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Aliases for SOD3 Gene

Aliases for SOD3 Gene

  • Superoxide Dismutase 3, Extracellular 2 3 5
  • EC 1.15.1.1 4 63
  • EC-SOD 3 4
  • Testicular Tissue Protein Li 175 3

External Ids for SOD3 Gene

Previous GeneCards Identifiers for SOD3 Gene

  • GC04P024921
  • GC04P024484
  • GC04P024546
  • GC04P024472
  • GC04P024139

Summaries for SOD3 Gene

Entrez Gene Summary for SOD3 Gene

  • This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]

GeneCards Summary for SOD3 Gene

SOD3 (Superoxide Dismutase 3, Extracellular) is a Protein Coding gene. Diseases associated with SOD3 include asbestosis and diabetic polyneuropathy. Among its related pathways are Cellular Senescence and Detoxification of Reactive Oxygen Species. GO annotations related to this gene include heparin binding and superoxide dismutase activity. An important paralog of this gene is CCS.

UniProtKB/Swiss-Prot for SOD3 Gene

  • Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Gene Wiki entry for SOD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOD3 Gene

Genomics for SOD3 Gene

Regulatory Elements for SOD3 Gene

Enhancers for SOD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SOD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOD3 Gene

Chromosome:
4
Start:
24,789,912 bp from pter
End:
24,800,845 bp from pter
Size:
10,934 bases
Orientation:
Plus strand

Genomic View for SOD3 Gene

Genes around SOD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOD3 Gene

Proteins for SOD3 Gene

  • Protein details for SOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08294-SODE_HUMAN
    Recommended name:
    Extracellular superoxide dismutase [Cu-Zn]
    Protein Accession:
    P08294
    Secondary Accessions:
    • Q5U781
    • Q6FHA2

    Protein attributes for SOD3 Gene

    Size:
    240 amino acids
    Molecular mass:
    25851 Da
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for SOD3 Gene

neXtProt entry for SOD3 Gene

Proteomics data for SOD3 Gene at MOPED

Selected DME Specific Peptides for SOD3 Gene

Post-translational modifications for SOD3 Gene

  • Glycosylation at Asn 107, Lys 229, and Lys 230
  • Modification sites at PhosphoSitePlus

Other Protein References for SOD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for SOD3 Gene

Protein Domains for SOD3 Gene

Suggested Antigen Peptide Sequences for SOD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08294

UniProtKB/Swiss-Prot:

SODE_HUMAN :
  • Belongs to the Cu-Zn superoxide dismutase family.
Family:
  • Belongs to the Cu-Zn superoxide dismutase family.
genes like me logo Genes that share domains with SOD3: view

No data available for Gene Families for SOD3 Gene

Function for SOD3 Gene

Molecular function for SOD3 Gene

GENATLAS Biochemistry:
superoxide dismutase 3,extracellular,predominantly expressed in heart,placenta,pancreas,lung,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity:
2 superoxide + 2 H(+) = O(2) + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Enzyme Numbers (IUBMB) for SOD3 Gene

Gene Ontology (GO) - Molecular Function for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding IBA --
genes like me logo Genes that share ontologies with SOD3: view
genes like me logo Genes that share phenotypes with SOD3: view

Animal Models for SOD3 Gene

MGI Knock Outs for SOD3:

Animal Model Products

miRNA for SOD3 Gene

miRTarBase miRNAs that target SOD3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOD3 Gene

Localization for SOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOD3 Gene

Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOD3 Gene COMPARTMENTS Subcellular localization image for SOD3 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 3
cytosol 2
mitochondrion 2
peroxisome 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with SOD3: view

Pathways & Interactions for SOD3 Gene

genes like me logo Genes that share pathways with SOD3: view

Gene Ontology (GO) - Biological Process for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IEA --
GO:0006979 response to oxidative stress IEA --
GO:0019430 removal of superoxide radicals IEA,TAS --
genes like me logo Genes that share ontologies with SOD3: view

No data available for SIGNOR curated interactions for SOD3 Gene

Drugs & Compounds for SOD3 Gene

(27) Drugs for SOD3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2102
Copper Pharma 161
Manganese Pharma 32
Hydrogen peroxide Pharma 47

(23) Additional Compounds for SOD3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
superoxide
  • Dioxidanidyl
  • Dioxide(1-)
  • Hyperoxid
  • Superoxide
  • Superoxide anion
11062-77-4
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with SOD3: view

Transcripts for SOD3 Gene

mRNA/cDNA for SOD3 Gene

Unigene Clusters for SOD3 Gene

Superoxide dismutase 3, extracellular:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOD3 Gene

No ASD Table

Relevant External Links for SOD3 Gene

GeneLoc Exon Structure for
SOD3
ECgene alternative splicing isoforms for
SOD3

Expression for SOD3 Gene

mRNA expression in normal human tissues for SOD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOD3 Gene

This gene is overexpressed in Artery - Aorta (x7.8), Esophagus - Muscularis (x4.5), and Artery - Coronary (x4.5).

Protein differential expression in normal tissues from HIPED for SOD3 Gene

This gene is overexpressed in Prostate (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SOD3 Gene



SOURCE GeneReport for Unigene cluster for SOD3 Gene Hs.2420

mRNA Expression by UniProt/SwissProt for SOD3 Gene

P08294-SODE_HUMAN
Tissue specificity: Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
genes like me logo Genes that share expression patterns with SOD3: view

Protein tissue co-expression partners for SOD3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SOD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SOD3 35
  • 83.19 (n)
  • 75.85 (a)
ECSOD 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOD3 35
  • 83.25 (n)
  • 73.21 (a)
SOD3 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sod3 35
  • 76.76 (n)
  • 70.67 (a)
Sod3 16
Sod3 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SOD3 35
  • 100 (n)
  • 100 (a)
SOD3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sod3 35
  • 76.13 (n)
  • 68.47 (a)
oppossum
(Monodelphis domestica)
Mammalia SOD3 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOD3 35
  • 57.14 (n)
  • 53.46 (a)
SOD3 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOD3 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sod3 35
  • 53.72 (n)
  • 50.49 (a)
zebrafish
(Danio rerio)
Actinopterygii sod3a 35
  • 54.48 (n)
  • 49.71 (a)
sod3a 36
  • 42 (a)
OneToMany
sod3b 36
  • 47 (a)
OneToMany
sod3b 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sod3 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sod-4 36
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOD1 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5360 36
  • 39 (a)
OneToMany
Species with no ortholog for SOD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOD3 Gene

ENSEMBL:
Gene Tree for SOD3 (if available)
TreeFam:
Gene Tree for SOD3 (if available)

Paralogs for SOD3 Gene

Paralogs for SOD3 Gene

(1) SIMAP similar genes for SOD3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SOD3: view

Variants for SOD3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SOD3 Gene

P08294-SODE_HUMAN
The variant Gly-231 which is found in about 2.2% of individual displays a 10-fold increased plasma EC-SOD content due to reduced heparin-binding affinity and thus the impairment of its binding ability to endothelial cell surface.

Sequence variations from dbSNP and Humsavar for SOD3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_014705 -
rs2536512 - 24,799,693(+) ACGGC(A/G)CGCTC nc-transcript-variant, reference, missense
rs17879876 - 24,799,792(+) CCCGC(A/G)CCAAG nc-transcript-variant, reference, missense
rs800444 -- 24,798,241(+) TTTCC(A/G)ACTGT intron-variant
rs800445 -- 24,798,261(+) TGTCT(C/T)CCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SOD3 Gene

Variant ID Type Subtype PubMed ID
nsv829887 CNV Gain+Loss 17160897

Variation tolerance for SOD3 Gene

Gene Damage Index Score: 7.32; 81.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOD3 Gene

HapMap Linkage Disequilibrium report
SOD3
Human Gene Mutation Database (HGMD)
SOD3

Disorders for SOD3 Gene

MalaCards: The human disease database

(11) MalaCards diseases for SOD3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asbestosis
  • idiopathic interstitial pneumonitis - from asbestos exposure
diabetic polyneuropathy
  • diabetes mellitus with polyneuropathy
amyotrophic lateral sclerosis-parkinsonism/dementia complex
  • amyotrophic lateral sclerosis-parkinsonism/dementia complex, susceptibility to
myocardial stunning
keratoconus
  • conical cornea
- elite association - COSMIC cancer census association via MalaCards
Search SOD3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SOD3

Genetic Association Database (GAD)
SOD3
Human Genome Epidemiology (HuGE) Navigator
SOD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOD3
genes like me logo Genes that share disorders with SOD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOD3 Gene

Publications for SOD3 Gene

  1. An arginine-213 to glycine mutation in human extracellular-superoxide dismutase reduces susceptibility to trypsin-like proteinases. (PMID: 8864862) Adachi T. … Hirano K. (J. Biochem. 1996) 3 4 23 67
  2. CpG methylation attenuates Sp1 and Sp3 binding to the human extracellular superoxide dismutase promoter and regulates its cell-specific expression. (PMID: 20079429) Zelko I.N. … Folz R.J. (Free Radic. Biol. Med. 2010) 3 23
  3. Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. (PMID: 18948423) Arcaroli J.J. … Crapo J.D. (Am. J. Respir. Crit. Care Med. 2009) 3 23
  4. Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (PMID: 19108943) Rosta K. … VAcr A. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2009) 3 23
  5. The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding. (PMID: 19289127) Antonyuk S.V. … Hasnain S.S. (J. Mol. Biol. 2009) 3 23

Products for SOD3 Gene

Sources for SOD3 Gene

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