Aliases for SOX5 Gene
External Ids for SOX5 Gene
Previous GeneCards Identifiers for SOX5 Gene
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOX5 Gene
SOX5 (SRY-Box 5) is a Protein Coding gene. Diseases associated with SOX5 include Lamb-Shaffer Syndrome. Among its related pathways are Neural Crest Differentiation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is SOX6.
UniProtKB/Swiss-Prot for SOX5 Gene
Binds specifically to the DNA sequence 5-AACAAT-3. Activates transcription of COL2A1 and AGC1 in vitro.