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Aliases for SOX15 Gene

Aliases for SOX15 Gene

  • SRY-Box 15 2 3 5
  • SRY (Sex Determining Region Y)-Box 20 2 3
  • SRY (Sex Determining Region Y)-Box 15 2 3
  • SRY Box 15 2 3
  • SOX20 3 4
  • SOX26 3 4
  • SOX27 3 4
  • Protein SOX-12 4
  • Protein SOX-20 4
  • SOX12 4

External Ids for SOX15 Gene

Previous HGNC Symbols for SOX15 Gene

  • SOX20

Previous GeneCards Identifiers for SOX15 Gene

  • GC17M007905
  • GC17M008231
  • GC17M007434
  • GC17M007692
  • GC17M007433
  • GC17M007436
  • GC17M007491
  • GC17M007385

Summaries for SOX15 Gene

Entrez Gene Summary for SOX15 Gene

  • This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX15 Gene

SOX15 (SRY-Box 15) is a Protein Coding gene. Among its related pathways are ERK Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is SOX11.

UniProtKB/Swiss-Prot for SOX15 Gene

  • Binds to the 5-AACAAT-3 sequence.

Gene Wiki entry for SOX15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX15 Gene

Genomics for SOX15 Gene

Regulatory Elements for SOX15 Gene

Enhancers for SOX15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SOX15 on UCSC Golden Path with GeneCards custom track

Promoters for SOX15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SOX15 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOX15 Gene

Chromosome:
17
Start:
7,588,178 bp from pter
End:
7,590,170 bp from pter
Size:
1,993 bases
Orientation:
Minus strand

Genomic View for SOX15 Gene

Genes around SOX15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX15 Gene

Proteins for SOX15 Gene

  • Protein details for SOX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60248-SOX15_HUMAN
    Recommended name:
    Protein SOX-15
    Protein Accession:
    O60248
    Secondary Accessions:
    • B4DWU7
    • D3DTQ0
    • P35717
    • Q9Y6W7

    Protein attributes for SOX15 Gene

    Size:
    233 amino acids
    Molecular mass:
    25251 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SOX15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOX15 Gene

Proteomics data for SOX15 Gene at MOPED

Post-translational modifications for SOX15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SOX15 Gene

Domains & Families for SOX15 Gene

Gene Families for SOX15 Gene

Protein Domains for SOX15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SOX15 Gene

Graphical View of Domain Structure for InterPro Entry

O60248

UniProtKB/Swiss-Prot:

SOX15_HUMAN :
  • Contains 1 HMG box DNA-binding domain.
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with SOX15: view

Function for SOX15 Gene

Molecular function for SOX15 Gene

UniProtKB/Swiss-Prot Function:
Binds to the 5-AACAAT-3 sequence.

Gene Ontology (GO) - Molecular Function for SOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SOX15: view
genes like me logo Genes that share phenotypes with SOX15: view

Animal Models for SOX15 Gene

MGI Knock Outs for SOX15:

Animal Model Products

Targeted motifs for SOX15 Gene
HOMER Transcription Factor Regulatory Elements motif SOX15
  • Consensus sequence: RAACAATGGN Submotif: canonical Cell Type: CPA GEO ID: GSE62909

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for SOX15 Gene

Localization for SOX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOX15 Gene COMPARTMENTS Subcellular localization image for SOX15 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for SOX15 Gene

Pathways & Interactions for SOX15 Gene

SuperPathways for SOX15 Gene

Superpath Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with SOX15: view

Pathways by source for SOX15 Gene

1 Qiagen pathway for SOX15 Gene

Gene Ontology (GO) - Biological Process for SOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS 17363903
GO:0006355 regulation of transcription, DNA-templated NAS 8332506
GO:0008584 male gonad development TAS 9540826
GO:0030154 cell differentiation ISS 16759287
GO:0043403 skeletal muscle tissue regeneration IEA --
genes like me logo Genes that share ontologies with SOX15: view

No data available for SIGNOR curated interactions for SOX15 Gene

Drugs & Compounds for SOX15 Gene

No Compound Related Data Available

Transcripts for SOX15 Gene

mRNA/cDNA for SOX15 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX15 Gene

SRY (sex determining region Y)-box 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOX15 Gene

No ASD Table

Relevant External Links for SOX15 Gene

GeneLoc Exon Structure for
SOX15
ECgene alternative splicing isoforms for
SOX15

Expression for SOX15 Gene

mRNA expression in normal human tissues for SOX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX15 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.9), Skin - Not Sun Exposed (Suprapubic) (x5.1), and Skin - Sun Exposed (Lower leg) (x4.2).

SOURCE GeneReport for Unigene cluster for SOX15 Gene Hs.95582

mRNA Expression by UniProt/SwissProt for SOX15 Gene

O60248-SOX15_HUMAN
Tissue specificity: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.
genes like me logo Genes that share expression patterns with SOX15: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SOX15 Gene

Orthologs for SOX15 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SOX15 35
  • 84.69 (n)
  • 81.12 (a)
SOX15 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOX15 35
  • 85.12 (n)
  • 84.55 (a)
SOX15 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sox15 35
  • 79.8 (n)
  • 74.46 (a)
Sox15 16
Sox15 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SOX15 35
  • 99.57 (n)
  • 99.57 (a)
SOX15 36
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sox19a 36
  • 26 (a)
ManyToMany
sox19b 36
  • 32 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta SoxN 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sox-2 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for SOX15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SOX15 Gene

ENSEMBL:
Gene Tree for SOX15 (if available)
TreeFam:
Gene Tree for SOX15 (if available)

Paralogs for SOX15 Gene

(17) SIMAP similar genes for SOX15 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SOX15 Gene

genes like me logo Genes that share paralogs with SOX15: view

Variants for SOX15 Gene

Sequence variations from dbSNP and Humsavar for SOX15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs16956818 -- 7,589,751(+) TGGAA(A/G)GGTCT utr-variant-5-prime
rs34793392 -- 7,590,717(+) AGAGG(C/T)CTGTG upstream-variant-2KB
rs12944649 -- 7,588,910(+) CAGTC(A/G)CCTGA intron-variant
rs59894475 -- 7,590,587(+) ACTTA(-/AGCCC)TCCCA upstream-variant-2KB
rs59209949 -- 7,590,582(+) AGAAA(-/ACT)TAAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SOX15 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907651 CNV Loss 21882294

Variation tolerance for SOX15 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOX15 Gene

HapMap Linkage Disequilibrium report
SOX15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOX15 Gene

Disorders for SOX15 Gene

Relevant External Links for SOX15

Genetic Association Database (GAD)
SOX15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOX15

No disorders were found for SOX15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOX15 Gene

Publications for SOX15 Gene

  1. SOX20, a new member of the SOX gene family, is located on chromosome 17p13. (PMID: 8978787) Meyer J. … Scherer G. (Cytogenet. Cell Genet. 1996) 2 3 4 67
  2. Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3. (PMID: 9730625) Critcher R. … Farr C.J. (Cytogenet. Cell Genet. 1998) 2 3
  3. SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/I^-catenin signaling. (PMID: 23318427) Thu K.L. … Tsao M.S. (Oncogene 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PMID: 22197929) Yu X.Q. … Liu J.J. (Nat. Genet. 2012) 3

Products for SOX15 Gene

Sources for SOX15 Gene

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