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Aliases for SP4 Gene

Aliases for SP4 Gene

  • Sp4 Transcription Factor 2 3
  • SPR-1 3 4
  • Transcription Factor Sp4 3
  • HF1B 3

External Ids for SP4 Gene

Summaries for SP4 Gene

GeneCards Summary for SP4 Gene

SP4 (Sp4 Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for SP4 Gene

  • Binds to GT and GC boxes promoters elements. Probable transcriptional activator

Gene Wiki entry for SP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP4 Gene

Genomics for SP4 Gene

Genomic Location for SP4 Gene

21,428,034 bp from pter
21,514,822 bp from pter
86,789 bases
Plus strand

Genomic View for SP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP4 Gene

Regulatory Elements for SP4 Gene

Proteins for SP4 Gene

  • Protein details for SP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor Sp4
    Protein Accession:
    Secondary Accessions:
    • O60402
    • Q32M52

    Protein attributes for SP4 Gene

    784 amino acids
    Molecular mass:
    81985 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SP4 Gene

Proteomics data for SP4 Gene at MOPED

Post-translational modifications for SP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SP4 Gene

Domains for SP4 Gene

Gene Families for SP4 Gene

  • ZNF :Zinc fingers, C2H2-type
  • SP :Specificity protein transcription factors

Protein Domains for SP4 Gene


  • Belongs to the Sp1 C2H2-type zinc-finger protein family.:
    • Q02446
  • Contains 3 C2H2-type zinc fingers.:
    • Q02446
genes like me logo Genes that share domains with SP4: view

Function for SP4 Gene

Molecular function for SP4 Gene

GENATLAS Biochemistry: transcription factor SP4,GT box binding protein
UniProtKB/Swiss-Prot Function: Binds to GT and GC boxes promoters elements. Probable transcriptional activator

Gene Ontology (GO) - Molecular Function for SP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SP4: view
genes like me logo Genes that share phenotypes with SP4: view

Animal Models for SP4 Gene

MGI Knock Outs for SP4:

miRNA for SP4 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SP4 Gene

Localization for SP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP4 Gene


Subcellular locations from

Jensen Localization Image for SP4 Gene COMPARTMENTS Subcellular localization image for SP4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0015630 microtubule cytoskeleton IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with SP4: view

Pathways for SP4 Gene

SuperPathways for SP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 12560508
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0008016 regulation of heart contraction IEA --
genes like me logo Genes that share ontologies with SP4: view

No data available for Pathways by source for SP4 Gene

Compounds for SP4 Gene

(1) Novoseek inferred chemical compound relationships for SP4 Gene

Compound -log(P) Hits PubMed IDs
zinc 17.6 1
genes like me logo Genes that share compounds with SP4: view

Transcripts for SP4 Gene

Unigene Clusters for SP4 Gene

Sp4 transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SP4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP2: -

Relevant External Links for SP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SP4 Gene

mRNA expression in normal human tissues for SP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SP4 Gene

SOURCE GeneReport for Unigene cluster for SP4 Gene Hs.88013

mRNA Expression by UniProt/SwissProt for SP4 Gene

Tissue specificity: Abundant in brain
genes like me logo Genes that share expressions with SP4: view

Orthologs for SP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SP4 36
  • 99.87 (n)
  • 100 (a)
SP4 37
  • 100 (a)
(Bos Taurus)
Mammalia SP4 36
  • 95.19 (n)
  • 96.55 (a)
SP4 37
  • 97 (a)
(Canis familiaris)
Mammalia SP4 36
  • 96.51 (n)
  • 98.47 (a)
SP4 37
  • 98 (a)
(Mus musculus)
Mammalia Sp4 36
  • 92.46 (n)
  • 97.19 (a)
Sp4 16
Sp4 37
  • 98 (a)
(Monodelphis domestica)
Mammalia SP4 37
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia SP4 37
  • 96 (a)
(Rattus norvegicus)
Mammalia Sp4 36
  • 92.84 (n)
  • 97.44 (a)
(Gallus gallus)
Aves SP4 36
  • 83.01 (n)
  • 89.62 (a)
SP4 37
  • 89 (a)
(Anolis carolinensis)
Reptilia SP4 37
  • 80 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68827 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sp4 36
  • 76.68 (n)
  • 83.99 (a)
(Danio rerio)
Actinopterygii sp4 36
  • 62.22 (n)
  • 65.96 (a)
sp4 37
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spps 37
  • 23 (a)
EP2237 38
  • 67 (a)
btd 38
  • 57 (a)
CG5669 38
  • 62 (a)
CG3065 38
  • 57 (a)
(Caenorhabditis elegans)
Secernentea sptf-3 37
  • 34 (a)
Y40B1A.4 38
  • 68 (a)
T22C8.5 38
  • 53 (a)
Species with no ortholog for SP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SP4 Gene

Gene Tree for SP4 (if available)
Gene Tree for SP4 (if available)

Paralogs for SP4 Gene Pseudogenes for SP4 Gene

genes like me logo Genes that share paralogs with SP4: view

Variants for SP4 Gene

Sequence variations from dbSNP and Humsavar for SP4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1771 -- 21,493,879(-) CTTAC(A/G)ATATT intron-variant
rs39302 -- 21,427,572(+) CCTGT(C/T)GGTGG upstream-variant-2KB
rs39303 -- 21,428,961(+) TTGAG(A/G)GTATA intron-variant
rs39304 -- 21,430,895(+) ACAAT(C/T)ATTGC intron-variant
rs40245 -- 21,430,918(+) ATTCT(A/T)AGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SP4 Gene

Variant ID Type Subtype PubMed ID
nsv830921 CNV Gain 17160897
nsv524775 CNV Loss 19592680
esv2734112 CNV Deletion 23290073
esv2734113 CNV Deletion 23290073

Relevant External Links for SP4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for SP4 Gene

Relevant External Links for SP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SP4: view

No data available for UniProtKB/Swiss-Prot for SP4 Gene

Publications for SP4 Gene

  1. Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease. (PMID: 17356515) Gao Y.Q. … Farber D.B. (Mol. Vis. 2007) 3 23 49
  2. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. (PMID: 1454515) Hagen G. … Suske G. (Nucleic Acids Res. 1992) 2 3 4
  3. Transcription factor SP4 is a susceptibility gene for bipolar disorder. (PMID: 19401786) Zhou X. … Kelsoe J.R. (PLoS ONE 2009) 3 23 49
  4. [Association of Sp4 gene polymorphism with pathological tortuosity of internal carotid arteries]. (PMID: 19656107) Voevoda M.I. … Smirnova I.u.V. (Kardiologiia 2009) 3 49
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for SP4 Gene

Sources for SP4 Gene

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