Aliases for SOD2 Gene
External Ids for SOD2 Gene
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOD2 Gene
SOD2 (Superoxide Dismutase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with SOD2 include microvascular complications of diabetes 6 and motor neuron disease. Among its related pathways are Cellular Senescence and PEDF Induced Signaling. GO annotations related to this gene include identical protein binding and oxygen binding.
UniProtKB/Swiss-Prot for SOD2 Gene
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.