Aliases for SRF Gene
External Ids for SRF Gene
Previous GeneCards Identifiers for SRF Gene
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
GeneCards Summary for SRF Gene
SRF (Serum Response Factor) is a Protein Coding gene. Diseases associated with SRF include fumarate hydratase deficiency and rheumatoid vasculitis. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.
UniProtKB/Swiss-Prot for SRF Gene
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5 of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.