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Aliases for SSR2 Gene

Aliases for SSR2 Gene

  • Signal Sequence Receptor, Beta (Translocon-Associated Protein Beta) 2 3
  • Signal Sequence Receptor Subunit Beta 3 4
  • TRAP-BETA 3 4
  • SSR-Beta 3 4
  • TRAPB 3 4
  • Translocon-Associated Protein Subunit Beta 3
  • Translocon-Associated Protein Beta 3
  • HSD25 3
  • TLAP 3

External Ids for SSR2 Gene

Previous GeneCards Identifiers for SSR2 Gene

  • GC01M153847
  • GC01M151744
  • GC01M152756
  • GC01M153195
  • GC01M152791
  • GC01M154246
  • GC01M155979
  • GC01M127340
  • GC01M155983
  • GC01M155989

Summaries for SSR2 Gene

Entrez Gene Summary for SSR2 Gene

  • The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSR2 Gene

SSR2 (Signal Sequence Receptor, Beta (Translocon-Associated Protein Beta)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression.

UniProtKB/Swiss-Prot for SSR2 Gene

  • TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins

Gene Wiki entry for SSR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSR2 Gene

Genomics for SSR2 Gene

Regulatory Elements for SSR2 Gene

Genomic Location for SSR2 Gene

Start:
156,009,048 bp from pter
End:
156,020,967 bp from pter
Size:
11,920 bases
Orientation:
Minus strand

Genomic View for SSR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSR2 Gene

Proteins for SSR2 Gene

  • Protein details for SSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43308-SSRB_HUMAN
    Recommended name:
    Translocon-associated protein subunit beta
    Protein Accession:
    P43308
    Secondary Accessions:
    • B2R9K9
    • D3DVA7
    • Q53HI0
    • Q5VY95
    • Q5VY96
    • Q6IB31
    • Q9BWE4

    Protein attributes for SSR2 Gene

    Size:
    183 amino acids
    Molecular mass:
    20135 Da
    Quaternary structure:
    • Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING.
    SequenceCaution:
    • Sequence=CAH72631.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72632.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SSR2 Gene

Proteomics data for SSR2 Gene at MOPED

Post-translational modifications for SSR2 Gene

  • Ubiquitination at Lys27
  • Glycosylation at Asn88 and Asn104
  • Modification sites at PhosphoSitePlus

Other Protein References for SSR2 Gene

No data available for DME Specific Peptides for SSR2 Gene

Domains for SSR2 Gene

Protein Domains for SSR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43308

UniProtKB/Swiss-Prot:

SSRB_HUMAN :
  • P43308
Family:
  • Belongs to the TRAP-beta family.
genes like me logo Genes that share domains with SSR2: view

No data available for Gene Families for SSR2 Gene

Function for SSR2 Gene

Molecular function for SSR2 Gene

GENATLAS Biochemistry: signal sequence receptor,beta (22kDa) involved in protein translocation process
UniProtKB/Swiss-Prot Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SSR2 Gene

Localization for SSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSR2 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSR2 Gene COMPARTMENTS Subcellular localization image for SSR2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3

Gene Ontology (GO) - Cellular Components for SSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 7789174
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSR2: view

Pathways for SSR2 Gene

genes like me logo Genes that share pathways with SSR2: view

Pathways by source for SSR2 Gene

Gene Ontology (GO) - Biological Process for SSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006613 cotranslational protein targeting to membrane TAS 7789174
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SSR2: view

Compounds for SSR2 Gene

(1) HMDB Compounds for SSR2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with SSR2: view

Transcripts for SSR2 Gene

Unigene Clusters for SSR2 Gene

Signal sequence receptor, beta (translocon-associated protein beta):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSR2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - -
SP10: - - -
SP11: - - - - - - - - -
SP12: - - - - - -
SP13: - - -

Relevant External Links for SSR2 Gene

GeneLoc Exon Structure for
SSR2
ECgene alternative splicing isoforms for
SSR2

Expression for SSR2 Gene

mRNA expression in normal human tissues for SSR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SSR2 Gene

SOURCE GeneReport for Unigene cluster for SSR2 Gene Hs.74564

genes like me logo Genes that share expressions with SSR2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSR2 Gene

Orthologs for SSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSR2 35
  • 100 (n)
  • 100 (a)
SSR2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSR2 35
  • 93.26 (n)
  • 97.27 (a)
SSR2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSR2 35
  • 91.44 (n)
  • 95.63 (a)
SSR2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssr2 35
  • 89.25 (n)
  • 97.27 (a)
Ssr2 16
Ssr2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSR2 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssr2 35
  • 89.62 (n)
  • 96.72 (a)
chicken
(Gallus gallus)
Aves SSR2 35
  • 80.15 (n)
  • 91.26 (a)
SSR2 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53499 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ssr2 35
  • 77.6 (n)
  • 87.43 (a)
Str.3091 35
zebrafish
(Danio rerio)
Actinopterygii Dr.1209 35
ssr2 35
  • 75.77 (n)
  • 86.34 (a)
ssr2 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005861 35
  • 55.3 (n)
  • 50.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta SsRbeta 35
  • 55.81 (n)
  • 49.44 (a)
SsRbeta 36
  • 47 (a)
OneToOne
SsRbgr 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea K08F4.3 36
  • 30 (a)
OneToMany
trap-2 35
  • 48.04 (n)
  • 39.66 (a)
trap-2 36
  • 37 (a)
OneToMany
Species with no ortholog for SSR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSR2 Gene

ENSEMBL:
Gene Tree for SSR2 (if available)
TreeFam:
Gene Tree for SSR2 (if available)

Paralogs for SSR2 Gene

Selected SIMAP similar genes for SSR2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SSR2: view

No data available for Paralogs for SSR2 Gene

Variants for SSR2 Gene

Sequence variations from dbSNP and Humsavar for SSR2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11530 -- 156,009,357(+) GGCTC(A/T)CGCAG utr-variant-3-prime
rs915178 -- 156,008,934(-) TGGGC(A/G)GGTCC downstream-variant-500B
rs1049286 -- 156,009,466(-) CAGAC(G/T)CCAAA utr-variant-3-prime
rs1475766 -- 156,011,698(+) AAACA(C/G)ACAGG intron-variant
rs1804478 -- 156,009,242(-) GCAAC(A/G)TGAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SSR2 Gene

Variant ID Type Subtype PubMed ID
nsv509513 CNV Insertion 20534489

Relevant External Links for SSR2 Gene

HapMap Linkage Disequilibrium report
SSR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSR2 Gene

Disorders for SSR2 Gene

(1) Novoseek inferred disease relationships for SSR2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for SSR2

Genetic Association Database (GAD)
SSR2
Human Genome Epidemiology (HuGE) Navigator
SSR2
genes like me logo Genes that share disorders with SSR2: view

No data available for UniProtKB/Swiss-Prot for SSR2 Gene

Publications for SSR2 Gene

  1. Isolation and mapping of the human beta-signal sequence receptor gene (SSR2). (PMID: 7789174) Chinen K. … Nakamura Y. (Cytogenet. Cell Genet. 1995) 2 3 4 23
  2. Cloning and sequence analysis of the beta subunit of the human translocon-associated protein. (PMID: 8286409) Bodescot M. … Brison O. (Biochim. Biophys. Acta 1994) 3 4
  3. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PMID: 12754519) Zhang H. … Aebersold R. (Nat. Biotechnol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SSR2 Gene

Sources for SSR2 Gene

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