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Aliases for SP4 Gene

Aliases for SP4 Gene

  • Sp4 Transcription Factor 2 3 5
  • SPR-1 3 4
  • HF1B 3

External Ids for SP4 Gene

Previous GeneCards Identifiers for SP4 Gene

  • GC07P021112
  • GC07P021177
  • GC07P021212
  • GC07P021240

Summaries for SP4 Gene

GeneCards Summary for SP4 Gene

SP4 (Sp4 Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SP1.

UniProtKB/Swiss-Prot for SP4 Gene

  • Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

Gene Wiki entry for SP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP4 Gene

Genomics for SP4 Gene

Regulatory Elements for SP4 Gene

Promoters for SP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SP4 Gene

Chromosome:
7
Start:
21,428,034 bp from pter
End:
21,514,822 bp from pter
Size:
86,789 bases
Orientation:
Plus strand

Genomic View for SP4 Gene

Genes around SP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP4 Gene

Proteins for SP4 Gene

  • Protein details for SP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02446-SP4_HUMAN
    Recommended name:
    Transcription factor Sp4
    Protein Accession:
    Q02446
    Secondary Accessions:
    • O60402
    • Q32M52

    Protein attributes for SP4 Gene

    Size:
    784 amino acids
    Molecular mass:
    81985 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SP4 Gene

Proteomics data for SP4 Gene at MOPED

Post-translational modifications for SP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SP4 Gene

Domains & Families for SP4 Gene

Protein Domains for SP4 Gene

Suggested Antigen Peptide Sequences for SP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q02446

UniProtKB/Swiss-Prot:

SP4_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SP4: view

Function for SP4 Gene

Molecular function for SP4 Gene

GENATLAS Biochemistry:
transcription factor SP4,GT box binding protein
UniProtKB/Swiss-Prot Function:
Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

Gene Ontology (GO) - Molecular Function for SP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SP4: view
genes like me logo Genes that share phenotypes with SP4: view

Animal Models for SP4 Gene

MGI Knock Outs for SP4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP4 Gene

Localization for SP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP4 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SP4 Gene COMPARTMENTS Subcellular localization image for SP4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 4
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SP4: view

Pathways & Interactions for SP4 Gene

SuperPathways for SP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SP4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SP4 Gene

Drugs & Compounds for SP4 Gene

(1) Drugs for SP4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SP4: view

Transcripts for SP4 Gene

Unigene Clusters for SP4 Gene

Sp4 transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SP4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for SP4 Gene

GeneLoc Exon Structure for
SP4
ECgene alternative splicing isoforms for
SP4

Expression for SP4 Gene

mRNA expression in normal human tissues for SP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SP4 Gene

This gene is overexpressed in CD8 Tcells (26.7), CD4 Tcells (21.7), Spleen (7.9), and Pancreas (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SP4 Gene



SOURCE GeneReport for Unigene cluster for SP4 Gene Hs.88013

mRNA Expression by UniProt/SwissProt for SP4 Gene

Q02446-SP4_HUMAN
Tissue specificity: Abundant in brain.
genes like me logo Genes that share expression patterns with SP4: view

Protein tissue co-expression partners for SP4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SP4 Gene

Orthologs for SP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SP4 35
  • 95.19 (n)
  • 96.55 (a)
SP4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SP4 35
  • 96.51 (n)
  • 98.47 (a)
SP4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sp4 35
  • 92.46 (n)
  • 97.19 (a)
Sp4 16
Sp4 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SP4 35
  • 99.87 (n)
  • 100 (a)
SP4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sp4 35
  • 92.84 (n)
  • 97.44 (a)
oppossum
(Monodelphis domestica)
Mammalia SP4 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SP4 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves SP4 35
  • 83.01 (n)
  • 89.62 (a)
SP4 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SP4 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sp4 35
  • 76.68 (n)
  • 83.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68827 35
zebrafish
(Danio rerio)
Actinopterygii sp4 35
  • 62.22 (n)
  • 65.96 (a)
sp4 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta btd 37
  • 57 (a)
CG3065 37
  • 57 (a)
CG5669 37
  • 62 (a)
EP2237 37
  • 67 (a)
Spps 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T22C8.5 37
  • 53 (a)
Y40B1A.4 37
  • 68 (a)
sptf-3 36
  • 34 (a)
OneToMany
Species with no ortholog for SP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SP4 Gene

ENSEMBL:
Gene Tree for SP4 (if available)
TreeFam:
Gene Tree for SP4 (if available)

Paralogs for SP4 Gene

Paralogs for SP4 Gene

Pseudogenes.org Pseudogenes for SP4 Gene

genes like me logo Genes that share paralogs with SP4: view

Variants for SP4 Gene

Sequence variations from dbSNP and Humsavar for SP4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1042848 - 21,429,754(+) AAATT(A/C)AGCTC nc-transcript-variant, reference, missense
rs1771 -- 21,493,879(-) CTTAC(A/G)ATATT intron-variant
rs39302 -- 21,427,572(+) CCTGT(C/T)GGTGG upstream-variant-2KB
rs39303 -- 21,428,961(+) TTGAG(A/G)GTATA intron-variant
rs39304 -- 21,430,895(+) ACAAT(C/T)ATTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SP4 Gene

Variant ID Type Subtype PubMed ID
nsv830921 CNV Gain 17160897
nsv524775 CNV Loss 19592680
esv2734112 CNV Deletion 23290073
esv2734113 CNV Deletion 23290073

Variation tolerance for SP4 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SP4 Gene

HapMap Linkage Disequilibrium report
SP4
Human Gene Mutation Database (HGMD)
SP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP4 Gene

Disorders for SP4 Gene

Relevant External Links for SP4

Genetic Association Database (GAD)
SP4
Human Genome Epidemiology (HuGE) Navigator
SP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SP4

No disorders were found for SP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SP4 Gene

Publications for SP4 Gene

  1. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. (PMID: 1454515) Hagen G. … Suske G. (Nucleic Acids Res. 1992) 2 3 4 67
  2. Confirmed rare copy number variants implicate novel genes in schizophrenia. (PMID: 20298200) Tam G.W. … Grant S.G. (Biochem. Soc. Trans. 2010) 3 23
  3. Transcription factor SP4 is a susceptibility gene for bipolar disorder. (PMID: 19401786) Zhou X. … Kelsoe J.R. (PLoS ONE 2009) 3 23
  4. Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease. (PMID: 17356515) Gao Y.Q. … Farber D.B. (Mol. Vis. 2007) 3 23
  5. Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx. (PMID: 15781457) Lerner L.E. … Farber D.B. (J. Biol. Chem. 2005) 3 23

Products for SP4 Gene

Sources for SP4 Gene

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