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Aliases for SQLE Gene

Aliases for SQLE Gene

  • Squalene Epoxidase 2 3 4
  • SE 3 4
  • Squalene Monooxygenase 2
  • EC 1.14.13.132 4
  • ERG1 4

External Ids for SQLE Gene

Previous GeneCards Identifiers for SQLE Gene

  • GC08P125035
  • GC08P126015
  • GC08P125679
  • GC08P125968
  • GC08P126079
  • GC08P121334
  • GC08P126010

Summaries for SQLE Gene

Entrez Gene Summary for SQLE Gene

  • Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for SQLE Gene

SQLE (Squalene Epoxidase) is a Protein Coding gene. Diseases associated with SQLE include tinea cruris and tinea corporis. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include oxidoreductase activity and squalene monooxygenase activity.

UniProtKB/Swiss-Prot for SQLE Gene

  • Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway

Gene Wiki entry for SQLE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SQLE Gene

Genomics for SQLE Gene

Regulatory Elements for SQLE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SQLE Gene

Chromosome:
8
Start:
124,998,478 bp from pter
End:
125,022,284 bp from pter
Size:
23,807 bases
Orientation:
Plus strand

Genomic View for SQLE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SQLE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SQLE Gene

Proteins for SQLE Gene

  • Protein details for SQLE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14534-ERG1_HUMAN
    Recommended name:
    Squalene monooxygenase
    Protein Accession:
    Q14534
    Secondary Accessions:
    • Q9UEK6

    Protein attributes for SQLE Gene

    Size:
    574 amino acids
    Molecular mass:
    63923 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • May form a complex with squalene synthase

neXtProt entry for SQLE Gene

Proteomics data for SQLE Gene at MOPED

Post-translational modifications for SQLE Gene

  • Ubiquitination at Lys 90, Lys 290, Lys 426, and Lys 436
  • Modification sites at PhosphoSitePlus

Other Protein References for SQLE Gene

No data available for DME Specific Peptides for SQLE Gene

Domains & Families for SQLE Gene

Protein Domains for SQLE Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SQLE Gene

Graphical View of Domain Structure for InterPro Entry

Q14534

UniProtKB/Swiss-Prot:

ERG1_HUMAN :
  • Belongs to the squalene monooxygenase family.
Family:
  • Belongs to the squalene monooxygenase family.
genes like me logo Genes that share domains with SQLE: view

No data available for Gene Families for SQLE Gene

Function for SQLE Gene

Molecular function for SQLE Gene

GENATLAS Biochemistry:
squalene epoxidase catalyzing the first oxygenation step in sterol biosynthesis
UniProtKB/Swiss-Prot CatalyticActivity:
Squalene + NADPH + O(2) = (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP(+) + H(2)O
UniProtKB/Swiss-Prot Function:
Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway

Enzyme Numbers (IUBMB) for SQLE Gene

Gene Ontology (GO) - Molecular Function for SQLE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004506 squalene monooxygenase activity TAS --
GO:0016491 oxidoreductase activity --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with SQLE: view
genes like me logo Genes that share phenotypes with SQLE: view

miRNA for SQLE Gene

miRTarBase miRNAs that target SQLE

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SQLE

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SQLE Gene

Localization for SQLE Gene

Subcellular locations from UniProtKB/Swiss-Prot for SQLE Gene

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SQLE Gene COMPARTMENTS Subcellular localization image for SQLE gene
Compartment Confidence
endoplasmic reticulum 5
cytoskeleton 2
cytosol 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SQLE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with SQLE: view

Pathways & Interactions for SQLE Gene

genes like me logo Genes that share pathways with SQLE: view

UniProtKB/Swiss-Prot Q14534-ERG1_HUMAN

  • Pathway: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3

Gene Ontology (GO) - Biological Process for SQLE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006695 cholesterol biosynthetic process TAS --
GO:0006725 cellular aromatic compound metabolic process IEA --
GO:0008203 cholesterol metabolic process --
GO:0010033 response to organic substance IEA --
GO:0016126 sterol biosynthetic process NAS 9286711
genes like me logo Genes that share ontologies with SQLE: view

No data available for SIGNOR curated interactions for SQLE Gene

Drugs & Compounds for SQLE Gene

(19) Drugs for SQLE Gene - From: NovoSeek, DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Butenafine Approved Pharma Target, inhibitor 3
Naftifine Approved Pharma Target, inhibitor 11
Terbinafine Approved, Investigational Pharma Target, inhibitor 33
FAD Approved Pharma 0
Amphotericin B Approved, Investigational Pharma 114

(17) Additional Compounds for SQLE Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
squalene
  • (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-Tetracosahexaene
  • (E,E,E,E)-Squalene
  • 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene
  • All-trans-Squalene
  • Nikko Squalane EX
111-02-4
(3S)-2,3-epoxy-2,3-dihydrosqualene
Ferrocytochrome
  • 553-12-8 (FREE ACID)
  • Ferrocytochrome b-561
  • H2ppIX
  • HEM
  • Kammerer'S porphyrin
1818-68-4
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with SQLE: view

Transcripts for SQLE Gene

Unigene Clusters for SQLE Gene

Squalene epoxidase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SQLE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SQLE Gene

No ASD Table

Relevant External Links for SQLE Gene

GeneLoc Exon Structure for
SQLE
ECgene alternative splicing isoforms for
SQLE

Expression for SQLE Gene

mRNA expression in normal human tissues for SQLE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SQLE Gene

This gene is overexpressed in Esophagus - Mucosa (x4.1).

Protein differential expression in normal tissues from HIPED for SQLE Gene

This gene is overexpressed in Fetal testis (35.4) and Fetal ovary (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SQLE Gene



SOURCE GeneReport for Unigene cluster for SQLE Gene Hs.71465

genes like me logo Genes that share expression patterns with SQLE: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SQLE Gene

Orthologs for SQLE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SQLE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SQLE 35
  • 89.04 (n)
  • 87.94 (a)
SQLE 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SQLE 35
  • 88.42 (n)
  • 87.78 (a)
SQLE 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sqle 35
  • 82.98 (n)
  • 84.44 (a)
Sqle 16
Sqle 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SQLE 35
  • 99.48 (n)
  • 99.3 (a)
SQLE 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sqle 35
  • 83.01 (n)
  • 83.94 (a)
oppossum
(Monodelphis domestica)
Mammalia SQLE 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SQLE 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SQLE 35
  • 73.71 (n)
  • 71.73 (a)
SQLE 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SQLE 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sqle 35
  • 67.21 (n)
  • 68.35 (a)
zebrafish
(Danio rerio)
Actinopterygii sqlea 35
  • 65.17 (n)
  • 65.77 (a)
sqlea 36
  • 65 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL141C 35
  • 45.93 (n)
  • 36.65 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15224g 35
  • 49.18 (n)
  • 38.84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG1 35
  • 49.62 (n)
  • 40 (a)
ERG1 36
  • 36 (a)
OneToOne
ERG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons XF1 35
  • 50.72 (n)
  • 45.13 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9714 35
rice
(Oryza sativa)
Liliopsida Os.20969 35
Os03g0231700 35
  • 51.91 (n)
  • 47.08 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7591 35
corn
(Zea mays)
Liliopsida Zm.7407 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08280 35
  • 47.52 (n)
  • 45.05 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes erg1 35
  • 50.04 (n)
  • 43.62 (a)
Species with no ortholog for SQLE:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for SQLE Gene

ENSEMBL:
Gene Tree for SQLE (if available)
TreeFam:
Gene Tree for SQLE (if available)

Paralogs for SQLE Gene

(2) SIMAP similar genes for SQLE Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SQLE Gene

genes like me logo Genes that share paralogs with SQLE: view

No data available for Paralogs for SQLE Gene

Variants for SQLE Gene

Sequence variations from dbSNP and Humsavar for SQLE Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs9940 -- 125,022,168(+) CATTT(A/G)AAAGA utr-variant-3-prime
rs966945 -- 125,018,482(+) GGTGA(C/T)TTTTT intron-variant
rs966946 -- 125,018,567(+) GGGGA(C/T)TATAA intron-variant
rs1048858 -- 125,003,300(+) TTTGG(C/T)AGCTG reference, missense
rs1130228 -- 125,003,422(+) TTGGT(C/T)TTGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SQLE Gene

Variant ID Type Subtype PubMed ID
nsv891434 CNV Gain 21882294
esv268241 CNV Insertion 20981092
esv274006 CNV Insertion 20981092

Variation tolerance for SQLE Gene

Residual Variation Intolerance Score: 48.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SQLE Gene

HapMap Linkage Disequilibrium report
SQLE
Human Gene Mutation Database (HGMD)
SQLE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SQLE Gene

Disorders for SQLE Gene

MalaCards: The human disease database

(4) MalaCards diseases for SQLE Gene - From: GeneCards

Disorder Aliases PubMed IDs
tinea cruris
  • dermatophytosis of groin and perianal area nos
tinea corporis
  • dermatophytosis of the trunk
pityriasis versicolor
  • infection by pityrosporum furfur
candida glabrata
  • torulopsis glabrata
- elite association
Search SQLE in MalaCards View complete list of genes associated with diseases

Relevant External Links for SQLE

Genetic Association Database (GAD)
SQLE
Human Genome Epidemiology (HuGE) Navigator
SQLE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SQLE
genes like me logo Genes that share disorders with SQLE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SQLE Gene

Publications for SQLE Gene

  1. In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenafine, against clinically important fungi in comparison with fluconazole and butenafine. (PMID: 16079485) Gao P.H. … Jiang Y.Y. (Biol. Pharm. Bull. 2005) 23 25 26 67
  2. Terbinafine: a review of its use in onychomycosis in adults. (PMID: 12477372) Darkes M.J. … Goa K.L. (Am J Clin Dermatol 2003) 23 25 26 67
  3. Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. (PMID: 12499173) Mukherjee P.K. … Ghannoum M.A. (Antimicrob. Agents Chemother. 2003) 23 25 26 67
  4. Interaction of terbinafine with human serum and serum proteins. (PMID: 1287164) Ryder N.S. … Frank I. (J. Med. Vet. Mycol. 1992) 23 25 26 67
  5. Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors. (PMID: 1951574) Vanden Bossche H. … Marichal P. (Am. J. Obstet. Gynecol. 1991) 23 25 26 67

Products for SQLE Gene

Sources for SQLE Gene

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