Aliases for SOX4 Gene
External Ids for SOX4 Gene
Previous GeneCards Identifiers for SOX4 Gene
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOX4 Gene
SOX4 (SRY-Box 4) is a Protein Coding gene. Diseases associated with SOX4 include pediatric ependymoma. Among its related pathways are Signaling by GPCR and MicroRNAs in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is SOX11.
UniProtKB/Swiss-Prot for SOX4 Gene
Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5-AACAAAG-3 motif.