Aliases for SRD5A1 Gene
External Ids for SRD5A1 Gene
Previous GeneCards Identifiers for SRD5A1 Gene
Steroid 5-alpha-reductase (EC 188.8.131.52) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]
GeneCards Summary for SRD5A1 Gene
SRD5A1 (Steroid 5 Alpha-Reductase 1) is a Protein Coding gene. Diseases associated with SRD5A1 include Prostatic Adenoma and Prostate Disease. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Metabolism of steroid hormones. GO annotations related to this gene include electron carrier activity and 3-oxo-5-alpha-steroid 4-dehydrogenase activity. An important paralog of this gene is SRD5A2.
UniProtKB/Swiss-Prot for SRD5A1 Gene
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.