Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SNX1 Gene

Aliases for SNX1 Gene

  • Sorting Nexin 1 2 3
  • Sorting Nexin 1A 3
  • Sorting Nexin-1 3
  • HsT17379 3
  • SNX1A 6
  • VPS5 3

External Ids for SNX1 Gene

Summaries for SNX1 Gene

Entrez Gene Summary for SNX1 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX1 Gene

SNX1 (Sorting Nexin 1) is a Protein Coding gene. Among its related pathways are TGF-beta Receptor Signaling Pathway. GO annotations related to this gene include phosphatidylinositol binding and protein transporter activity. An important paralog of this gene is SNX4.

UniProtKB/Swiss-Prot for SNX1 Gene

  • Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).

Gene Wiki entry for SNX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX1 Gene

Genomics for SNX1 Gene

Genomic Location for SNX1 Gene

Start:
64,094,076 bp from pter
End:
64,146,090 bp from pter
Size:
52,015 bases
Orientation:
Plus strand

Genomic View for SNX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX1 Gene

Regulatory Elements for SNX1 Gene

Proteins for SNX1 Gene

  • Protein details for SNX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13596-SNX1_HUMAN
    Recommended name:
    Sorting nexin-1
    Protein Accession:
    Q13596
    Secondary Accessions:
    • A6NM19
    • A8K6T7
    • H0Y2M5
    • O60750
    • O60751
    • Q6ZRJ8

    Protein attributes for SNX1 Gene

    Size:
    522 amino acids
    Molecular mass:
    59070 Da
    Quaternary structure:
    • Predominantly forms heterodimers with BAR domain-containing sorting nexins SNX5, SNX6 and SNX32; can self-associate to form homodimers (PubMed:23085988). The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS) and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity (Probable). Interacts with SNX5, SNX6, SNX32, VPS26A, VPS29, VPS35, DRD5, DENND5A, KALRN, RHOG (GDP-bound form) (PubMed:9819414, PubMed:11102511, PubMed:19619496, PubMed:19935774, PubMed:19619496, PubMed:20604901, PubMed:23085988, PubMed:23152498). The interaction with SNX2 is reported controversially (PubMed:9819414, PubMed:11997453, PubMed:19619496, PubMed:23085988). Interacts with DNAJC13; prevented by presence of HGS (PubMed:19874558). Interacts with HGS (By similarity).
    Miscellaneous:
    • Binds phosphatidylinositol 3-phosphate (PtdIns-(3)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2) in liposome-based assays. Can bind PtdIns(3,4,5)P3 in protein:lipid overlay assays, but not in liposome-based assays

    Three dimensional structures from OCA and Proteopedia for SNX1 Gene

    Alternative splice isoforms for SNX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX1 Gene

Proteomics data for SNX1 Gene at MOPED

Post-translational modifications for SNX1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys286

No data available for DME Specific Peptides for SNX1 Gene

Domains for SNX1 Gene

Gene Families for SNX1 Gene

HGNC:
  • SNX :Sorting nexins

Protein Domains for SNX1 Gene

UniProtKB/Swiss-Prot:

SNX1_HUMAN
Domain:
  • The BAR domain is able to sense membrane curvature upon dimerization (PubMed:19816406). Membrane remodeling seems to implicate insertion of a N-terminal amphipatric helix (AH) in the membrane (Probable).:
    • Q13596
  • Contains 1 BAR domain.:
    • Q13596
  • Contains 1 PX (phox homology) domain.:
    • Q13596
Family:
  • Belongs to the sorting nexin family.:
    • Q13596
genes like me logo Genes that share domains with SNX1: view

Function for SNX1 Gene

Molecular function for SNX1 Gene

GENATLAS Biochemistry: sorting nexin 1,sorting the internalized receptors from endosome to lysosome
UniProtKB/Swiss-Prot Function: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).

Gene Ontology (GO) - Molecular Function for SNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IDA 9819414
GO:0005158 insulin receptor binding IDA 9819414
GO:0005515 protein binding IPI 11102511
GO:0035091 phosphatidylinositol binding IDA 15498486
GO:0042802 identical protein binding IPI 11102511
genes like me logo Genes that share ontologies with SNX1: view

Phenotypes for SNX1 Gene

genes like me logo Genes that share phenotypes with SNX1: view

Animal Models for SNX1 Gene

MGI Knock Outs for SNX1:

miRNA for SNX1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SNX1 Gene

Localization for SNX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX1 Gene

Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalizes with DNAJC13 and Shiginella dysenteria toxin stxB on early endosomes (PubMed:19874558). Colocalized with F-actin at the leading edge of lamellipodia in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269 PubMed:15498486, ECO:0000269 PubMed:18088323, ECO:0000269 PubMed:20604901}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX1 Gene COMPARTMENTS Subcellular localization image for SNX1 gene
Compartment Confidence
endosome 5
cytosol 3
golgi apparatus 3
nucleus 2
vacuole 2
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11279102
GO:0005768 endosome --
GO:0005769 early endosome --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with SNX1: view

Pathways for SNX1 Gene

genes like me logo Genes that share pathways with SNX1: view

Pathways by source for SNX1 Gene

1 BioSystems pathway for SNX1 Gene

Gene Ontology (GO) - Biological Process for SNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IMP 15498486
GO:0016050 vesicle organization IBA --
GO:0016197 endosomal transport --
GO:0031623 receptor internalization IMP 20070609
GO:0034498 early endosome to Golgi transport IMP 15498486
genes like me logo Genes that share ontologies with SNX1: view

Compounds for SNX1 Gene

(6) Novoseek inferred chemical compound relationships for SNX1 Gene

Compound -log(P) Hits PubMed IDs
mannose 6-phosphate 72.5 3
ptdins(3)p 65.6 2
phosphatidylinositol 41.5 4
phosphoinositide 25.3 3
tyrosine 9.29 3
genes like me logo Genes that share compounds with SNX1: view

Transcripts for SNX1 Gene

Unigene Clusters for SNX1 Gene

Sorting nexin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - - -
SP7:

Relevant External Links for SNX1 Gene

GeneLoc Exon Structure for
SNX1
ECgene alternative splicing isoforms for
SNX1

Expression for SNX1 Gene

mRNA expression in normal human tissues for SNX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX1 Gene

SOURCE GeneReport for Unigene cluster for SNX1 Gene Hs.188634

genes like me logo Genes that share expressions with SNX1: view

Orthologs for SNX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX1 36
  • 99.68 (n)
  • 99.81 (a)
SNX1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX1 36
  • 93.81 (n)
  • 96.55 (a)
SNX1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX1 36
  • 94.24 (n)
  • 98.08 (a)
SNX1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx1 36
  • 89.96 (n)
  • 94.43 (a)
Snx1 16
Snx1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX1 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX1 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx1 36
  • 90.04 (n)
  • 95.02 (a)
chicken
(Gallus gallus)
Aves SNX1 36
  • 78.95 (n)
  • 85.1 (a)
SNX1 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX1 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx1 36
  • 71.25 (n)
  • 78.49 (a)
zebrafish
(Danio rerio)
Actinopterygii snx1a 36
  • 68.15 (n)
  • 74.21 (a)
snx1a 37
  • 55 (a)
OneToMany
snx1b 37
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Snx1 37
  • 42 (a)
OneToMany
CG2774 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea snx-1 37
  • 33 (a)
OneToMany
C05D9.1 38
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX4 37
  • 16 (a)
OneToMany
VPS5 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToMany
Species with no ortholog for SNX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX1 Gene

ENSEMBL:
Gene Tree for SNX1 (if available)
TreeFam:
Gene Tree for SNX1 (if available)

Paralogs for SNX1 Gene

Paralogs for SNX1 Gene

genes like me logo Genes that share paralogs with SNX1: view

Variants for SNX1 Gene

Sequence variations from dbSNP and Humsavar for SNX1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs9664 -- 64,137,819(+) AGAAT(A/G)GTTTC intron-variant, utr-variant-3-prime
rs332255 -- 64,099,061(+) CAATA(A/C)ATGCT intron-variant
rs332256 -- 64,097,544(+) AAGTT(C/T)CCTGC intron-variant
rs332257 -- 64,096,655(+) AAAGG(C/T)CCTTT intron-variant
rs749504 -- 64,138,408(-) AGAGA(A/G)CCCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SNX1 Gene

Variant ID Type Subtype PubMed ID
nsv833036 CNV Loss 17160897
esv273472 CNV Insertion 20981092
esv2560472 CNV Deletion 19546169

Relevant External Links for SNX1 Gene

HapMap Linkage Disequilibrium report
SNX1

Disorders for SNX1 Gene

No disorders were found for SNX1 Gene.

No data available for UniProtKB/Swiss-Prot for SNX1 Gene

Publications for SNX1 Gene

  1. Enhanced degradation of EGF receptors by a sorting nexin, SNX1. (PMID: 8638121) Kurten R.C. … Gill G.N. (Science 1996) 2 3 4 23
  2. Determinants of the endosomal localization of sorting nexin 1. (PMID: 15673616) Zhong Q. … Gill G.N. (Mol. Biol. Cell 2005) 3 4 23
  3. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. (PMID: 17101778) Rojas R. … Bonifacino J.S. (Mol. Cell. Biol. 2007) 3 4 23
  4. Identification of a family of sorting nexin molecules and characterization of their association with receptors. (PMID: 9819414) Haft C.R. … Taylor S.I. (Mol. Cell. Biol. 1998) 3 4 23
  5. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. (PMID: 11102511) Renfrew Haft C. … Taylor S.I. (Mol. Biol. Cell 2000) 3 4 23

Products for SNX1 Gene

Sources for SNX1 Gene

Back to Top

Content