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Aliases for SRF Gene

Aliases for SRF Gene

  • Serum Response Factor (C-Fos Serum Response Element-Binding Transcription Factor) 2 3
  • Serum Response Factor 3
  • MCM1 3

External Ids for SRF Gene

Summaries for SRF Gene

Entrez Gene Summary for SRF Gene

  • This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for SRF Gene

SRF (Serum Response Factor (C-Fos Serum Response Element-Binding Transcription Factor)) is a Protein Coding gene. Diseases associated with SRF include miller fisher syndrome and rheumatoid nodulosis. Among its related pathways are MAPK signaling pathway and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding.

UniProtKB/Swiss-Prot for SRF Gene

  • SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5 of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation

Gene Wiki entry for SRF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRF Gene

Genomics for SRF Gene

Genomic Location for SRF Gene

Start:
43,171,182 bp from pter
End:
43,181,507 bp from pter
Size:
10,326 bases
Orientation:
Plus strand

Genomic View for SRF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRF Gene

Regulatory Elements for SRF Gene

Proteins for SRF Gene

  • Protein details for SRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11831-SRF_HUMAN
    Recommended name:
    Serum response factor
    Protein Accession:
    P11831
    Secondary Accessions:
    • Q5T648

    Protein attributes for SRF Gene

    Size:
    508 amino acids
    Molecular mass:
    51593 Da
    Quaternary structure:
    • Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1 (By similarity). Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1 (By similarity). Forms a nuclear ternary complex with MKL1 and SCAI. Interacts with LPXN.

    Three dimensional structures from OCA and Proteopedia for SRF Gene

neXtProt entry for SRF Gene

Proteomics data for SRF Gene at MOPED

Post-translational modifications for SRF Gene

  • Phosphorylated by PRKDC.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser277, Ser307, Ser309, Ser316, and Ser383

Other Protein References for SRF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRF Gene

Domains for SRF Gene

Protein Domains for SRF Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11831

UniProtKB/Swiss-Prot:

SRF_HUMAN
Domain:
  • Contains 1 MADS-box domain.:
    • P11831
genes like me logo Genes that share domains with SRF: view

No data available for Gene Families for SRF Gene

Function for SRF Gene

Molecular function for SRF Gene

UniProtKB/Swiss-Prot Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5 of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation

Gene Ontology (GO) - Molecular Function for SRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS --
GO:0000983 contributes_to RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IMP 18296735
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 20808827
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS --
genes like me logo Genes that share ontologies with SRF: view
genes like me logo Genes that share phenotypes with SRF: view

Animal Models for SRF Gene

MGI Knock Outs for SRF:

Transcription Factor Targeting for SRF Gene

Selected GeneGlobe predicted Target genes for SRF
Targeting motifs for SRF Gene
HOMER Transcription Factor Regulatory Elements motif SRF
  • Consensus sequence: CCATATATGGNA Submotif: canonical Cell Type: PUER

No data available for Enzyme Numbers (IUBMB) for SRF Gene

Localization for SRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRF Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRF Gene COMPARTMENTS Subcellular localization image for SRF gene
Compartment Confidence
nucleus 5
cytoskeleton 3
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus IDA 2108863
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 15180964
genes like me logo Genes that share ontologies with SRF: view

Pathways for SRF Gene

genes like me logo Genes that share pathways with SRF: view

Gene Ontology (GO) - Biological Process for SRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 patterning of blood vessels IEA --
GO:0001666 response to hypoxia IEP 19098903
GO:0001701 in utero embryonic development --
GO:0001707 mesoderm formation IEA --
GO:0001764 neuron migration IEA --
genes like me logo Genes that share ontologies with SRF: view

Compounds for SRF Gene

(95) Novoseek inferred chemical compound relationships for SRF Gene

Compound -log(P) Hits PubMed IDs
mdi-a 60.5 3
jasplakinolide 51.2 4
ganglioside gq1b 47.4 1
phosphatidylinositol 28.6 3
cyclic amp 26.2 8
genes like me logo Genes that share compounds with SRF: view

Transcripts for SRF Gene

mRNA/cDNA for SRF Gene

Unigene Clusters for SRF Gene

Serum response factor (c-fos serum response element-binding transcription factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRF Gene

No ASD Table

Relevant External Links for SRF Gene

GeneLoc Exon Structure for
SRF
ECgene alternative splicing isoforms for
SRF

Expression for SRF Gene

mRNA expression in normal human tissues for SRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRF Gene

SOURCE GeneReport for Unigene cluster for SRF Gene Hs.520140

genes like me logo Genes that share expressions with SRF: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRF Gene

Orthologs for SRF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRF 35
  • 98.47 (n)
  • 98.11 (a)
SRF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRF 35
  • 93.96 (n)
  • 96.65 (a)
SRF 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRF 35
  • 94.52 (n)
  • 96.63 (a)
SRF 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srf 35
  • 94.91 (n)
  • 96.43 (a)
Srf 16
Srf 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRF 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srf 35
  • 94.58 (n)
  • 96.63 (a)
chicken
(Gallus gallus)
Aves SRF 35
  • 82.11 (n)
  • 86.41 (a)
SRF 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRF 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia srf-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia srf 35
  • 68.2 (n)
  • 70.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13739 35
zebrafish
(Danio rerio)
Actinopterygii srf 35
SRF (1 of 2) 36
  • 55 (a)
OneToMany
srfa 35
  • 67.85 (n)
  • 70.38 (a)
srfa 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta bs 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-120 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARG80 36
  • 32 (a)
OneToMany
ARG80 38
MCM1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3406 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10664 36
  • 42 (a)
OneToOne
Species with no ortholog for SRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRF Gene

ENSEMBL:
Gene Tree for SRF (if available)
TreeFam:
Gene Tree for SRF (if available)

Paralogs for SRF Gene

No data available for Paralogs for SRF Gene

Variants for SRF Gene

Sequence variations from dbSNP and Humsavar for SRF Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2275070 -- 43,176,087(-) TGGCC(C/T)CTATT intron-variant
rs3730363 -- 43,176,316(+) CAACT(A/G)AAGAA intron-variant
rs3805928 -- 43,174,666(-) AGCCC(C/T)ACCCC intron-variant
rs4711741 -- 43,176,880(+) AAATT(A/G)GGGAC intron-variant
rs6902679 -- 43,174,535(+) GGGAC(A/T)ACCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRF Gene

Variant ID Type Subtype PubMed ID
nsv521730 CNV Loss 19592680
nsv819840 CNV Gain 19587683

Relevant External Links for SRF Gene

HapMap Linkage Disequilibrium report
SRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRF Gene

Disorders for SRF Gene

(91) Novoseek inferred disease relationships for SRF Gene

Disease -log(P) Hits PubMed IDs
rheumatoid arthritis 52.4 13
leukemia t-cell 52.3 7
megakaryoblastic leukemia acute 51.8 1
rheumatoid nodule 44.1 3
rheumatoid vasculitis 28.9 1

Relevant External Links for SRF

Genetic Association Database (GAD)
SRF
Human Genome Epidemiology (HuGE) Navigator
SRF
genes like me logo Genes that share disorders with SRF: view

No data available for UniProtKB/Swiss-Prot for SRF Gene

Publications for SRF Gene

  1. Localization of O-GlcNAc modification on the serum response transcription factor. (PMID: 1512232) Reason A.J. … Dell A. (J. Biol. Chem. 1992) 3 4 23
  2. C-terminal phosphorylation of the serum-response factor. (PMID: 8375385) Janknecht R. … Nordheim A. (Eur. J. Biochem. 1993) 3 4 23
  3. The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites. (PMID: 8407951) Liu S.-H. … Ng S.-Y. (J. Biol. Chem. 1993) 3 4 23
  4. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. (PMID: 3203386) Norman C. … Treisman R. (Cell 1988) 2 3 4
  5. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. (PMID: 16054032) Liu Z.-P. … Olson E.N. (Dev. Cell 2005) 3 4

Products for SRF Gene

  • Addgene plasmids for SRF

Sources for SRF Gene

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