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Aliases for SPIB Gene

Aliases for SPIB Gene

  • Spi-B Transcription Factor (Spi-1/PU.1 Related) 2 3
  • Transcription Factor Spi-B 3
  • SPI-B 3

External Ids for SPIB Gene

Summaries for SPIB Gene

Entrez Gene Summary for SPIB Gene

  • The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for SPIB Gene

SPIB (Spi-B Transcription Factor (Spi-1/PU.1 Related)) is a Protein Coding gene. Diseases associated with SPIB include primary biliary cirrhosis and blastic plasmacytoid dendritic cell. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is SPI1.

UniProtKB/Swiss-Prot for SPIB Gene

  • Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5-GAGGAA-3) that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.

Gene Wiki entry for SPIB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIB Gene

Genomics for SPIB Gene

Genomic Location for SPIB Gene

Start:
50,418,938 bp from pter
End:
50,431,313 bp from pter
Size:
12,376 bases
Orientation:
Plus strand

Genomic View for SPIB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIB Gene

Regulatory Elements for SPIB Gene

Proteins for SPIB Gene

  • Protein details for SPIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01892-SPIB_HUMAN
    Recommended name:
    Transcription factor Spi-B
    Protein Accession:
    Q01892
    Secondary Accessions:
    • A8K9C9
    • B4DUG6
    • Q15359

    Protein attributes for SPIB Gene

    Size:
    262 amino acids
    Molecular mass:
    28819 Da
    Quaternary structure:
    • Can form homotypic interactions. Interacts with IRF4. May also interact with CREBBP, EP300, SPI1/PU.1 related, JUN and TBP.

    Alternative splice isoforms for SPIB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPIB Gene

Proteomics data for SPIB Gene at MOPED

Post-translational modifications for SPIB Gene

No Post-translational modifications

No data available for DME Specific Peptides for SPIB Gene

Domains for SPIB Gene

Protein Domains for SPIB Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SPIB_HUMAN
Domain:
  • The protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich in proline, serine and threonine. Each of these domains may be required for transcriptional activation of a subset of target genes.:
    • Q01892
  • Contains 1 ETS DNA-binding domain.:
    • Q01892
Family:
  • Belongs to the ETS family.:
    • Q01892
genes like me logo Genes that share domains with SPIB: view

No data available for Gene Families for SPIB Gene

Function for SPIB Gene

Molecular function for SPIB Gene

GENATLAS Biochemistry: transcription factor SPI-B,homolog to Spi-1/PU.1 putative oncogene,expressed in various hematopoietic cell lines
UniProtKB/Swiss-Prot Function: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5-GAGGAA-3) that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.

Gene Ontology (GO) - Molecular Function for SPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with SPIB: view
genes like me logo Genes that share phenotypes with SPIB: view

Animal Models for SPIB Gene

MGI Knock Outs for SPIB:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SPIB Gene

Localization for SPIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIB Gene

Isoform 1: Nucleus.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPIB Gene COMPARTMENTS Subcellular localization image for SPIB gene
Compartment Confidence
nucleus 5
cytoskeleton 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm TAS 8670269
genes like me logo Genes that share ontologies with SPIB: view

Pathways for SPIB Gene

SuperPathways for SPIB Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with SPIB: view

No data available for Pathways by source for SPIB Gene

Compounds for SPIB Gene

(1) Novoseek inferred chemical compound relationships for SPIB Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 1
genes like me logo Genes that share compounds with SPIB: view

Transcripts for SPIB Gene

Unigene Clusters for SPIB Gene

Spi-B transcription factor (Spi-1/PU.1 related):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPIB Gene

No ASD Table

Relevant External Links for SPIB Gene

GeneLoc Exon Structure for
SPIB
ECgene alternative splicing isoforms for
SPIB

Expression for SPIB Gene

mRNA expression in normal human tissues for SPIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPIB Gene

SOURCE GeneReport for Unigene cluster for SPIB Gene Hs.437905

mRNA Expression by UniProt/SwissProt for SPIB Gene

Q01892-SPIB_HUMAN
Tissue specificity: Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver.
genes like me logo Genes that share expressions with SPIB: view

Orthologs for SPIB Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 87 (a)
OneToMany
SPIB 36
  • 87.48 (n)
  • 87.36 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 86 (a)
OneToMany
SPIB 36
  • 87.53 (n)
  • 87.4 (a)
mouse
(Mus musculus)
Mammalia Spib 36
  • 83.72 (n)
  • 84.73 (a)
Spib 16
Spib 37
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Spib 36
  • 84.48 (n)
  • 85.11 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 36 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC53020 36
tropical clawed frog
(Silurana tropicalis)
Amphibia spib 36
  • 59.81 (n)
  • 52.82 (a)
zebrafish
(Danio rerio)
Actinopterygii spi1a 37
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 17 (a)
OneToMany
Species with no ortholog for SPIB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIB Gene

ENSEMBL:
Gene Tree for SPIB (if available)
TreeFam:
Gene Tree for SPIB (if available)

Paralogs for SPIB Gene

Paralogs for SPIB Gene

Selected SIMAP similar genes for SPIB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SPIB: view

Variants for SPIB Gene

Sequence variations from dbSNP and Humsavar for SPIB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1137891 -- 50,428,638(+) GCAGT(G/T)CTTCC utr-variant-3-prime
rs1137894 -- 50,428,647(+) CCAGA(A/G)TCCCA utr-variant-3-prime
rs1137895 -- 50,428,707(+) GGGAC(C/G)TTTTT utr-variant-3-prime
rs1274613 -- 50,429,433(+) ggcaa(C/T)ggctc utr-variant-3-prime
rs1274614 -- 50,429,574(+) tgggg(A/G)tgaac utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPIB Gene

Variant ID Type Subtype PubMed ID
dgv3976n71 CNV Loss 21882294
nsv912281 CNV Loss 21882294
nsv912282 CNV Loss 21882294
esv2661463 CNV Deletion 23128226

Relevant External Links for SPIB Gene

HapMap Linkage Disequilibrium report
SPIB

Disorders for SPIB Gene

(1) University of Copenhagen DISEASES for SPIB Gene

(1) Novoseek inferred disease relationships for SPIB Gene

Disease -log(P) Hits PubMed IDs
leukemia 0.696 2

Relevant External Links for SPIB

Genetic Association Database (GAD)
SPIB
genes like me logo Genes that share disorders with SPIB: view

No data available for UniProtKB/Swiss-Prot for SPIB Gene

Publications for SPIB Gene

  1. Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. (PMID: 1406622) Ray D. … Moreau-Gachelin F. (Mol. Cell. Biol. 1992) 2 3 4 23
  2. Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. (PMID: 11841448) Nagy M. … Matthes T. (Br. J. Haematol. 2002) 3 4 23
  3. Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb. (PMID: 11864910) Yamamoto H. … Oikawa T. (Cell Growth Differ. 2002) 3 4 23
  4. The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development. (PMID: 12393575) Schotte R. … Spits H. (Blood 2003) 3 4 23
  5. An alternatively spliced isoform of the Spi-B transcription factor. (PMID: 8670269) Ray-Gallet D. … Moreau-Gachelin F. (Biochem. Biophys. Res. Commun. 1996) 3 4 23

Products for SPIB Gene

Sources for SPIB Gene

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