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Aliases for SPIB Gene

Aliases for SPIB Gene

  • Spi-B Transcription Factor 2 3
  • Spi-B Transcription Factor (Spi-1/PU.1 Related) 2 3 5
  • SPI-B 3

External Ids for SPIB Gene

Previous GeneCards Identifiers for SPIB Gene

  • GC19P051551
  • GC19P051283
  • GC19P055598
  • GC19P055614
  • GC19P050922
  • GC19P047261

Summaries for SPIB Gene

Entrez Gene Summary for SPIB Gene

  • The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for SPIB Gene

SPIB (Spi-B Transcription Factor) is a Protein Coding gene. Diseases associated with SPIB include Primary Biliary Cirrhosis and Blastic Plasmacytoid Dendritic Cell. Among its related pathways are NF-kappaB Signaling and Dendritic Cells Developmental Lineage Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SPI1.

UniProtKB/Swiss-Prot for SPIB Gene

  • Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5-GAGGAA-3) that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.

Gene Wiki entry for SPIB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIB Gene

Genomics for SPIB Gene

Regulatory Elements for SPIB Gene

Enhancers for SPIB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPIB on UCSC Golden Path with GeneCards custom track

Promoters for SPIB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPIB on UCSC Golden Path with GeneCards custom track

Genomic Location for SPIB Gene

Chromosome:
19
Start:
50,418,938 bp from pter
End:
50,431,313 bp from pter
Size:
12,376 bases
Orientation:
Plus strand

Genomic View for SPIB Gene

Genes around SPIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIB Gene

Proteins for SPIB Gene

  • Protein details for SPIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01892-SPIB_HUMAN
    Recommended name:
    Transcription factor Spi-B
    Protein Accession:
    Q01892
    Secondary Accessions:
    • A8K9C9
    • B4DUG6
    • Q15359

    Protein attributes for SPIB Gene

    Size:
    262 amino acids
    Molecular mass:
    28819 Da
    Quaternary structure:
    • Can form homotypic interactions. Interacts with IRF4. May also interact with CREBBP, EP300, SPI1/PU.1 related, JUN and TBP.

    Alternative splice isoforms for SPIB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPIB Gene

Proteomics data for SPIB Gene at MOPED

Post-translational modifications for SPIB Gene

No Post-translational modifications

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SPIB (SPIB)

No data available for DME Specific Peptides for SPIB Gene

Domains & Families for SPIB Gene

Gene Families for SPIB Gene

Protein Domains for SPIB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPIB Gene

Graphical View of Domain Structure for InterPro Entry

Q01892

UniProtKB/Swiss-Prot:

SPIB_HUMAN :
  • The protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich in proline, serine and threonine. Each of these domains may be required for transcriptional activation of a subset of target genes.
  • Belongs to the ETS family.
Domain:
  • The protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich in proline, serine and threonine. Each of these domains may be required for transcriptional activation of a subset of target genes.
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with SPIB: view

Function for SPIB Gene

Molecular function for SPIB Gene

GENATLAS Biochemistry:
transcription factor SPI-B,homolog to Spi-1/PU.1 putative oncogene,expressed in various hematopoietic cell lines
UniProtKB/Swiss-Prot Function:
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5-GAGGAA-3) that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.

Gene Ontology (GO) - Molecular Function for SPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with SPIB: view
genes like me logo Genes that share phenotypes with SPIB: view

Human Phenotype Ontology for SPIB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SPIB Gene

MGI Knock Outs for SPIB:

Animal Model Products

miRNA for SPIB Gene

miRTarBase miRNAs that target SPIB
Targeted motifs for SPIB Gene
HOMER Transcription Factor Regulatory Elements motif SPIB
  • Consensus sequence: AAAGRGGAAGTG Submotif: canonical Cell Type: OCILY3 GEO ID: GSE56857

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for SPIB Gene

Localization for SPIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIB Gene

Isoform 1: Nucleus.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPIB Gene COMPARTMENTS Subcellular localization image for SPIB gene
Compartment Confidence
nucleus 4
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SPIB Gene

Pathways & Interactions for SPIB Gene

genes like me logo Genes that share pathways with SPIB: view

Pathways by source for SPIB Gene

1 Cell Signaling Technology pathway for SPIB Gene
1 R&D Systems pathway for SPIB Gene

SIGNOR curated interactions for SPIB Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for SPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with SPIB: view

Drugs & Compounds for SPIB Gene

(1) Drugs for SPIB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SPIB: view

Transcripts for SPIB Gene

Unigene Clusters for SPIB Gene

Spi-B transcription factor (Spi-1/PU.1 related):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPIB Gene

No ASD Table

Relevant External Links for SPIB Gene

GeneLoc Exon Structure for
SPIB
ECgene alternative splicing isoforms for
SPIB

Expression for SPIB Gene

mRNA expression in normal human tissues for SPIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPIB Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPIB Gene



SOURCE GeneReport for Unigene cluster for SPIB Gene Hs.437905

mRNA Expression by UniProt/SwissProt for SPIB Gene

Q01892-SPIB_HUMAN
Tissue specificity: Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver.
genes like me logo Genes that share expression patterns with SPIB: view

Protein tissue co-expression partners for SPIB Gene

Primer Products

No data available for mRNA differential expression in normal tissues for SPIB Gene

Orthologs for SPIB Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPIB 35
  • 87.48 (n)
  • 87.36 (a)
-- 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SPIB 35
  • 87.53 (n)
  • 87.4 (a)
-- 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Spib 35
  • 83.72 (n)
  • 84.73 (a)
Spib 16
Spib 36
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Spib 35
  • 84.48 (n)
  • 85.11 (a)
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia spib 35
  • 59.81 (n)
  • 52.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53020 35
zebrafish
(Danio rerio)
Actinopterygii spi1a 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for SPIB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIB Gene

ENSEMBL:
Gene Tree for SPIB (if available)
TreeFam:
Gene Tree for SPIB (if available)

Paralogs for SPIB Gene

Paralogs for SPIB Gene

(2) SIMAP similar genes for SPIB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SPIB: view

Variants for SPIB Gene

Sequence variations from dbSNP and Humsavar for SPIB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11546996 - 50,423,008(+) TCCCT(A/C/G)CATAC intron-variant, reference, synonymous-codon, missense
rs12978475 -- 50,420,669(+) GTCAC(C/T)CAGGC intron-variant
rs8102583 -- 50,426,063(+) aatta(C/G)ctggg intron-variant
rs66579172 -- 50,425,013(+) TAATT(A/T)ATTTA intron-variant
rs71332003 -- 50,426,948(+) ACATA(-/A)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPIB Gene

Variant ID Type Subtype PubMed ID
dgv3976n71 CNV Loss 21882294
nsv912281 CNV Loss 21882294
nsv912282 CNV Loss 21882294
esv2661463 CNV Deletion 23128226

Variation tolerance for SPIB Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPIB Gene

Disorders for SPIB Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPIB Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
primary biliary cirrhosis
  • biliary liver cirrhosis
blastic plasmacytoid dendritic cell
  • blastic nk-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search SPIB in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPIB

Genetic Association Database (GAD)
SPIB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPIB
genes like me logo Genes that share disorders with SPIB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPIB Gene

Publications for SPIB Gene

  1. Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. (PMID: 1406622) Ray D. … Moreau-Gachelin F. (Mol. Cell. Biol. 1992) 2 3 4 23 67
  2. Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression. (PMID: 18552212) Schmidlin H. … Blom B. (Blood 2008) 3 23
  3. Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B. (PMID: 18792017) Nagasawa M. … Blom B. (Eur. J. Immunol. 2008) 3 23
  4. Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B. (PMID: 16317090) Dontje W. … Blom B. (Blood 2006) 3 23
  5. c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter. (PMID: 16263717) Geng C.D. … Vedeckis W.V. (J. Biol. Chem. 2005) 3 23

Products for SPIB Gene

Sources for SPIB Gene

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