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Aliases for SNX2 Gene

Aliases for SNX2 Gene

  • Sorting Nexin 2 2 3 5
  • Transformation-Related Gene 9 Protein 3 4
  • TRG-9 3 4
  • CTB-36H16.2 3

External Ids for SNX2 Gene

Previous GeneCards Identifiers for SNX2 Gene

  • GC05P121741
  • GC05P122437
  • GC05P122141
  • GC05P122186
  • GC05P122138
  • GC05P122110
  • GC05P117298

Summaries for SNX2 Gene

Entrez Gene Summary for SNX2 Gene

  • This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013]

GeneCards Summary for SNX2 Gene

SNX2 (Sorting Nexin 2) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and TGF-beta Receptor Signaling Pathway. GO annotations related to this gene include phosphatidylinositol binding and epidermal growth factor receptor binding. An important paralog of this gene is SNX5.

UniProtKB/Swiss-Prot for SNX2 Gene

  • Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901).

Gene Wiki entry for SNX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX2 Gene

Genomics for SNX2 Gene

Regulatory Elements for SNX2 Gene

Enhancers for SNX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNX2 on UCSC Golden Path with GeneCards custom track

Promoters for SNX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX2 Gene

Chromosome:
5
Start:
122,774,996 bp from pter
End:
122,834,539 bp from pter
Size:
59,544 bases
Orientation:
Plus strand

Genomic View for SNX2 Gene

Genes around SNX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX2 Gene

Proteins for SNX2 Gene

  • Protein details for SNX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60749-SNX2_HUMAN
    Recommended name:
    Sorting nexin-2
    Protein Accession:
    O60749
    Secondary Accessions:
    • B3KN44
    • B4DEK4
    • B7Z408
    • O43650
    • P82862
    • Q53XK8
    • Q597H6
    • Q9BTS8

    Protein attributes for SNX2 Gene

    Size:
    519 amino acids
    Molecular mass:
    58471 Da
    Quaternary structure:
    • Predominantly forms heterodimers with BAR domain-containing sorting nexins SNX5, SNX6 and SNX32; can self-associate to form homodimers (PubMed:23085988). The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also descibed as vacuolar protein sorting subcomplex (VPS), and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity (Probable). Interacts with SNX5, SNX6, SNX32, VPS26A, VPS29, VPS35, FNBP1, KALRN, RHOG (GDP-bound form) (PubMed:11438682, PubMed:14596906, PubMed:17101778, PubMed:19935774., PubMed:19619496, PubMed:20604901, PubMed:23085988).

    Alternative splice isoforms for SNX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX2 Gene

Proteomics data for SNX2 Gene at MOPED

Post-translational modifications for SNX2 Gene

  • Ubiquitination at Lys 116 and Lys 248
  • Modification sites at PhosphoSitePlus

Other Protein References for SNX2 Gene

No data available for DME Specific Peptides for SNX2 Gene

Domains & Families for SNX2 Gene

Gene Families for SNX2 Gene

Protein Domains for SNX2 Gene

Suggested Antigen Peptide Sequences for SNX2 Gene

Graphical View of Domain Structure for InterPro Entry

O60749

UniProtKB/Swiss-Prot:

SNX2_HUMAN :
  • The BAR domain is able to sense membrane curvature upon dimerization. Membrane remodeling seems to implicate insertion of a N-terminal amphipatric helix (AH) in the membrane (Probable).
  • Belongs to the sorting nexin family.
Domain:
  • The BAR domain is able to sense membrane curvature upon dimerization. Membrane remodeling seems to implicate insertion of a N-terminal amphipatric helix (AH) in the membrane (Probable).
  • Contains 1 BAR domain.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX2: view

Function for SNX2 Gene

Molecular function for SNX2 Gene

UniProtKB/Swiss-Prot Function:
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901).

Gene Ontology (GO) - Molecular Function for SNX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278302
GO:0035091 phosphatidylinositol binding IEA,IBA --
genes like me logo Genes that share ontologies with SNX2: view
genes like me logo Genes that share phenotypes with SNX2: view

Animal Models for SNX2 Gene

MGI Knock Outs for SNX2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNX2 Gene

Localization for SNX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX2 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269 PubMed:18088323, ECO:0000269 PubMed:20604901}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX2 Gene COMPARTMENTS Subcellular localization image for SNX2 gene
Compartment Confidence
endosome 5
extracellular 5
cytosol 3
golgi apparatus 2
lysosome 2
nucleus 2
vacuole 2

Gene Ontology (GO) - Cellular Components for SNX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol NAS 26220253
GO:0016020 membrane IDA 9819414
GO:0030027 lamellipodium IEA --
GO:0030904 retromer complex IDA 11102511
genes like me logo Genes that share ontologies with SNX2: view

Pathways & Interactions for SNX2 Gene

genes like me logo Genes that share pathways with SNX2: view

Pathways by source for SNX2 Gene

Gene Ontology (GO) - Biological Process for SNX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IBA --
GO:0016050 vesicle organization IBA --
genes like me logo Genes that share ontologies with SNX2: view

No data available for SIGNOR curated interactions for SNX2 Gene

Drugs & Compounds for SNX2 Gene

(1) Additional Compounds for SNX2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNX2: view

Transcripts for SNX2 Gene

Unigene Clusters for SNX2 Gene

Sorting nexin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX2 Gene

No ASD Table

Relevant External Links for SNX2 Gene

GeneLoc Exon Structure for
SNX2
ECgene alternative splicing isoforms for
SNX2

Expression for SNX2 Gene

mRNA expression in normal human tissues for SNX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNX2 Gene

This gene is overexpressed in Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX2 Gene



SOURCE GeneReport for Unigene cluster for SNX2 Gene Hs.713554

genes like me logo Genes that share expression patterns with SNX2: view

Protein tissue co-expression partners for SNX2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX2 Gene

Orthologs for SNX2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNX2 35
  • 94.8 (n)
  • 97.3 (a)
SNX2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX2 35
  • 96.19 (n)
  • 99.25 (a)
SNX2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx2 35
  • 92.36 (n)
  • 98.07 (a)
Snx2 16
Snx2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNX2 35
  • 99.74 (n)
  • 99.42 (a)
SNX2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx2 35
  • 92.94 (n)
  • 97.69 (a)
oppossum
(Monodelphis domestica)
Mammalia SNX2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX2 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX2 35
  • 85.71 (n)
  • 90.93 (a)
SNX2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx2 35
  • 78.69 (n)
  • 87.52 (a)
Str.6438 35
African clawed frog
(Xenopus laevis)
Amphibia snx2-prov 35
zebrafish
(Danio rerio)
Actinopterygii snx2 35
  • 69.17 (n)
  • 76.83 (a)
wufj81a03 35
SNX2 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2774 37
  • 52 (a)
Snx1 35
  • 53.26 (n)
  • 53 (a)
Snx1 36
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009255 35
  • 55.81 (n)
  • 53.08 (a)
worm
(Caenorhabditis elegans)
Secernentea C05D9.1 37
  • 35 (a)
snx-1 35
  • 46.97 (n)
  • 37.86 (a)
snx-1 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX4 36
  • 18 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04137 35
  • 45.82 (n)
  • 37.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for SNX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX2 Gene

ENSEMBL:
Gene Tree for SNX2 (if available)
TreeFam:
Gene Tree for SNX2 (if available)

Paralogs for SNX2 Gene

Paralogs for SNX2 Gene

(3) SIMAP similar genes for SNX2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SNX2 Gene

genes like me logo Genes that share paralogs with SNX2: view

Variants for SNX2 Gene

Sequence variations from dbSNP and Humsavar for SNX2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs995191 -- 122,777,756(-) aggta(C/T)tgaaa intron-variant
rs6595408 -- 122,777,980(+) ctatt(A/G)gcctc intron-variant
rs6595409 -- 122,778,061(+) gagta(A/G)gaaca intron-variant
rs3756360 -- 122,786,936(-) TAGTA(C/T)GCAGG intron-variant
rs3756361 -- 122,786,759(-) AGGCC(A/G)ACTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX2 Gene

Variant ID Type Subtype PubMed ID
nsv830471 CNV Gain 17160897

Variation tolerance for SNX2 Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SNX2 Gene

Disorders for SNX2 Gene

Relevant External Links for SNX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX2

No disorders were found for SNX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX2 Gene

Publications for SNX2 Gene

  1. Identification of a family of sorting nexin molecules and characterization of their association with receptors. (PMID: 9819414) Haft C.R. … Taylor S.I. (Mol. Cell. Biol. 1998) 2 3 4 23 67
  2. Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin. (PMID: 20138391) Lieu Z.Z. … Gleeson P.A. (Eur. J. Cell Biol. 2010) 3 23
  3. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. (PMID: 17101778) Rojas R. … Bonifacino J.S. (Mol. Cell. Biol. 2007) 3 23
  4. Abstrakt interacts with and regulates the expression of sorting nexin-2. (PMID: 15690390) Abdul-Ghani M. … Ngsee J.K. (J. Cell. Physiol. 2005) 3 23
  5. The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. (PMID: 11438682) Fuchs U. … Borkhardt A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 23

Products for SNX2 Gene

Sources for SNX2 Gene

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