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Aliases for SPARC Gene

Aliases for SPARC Gene

  • Secreted Protein Acidic And Cysteine Rich 2 3
  • Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) 3 5
  • Secreted Protein Acidic And Rich In Cysteine 2 4
  • Basement-Membrane Protein 40 3 4
  • Osteonectin 2 4
  • BM-40 3 4
  • ON 3 4
  • Cysteine-Rich Protein 2
  • OI17 3

External Ids for SPARC Gene

Previous HGNC Symbols for SPARC Gene

  • ON

Previous GeneCards Identifiers for SPARC Gene

  • GC05M151110
  • GC05M151025
  • GC05M151070
  • GC05M151021
  • GC05M146186

Summaries for SPARC Gene

Entrez Gene Summary for SPARC Gene

  • This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]

GeneCards Summary for SPARC Gene

SPARC (Secreted Protein Acidic And Cysteine Rich) is a Protein Coding gene. Diseases associated with SPARC include osteogenesis imperfecta, type xvii and osteogenesis imperfecta, type iv. Among its related pathways are Platelet activation, signaling and aggregation and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is SPARCL1.

UniProtKB/Swiss-Prot for SPARC Gene

  • Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

Gene Wiki entry for SPARC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPARC Gene

Genomics for SPARC Gene

Regulatory Elements for SPARC Gene

Promoters for SPARC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPARC on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SPARC gene promoter:

Genomic Location for SPARC Gene

Chromosome:
5
Start:
151,661,096 bp from pter
End:
151,687,165 bp from pter
Size:
26,070 bases
Orientation:
Minus strand

Genomic View for SPARC Gene

Genes around SPARC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPARC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPARC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPARC Gene

Proteins for SPARC Gene

  • Protein details for SPARC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09486-SPRC_HUMAN
    Recommended name:
    SPARC
    Protein Accession:
    P09486
    Secondary Accessions:
    • D3DQH9
    • Q6IBK4

    Protein attributes for SPARC Gene

    Size:
    303 amino acids
    Molecular mass:
    34632 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA60993.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPARC Gene

neXtProt entry for SPARC Gene

Proteomics data for SPARC Gene at MOPED

Post-translational modifications for SPARC Gene

  • Glycosylation at Asn 116
  • Modification sites at PhosphoSitePlus

Other Protein References for SPARC Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SPARC (SPARC)

No data available for DME Specific Peptides for SPARC Gene

Domains & Families for SPARC Gene

Graphical View of Domain Structure for InterPro Entry

P09486

UniProtKB/Swiss-Prot:

SPRC_HUMAN :
  • Contains 1 EF-hand domain.
  • Belongs to the SPARC family.
Domain:
  • Contains 1 EF-hand domain.
  • Contains 1 follistatin-like domain.
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the SPARC family.
genes like me logo Genes that share domains with SPARC: view

No data available for Gene Families for SPARC Gene

Function for SPARC Gene

Molecular function for SPARC Gene

GENATLAS Biochemistry:
glycoprotein,acidic,cysteine rich,into the basement membrane,involved in extracellular matrix remodeling,interacting with collagen,thrombospondin,regulator of cell growth (osteonectin/BM40),and of activator of MMP2 at the cell surface,contributing to the proteolytic pathway associated with tumor invasion,overexpressed in hepatocellular carcinoma
UniProtKB/Swiss-Prot Function:
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
genes like me logo Genes that share phenotypes with SPARC: view

Human Phenotype Ontology for SPARC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SPARC Gene

MGI Knock Outs for SPARC:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPARC

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for SPARC Gene

Localization for SPARC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPARC Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPARC Gene COMPARTMENTS Subcellular localization image for SPARC gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 3
cytoskeleton 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPARC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005737 NOT cytoplasm IDA 1737102
GO:0005739 NOT mitochondrion IDA 1737102
GO:0016363 nuclear matrix IDA 15389586
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with SPARC: view

Pathways & Interactions for SPARC Gene

genes like me logo Genes that share pathways with SPARC: view

Gene Ontology (GO) - Biological Process for SPARC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IDA 12867428
GO:0006898 receptor-mediated endocytosis TAS --
GO:0007165 signal transduction IEA --
GO:0009629 response to gravity IEA --
GO:0010595 positive regulation of endothelial cell migration IDA 12867428
genes like me logo Genes that share ontologies with SPARC: view

No data available for SIGNOR curated interactions for SPARC Gene

Drugs & Compounds for SPARC Gene

(35) Drugs for SPARC Gene - From: Novoseek, HMDB, DGIdb, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paclitaxel Approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2621
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1881
Abraxane Approved October 2012 Pharma Biomarker Taxanes 0
calcium Nutra 0
Albumin-Bound Paclitaxel Pharma 2621

(28) Additional Compounds for SPARC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPARC: view

Transcripts for SPARC Gene

Unigene Clusters for SPARC Gene

Secreted protein, acidic, cysteine-rich (osteonectin):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPARC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c
SP1:
SP2: - -
SP3: - - - - -
SP4:

Relevant External Links for SPARC Gene

GeneLoc Exon Structure for
SPARC
ECgene alternative splicing isoforms for
SPARC

Expression for SPARC Gene

mRNA expression in normal human tissues for SPARC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPARC Gene

This gene is overexpressed in Artery - Aorta (x4.0).

Protein differential expression in normal tissues from HIPED for SPARC Gene

This gene is overexpressed in Amniocyte (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPARC Gene



SOURCE GeneReport for Unigene cluster for SPARC Gene Hs.111779

genes like me logo Genes that share expression patterns with SPARC: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPARC Gene

Orthologs for SPARC Gene

This gene was present in the common ancestor of animals.

Orthologs for SPARC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPARC 35
  • 92.96 (n)
  • 99.01 (a)
SPARC 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPARC 35
  • 92.63 (n)
  • 97.36 (a)
SPARC 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sparc 35
  • 88.3 (n)
  • 91.06 (a)
Sparc 16
Sparc 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPARC 35
  • 99.34 (n)
  • 100 (a)
SPARC 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sparc 35
  • 87.49 (n)
  • 90.37 (a)
oppossum
(Monodelphis domestica)
Mammalia SPARC 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPARC 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPARC 35
  • 84.56 (n)
  • 86.24 (a)
SPARC 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPARC 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76263 35
sparc 35
  • 77 (n)
  • 81.67 (a)
zebrafish
(Danio rerio)
Actinopterygii sparc 35
  • 76.86 (n)
  • 78.69 (a)
sparc 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8852 35
fruit fly
(Drosophila melanogaster)
Insecta BM-40-SPARC 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ost-1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for SPARC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPARC Gene

ENSEMBL:
Gene Tree for SPARC (if available)
TreeFam:
Gene Tree for SPARC (if available)

Paralogs for SPARC Gene

Paralogs for SPARC Gene

(2) SIMAP similar genes for SPARC Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SPARC: view

Variants for SPARC Gene

Sequence variations from dbSNP and Humsavar for SPARC Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_050431 -
rs13359508 - 151,671,694(+) AGGGA(C/T)CTGTA reference, missense
VAR_075142 Osteogenesis imperfecta 17 (OI17)
VAR_075143 Osteogenesis imperfecta 17 (OI17)
rs1023 -- 151,661,582(+) TATCT(C/G)TAAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPARC Gene

Variant ID Type Subtype PubMed ID
dgv6360n71 CNV Loss 21882294
nsv883038 CNV Loss 21882294
nsv5069 CNV Insertion 18451855

Variation tolerance for SPARC Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPARC Gene

HapMap Linkage Disequilibrium report
SPARC
Human Gene Mutation Database (HGMD)
SPARC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPARC Gene

Disorders for SPARC Gene

MalaCards: The human disease database

(32) MalaCards diseases for SPARC Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
osteogenesis imperfecta, type xvii
  • osteogenesis imperfecta 17
osteogenesis imperfecta, type iv
  • oi type iv
sparc-related osteogenesis imperfecta
  • osteogenesis imperfecta type xvii
osteofibrous dysplasia
  • ossifying fibroma
clear cell chondrosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search SPARC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SPRC_HUMAN
  • Osteogenesis imperfecta 17 (OI17) [MIM:616507]: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. {ECO:0000269 PubMed:26027498}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SPARC

Genetic Association Database (GAD)
SPARC
Human Genome Epidemiology (HuGE) Navigator
SPARC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPARC
genes like me logo Genes that share disorders with SPARC: view

No data available for Genatlas for SPARC Gene

Publications for SPARC Gene

  1. Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin). (PMID: 3410046) Lankat-Buttgereit B. … Krieg T. (FEBS Lett. 1988) 2 3 4 67
  2. Reduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC. (PMID: 19236378) Mawrin C. … Lendeckel U. (Brain Pathol. 2010) 3 23
  3. The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine. (PMID: 20087345) Bhoopathi P. … Lakka S.S. (Br. J. Cancer 2010) 3 23
  4. SPARC: a key player in the pathologies associated with obesity and diabetes. (PMID: 20195270) Kos K. … Wilding J.P. (Nat Rev Endocrinol 2010) 3 23
  5. SPARC mRNA expression as a prognostic marker for pancreatic adenocarcinoma patients. (PMID: 20393008) Miyoshi K. … Tanaka M. (Anticancer Res. 2010) 3 23

Products for SPARC Gene

Sources for SPARC Gene

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