Aliases for SOS1 Gene
External Ids for SOS1 Gene
Previous HGNC Symbols for SOS1 Gene
Previous GeneCards Identifiers for SOS1 Gene
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOS1 Gene
SOS1 (Son Of Sevenless Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with SOS1 include sos1-related noonan syndrome and fibromatosis, gingival, 1. Among its related pathways are PI3K-Akt signaling pathway and PI3K/AKT Signaling in Cancer. GO annotations related to this gene include protein heterodimerization activity and SH3 domain binding. An important paralog of this gene is RALGDS.
UniProtKB/Swiss-Prot for SOS1 Gene
Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).