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Aliases for SOD3 Gene

Aliases for SOD3 Gene

  • Superoxide Dismutase 3 2 3 5
  • Superoxide Dismutase 3, Extracellular 2 3
  • EC 4 58
  • EC-SOD 3 4
  • Extracellular Superoxide Dismutase [Cu-Zn] 3
  • Testicular Tissue Protein Li 175 3

External Ids for SOD3 Gene

Previous GeneCards Identifiers for SOD3 Gene

  • GC04P024921
  • GC04P024484
  • GC04P024546
  • GC04P024472
  • GC04P024139

Summaries for SOD3 Gene

Entrez Gene Summary for SOD3 Gene

  • This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]

GeneCards Summary for SOD3 Gene

SOD3 (Superoxide Dismutase 3) is a Protein Coding gene. Diseases associated with SOD3 include Asbestosis and Diabetic Polyneuropathy. Among its related pathways are Cellular Senescence (REACTOME) and Selenium Micronutrient Network. GO annotations related to this gene include heparin binding and superoxide dismutase activity. An important paralog of this gene is CCS.

UniProtKB/Swiss-Prot for SOD3 Gene

  • Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Gene Wiki entry for SOD3 Gene

Additional gene information for SOD3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOD3 Gene

Genomics for SOD3 Gene

Regulatory Elements for SOD3 Gene

Enhancers for SOD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H024855 1 Ensembl ENCODE 11.3 +67.6 67602 3 CBFB JUNB DPF2 BATF JUND POLR2A BCL11A EED IKZF1 FOS SOD3 LGI2 GC04M024806 GC04P024947
GH04H024762 0.6 ENCODE 17.1 -25.9 -25865 2.2 CTBP1 PKNOX1 GATA3 SIN3A DPF2 FOXA1 SOD3 ENSG00000251638 PIR57270
GH04H024687 0.7 ENCODE 9.8 -102.6 -102563 0.6 CTCF PKNOX1 ATF1 RB1 TRIM22 ZNF384 REST RAD21 GATA3 GATA2 DHX15 MIR573 SOD3 LINC02473 PIR57270
GH04H024752 0.6 ENCODE 11.2 -36.0 -36049 2 PKNOX1 RFX1 MNT DPF2 FOXA1 CREB1 CUX1 FOS NFE2L2 SOD3 LGI2 ENSG00000251638 PIR57270
GH04H024730 0.4 ENCODE 16 -59.1 -59146 1.3 JUND ZBTB40 SOD3 CCDC149 PIR57270 ENSG00000251638
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SOD3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SOD3 Gene

Genomic Locations for SOD3 Gene
10,934 bases
Plus strand

Genomic View for SOD3 Gene

Genes around SOD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOD3 Gene

Proteins for SOD3 Gene

  • Protein details for SOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Extracellular superoxide dismutase [Cu-Zn]
    Protein Accession:
    Secondary Accessions:
    • Q5U781
    • Q6FHA2

    Protein attributes for SOD3 Gene

    240 amino acids
    Molecular mass:
    25851 Da
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for SOD3 Gene

neXtProt entry for SOD3 Gene

Selected DME Specific Peptides for SOD3 Gene


Post-translational modifications for SOD3 Gene

  • Glycosylation at Asn107, isoforms=229, and isoforms=230
  • Modification sites at PhosphoSitePlus

Other Protein References for SOD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SOD3 Gene

Gene Families for SOD3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SOD3 Gene


Suggested Antigen Peptide Sequences for SOD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Cu-Zn superoxide dismutase family.
  • Belongs to the Cu-Zn superoxide dismutase family.
genes like me logo Genes that share domains with SOD3: view

Function for SOD3 Gene

Molecular function for SOD3 Gene

GENATLAS Biochemistry:
superoxide dismutase 3,extracellular,predominantly expressed in heart,placenta,pancreas,lung,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity:
2 superoxide + 2 H(+) = O(2) + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Enzyme Numbers (IUBMB) for SOD3 Gene

Phenotypes From GWAS Catalog for SOD3 Gene

Gene Ontology (GO) - Molecular Function for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004784 superoxide dismutase activity TAS,IBA --
GO:0005507 copper ion binding IBA --
GO:0005515 protein binding IPI 15528465
GO:0008201 heparin binding IEA --
GO:0008270 zinc ion binding IBA --
genes like me logo Genes that share ontologies with SOD3: view
genes like me logo Genes that share phenotypes with SOD3: view

Animal Models for SOD3 Gene

MGI Knock Outs for SOD3:

miRNA for SOD3 Gene

miRTarBase miRNAs that target SOD3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOD3 Gene

Localization for SOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOD3 Gene

Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOD3 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 3
mitochondrion 2
peroxisome 2
plasma membrane 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IDA 20551380
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with SOD3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SOD3 Gene

Pathways & Interactions for SOD3 Gene

genes like me logo Genes that share pathways with SOD3: view

Gene Ontology (GO) - Biological Process for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006801 superoxide metabolic process IEA --
GO:0006979 response to oxidative stress IEA --
GO:0019430 removal of superoxide radicals IEA --
GO:0034599 cellular response to oxidative stress TAS --
genes like me logo Genes that share ontologies with SOD3: view

No data available for SIGNOR curated interactions for SOD3 Gene

Drugs & Compounds for SOD3 Gene

(27) Drugs for SOD3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved Pharma 188
Oxygen Approved, Vet_approved Pharma 0
Zinc Approved Pharma 2359
Manganese Approved Nutra 35
Hydrogen peroxide Approved, Vet_approved Pharma 68

(23) Additional Compounds for SOD3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
  • Dioxidanidyl
  • Dioxide(1-)
  • Hyperoxid
  • Superoxide
  • Superoxide anion
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with SOD3: view

Transcripts for SOD3 Gene

mRNA/cDNA for SOD3 Gene

Unigene Clusters for SOD3 Gene

Superoxide dismutase 3, extracellular:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOD3 Gene

No ASD Table

Relevant External Links for SOD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOD3 Gene

This gene is overexpressed in Artery - Aorta (x7.8), Esophagus - Muscularis (x4.5), and Artery - Coronary (x4.5).

Protein differential expression in normal tissues from HIPED for SOD3 Gene

This gene is overexpressed in Prostate (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SOD3 Gene

Protein tissue co-expression partners for SOD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SOD3 Gene:


SOURCE GeneReport for Unigene cluster for SOD3 Gene:


mRNA Expression by UniProt/SwissProt for SOD3 Gene:

Tissue specificity: Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.

Evidence on tissue expression from TISSUES for SOD3 Gene

  • Blood(4.5)
  • Liver(4.3)
  • Intestine(4.2)
  • Bone marrow(4)
  • Lung(2.9)
  • Nervous system(2.9)
  • Heart(2.6)
  • Kidney(2.5)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with SOD3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SOD3 Gene

Orthologs for SOD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SOD3 34 33
  • 100 (n)
(Canis familiaris)
Mammalia SOD3 34 33
  • 83.25 (n)
(Bos Taurus)
Mammalia SOD3 33
  • 83.19 (n)
  • 70 (a)
(Mus musculus)
Mammalia Sod3 16 34 33
  • 76.76 (n)
(Rattus norvegicus)
Mammalia Sod3 33
  • 76.13 (n)
(Monodelphis domestica)
Mammalia SOD3 34
  • 50 (a)
(Gallus gallus)
Aves SOD3 34 33
  • 57.14 (n)
(Anolis carolinensis)
Reptilia SOD3 34
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sod3 33
  • 53.72 (n)
(Danio rerio)
Actinopterygii sod3a 33 34
  • 54.48 (n)
sod3b 34 34
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sod3 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea sod-4 34
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOD1 34
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5360 34
  • 39 (a)
Species where no ortholog for SOD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOD3 Gene

Gene Tree for SOD3 (if available)
Gene Tree for SOD3 (if available)

Paralogs for SOD3 Gene

Paralogs for SOD3 Gene

(1) SIMAP similar genes for SOD3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SOD3: view

Variants for SOD3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SOD3 Gene

The variant Gly-231 which is found in about 2.2% of individual displays a 10-fold increased plasma EC-SOD content due to reduced heparin-binding affinity and thus the impairment of its binding ability to endothelial cell surface.

Sequence variations from dbSNP and Humsavar for SOD3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1799895 Pathogenic 24,800,212(+) AGAAG(C/G)GGCGG nc-transcript-variant, reference, missense
rs1001239092 -- 24,799,068(+) CGTAG(C/T)ACATG intron-variant
rs1001999409 -- 24,800,483(+) ATTTG(C/T)ACCGA nc-transcript-variant, utr-variant-3-prime
rs1002154904 -- 24,795,394(+) AACCC(A/C)AAAAT upstream-variant-2KB
rs1002493412 -- 24,794,265(+) CTCAG(A/C)GGGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SOD3 Gene

Variant ID Type Subtype PubMed ID
nsv829887 CNV gain+loss 17160897

Variation tolerance for SOD3 Gene

Gene Damage Index Score: 7.32; 81.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOD3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for SOD3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SOD3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • idiopathic interstitial pneumonitis - from asbestos exposure
diabetic polyneuropathy
  • diabetes mellitus with polyneuropathy
myocardial stunning
optic neuritis
diabetic neuropathy
  • diabetic neuropathies
- elite association - COSMIC cancer census association via MalaCards
Search SOD3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SOD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SOD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOD3 Gene

Publications for SOD3 Gene

  1. Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. (PMID: 18948423) Arcaroli JJ … Crapo JD (American journal of respiratory and critical care medicine 2009) 3 22 45 60
  2. Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (PMID: 19108943) Rosta K … Vér A (European journal of obstetrics, gynecology, and reproductive biology 2009) 3 22 45 60
  3. The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding. (PMID: 19289127) Antonyuk SV … Hasnain SS (Journal of molecular biology 2009) 3 4 22 60
  4. Manganese and extracellular superoxide dismutase polymorphisms and risk for asbestosis. (PMID: 19636420) Franko A … Dolzan V (Journal of biomedicine & biotechnology 2009) 3 22 45 60
  5. A haplotype-based case-control study examining human extracellular superoxide dismutase gene and essential hypertension. (PMID: 18971527) Naganuma T … Usami R (Hypertension research : official journal of the Japanese Society of Hypertension 2008) 3 22 45 60

Products for SOD3 Gene

Sources for SOD3 Gene

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