Aliases for SOD3 Gene
External Ids for SOD3 Gene
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOD3 Gene
SOD3 (Superoxide Dismutase 3, Extracellular) is a Protein Coding gene. Diseases associated with SOD3 include keratopathy and coronary stenosis. Among its related pathways are Cellular Senescence and Selenium Pathway. GO annotations related to this gene include heparin binding and superoxide dismutase activity. An important paralog of this gene is CCS.
UniProtKB/Swiss-Prot for SOD3 Gene
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen