Gene

GeneLoc Exon Structure for
SSRP1
ECgene alternative splicing isoforms for
SSRP1

Expression for SSRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSRP1 Gene

This gene is overexpressed in Fetal ovary (10.8), Peripheral blood mononuclear cells (7.4), and Stomach (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSRP1 Gene



Protein tissue co-expression partners for SSRP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SSRP1 Gene:

SSRP1

SOURCE GeneReport for Unigene cluster for SSRP1 Gene:

Hs.523680

Evidence on tissue expression from TISSUES for SSRP1 Gene

  • Lung(4.6)
  • Liver(4.3)
  • Nervous system(3.6)
  • Eye(2.7)
  • Intestine(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SSRP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSRP1 Gene

Orthologs for SSRP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SSRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSRP1 34 35
  • 99.29 (n)
oppossum
(Monodelphis domestica)
Mammalia SSRP1 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSRP1 34 35
  • 91.77 (n)
cow
(Bos Taurus)
Mammalia SSRP1 34 35
  • 89.99 (n)
rat
(Rattus norvegicus)
Mammalia Ssrp1 34
  • 89.89 (n)
mouse
(Mus musculus)
Mammalia Ssrp1 34 16 35
  • 89.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves SSRP1 34 35
  • 81.74 (n)
lizard
(Anolis carolinensis)
Reptilia SSRP1 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssrp1 34
  • 72.84 (n)
Str.15184 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.336 34
zebrafish
(Danio rerio)
Actinopterygii ssrp1a 35
  • 74 (a)
OneToMany
ssrp1b 34 35
  • 70.91 (n)
Dr.20690 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9262 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012335 34
  • 59.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ssrp 36 34 35
  • 56.63 (n)
HmgZ 35
  • 50 (a)
OneToMany
HmgD 35
  • 48 (a)
OneToMany
CG7045 35
  • 29 (a)
OneToMany
CG7046 35
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hmg-4 36 34 35
  • 50.44 (n)
hmg-3 36 35
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 35 37
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons HMG 34
  • 47.51 (n)
rice
(Oryza sativa)
Liliopsida Os01g0184900 34
  • 48.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5813 35
  • 54 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.538 34
Species where no ortholog for SSRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSRP1 Gene

ENSEMBL:
Gene Tree for SSRP1 (if available)
TreeFam:
Gene Tree for SSRP1 (if available)

Paralogs for SSRP1 Gene

Paralogs for SSRP1 Gene

(1) SIMAP similar genes for SSRP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SSRP1: view

Variants for SSRP1 Gene

Sequence variations from dbSNP and Humsavar for SSRP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000044629 -- 57,333,601(+) GACTT(C/G)AATGT intron-variant
rs1000078696 -- 57,333,835(+) CAAAA(A/T)GGAAA intron-variant
rs1000723699 -- 57,333,289(+) GTATA(C/T)TGTAG intron-variant
rs1001663300 -- 57,326,551(+) GGCCC(C/G)CAATT intron-variant, upstream-variant-2KB
rs1002078591 -- 57,327,981(+) TGGAG(A/G)ACTAA intron-variant

Variation tolerance for SSRP1 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSRP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SSRP1 Gene

Disorders for SSRP1 Gene

Relevant External Links for SSRP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSRP1

No disorders were found for SSRP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSRP1 Gene

Publications for SSRP1 Gene

  1. Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. (PMID: 1372440) Bruhn S.L. … Lippard S.J. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 22 64
  2. Coupling caspase cleavage and ubiquitin-proteasome-dependent degradation of SSRP1 during apoptosis. (PMID: 16498457) Landais I. … Lu H. (Cell Death Differ. 2006) 3 4 22 64
  3. CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity. (PMID: 15659405) Li Y. … Lu H. (J. Biol. Chem. 2005) 3 4 22 64
  4. High prevalence of autoantibodies against the nuclear high mobility group (HMG) protein SSRP1 in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases. (PMID: 11824977) Santoro P. … Gariglio M. (J. Rheumatol. 2002) 3 4 22 64
  5. SSRP1 functions as a co-activator of the transcriptional activator p63. (PMID: 12374749) Zeng S.X. … Lu H. (EMBO J. 2002) 3 4 22 64

Products for SSRP1 Gene

  • Addgene plasmids for SSRP1

Sources for SSRP1 Gene

Content
Loading form....