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Aliases for SRF Gene

Aliases for SRF Gene

  • Serum Response Factor 2 3 5
  • C-Fos Serum Response Element-Binding Transcription Factor 2 3
  • Minichromosome Maintenance 1 Homolog (S. Cerevisiae) 2
  • Minichromosome Maintenance 1 Homolog 3
  • MCM1 3

External Ids for SRF Gene

Previous GeneCards Identifiers for SRF Gene

  • GC06P043141
  • GC06P043185
  • GC06P043247
  • GC06P042855

Summaries for SRF Gene

Entrez Gene Summary for SRF Gene

  • This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for SRF Gene

SRF (Serum Response Factor) is a Protein Coding gene. Diseases associated with SRF include Lymphangioleiomyomatosis and Fumarate Hydratase Deficiency. Among its related pathways are Mesodermal Commitment Pathway and Immune response_IL-6 signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for SRF Gene

  • SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5 of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.

Gene Wiki entry for SRF Gene

Additional gene information for SRF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRF Gene

Genomics for SRF Gene

Regulatory Elements for SRF Gene

Enhancers for SRF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H044154 1.2 Ensembl ENCODE 5.5 +984.8 984805 2 FOXA2 ATF1 MLX ARID4B SLC30A9 PAF1 SP5 NFYC MIER2 PPARG TMEM63B MRPL14 SRF PIR60878 CAPN11
GH06H043169 1.4 ENCODE dbSUPER 0.7 +2.1 2065 6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B DNPH1 POLR1C CUL7 ABCC10 PTK7 RPS2P29 ENSG00000271754 SRF CUL9
GH06H043180 1.4 ENCODE dbSUPER 0.4 +10.9 10869 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YBX1 ZNF766 ZNF143 CUL7 ZNF318 POLH GTPBP2 RPS2P29 DNPH1 ABCC10 BICRAL XPO5 POLR1C
GH06H043141 1.3 Ensembl ENCODE 0.3 -27.8 -27833 3 HDGF ARID4B SIN3A ZNF2 ZNF143 SP5 MXD4 REST ZNF592 KAT8 CUL7 DNPH1 KLC4 RN7SL403P KLHDC3 MEA1 PPP2R5D RPL7L1 SRF PIR51341
GH06H043113 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.2 -55.9 -55877 4 HDGF PKNOX1 ARNT FEZF1 ZNF2 ZNF766 ZNF592 MEF2D SMARCA4 NBN CUL7 GTPBP2 UBR2 POLH RPS2P29 ZNF318 BICRAL RRP36 DNPH1 ABCC10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRF on UCSC Golden Path with GeneCards custom track

Promoters for SRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197100 206 3000 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for SRF Gene

Chromosome:
6
Start:
43,171,295 bp from pter
End:
43,181,507 bp from pter
Size:
10,213 bases
Orientation:
Plus strand

Genomic View for SRF Gene

Genes around SRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRF Gene

Proteins for SRF Gene

  • Protein details for SRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11831-SRF_HUMAN
    Recommended name:
    Serum response factor
    Protein Accession:
    P11831
    Secondary Accessions:
    • Q5T648

    Protein attributes for SRF Gene

    Size:
    508 amino acids
    Molecular mass:
    51593 Da
    Quaternary structure:
    • Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1 (By similarity). Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1 (By similarity). Forms a nuclear ternary complex with MKL1 and SCAI (PubMed:19350017). Interacts with LPXN (PubMed:18497331). Interacts with OLFM2; the interaction promotes dissociation of SRF from the transcriptional repressor HEY2, facilitates binding of SRF to target genes and promotes smooth muscle differentiation (PubMed:25298399).

    Three dimensional structures from OCA and Proteopedia for SRF Gene

neXtProt entry for SRF Gene

Post-translational modifications for SRF Gene

  • Phosphorylated by PRKDC.
  • Glycosylation at posLast=277277, posLast=307307, Ser309, posLast=316316, and Ser383
  • Modification sites at PhosphoSitePlus

Other Protein References for SRF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SRF (SRF)

No data available for DME Specific Peptides for SRF Gene

Domains & Families for SRF Gene

Gene Families for SRF Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SRF Gene

Suggested Antigen Peptide Sequences for SRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SRF: view

No data available for UniProtKB/Swiss-Prot for SRF Gene

Function for SRF Gene

Molecular function for SRF Gene

UniProtKB/Swiss-Prot Function:
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5 of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.

Gene Ontology (GO) - Molecular Function for SRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS --
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0000983 contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific IMP 18296735
GO:0000987 core promoter proximal region sequence-specific DNA binding IEA --
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IEA --
genes like me logo Genes that share ontologies with SRF: view
genes like me logo Genes that share phenotypes with SRF: view

Animal Models for SRF Gene

MGI Knock Outs for SRF:

Animal Model Products

CRISPR Products

Transcription Factor Targets for SRF Gene

Selected GeneGlobe predicted Target genes for SRF
Targeted motifs for SRF Gene
HOMER Transcription Factor Regulatory Elements motif SRF
  • Consensus sequence: CCATATATGGNA Submotif: canonical Cell Type: PUER

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRF
  • Applied Biological Materials Clones for SRF
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog and Human Phenotype Ontology for SRF Gene

Localization for SRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRF Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRF gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus IDA,IEA 2108863
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,TAS 15180964
genes like me logo Genes that share ontologies with SRF: view

Pathways & Interactions for SRF Gene

genes like me logo Genes that share pathways with SRF: view

SIGNOR curated interactions for SRF Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for SRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 branching involved in blood vessel morphogenesis IEA --
GO:0001666 response to hypoxia IEP 19098903
GO:0001701 in utero embryonic development IEA --
GO:0001707 mesoderm formation IEA --
GO:0001764 neuron migration IEA --
genes like me logo Genes that share ontologies with SRF: view

Drugs & Compounds for SRF Gene

(56) Drugs for SRF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(39) Additional Compounds for SRF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRF: view

Transcripts for SRF Gene

mRNA/cDNA for SRF Gene

Unigene Clusters for SRF Gene

Serum response factor (c-fos serum response element-binding transcription factor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRF
  • Applied Biological Materials Clones for SRF
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SRF Gene

No ASD Table

Relevant External Links for SRF Gene

GeneLoc Exon Structure for
SRF
ECgene alternative splicing isoforms for
SRF

Expression for SRF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRF Gene

This gene is overexpressed in Adipocyte (18.2), Fetal gut (15.8), CD8 Tcells (15.8), Fetal heart (10.0), and Prostate (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRF Gene



NURSA nuclear receptor signaling pathways regulating expression of SRF Gene:

SRF

SOURCE GeneReport for Unigene cluster for SRF Gene:

Hs.520140

Evidence on tissue expression from TISSUES for SRF Gene

  • Liver(4.4)
  • Lung(4.4)
  • Muscle(3.9)
  • Heart(3.4)
  • Nervous system(2.9)
  • Intestine(2.1)
  • Kidney(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SRF: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRF Gene

Orthologs for SRF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRF 33 34
  • 98.47 (n)
mouse
(Mus musculus)
Mammalia Srf 33 16 34
  • 94.91 (n)
rat
(Rattus norvegicus)
Mammalia Srf 33
  • 94.58 (n)
dog
(Canis familiaris)
Mammalia SRF 33 34
  • 94.52 (n)
cow
(Bos Taurus)
Mammalia SRF 33 34
  • 93.96 (n)
oppossum
(Monodelphis domestica)
Mammalia SRF 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRF 33 34
  • 82.11 (n)
lizard
(Anolis carolinensis)
Reptilia SRF 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srf 33
  • 68.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia srf-A 33
zebrafish
(Danio rerio)
Actinopterygii srfa 33 34
  • 67.85 (n)
SRF (1 of 2) 34
  • 55 (a)
OneToMany
srf 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13739 33
fruit fly
(Drosophila melanogaster)
Insecta bs 34
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-120 34
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM1 34
  • 33 (a)
OneToMany
ARG80 34 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10664 34
  • 42 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3406 33
Species where no ortholog for SRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRF Gene

ENSEMBL:
Gene Tree for SRF (if available)
TreeFam:
Gene Tree for SRF (if available)

Paralogs for SRF Gene

No data available for Paralogs for SRF Gene

Variants for SRF Gene

Sequence variations from dbSNP and Humsavar for SRF Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000391147 -- 43,171,272(+) GGAAA(C/T)ATTGT upstream-variant-2KB
rs1000504782 -- 43,181,462(+) GTATT(-/A)AAAAA upstream-variant-2KB, utr-variant-3-prime
rs1000806155 -- 43,169,687(+) GCAGA(C/G)GTTGC upstream-variant-2KB
rs1001176403 -- 43,169,846(+) CAGGC(A/G)CAGGG upstream-variant-2KB
rs1001374789 -- 43,176,344(+) GGGCA(A/G)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRF Gene

Variant ID Type Subtype PubMed ID
esv3571027 CNV loss 25503493
nsv1017398 CNV gain 25217958
nsv521730 CNV loss 19592680
nsv819840 CNV gain 19587683

Variation tolerance for SRF Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRF Gene

Disorders for SRF Gene

MalaCards: The human disease database

(6) MalaCards diseases for SRF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphangioleiomyomatosis
  • lymphangioleiomyomatosis, somatic
fumarate hydratase deficiency
  • fumarase deficiency
myopericytoma
heart disease
  • congestive heart failure
rheumatoid vasculitis
- elite association - COSMIC cancer census association via MalaCards
Search SRF in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRF

Genetic Association Database (GAD)
SRF
Human Genome Epidemiology (HuGE) Navigator
SRF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRF
genes like me logo Genes that share disorders with SRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRF Gene

Publications for SRF Gene

  1. C-terminal phosphorylation of the serum-response factor. (PMID: 8375385) Janknecht R … Nordheim A (European journal of biochemistry 1993) 3 4 22 60
  2. The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites. (PMID: 8407951) Liu SH … Ng SY (The Journal of biological chemistry 1993) 3 4 22 60
  3. Localization of O-GlcNAc modification on the serum response transcription factor. (PMID: 1512232) Reason AJ … Dell A (The Journal of biological chemistry 1992) 3 4 22 60
  4. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. (PMID: 3203386) Norman C … Treisman R (Cell 1988) 2 3 4 60
  5. Olfactomedin 2, a novel regulator for transforming growth factor-β-induced smooth muscle differentiation of human embryonic stem cell-derived mesenchymal cells. (PMID: 25298399) Shi N … Chen SY (Molecular biology of the cell 2014) 3 4 60

Products for SRF Gene

  • Addgene plasmids for SRF

Sources for SRF Gene

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